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Metode Menurunkan Angka Medication Error Pada Tahap Dispensing Di Instalasi Farmasi Rumah Sakit: Artikel Review Wahyuni, Dilla; Seftika Sari; Neni Frimayanti
The Journal Of Pharmacy Vol. 2 No. 2 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Mengurangi angka kejadian kesalahan pengobatan (medication error) pada tahap dispensing di instalasi farmasi rumah sakit adalah salah satu tantangan yang besar dalam pelayanan kesehatan. Kesalahan ini bisa terjadi akibat berbagai faktor, seperti kesalahan dalam penulisan resep dan komunikasi yang kurang efektif. Untuk meminimalkan risiko tersebut, berbagai metode telah diterapkan, termasuk sistem verifikasi ganda (double check), peningkatan komunikasi antara apoteker dan dokter, serta penerapan teknologi dan sistem otomatisasi. Selain itu, pelatihan berkelanjutan bagi staf farmasi dan pengembangan budaya keselamatan sangat diperlukan untuk mendukung upaya ini. Meskipun terdapat beberapa kendala dalam penerapan metode tersebut, seperti biaya teknologi yang tinggi dan kepatuhan staf, pendekatan yang komprehensif dan berkelanjutan diharapkan mampu secara signifikan menurunkan angka kesalahan pengobatan. Dengan demikian, keselamatan pasien dan kualitas pelayanan kesehatan dapat meningkat secara menyeluruh
Molecular docking, prediction of drug-likeness properties, and toxicity risk assessment of compounds from Cinnamomum zeylanicum as inhibitors of Dengue DEN2 NS2B/NS3. Frimayanti, Neni; Fernando, Armon; Rahmah, Rizka I’zaa; Iskandar, Benni
Chempublish Journal Vol. 9 No. 2 (2025): Chempublish Journal (July - December)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i2.43598

Abstract

Dengue hemorrhagic fever (DHF) is a serious mosquito-borne disease caused by the dengue virus, most often transmitted by the bite of female Aedes aegypti mosquitoes. In Indonesia, the number of DHF cases has steadily increased since the disease was first reported, underscoring the urgent need for effective treatments. This study used in silico methods to explore the potential of three bioactive compounds from Cinnamomum zeylanicum i.e. cinnamaldehyde, α-terpineol, and chavicol as inhibitors of the dengue virus NS2B/NS3 protease and evaluated their drug-likeness and potential toxicity. The compounds sourced from the NADI database were compared with panduratin A as a positive control. Molecular docking was performed using the Molecular Operating Environment (MOE) 2023.0901 software, and drug-likeness and toxicity predictions were performed using SwissADME and Protox-II. Among the tested compounds, α-terpineol exhibited the strongest potential to inhibit NS2B/NS3, while all three met the standard drug-likeness criteria. Notably, α-terpineol demonstrated the most favorable safety profile compared to cinnamaldehyde, chavicol, and panduratin A.
Molecular Docking Study of Chalcone Analogue Compounds with Hydroxy and Methoxy Subtituents as Bcl-2 Inhibitors Frimayanti, Neni; Dona, Rahma; Solihin, Tabah
Chempublish Journal Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.17487

Abstract

Molecular docking study of 6 chalcone analogues with protein target from the crystallographic structure modeling of Bcl-2 protein with PDB code 2W3L was carried out using computational media using the Molecular Operating Environment (MOE) program. The aim of this study is to determine the potentiality of the 6 chalcone analogue compounds as Bcl-2 inhibitors using molecular docking studies. In this study, venetoclax was used as positive control. Based on docking results, binding free energy was used as information to know which wheather chalcone analogue compounds are active or not as Bcl-2 inhibitors. According to the docking results that have been carried out, it showed that the 6 chalcone analogue compounds have no potential as Bcl-2 inhibitors. Due to the superimposition of the 6 compounds that did not stick to the positive control and most importantly the binding free energy values ​​(S) of the 6 chalcone analogue compounds were higher than the binding free energy values ​​of the positive control (Venetoclax).
Sintesis dan Kajian Docking Molekular Senyawa 2’-Hidroksicalkon dan Flavonol Tersubstitusi Dimetoksi sebagai Inhibitor Kompleks NS2B-NS3 Serine Protease pada Virus Dengue-2 (DENV-2) Ikhtiarudin, Ihsan; Frimayanti, Neni; Hendra, Rudi; Teruna, Hilwan Yuda; Rahim, Fatma; Mora, Enda; Septama, Abdi Wira
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.347

Abstract

Exploration of the potential compounds as dengue antivirals is one of the efforts that must be considered, because no specific therapy has been found with antiviral drugs that is effective in treating dengue hemorrhagic fever (DHF) patients. The aim of this study is to synthesize and explore the potential of the (E)-3-(2,5-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (compound 1) and 2-(2,5-dimethoxyphenyl)-3-hydroxy-4H-chromen-4-one (compound 2) as inhibitors of NS2B-NS3 serine protease complex of DENV-2. Synthesis of compounds 1 and 2 was carried out by stirring using a magnetic stirrer. The structures of the two synthesized compounds have been confirmed through UV-Vis, FT-IR and 1H NMR spectroscopic analyses. Molecular docking was performed using NS2B-NS3 complex (PDB ID: 2FOM) as a receptor. Compounds 1 and 2 were obtained in 21.11% and 66.84% yield, respectively. Based on the molecular docking studies, compounds 2 exhibited more negative binding free energy than compound 1 and panduratin A as a reference inhibitor. Compound 2 was observed to bind to the catalytic triad of NS2B-NS3 complex (His51, Asp75, Ser135) and form hydrogen bond with Gly153. Based on the results, it can be concluded that compounds 1 and 2 can be synthesized by stirring method and the compound 2 showed good potency to be developed as inhibitors of the NS2B-NS3 serine protease complex of DENV-2.
Potensi Pengembangan Antioksidan/Antidiabetes Turunan Piridazinon sebagai Agen yang Menjanjikan untuk Terapi Penyakit Diabetes: Review Fatisa, Yuni; Frimayanti, Neni; Teruna, Hilwan Yuda; Jasril , Jasril
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.390

Abstract

Hyperglycemia can induce oxidative stress that can develop towards the pathogenesis of diabetic complications. Treatment strategies usually use antidiabetic and antioxidant drugs to help manage diabetes in patients. The discovery of drugs with dual activity properties will work on two targets at once and can minimize side effects. This review analyzes the potential for developing new antidiabetic and antioxidant agents from pyridazinone derivative compounds. The literature review study methodology uses the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) technique. Electronic database searches were conducted through Google Scholar, PubMed, and Science Direct to obtain relevant literature until 2024. The inclusion criteria were pyridazinone derivatives as antidiabetics and antioxidants using in silico, in vitro, and in vivo tests. A total of 24 original research journals have been described for the discussion of this review. The review results found that pyridazinone derivatives have the potential as α-Glucosidase inhibitors, antihyperglycemic, and aldose reductase inhibitors with moderate-strong activity levels. Several studies have also found that pyridazinone derivatives are antioxidants. These results are supported by the prediction through molecular docking approach studies.  However, only two studies have reported pyridazinone derivatives that have antidiabetic and antioxidant properties at the same time. There is a connection between the active groups bound to the pyridazinone ring and the strength of its pharmacological effects. This review opens up opportunities for the potential development of pyridazinone derivatives with dual bioactivity. In addition, broader and deeper research with structural modification of pyridazinone derivatives as candidate therapeutic agents for diabetes patients needs to be continued.
Edukasi Cara Identifikasi Boraks Pada Bakso Menggunakan Sari Bunga Telang (Clitoria ternatea L.) Di Desa Sungai Pinang Frimayanti, Neni; Susanti, Emma; Dona, Rahma; Arsad, Larasati; Fitriani, Rizda; Kirana, Fharisti; Vasmawati, Della; Fitriani, R. Rizatita; Azlin, Kiranti; Sisilawati, Kolista; alhamdania Balqis, Salsabila; adli husin, Raja; Zahirah Ananda, Salsabila; Aulia Wibowo, Selvi; amanda, Denisya; Yueflen, Fadiyah; safitri, Ramanda
BATOBO: Jurnal Pengabdian Kepada Masyarakat Vol 1 No 2 (2023): BATOBO: Desember 2023
Publisher : Jurusan Teknik Elektro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/batobo.1.2.49-55

Abstract

Pengabdian kepada masyarakat ini dilaksanakan di Desa Sungai Pinang, Kecamatan Tambang, Kabupaten Kampar, Provinsi Riau dengan sasarannya masyarakat yang ada di desa tersebut. Pengabdian ini bertujuan agar masyarakat dapat mengetahui dan memahami identifikasi boraks pada makanan terutama bakso dengan penambahan boraks menggunakan sari bunga telang (Clitoria ternatea L) sebagai indikator alami. Diharapkan kepada masyarakat dapat melakukan identifikasi boraks secara mandiri sebagai bentuk kewaspadaan terhadap makanan yang belum diketahui keamanannya. Selain itu agar masyarakat dapat memahami perbedaan antara bakso yang baik (non boraks) dengan bakso yang sudah terpapar boraks. Pengabdian ini dilaksanakan pada 3 Agustus 2023 dan diikuti oleh 40 masyarakat desa. Bentuk kegiatan berupa edukasi melalui penyuluhan dan penampilan video yang menunjukkan langkah-langkah dalam mengidentifikasi boraks pada bakso menggunakan sari bunga telang sebagai indikator. Adapun untuk mengetahui tingkat pengetahuan masyarakat desa maka dilakukan pemberian kuisioner pre-test dan post-test. Hasil didapatkan bahwa kegiatan pengabdian masyarakat oleh Sekolah Tinggi Ilmu Farmasi Riau berjalan dengan baik karena adanya peningkatan pengetahuan masyarakat sesudah penyuluhan dibandingkan sebelum penyuluhan.
Analisis Tantangan Dan Solusi Manajemen Rantai Dingin Penyimpanan Obat Di Puskesmas: Kajian Literatur Putri, Monica Rifa; Sari, Seftika; Frimayanti, Neni
Action Research Literate Vol. 9 No. 2 (2025): Action Research Literate
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/arl.v9i2.2578

Abstract

Penyimpanan obat dengan sistem rantai dingin di fasilitas kesehatan primer, seperti puskesmas, merupakan elemen krusial untuk menjaga efektivitas obat, terutama vaksin dan obat biologis. Penelitian ini bertujuan untuk menganalisis tantangan yang dihadapi dalam manajemen rantai dingin di puskesmas serta memberikan solusi yang efektif. Metode yang digunakan adalah tinjauan literatur dari berbagai sumber akademik yang relevan, dengan fokus pada artikel yang diterbitkan antara tahun 2020 hingga 2024. Penelitian ini menemukan bahwa tantangan utama dalam pengelolaan rantai dingin meliputi ketidaksesuaian suhu, keterbatasan infrastruktur, dan kurangnya pelatihan bagi tenaga kesehatan. Berdasarkan temuan ini, solusi yang disarankan termasuk penerapan teknologi pemantauan suhu berbasis Internet of Things (IoT), peningkatan pelatihan bagi petugas kesehatan, serta perbaikan infrastruktur penyimpanan. Implikasi dari penelitian ini menunjukkan bahwa manajemen rantai dingin yang efektif memerlukan pendekatan yang komprehensif dengan kolaborasi antara berbagai pemangku kepentingan, termasuk pemerintah dan masyarakat, untuk memastikan kualitas dan keamanan obat yang disimpan, yang pada gilirannya mendukung keberhasilan program imunisasi dan kesehatan masyarakat.
A New Insight Into Toxicity of Database Compounds from Ginger (Zingiber officinale) by Modelling Study Frimayanti, Neni; Febrina, Mira; Yuri Amalia, Annisa
Jurnal Riset Kimia Vol. 15 No. 1 (2024): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v15i1.638

Abstract

Dengue haemorrhagic fever (DHF) is an infectious disease caused by the dengue virus. The dengue virus is transmitted through female mosquitoes, especially Aedes aegypti and Aedes albopictus. Indonesia is a dengue endemic country, and almost all provinces in Indonesia are infected with dengue. However, targeted antiviral drugs against dengue virus (DENV) are not yet available. This study aimed to determine the potential of three compounds isolated from ginger (Zingiber officinale) as dengue NS2B/NS3 inhibitors, and to predict the physicochemical properties (drug-likeness) and potential toxicity of drug candidates. Ginger isolates in the form of [8]-gingerol, [6]-paradol, shogaol were obtained from the Natural Discovery Database (NADI). Toxicity and drug-likeness predictions were performed using ProTox-II and SwissADME, and Molecular Operating Environment (MOE) 2022.0901 was used for the molecular docking process. Results: The results showed that the ginger compound (Zingiber officinale), [8]-Gingerol, [6]-Paradol, and Shogaol, had binding free energy of -7.18, -7.10 and -6.88 kcal/mol, respectively. It is indicated that three compounds had  potentiality to inhibit the NS2B/NS3 protein complex with a binding free energy that was almost equivalent to that of the positive control, panduratin A, and similar to that of the positive control, which can be seen in superimposition. In addition, three compounds isolated from ginger met the drug-likeness parameters. Based on the analysis of in silico toxicity studies, the three compounds isolated from ginger showed different levels of toxicity. Therefore, based on the safety level of oral use, the [8]-gingerol compound is safer to develop as a dengue antiviral drug, where the LD50 value of [8]-gingerol is 2.580 mg/kg with a class V toxicity level that is practically nontoxic.
Optimizing carrot extract serum (Daucus carota L.) for anti-aging: efficacy in moisturizing and pore size reduction using Box-Behnken design method Iskandar, Benni; Antasya, Vaylia; Nasution, Musyirna Rahmah; Frimayanti, Neni; Peng-Wei, Ching; Khairani, Sondang
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1566

Abstract

Carrot extract (Daucus carota L.) contains various bioactive compounds, including vitamins A, B, and C, alkaloids, flavonoids, tannins, anthraquinones, saponins, diterpenes, steroids, beta-carotene, phenols, terpenoids, and minerals, all of which possess antioxidant properties. These compounds are known to help slow down the aging process. The aim of this study was to determine the optimal concentrations of gelling and alkalizing agents, assess their interactions, and evaluate the anti-aging effects of the most effective serum formulation. The formulation was optimized using the Box–Behnken design with two key factors: Carbopol 940 concentration (0.5–1%) and triethanolamine (0.5–1%). The effects on pH, adhesion, and spreadability were evaluated. The best formulation was achieved with 0.837% Carbopol 940 and 0.855% triethanolamine, showing a pH error of 2.45%, adhesion error of 0.76%, and spreadability error of 1.01%, all within acceptable limits (errors < 10%). After four weeks of stability testing, the formulation remained stable, well-mixed, with a pH of 5.16, an adhesion time of 1.60 seconds, and spreadability of 6.73 cm, with no discomfort. The combination of Carbopol 940 and triethanolamine improved the physical properties, enhancing anti-aging effects compared to the base formula. The optimized serum increased skin moisture by 84.62%, reduced pore size by 64.71%, lightened spots by 62.79%, and reduced wrinkles by 67.50%. This indicates the optimized carrot extract serum is stable, safe, and effective as an anti-aging agent, making it a promising natural skincare product.
Synthesıs and in Sılıco Studıes of 1,3,5-Trıaryl-2-Pyrazolıne Derıvatıves Contaınıng Chloro Substıtuent and Pyrrolıdıne Moıety Jasril, Jasril; Iktiarudin, Ihsan; Ulhukmi, Nisa; Novianty, Riryn; Syaifullah, Mhd Muslim; Frimayanti, Neni
Molekul Vol 21 No 1 (2026)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2026.21.1.11084

Abstract

ABSTRACT. Pyrazoline is a well-known group of five-ring heterocyclic compound containing two nitrogen atoms that has a wide range of promising biological activities. The aim of this research is to synthesize 1,3,5-triaryl-2-pyrazoline derivatives with chloro substituent and pyrrolidine moiety and to explore their potency as inhibitors for cervical cancer. The synthesis was performed through three-steps reactions. Firstly, synthesis of chlorinated naphthalenyl chalcones through Claisen-Schmidt condensation. Secondly, synthesis of chlorinated naphthalenyl pyrazolines through nucleophilic addition of phenylhydrazine to the chalcone and followed by intramolecular cyclization. Thirdly, synthesis of pyrazoline derivatives by adding the pyrrolidine moiety through O-alkylation reaction. Then, the in silico studies through molecular docking, ADME profiling, and toxicity prediction were performed to explore the potency of the synthesized compounds as inhibitors of cervical cancer by inhibiting the activity of Sirtuin-1 (SIRT-1) (PDB ID: 4I5I). The structure of all pyrazoline derivatives (4a-4c) were confirmed by spectroscopic analysis including UV, FT-IR, HRMS, and NMR. Based on the docking study, compound 4a with binding free energy of -12.59 kcal/mol exhibited better potency as SIRT-1 inhibitor than previously reported inhibitor (EX527). Then, based on the ADME profiling and toxicity prediction, it can be concluded that compound 4a exhibited reasonable drug properties with low toxicity potency (predicted LD50 = 1000 mg/kg). Keywords: : Cervical cancer, molecular docking, pyrazoline-pyrrolidine, pyrazoline synthesis, sirtuin-1
Co-Authors Abdi Wira Septama Abdi Wira Septama Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel zamri adli husin, Raja agistia, nesa Agustini, Tiara Tri alhamdania Balqis, Salsabila Alifah Nurul Khusnah Amanda, Denisya Amrina Rossada Septilapani Anfasa Mashudi, Fristio Anggraeni, Ica Winanda Anita Lukman Antasya, Vaylia Armon Fernando Arsad, Larasati Aulia Wibowo, Selvi Azlin, Kiranti Bella Parina, Ana BENNI ISKANDAR Daniel Sialagan Dea Dwi Putri Difa, Faradini Ramsanjami Efendi, Apriyani Elsa Etavianti Elsa Natia Elvi Khairani, Mai Elviyenti, Elviyenti Enda Mora Etavianti, Elsa Fatmalia, Anggun Ferdy Firmansya Ferdy Firmansyah Fikri Maulana Fikri Maulana, Fikri Fina Aryani, Fina Fitriani, R. Rizatita Fitriani, Rizda Fri Murdiya, Fri Furi, Mustika Guntur Guntur Haiyul Fadhli Hamzah, Hasyrul Haryeni Sastra Anggraini Hendra, Rudi Herfindo, Nofal Herfindo, Noval Hery Widijanto Hilwan Y. Teruna Hilwan Yuda Teruna Husnawati Husnawati Ihsan Ikhtiarudin Ikhtiaruddin, Ihsan Iktiarudin, Ihsan Irfan Maulana Iriani, Revy Jasril , Jasril Jasril Jasril Kirana, Fharisti Kolista Sisilawati Kurniawan Putri, Nurafika Lala Azela Livia Nathania Mazaya Putri Anabesi Meiriza Djohari, Meiriza Melzi Octaviani Meri Ernilawati Meridona Mira Febrina, Mira Muharani, Siska Muhtadi, Wildan Khairi Mulia Rizki Musyirna Rahmah Nst Mutiara Salsabillah Muttaqin, Fauzan Zein Nadea Zahra Ramadhani Nadila Putri Nahdiah Nahdiah Nahdiah Nahdiah, Nahdiah Nelly Oscifiani Nelly Oscifiani Ningsih, Yozi Fiedya Nisa Novrianti Nofriyanti Nova Tantri Silalahi Noval Herfindo Noval Herfindo Noval Herfindo Noval Herfindo Noval Herfindo Novianty, Riryn Nurul fadillah, Nurul Nurul Susianti Oscifiani, Nelly Panjaitan, Pretty Farida Peng-Wei, Ching Putri Rizki Rahmadani Putri, Eka Marisa Putri, Monica Rifa Qurnia Pratiwi, Putri Rabiatul Adawiyah Rahayu Rahayu Rahayu Rahayu Rahayu Rahayu Rahayu Utami Rahim, Fatma Rahma Dona Rahma Dona, Rahma Rahmah, Rizka I’zaa Retika, ⁠ Chindy Ricardo, Nadira Atiqah Rickha Octavia Rindiyani Rindiyani Riska Prasetiawati Rizki Anugrah Rodhia Ulfa Rohim, Muhammad Ronapadua Musyirna Rahmah Nasution Sahara dan Emma Susanti Rosnita Dewi Rahmawati Rossi Passarella Ruska, Shinta Liana Rusnedy, Rahmayati S.Farm., M.Farm., Apt, Sondang Khairani Safitri, Ramanda Salsabila, Aulia Sari, Rinita Shafira Melsonia Silalahi, Nova Tantri Siregar, Lisa Andriyani Sisilawati, Kolista Sitanggang, Sarah Dianora Solihin, Tabah Syaifullah, Mhd Muslim Teguh Utama Tria Harlianti Ulhukmi, Nisa Vasmawati, Della Vella kurnia Wahyuni Veza Azteria viola Afrilizetira, Garnis Wahyuni, Dilla Widya Ari Sandi Winda Yusma Ameliah Wulandari, Zertiks Yasthophi, Arif Yueflen, Fadiyah Yuli Haryani Yum Eryanti Yum Eryanti Yum Eryanti Yuni Fatisa Yuri Amalia, Annisa Zafarani, Welly Zahirah Ananda, Salsabila