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All Journal HAYATI Journal of Biosciences VALENSI JURNAL KIMIA SAINS DAN APLIKASI Jurnal Ilmu dan Teknologi Hasil Ternak The Journal of Experimental Life Sciences (JELS) Journal of Degraded and Mining Lands Management Indonesian Green Technology Journal Jurnal Pembangunan dan Alam Lestari Natural B The Journal of Pure and Applied Chemistry Research Journal of Mathematical and Fundamental Sciences JURNAL PENGABDIAN KEPADA MASYARAKAT Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry JMM (Jurnal Masyarakat Mandiri) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Pengabdian kepada Masyarakat Nusantara
Arie Srihardyastutie
Chemistry Department Brawijaya University
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Journal : Indonesian Green Technology Journal

 1 
Study of Eugenol and Salicylic Acid Interactions in Hybrid Molecule Encapsulated for Enhanced Antioxidant Endah Setiani Astuti; Warsito, Warsito; Srihardyastutie, Arie
Indonesian Green Technology Journal Vol. 12 No. 2 (2023): Indonesian Green Technology Journal
Publisher : Sekolah Pascasarjana, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.igtj.2023.012.02.02

Abstract

Drug development continues to be carried out so that drugs can work effectively. Creating a drug formula can be achieved by combining two or more synergistic drug compounds by hybridization, blending, or synthesis. This study reports findings of antioxidant activity using the good DPPH method from the synthesis of eugenol and salicylic acid using the encapsulation technique. The encapsulation technique uses chitosan as a coating material to protect the active ingredients, taking advantage of its unique functional characteristics, including the ability to form bonds with the crosslink agent sodium tripolyphosphate (Na-TPP) at a speed of 13,500 rpm with a pH of 4.2 to optimize the formulation. The encapsulation system produced majority particles measuring 241.0 ± 19.8 nm, with an encapsulation efficiency of 58.29 ± 0.40%. The results of the compound antioxidant test (CS-ES NP) showed better results than pure ES, with an IC50 value of 1.64 ?g/mL. The morphology results after encapsulation showed round and dense particles, indicating that the ES compound was successfully encapsulated. Keywords: encapsulation, antioxidant, eugenyl salicylate, blending
Mikroenkapsulasi Berbasis Gum Arabik dari Ekstrak Air Pletekan (Ruellia tuberosa L.) dan Aktivitas Inhibisi Terhadap Alpha Amilase Gunawan, Firza Rajasa; Srihardyastutie, Arie; Roosdiana, Anna; Safitri, Anna
Indonesian Green Technology Journal Vol. 11 No. 2 (2022): Indonesian Green Technology Journal
Publisher : Sekolah Pascasarjana, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.igtj.2022.011.02.05

Abstract

Tanaman pletekan (Ruellia tuberosa L.) diketahui memiliki kandungan metabolit sekunder seperti flavonoid, fitosterol, sehingga diusulkan memiliki aktivitas biologis sebagai inhibitor enzim alpha-amilase. Mikroenkapsulasi merupakan metode yang dapat melindungi serta mengontrol pelepasan senyawa aktif. Penelitian ini bertujuan untuk melakukan fabrikasi terhadap ekstrak air pletekan dengan menggunakan bahan penyalut gum Arabik dan menguji aktivitasnya sebagai inhibitor untuk enzim alpha-amilase, serta mengetahui karakter mikrokapsul ekstrak air pletekan yang dihasilkan. Mikroenkapsulasi dilakukan pada variasi pH (3, 4, 5, dan 6) dan waktu pengadukan (30, 60, 90, dan 120 menit). Kondisi optimum mikrokapsul ditentukan berdasarkan penentuan efisiensi mikroenkapsulasi. Hasil penelitian menunjukkan bahwa pH 5 merupakan kondisi optimum dengan nilai efisiensi mikroenkapsulasi sebesar 51,3%. Sedangkan waktu pengadukan 90 menit merupakan kondisi optimum dengan nilai efisiensi mikroenkapsulasi sebesar 52,7%. Uji aktivitas inhibisi enzim alpha-amilase pada mikrokapsul dilakukan pada kondisi optimum menghasilkan nilai IC50 sebesar 71,61 µg/mL.. Karakterisasi menggunakan spektrofotometer FTIR menghasilkan bilangan gelombang 3401,51 cm-1 (O-H), 1608,77 cm-1 (C=C), dan 1081,07 cm-1 (C-O-C) yang menandakan terbentuknya mikrokapsul ekstrak air pletekan. Sedangkan hasil karakterisasi menggunakan SEM menunjukkan bahwa permukaan mikrokapsul yang dihasilkan masih heterogeny, dengan kecenderunagn berbentuk bulat, dan menghasilkan ukuran yang beragam berkisar antara 0,933 – 3,08 µm. Kata kunci: alpha-amilase, flavonoid, mikroenkapsulasi, pH, R. tuberosa L., waktu pengadukan
The Activity of Lipase From Jatropha Seed (Jatropha Curcas L.) And Its Application On Hydrolysis of Castor Oil In Organic Solvent Faradis, Taritsu Hazal; Srihardyastutie, Arie; Iftitah, Elvina Dhiaul
Indonesian Green Technology Journal Vol. 11 No. 2 (2022): Indonesian Green Technology Journal
Publisher : Sekolah Pascasarjana, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.igtj.2022.011.02.02

Abstract

Jatropha curcas L. is one of the seed plants that have lipase activity and can work well in hydrolysis reactions and chemical synthesis. This study aims to determine lipase activity that reacts with castor oil in organic solvents. In this research, organic solvents, especially hydrophobic solvents, were used in the hydrolysis reaction to increase lipase's catalytic activity. The organic solvent used has a hydrophobicity level between 2 and 4, namely hexane. The research stages consisted of lipase isolation, lipase assay, the effect of adding metal ions assay, and analysis of the compound of castor oil. The results showed that jatropha seeds had lipase activity in crude of 0.603 U/mL and increased to 0.911 U/mL after the addition of K+. The result of hydrolysis and transesterification of castor oil by lipase is ricinoleic acid (4,58%) and methyl ricinoleic (11,67%), and the concentration of ricinoleic acid (17.09%) and methyl ricinoleic (60.83%) were increased after addition of K+. The esterification reaction produces alkyl ester compounds such as methyl palmitate, ethyl pentadecanoate, methyl linoleate, methyl oleate, and methyl stearate. The lipase isolated from jatropha seeds not only catalyzes the hydrolysis reaction but also catalyzes chemical synthesis reactions such as esterification and transesterification. Keywords: lipase enzyme, Jatropha seeds, isolation, biocatalyst, hexane.
Co-Authors Achmad Rudijanto Agustina Shinta Hartati Wahyuningtyas Akhmad Sabarudin Alyaa Farrah Dibha Andreas Budi Wijaya Angelina Rosmawati Ani Mulyasuryani Anisa Aprilia Anna Roosdiana Anna Roosdiana Anna Roosdiana Anna Roosdiana Antula, Yulianti Astuti, Luluk Indri Asyfariatus Zulfa Azhar Aulanni'am Aulanni'am Aulanni'am, Aulanni'am Aulanni'am, Aulanni'am Aulanni`am Aulanni`am Aulanni’am Aulanni’am Aulanni’am Aulanni’am Aulanni’am Aulanni’am Aulanni’am, Aulanni’am Azhar, Asyfariatus Zulfa Azor Yulianus Tefa Bambang Poerwadi Barlah Rumhayati Barlah Rumhayati Barlah Rumhayati Chanif Mahdi Chanif Mahdi Chanif Mahdi Chanif Mahdi Chanif Mahdi Chanif Mahdi Danar Purwonugroho Danar Purwonugroho Destyana Ellingga Pratiwi Destyana Ellingga Pratiwi Devi Ramadani Dewi Permatasari, Dewi Diah Mardiana Dyah Kinasih Wuragil Elok Zubaidah Elvina Dhiaul Iftitah Endah Setiani Astuti Eny Rahma Wati Eva Nur Laili Octaviana Fahmi, Ahmad Luthfi Fahriyah Fahriyah Faijal Fachrudin Mbabho Faradis, Taritsu Hazal Fiddaroini, Saidun Fitria Rahmawati Gunawan, Firza Rajasa Hani Susanti, Hani Janatun Na’imah Karti'a, Galuh Wahyu KIKI FIBRIANTO Komara, Acep Nana Latifah Tribuana Dewi Made Oka Adnyana Made Oka Adnyana Maria Natalia Wewo Masruri Masruri Maulidiyah, Nuris Shobah Moh. Farid Rahman Mora, Giral Baines Muhammad Asadullah Muhammad Iman Hidayat, Muhammad Iman Nabila, Sofi Naila Azmi Adiba Neno, Dolly Irnawati Nur Aeni Nur Lailah Nur Samsu Pertiwi, Vi’in Ayu Pertiwi, Vi’in Ayu Putranty Widha Nugraheni Qonitah Fardiyah Riawati Riawati Riyanti Isaskar Roja’i, Abdul Munir Rulli Rosandi Rurini Retnowati Safitri, Anna Salsabila, Isadora Evani Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Siti Nurul Afifah Sofi Nabila Sukardi, Ernawati Sulistiyaningrum, Dwi Rakhmatun Sutrisno Sutrisno Sutrisno, Sutrisno Tri Ardiyati Tri Ardyati Tri Ardyati Velayaty Labone Azzahra Vi’in Ayu Pertiwi Wahyudi, Aleyda Nur Halizah Warsito Warsito Warsito Warsito Wasino Wasino Yudita Prihatini Puji Rahma Sari Yuniar Ponco Prananto Yusri Fajar Yusrina, Nur