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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN JURNAL GIZI INDONESIA Nurse Media Journal of Nursing Jurnal Kedokteran Brawijaya Jurnal Kedokteran Diponegoro Majalah Kedokteran Bandung Journal of Biomedicine and Translational Research Jurnal NERS Jurnal Keperawatan dan Kesehatan Masyarakat CENDEKIA UTAMA Jurnal Kesehatan Jurnal Ilmu Keperawatan dan Kebidanan Belitung Nursing Journal Jurnal Gizi Klinik Indonesia Jurnal Keperawatan Silampari Media Medika Muda International Journal of Nursing and Health Services (IJNHS) Indonesian Journal of Nursing Research (IJNR) JURNAL ILKES (Jurnal Ilmu Kesehatan) Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) AVICENNA Jurnal Midpro Adi Husada Nursing Journal Indonesian Journal of Global Health research JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Borneo Cendekia DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN Jurnal Penelitian

Andrew Johan

Department Of Medical Biology And Biochemistry, Faculty Of Medicine, Diponegoro University

Author-ID : 292646

Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Pengaruh jamur tiram putih (pleurotus ostreatus) terhadap kadar glukosa darah, profil lipid dan kadar MDA pada tikus (rattus norvegicus) diabetes melitus Purbowati, Purbowati; Johan, Andrew; RMD, RA Kisdjamiatun
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 4, No 2 (2016)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background : Diabetes mellitus is a chronic disease caused by acquired deficiency in insulin production by the pancreas, or by the ineffectiveness of using the produced insulin. Oyster mushroom (Pleurotus ostreatus) can help lower blood glucose levels, improve lipid profile and reduce levels of MDA.Objective : to analyze the effect of oyster mushroom on blood glucose levels, lipid profile and MDA levels in STZ induced rats as type 1 DM model. Methods : thirty Sprague Dawley rats were randomly divided into 3 groups: one positive group (1) and two treated group which received 100 mg/kgBB (2) and 200 mg/kgBB (3) oyster mushroom extract, respectively. The interventions were carried out for 30 days. The examination of blood glucose levels, lipid profile and MDA levels was before and after the intervention. The differences inthe datapre-post interventions were analyzed by paired t-test, whereas the differences between the groups were analyzed by one-way ANOVA and kruskal wallis followed by post hoc analysis. Results : the treatment group experienced a decrease in blood glucose levels, total cholesterol, LDL cholesterol, triglycerides, MDA and an increase in HDL cholesterol levels post-intervention (p < 0,001). Oyster mushroom extract with the dose of 200 mg/kg was more effective in lowering blood glucose levels, MDA levels and improving lipid profiles (p < 0,001).Conclusion : Oyster mushrooms administration lowers blood glucose levels, total cholesterol, LDL cholesterol, triglycerides, MDA and increases HDL cholesterol levels.Â

Pengaruh pemberian seng terhadap indeks fagositosis makrofag dan kadar nitric oxyde mencit balb/c yang terpapar lipopolisakarida e.coli Fardian, Nur; Johan, Andrew; RMD, RA Kisdjamiatun
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 3, No 2 (2015)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Latar Belakang : Sistem imun tubuh merespons LPS dengan mengaktifkan makrofag dan memproduksi NO. Seng memiliki sifat sebagai antioksidan dan imunomodulator. Penelitian bertujuan untuk membuktikan pemberian seng berbagai dosis berpengaruh terhadap indeks fagositosis makrofag dan kadar NO.Metode : The post test only controlled group design pada mencit Balb/C terbagi atas 4 kelompok. Perbedaan indeks fagositosis dan kadar NO dianalisis menggunakan uji one way ANOVA dan dilanjutkan dengan uji Bonferroni. Hasil : Rerata indeks fagositosis makrofag adalah 106,60(Â±023,31), 428,40(Â±159,58), 285,70(Â±90,45) dan 208,07(Â±43,85) berturut turut untuk kelompok kontrol, perlakuan dosis 30 ppm, perlakuan dosis 60 ppm dan perlakuan dosis 120 ppm. Terdapat perbedaan bermakna atas indeks fagositosis makrofag antara kelompok kontrol dan perlakuan (p = 0,000). Rerata kadar NO adalah 0,08(Â±0,03), 0,12(Â±0.06), 0,09(Â±0,03) dan 0,20Â±0,08 berturut turut untuk kelompok kontrol, perlakuan dosis 30 ppm, perlakuan dosis 60 ppm dan perlakuan dosis 120 ppm. Terdapat perbedaan bermakna atas kadar NO antara kelompok kontrol dan perlakuan (p= 0,013).Kesimpulan : Indeks fagositosis makrofag seluruh kelompok perlakuan dengan dosis seng bertingkat 30 ppm, 60 ppm dan 120 ppm lebih tinggi secara bermakna dibanding kelompok kontrol. Kadar NO kelompok perlakuan dengan dosis seng 120 ppm lebih tinggi secara bermakna dibanding kelompok kontrol. Sedangkan dosis pemberian seng 30 ppm terbukti memiliki indeks fagositosis tertinggi dan dosis 120 ppm terbukti memiliki kadar NO tertinggi.

Pengaruh pemberian jus mangga terhadap profil lipid dan malondialdehyde pada tikus yang diberi minyak jelantah Zaki, Ibnu; Johan, Andrew; W, Nyoman Suci
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 3, No 2 (2015)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Latar belakang : Pemberian minyak jelantah menyebabkan peningkatan profil lipid (kolesterol total, trigliserida, kolesterol LDL) dan Malondialdehyde(MDA) darah serta menurunkan kolesterol HDL. Jus mangga mengandung serat, vitamin C, E dan betakaroten yang berpotensi memperbaiki profil lipid dan menurunkan MDA.Tujuan :menganalisis pengaruh jus mangga terhadap profil lipid dan MDA tikus yang diberi minyak jelantah.Metode : Penelitian eksperimental dengan randomized controlled pre-post test design. Tikus Sprague Dawley di bagi acak menjadi tiga kelompok yaitu kelompok K diberi Aquades, kelompok P1 diberi minyak jelantah, dan kelompok P2 diberi minyak jelantah, jus mangga). Pemberian jus mangga diberikan 1x/hari peroral selama 14 hari. Kolesterol total, LDL, HDL diukur dengan metoda CHOD-PAP. Kadar Trigliserida diukur dengan metoda GPO-PAP. Analisis kadar MDA darah dengan metoda TBARS.Hasil : Terjadi peningkatan kolesterol total, trigliserida, LDL dan MDA serta penururnan HDLdarah setelah pemberian minyak jelantah. Pemberian jus mangga secara bermakna menurunkan kolesterol total, trigliserida, LDL dan MDA darah serta meningkatkan HDL. Rerata perubahan setelah pemberian jus mangga pada P2 kolesterol total -72,90Â±9,33 mg/dl,trigliserida -39,29Â±8,13 mg/dl, LDL -8,71Â±3,05mg/dldan MDA -4,25Â±0,52. Rerata Peningkatan HDL 13,70Â±4,16 mg/dl.Simpulan : Pemberian jus mangga menurunkan kolesterol total, trigliserida, LDL, MDA dan meningkatkan HDL.

Efek pemberian Chlorophyllin terhadap kadar nitric oxide dan malondialdehida tikus hiperkolesterolemia Pontang, Galeh S; Johan, Andrew; Subagio, Hertanto W
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 3, No 1 (2014)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background : Endothelial dysfunction is well-known as an early stage of atherosclerosis. Increased oxidative stress inhypercholesterolemia triggers endothelial dysfunction that is characterized by decreased biological availability ofnitric oxide (NO). Experimental studies showed that chlorophyllin had an effective antioxidant activity.Objectives : To determine the effect of chlorophyllin on nitric oxide (NO) and malondialdehyde (MDA) level ofhypercholesterolemic rats.Methods : Post test only randomized control groupusedtwenty four male Sprague Dawley rats were randomly dividedinto four groups: without treatment (technical control/K1), hypercholesterolemic (negative control/K2),hypercholesterolemic with chlorophyllin at dose of 1,8 mg/200 g/d (P1) and hypercholesterolemic with chlorophyllin atdose of 3,34 mg/200g/d (P2). Chlorophyllin was dissolved in water and was given via nasogastric tube for 21 days afterthe rats got hypercholesterolemia. Total cholesterol level of blood was measured by CHOD-PAP method, level of NOplasma was measured by Griess reaction and level of MDA plasma was measured by TBARS method. Hypothesis testwas analyzed by One Way Anova continued by Post hoc LSD test and Kruskall Wallis by significant level of 0,05.Results :NO plasma level was the lowest in group P2 (0.203+0.015 Î¼M) and the highest in the group K2 (0,224Â±0,001Î¼M), but no difference of NO plasma level among groups (p = 0.118). There were differences in MDA plasma levelamong the groups (p = 0.001). P1 and P2 groups had lower MDA plasma level than K2 (2.40+0.11 nmol/ml), indicatedby (1.94 +0.07 nmol/ml, p=0.0001) and (1,37 +0.13 nmol/ml, p=0.0001) respectively, but still higher than K1(0.94+0.05 nmol/ml, p=0.0001).Conclusion : The treatment of chlrophyllin does not have an effect of NO plasma level, but gives an effect of lowerMDA plasma level.

Sitotoksisitas in vitro ekstrak etanolik buah parijoto (Medinilla speciosa, reinw.ex bl.) terhadap sel kanker payudara T47D Tusanti, Iin; Johan, Andrew; Kisdjamiatun, RA
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 2, No 2 (2014)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: Several studies focused on phytochemical as agents of cancer prevention and co-chemotherapy. One of Indonesian plant which has edible fruit but it hasnâ€™t been completely explored is Medinilla speciosa (Reinw.ex Bl.). Objective : The aim of this study is to examine the cytotoxic activity (IC50 value) of Medinilla speciosa (Reinw.ex Bl.) fruit ethanolic extract. Methods : Medinilla speciosa (Reinw.ex Bl.) fruit ethanolic extract was used in this study. The cytotoxic activity was investigated in vitro on human breast cancer T47D cell-line. The cells viability were assessed using MTT colorimetric assay. Breast cancer T47D cell lines was treated with fruit ethanolic extract (10, 25, 50, 100, 250, 500 and 1000 Âµg/ml) for 24 hour of incubation. This study also identified phytochemical compound of the fruit with thin layer chromatography (TLC). Results: The result showed that ethanolic extract of Medinilla speciosa (Reinw.ex Bl.) has moderate cytotoxicity on breast cancer T47D cell line with IC50 value of 614.50 Âµg/ml and yield the decrease of cell viability at higher concentration. Medinilla speciosa fruit can not be used as anticancer agent but chemoprevention agent. Phytochemical test showed that the fruit extract contain flavonoid and saponin compound. Conclusion: Ethanolic extract of Medinilla speciosa fruit exhibited moderate cytotocicity on breast cancer T47D cell lines with IC50 value was 614,50 Âµg/ml thus it can be used as chemopreventioan agent.

Pengaruh ekstrak buah naga daging merah (Hylocereus polyrhizus) terhadap berat badan, indeks fagositosis makrofag dan produksi nitrit oksida makrofag (Studi pada mencit BALB/c yang diinfeksi Salmonella typhimurium) Kusdalinah, Kusdalinah; Johan, Andrew; Wijayahadi, Noor
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 2, No 2 (2014)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: Salmonella typhimurium has ability to avoid the phagosome and escape from the trap-free in cytoplasm.Macrophage was activated to phagocyte microbe and produced microbicidal agent nitric oxide (NO).Polyphenolic compounds are proved as an immunomodulatory agent.Hylocereus polyrhizus contains high level of polyphenols and thus increases appetite.Objective: Proving the effects various doses (6 mg, 12 mg, and 24 mg/20 g miceâ€™s weight) of Hylocereus polyrhizus extract to increase weight, increase macrophage phagocytosis and NO production of macrophage.Methods:True experiment research for fourteen day on males BALB/c mice, post-test only controlled group design.The treatment groups wereÂ a dose of 6 mg/day (X1), 12 mg/day (X2), and 24 mg/day (X3), whereas the control group (K) was not given the extract of Hylocereus polyrhizus.All treatment and control groups were infected by Salmonella typhimurium intraperitoneally 105 CFU in tenth day.Results: Weight in the treatment group was higher than the control group (p=0.037). Index of macrophage phagocytosis was higher in the treatment group compared to the control group but it was not significant (p=0.154). Macrophage NO production was higher in the treatment group compared to the control group but was not significant (p=0.332).Conclusion: Weight increased significantly.Increasing of macrophage phagocytosis index and macrophage NO production were not significant.

Protective roles of the red-dragon fruit peels (Hylocereus costaricensis) against the cigarette-smoke harmful effect in Wistar rats Ardhianditto, Decca; Murwani, Retno; Johan, Andrew; Ariyanto, Diaza Okadimar
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 1 (2023): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.1.1-8

Background: Many people are exposed to cigarette smoke unintentionally in numerous places worldwide. Cigarette smoke contains carbon monoxide, nicotine, and polycyclic aromatic hydrocarbons, which are toxic and can trigger the production of free radicals in the body.Objective: To study the impact of cigarette-smoke exposure twice daily for 30 days on 4-5 weeks Rattus norvegicus L. without or with a daily intake of the juice or ethanol extract of the red-dragon fruit peels H. costaricensis. Materials and Methods: Twenty-eight 4-5 weeks old male Wistar rats were randomly allocated into Control (not exposed to cigarette-smoke), exposed to cigarette-smoke only (Csmoke), exposed to cigarette-smoke and H. Costaricensis-peel juice (JcHc), exposed to cigarette-smoke and had H. Costaricensis-peel extract (ExHc). Cigarette-smoke exposure was given twice daily. The juice (3g/mL) and extract (3.15g/mL) were given for 30 days ad libitum. Feed and drink intake, body weight, and serum biochemistry (MDA, bilirubin, ALT and AST) were determined. Data were analyzed by ANOVA.Results: The positive control group with cigarette-smoke exposure (Csmoke) had a significant elevation in serum malondialdehyde (MDA), alanine-transaminase (ALT), and aspartate-transaminase (AST) and drinking water intake (p<0.05) but reduced feed intake and body weight (p<0.05). The JcHc and ExHc groups had reduced serum MDA, ALT, and AST and higher body weight and feed intake than the Csmoke, and the extract had a better reduction than the juice (p<0.05). Furthermore, the extract had a lower biochemical profile than the Control group (p<0.05).Conclusion: The disturbance in serum MDA, ALT, AST, water and feed intake, and body weight by cigarette smoke was ameliorated by H. costaricensis peel juice or extract daily for 30 days. H. costaricensis peel juice or extract can be used to prevent the adverse effects of cigarette smoke exposure and has the potential to be developed into valuable products.

Co-Authors - Anggorowati - Sarjadi, - -, Sarjadi A.A. Ketut Agung Cahyawan W Achmad Zulfa Juniarto Adiyati Mardiyah Anastasia Diah Larasati Ardhianditto, Decca Arief Wildan Arif R Sadad Arif Wildan Ariyanto, Diaza Okadimar Ary Astuti Astuti, Hery Yuliani Banundari Rachmawati Chandra Bagus Ropyanto Devita Anugrah Anggraini Dhega Anindita Wibowo, Dhega Anindita Djuara P Lubis Dodi Setiawan Dwi Ngestiningsih Dwi Uswatun Khasanah Dwiantoro, Luky Fida’ Husain Fitria Handayani Fitriani, Evi Tunjung Galeh S Pontang, Galeh S harun, sigit Hendro Wahyono Henni Kusuma Hertanto W Subagio, Hertanto W Iin Tusanti Innawati Jusuf Innawati Jusup Intarniati Nur Rormah Kartika, Nadini Khoirya, Ainun Kis Djamiatun Kristiana Prasetya Handayani Kurnia Wijayanti Kurniati, Steffi Kusdalinah Kusdalinah Kusmiyati Tjahjono Laksono, Eko Budi Lusiana Batubara Maksum Maksum Meira Erawati Meira Erawati Michelle Abigail Miftakhul Nizar, Angga Muhammad Irfan Dwiputra Rianil Muhammad Sulchan Muhammad Sulchan Mulyono, Yehezkiel Andrew Nadini Kartika Nafisah Zahra Nana Rochana Nazila Tsalisati Hadaita Niken Safitri Dyan Kusumaningrum Nila Putri Purwandari Noor Wijayahadi Nur Fardian, Nur Nurmasari Widyastuti Nyoman Suci W, Nyoman Suci Prawara, Ananta Siddhi Prihasna, Septika Nuri Purbowati Purnomo Purnomo Purnomo Purnomo PUTRI EKA SARI, PUTRI EKA RA Kisdjamiatun RMD, RA Kisdjamiatun RA Kisdjamiatun, RA Ratna Sulistyorini, Ratna Retno Murwani Ricky Prawira Rifky Ismail Rirra Hayuning Handikasari Rizky Indra Puspito Rusmiyati - Rusmiyati -, Rusmiyati Santoso Jaeri Sarjadi - Sarjadi Sarjadi Suhartini Ismail Suhartini Ismail, Suhartini Untung Sujianto Upami, Prakerti Tri Wenda Yoanda Wikanta, Edmond Rukmana Wiwin Efrizal Y.L Aryoko Widodo Yulian Fajariyanti Yuliana Yuliana Zaki, Ibnu

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