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All Journal Jurnal Pendidikan Matematika dan IPA Jurnal Bioterdidik: Wahana Ekspresi Ilmiah MEDISAINS Jurnal Kebidanan Edu Sains: Jurnal Pendidikan Sains dan Matematika Pharmascience Jurnal Bioedukasi Jurnal Fitofarmaka Indonesia JURNAL KESEHATAN LINGKUNGAN: Jurnal dan Aplikasi Teknik Kesehatan Lingkungan BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) BIOEDUSCIENCE Jurnal SOLMA Biosel: Biologi Science and Education Indonesian Journal of Biology Education Bioedusiana: Jurnal Pendidikan Biologi Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Ilmiah Biologi UMA (JIBIOMA) BioEksakta : Jurnal Ilmiah Biologi Unsoed Indigenous Biologi Jurnal Insan Farmasi Indonesia Bioscientist : Jurnal Ilmiah Biologi Jurnal Penelitian Sains dan Pendidikan (JPSP) Jurnal Ilmiah Kesehatan (JIKA) Madani: Jurnal Pengabdian Ilmiah. Asalibuna Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Kapas: Kumpulan Artikel Pengabdian Masyarakat Jurnal Pengabdian Kepada Masyarakat Radisi Jurnal KALANDRA Ardhi: Jurnal Pengabdian dalam Negri Jurnal Medika Veterinaria Biodik: Jurnal Ilmiah Pendidikan Biologi Tifani : Jurnal Penelitian dan Pengabdian Kepada Masyarakat Manfaat: Jurnal Pengabdian Pada Masyarakat Indonesia Jurnal Pelayanan Masyarakat Jurnal Pengabdian Masyarakat Mentari Masyarakat Berkarya: Jurnal Pengabdian dan Perubahan Sosial Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Noor Hujjatusnaini
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : MEDISAINS

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Antihyperglicemic effect of Musa paradisiaca extract in vivo Hujjatusnaini, Noor; Nirmalasari, Ridha
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.18814

Abstract

Background: Musa paradisiaca has  been widely studied for its antihyperglycemic effects, showing potential as an alternative natural remedy for diabetes. However, variability in genetic factors, environmental conditions, and geographical origins may influence its bioactive compound composition and efficacy. Thus, further validation through controlled studies is required to ensure consistent therapeutic effects.Purpose: : This study aimed to evaluate the antihyperglycemic effect of Musa paradisiaca stem extract in vivo, providing additional validation for its therapeutic potential and determining the optimal concentration for clinical relevance.Method: An experimental posttest-only control group design was used. Thirty-five male Balb/c strain mice were induced into hyperglycemia using alloxan. They were then randomly divided into treatment groups receiving different concentrations of Musa paradisiaca stem extract (5%, 15%, 25%, 35%, and 45%), a positive control group (metformin), and a negative control group. Blood glucose levels were measured and analyzed statistically using One-Way ANOVA.Result: Administration of the stem extract at 15% concentration showed the most significant antihyperglycemic effect, with an average blood glucose level reduction to 63.8 mg/dL, comparable to the positive control group (metformin). Conversely, the highest concentration tested (45%) exhibited minimal effectiveness, with an average glucose level of 151.8 mg/dL, indicating reduced antihyperglycemic activity.Conclusion: The optimal antihyperglycemic effect of Musa paradisiaca stem extract was achieved at a concentration of 15%, demonstrating therapeutic efficacy comparable to metformin. This extract shows promise as a natural alternative agent in diabetes treatment. Further studies, including clinical trials, are recommended to confirm these findings.
Antimicrobial activity of Etlingera elatior leaf extract in Staphylococcus aureus-induced cystitis: an in vivo study Ridha Nirmalasari; Hujjatusnaini, Noor; Sari, Mita; Wahyuni Nurqadriyani Bustan
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.24470

Abstract

Background: Etlingera elatior has been reported to possess antimicrobial properties; however, its therapeutic effects in bacterial cystitis, particularly those caused by Staphylococcus aureus (S. aureus), remain inadequately explored in vivo. Objective: This study aimed to evaluate the antimicrobial and anti-inflammatory effects of Etlingera elatior leaf extract in an experimental model of S. aureus cystitis. Methods: A true experimental posttest-only design was conducted using 28 male BALB/c mice induced with S. aureus. The animals were allocated into control and treatment groups receiving Etlingera elatior leaf extract at concentrations of 40%, 50%, 60%, 70%, and 80%. Therapeutic outcomes were assessed based on urinary tract mucosal fluid secretion and bacterial colony counts. Data were analyzed using one-way ANOVA followed by post hoc testing. Results: Treatment with Etlingera elatior leaf extract significantly reduced cystitis severity compared with the infected control group (p < 0.05). The extract demonstrated both antimicrobial and anti-inflammatory effects, as indicated by reductions in bacterial load and mucosal secretion. Among the tested concentrations, the 40% extract showed the most consistent therapeutic effect, with outcomes comparable to ciprofloxacin. Conclusions: Etlingera elatior leaf extract exhibits potential as an alternative therapeutic agent for bacterial cystitis. Its antimicrobial and anti-inflammatory properties support its further development as a complementary treatment for urinary tract infections.
Co-Authors Aín, Latifah Nur Adiansyah, Romi Afriliani, Hesti Agriana, Brenda Mila ahmad yani Ahmad, Dony Ajiza, Pratisa Defiera Ajiza, Pratisa Deifirera Alia, Rahmah Alya Meiana, Nurma Amelia Fitriani, Amelia Amin, Astuti Muh Anggraeni, Cici Ramadhan Artani Hasbi Astina Astina Astina Astina, Astina astuti muh amin Awaluddin, Annisa Maharani Ayatusa'adah, Ayatusa'adah Ayu Handayani Ayu Tiara Putri, Ayu Tiara Azizah, Sarah Azzahra, Jahida Bismillah, Alif Bunga Nur Siammukaromah, Jamalika Dalila, Aupi Damayanti, Annisa Darma, Rizki Novia Dwi Rini Kurnia Fitri Erawaty, Yenny Fatimah Febrianty, Riafany Hadi Kusuma, Muhammad Prayoga Hamid, Nasim HAMIDAH Hidayati, Maulidia Ihsan, Afifi Raima Indahsari, Lilin Ika Nur Indriani, Amanda Jamalika Bunga Nur Siammukaromah Jarkani, Muhammad Jubaidah, Jubaidah Jumrodah Jumrodah Jumrodah Jumrodah, Jumrodah Karlina, Siti Karmila, Fitriyah Kartika, Cindy Khotimah, Ayu Husnul LINTAL MUNA M, Mila Maisyarah, Annisa Maradona, Maradona Marshanda, Utin Tria Marsiah Marsiah, Marsiah Maulana, Muhammad Akmal Maulida Maulida, Elyami Mega Selfia Mila Mila mila Mila, Nor Mufaddilah, Fira Muh Amin , Astuti Muh.Amin, Astuti Muhammad Nor Muhammad Ridho Muhammad Syaiful Anwar Muhammad Taufiq Muhammad Yusuf Mukhlis Rohmadi Nada, Ara Aulia Nadi, Nadi Najwa, Fatri Nasution, Aulia Fajrurramadhina Nirmalasari, Ridha Nisa, Zahratun Noor, Muhammad Arifin Nur Annisa Nur Indah Sari, Lilin Ika Nur Siammukaromah, Jamalika Bunga Nurindahsari, Lilin Ika Nurohman, Farkhan Nursalina, Nursalina Nurul Septiana, Nurul Nurul Wahdah Penia Penia Pitria, Pitria Purwanti, Devi Yuni Purwita Sari, Purwita Puteri Maharani, Septia Rahmadini, Lika Rahmadiyah, Novia Rahman, Luthfi Aulia Ramadhan, Ahmad Ananda Ramadhanti, Noor Raniah, Nor Reski Saputra, Reski Respi, Respi Ridha Nirmalasari Rita Sukaesih Rita, Ambar Sari, Lilin Ika Nur Indah SARI, MITA Sasmita Sasmita Sa’adah, Ayatus Septianingrum, Dwi Dian Setyowati, Ais Rantauni Siti Maysaroh Sonia Sukmawati, Erviana Swestyani, Sondra Tenani, Miya Tuanfareena, Tuanfareena Tumini Tumini, Tumini Uswatun Khasanah, Purnama Wahyuni Nurqadriyani Bustan Wati, Helda Widya Ningsih, Sri Indah Widyadana, Rafif Ibnu Widyadana, Rafiq Ibnu Wulandari, Noor Sari Yantiah Yantiah Yuliyana, Via Ziya, Kholida