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HUBUNGAN DRUG RELATED PROBLEMS (DRPs) KATEGORI DOSIS OBAT AMLODIPIN DAN KAPTOPRIL TERHADAP KONDISI TEKANAN DARAH PADA PASIEN HIPERTENSI Husnatika; Nurmainah; Rizkifani, Shoma
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 2 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i2.1381

Abstract

The incidence of drug-related problems (DRPs) in the dose category on the use of antihypertensive drugs has been associated with the failure of the patient's optimal blood pressure target. The study aims to analyze the relationship between drug-related problems (DRPs) on administering amlodipine and captopril drugs to the blood pressure conditions of elderly hypertensive patients in Puskesmas. This research is observational research with a cross-sectional design of analytical nature—purposive sampling techniques. The total number of samples meeting the inclusion and exclusion criteria was 435 patients. Analysis of DRPs dose category relationship data on administration of amlodipine and captopril against blood pressure conditions using a chi-square test. The results of the study showed that the characteristics of patients visited tended to be aged 65-69 years (53.33%), female (68,51%), stage II hypertensive (62.1%), amlodipine (80.92%). The incidence of the DRP dose category in stage II hypertensive (7.6%). Statistically known DRPs of amlodipine and captopril dosing categories showed different significance in each patient's condition of prehypertension (p=0.260), hypertension stage I (p = <0,001), hypertensive stage II (p<0,001). This study concludes, there is a relationship between the incidence of DRPs in the dose category in patients with stage I and stage II hypertension.
Clinical Trial of Bawang Dayak Leaves Capsules (Eleutherine americana) in Active Smokers Wahdaningsih, Sri; Untari, Eka Kartika; Rizkifani, Shoma
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.86496

Abstract

Smoking is an unhealthy behavior, particularly for the respiratory system's health due to the free radicals found in cigarette smoke. Eleutherine americana or Bawang Dayak has antioxidant properties which can neutralize the harmful free radicals penetrating the body. Additionally, malondialdehyde (MDA) is one of the stress oxidative biomarkers often applied to identify reactive stress. This study was conducted to determine the effect of Malondialdehyde on active smokers who consumed Bawang Dayak Leaves capsules. This study was a pre and post-test design involving 30 smokers who met the inclusion. The participants consumed 1 capsule containing 400 mg Bawang Dayak leaves extract for 7 days. The subject's blood was taken before and after the consumption of the capsules for MDA examination. The results of this study were that the MDA level between before and after Bawang Dayak capsules consumed statistically significant. Moreover, MDA pre and post-test level respectively were 12.074 nmol/ml and 11.869 nmol/ml. The usage of Bawang Dayak leaves capsules for a week can reduce MDA levels and likely has an antioxidant potential for active smokers.
The Correlation Analysis Between Self-Care and Life Quality of Congestive Heart Failure Patients Putri, Arsalna Daersa; Rizkifani, Shoma; Nurbaeti, Siti Nani
Media Karya Kesehatan Vol 6, No 2 (2023): Media Karya Kesehatan
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mkk.v6i2.50412

Abstract

Congestive heart failure (CHF) is a failure of the heart to transport blood and oxygen throughout the body caused by abnormalities in the heart's function and structure. CHF patients will experience obstacles in their daily routine activities, which can affect the patient's self-care. Self-care is the ability or behavior of a person to manage himself. Self-care will affect the quality of life of a patient with CHF. Quality of life is a person's ability to perform activities according to the outlook of his role in everyday life. The aim of this study is to analyze the relationship of self-care with the quality of life of CHF patients in heart polyclinic RSUD dr. Soedarso. The research method used in this case is cross sectional with correlation design. The samples were taken using purposive sampling with a total sample of 83 patients. The inclusion criteria for this study is patients suffering from CHF disease (more than 1 month), patients who can read, write, communicate well with the researchers, patients over 18 years of age, and patients who are willing to fill in informed consent, questionnaires/interviews. The results of the study showed that the self-care of patients was in the good range of 56 patients (67,5%) and 27 patients (32,5%) were in the poor range. The quality of life of patients is also in the high range of 57 patients (68.7%) and low range of 26 patients (31.3%). The data analysis using the spearman rank correlation test resulted in a p value of 0.001 (<0.05) and a correlation coefficient of (r)=0.363. The conclusion of the study is that there is a positive correlation between self-care and the quality of life of CHF patients in heart polyclinic RSUD dr. Soedarso. Keywords: Congestive heart failure, selfcare, quality of life.
ANTI-AGING PEEL-OFF MASK OF DRAGON FRUIT PEEL EXTRACT (HYLOCEREUS POLYRHIZUS) Wahdaningsih, Sri; Rizkifani, Shoma; Utari, Eka Kartika
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.8837

Abstract

Antioxidants can be used to protect the skin from damage caused by oxidation to prevent premature aging. The more increasing consumption level of red dragon fruit (Hylocereus polyrhizus) affects the amount of unused remaining fruit peels. In fact, the peel of red dragon fruit is considerably potential for natural antioxidant. Pitaya or dragon fruit is reported to contain betacyanin color pigment, with antioxidant activity. The use of cosmetics containing antioxidant compounds can prevent premature aging due to free radicals. One of the interesting forms of cosmetic preparations for skin care is the peel-off gel mask. The base that can be used as a film former for peel-off gel facial masks is polyvinyl alcohol (PVA). This study aims to determine the effectiveness of red dragon fruit peel extract peel-off masks as anti-aging. Anti-aging effectiveness testing was carried out on 10 volunteers and divided into two groups, namely the blank group (F0) and the extract group (FIII) for four weeks, and anti-aging activity was measured using a skin analyzer). Based on the results and discussions in this study, it can be concluded that the application of a peel-off mask of red dragon fruit peel extract (Hylocereus polyrhizus) is effective for repairing the skin and providing an anti-aging effect.
Analisis Tingkat Pengetahuan dan Perilaku Swamedikasi Diare terhadap Mahasiswa Farmasi Universitas Tanjungpura: Knowledge and Behaviour Assessment of Diarrhea Self-Medication among Pharmacy Undergraduate in Tanjungpura University Agvina Felicia Esperanza; Liza Pratiwi; Shoma Rizkifani
Jurnal Sains dan Kesehatan Vol. 5 No. 4 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i4.1277

Abstract

Self-medication is done to treat minor illnesses, such as diarrhea. Knowledge and behaviour of drugs usage in each individual affect self-medication so that irrational drugs usage can be prevent. This study determines the relationship between semester, knowledge and behaviour about diarrhea self-medication of pharmacy students at Tanjungpura University 2021/2022. The research method was carried out retrospectively in the form of a cross-sectioned questionnaire. Stratified random sampling method was used for sample selection. Rank-spearman analysis was used to analyze the relationship between semester level, knowledge and behaviour of diarrhea self-medication. Based on research, out of 232 respondents, majority of respondents were women, aged 21, obtained drugs from pharmacies without prescription (81,03%) and used adsorbent class for antidiarrheal drugs. Knowledges are classified from good (9,91%), moderate (28,45%) and low (61,64%). Behaviours are classified as appropiate (79,74%) and inappropriate (20,26%). The p-value results show the relationship between semester and knowledge 0,142; relationship between semester and behaviour 0,256 and relationship between knowledge and behaviour 0,318. The conclusion of this study is the relationship between semester and knowledge are categoried very low with positive significant relationship. Relationship between semester and behaviour and relationship between knowledge and behaviour are categoried low with positive significant relationship. Keywords: behaviour, diarrhea, knowledge, self-medication Abstrak Swamedikasi dilakukan untuk mengatasi keluhan atau penyakit ringan seperti penyakit diare. Tingkat pengetahuan dan perilaku individu dalam penentuan dan penggunaan obat diare dapat mempengaruhi swamedikasi diare sehingga tidak terjadi penggunaan obat yang tidak rasional. Penelitian ini bertujuan mengetahui hubungan tingkat semester, pengetahuan dan perilaku mahasiswa farmasi Universitas Tanjungpura tahun 2021/2022 terhadap swamedikasi diare. Metode penelitian dilakukan secara retrospektif potong lintang berbentuk kuesioner. Metode stratified random sampling digunakan untuk pemilihan sampel. Analisis rank-spearman digunakan untuk menganalisis hubungan tingkat semester, pengetahuan dan perilaku responden terhadap swamedikasi diare. Berdasarkan penelitian menunjukkan bahwa dari 232 responden, mayoritas responden adalah perempuan, berusia 21 tahun, memperoleh obat dari apotek tanpa resep (81,03%), dan menggunakan obat diare golongan adsorben. Responden memiliki tingkat pengetahuan yang baik (9,91%), cukup (28,45%) dan kurang (61,64%) dan tingkat perilaku tepat (79,74%) dan tidak tepat (20,26%). Hasil p-value menunjukkan hubungan tingkat semester terhadap pengetahuan yaitu 0,142; hubungan tingkat semester terhadap perilaku 0,256 dan hubungan tingkat pengetahuan dan perilaku 0,318. Kesimpulan dari penelitian ini adalah terdapat hubungan signifikan positif berkategorikan sangat rendah pada tingkat semester terhadap pengetahuan dan hubungan signifikan positif berkategorikan rendah pada tingkat semester terhadap perilaku dan hubungan tingkat pengetahuan terhadap perilaku berkategorikan rendah. Kata Kunci: diare, pengetahuan, perilaku, swamedikasi
Studi Penggunaan Obat Golongan Statin pada Pasien Penyakit Jantung Koroner di Ruang ICCU RSUD dr. Soedarso Pontianak: Study of Drug Use Classification Statins in Heart Disease Patients Coronary in the ICCU Room RSUD dr. Soedarso Pontianak Dhenaya Pradina; Shoma Rizkifani; Siti Nani Nurbaeti
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1979

Abstract

Coronary Heart Disease (CHD) is a cardiovascular disease that occurs due to narrowing of the coronary arteries from atherosclerosis process. High levels of lipids in the blood can be the one of the key factor that can increase the risk of cardiovascular disease, one of which is CHD. So this problem is used as the main target in CHD treatment. One of the drugs used in the treatment of CHD is the statin group. This study aims to examine the pattern of statins use in CHD patients in the ICCU RSUD dr. Soedarso Pontianak. Data collection was done retrospectively based on the medical records of CHD patients in 2021. This study is an observational cross-sectional descriptive study. Data was collected using a total sampling technique, and a sample of 45 patients who met the inclusion criteria were obtained. The results showed that the most widely used statin class of drugs in CHD patients in the ICCU was Atorvastatin (95.55%) compared to Simvastatin (4.44%) with the dose used was Atorvastatin 20 mg (66.66%), Atorvastatin 40 mg (28.88%), and Simvastatin 20 mg (4.4%). The frequency of using Atorvastatin and Simvastatin in the ICCU is once a day orally. The conclusion of this study is based on medical record data of CHD patients in the ICCU room at RSUD dr. Soedarso Pontianak, the most widely used statin class drug is Atorvastatin with an average dose of 20 mg of Atorvastatin at a frequency of administration once a day orally. Keywords:          Coronary Heart Disease, Statin Class, Atorvastatin, Simvastatin   Abstrak Penyakit Jantung Koroner (PJK) adalah salah satu penyakit kardiovaskular yang terjadi karena penyempitan pada arteri koroner yang berasal dari proses aterosklerosis. Tingginya kadar lipid dalam darah menjadi aspek kunci yang dapat memberikan risiko penyakit kardiovaskular salah satunya pada PJK. Sehingga masalah ini digunakan sebagai target utama pada pengobatan PJK. Salah satu obat yang digunakan pada pengobatan PJK adalah golongan statin. Penelitian ini bertujuan untuk melihat bagaimana pola golongan statin digunakan oleh pasien PJK di ICCU RSUD Dr. Soedarso Pontianak. Pengumpulan data dilakukan secara retrospektif menurut rekam medis pasien PJK tahun 2021. Penelitian ini merupakan penelitian observasional dengan rancangan studi cross-sectional dengan sifat deskriptif. Teknik total sampling ini digunakan dalam  proses pengumpulan data, dan diperoleh 45 sampel pasien yang masuk pada kriteria inklusi. Hasil penelitian memperlihatkan bahwa penggunaan obat golongan statin yang digunakan pada pasien PJK di ICCU adalah Atorvastatin (95,55%) dan Simvastatin (4,44%) dengan dosis yang digunakan adalah Atorvastatin 20 mg (66,66%), Atorvastatin 40 mg (28,88%), dan Simvastatin 20 mg (4,4%). Frekuensi penggunaan Atorvastatin dan Simvastatin di ICCU adalah 1 kali sehari secara per oral. Kesimpulan pada penelitian ini adalah berdasarkan data rekam medis pasien PJK di ruang ICCU RSUD dr. Soedarso Pontianak, obat golongan statin yang paling banyak dikonsumsi adalah Atorvastatin dengan rata-rata penggunaan dosis Atorvastatin 20 mg pada frekuensi pemberian 1 kali sehari secara per oral. Kata Kunci:         Atorvastatin, Golongan Statin, Penyakit Jantung Koroner, Simvastatin
Edukasi Imunisasi Dasar Lengkap pada Anak bagi Anggota PKK Wajok Hilir Kecamatan Jongkat Kabupaten Mempawah: Basic Immunization Education in Children for PKK Members at Wajok Hilir, Jongkat District, Mempawah Regency Ropiqa, Meri; Wahdaningsih, Sri; Nurbaeti, Siti Nani; Rizkifani, Shoma; Agustriangga, Muhammad Rafly; Indriyani, Risa
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 3 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i3.6426

Abstract

Immunization is a safe and effective method to protect a person from dangerous diseases before exposure to disease-causing agents. Immunization for children is essential to strengthen the body's defense system so it's immune to disease attacks. Community Service Activities (PKM) aim to equip the Wajok Hilir cadres or PKK mothers with information, education, and skills regarding complete basic immunization information for children. This PKM activity consists of several activities, including designing educational methods, creating complete basic immunization educational media, administering pretest and posttest, and evaluating the level of understanding. The results show that there has been an increase in the understanding of cadres or PKK mothers with the indicator that the average pretest score is 39.58 and the average posttest score is 65.72. The conclusion, there has been an increase in the understanding of the Wajok Hilir cadres or PKK mothers.
PENILAIAN PERAWATAN DIRI DAN EVALUASI POTENSI INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN GAGAL JANTUNG DI RSUD dr. SOEDARSO PONTIANAK Rizkifani, Shoma; Yuswar, Muhammad Akib
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 1 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penderita gagal jantung dalam melakukan aktivitas sehari-hari memiliki keterbatasan sehingga mempengaruhi perawatan diri. Penderita gagal jantung juga dikenal mengonsumsi berbagai macam obat memiliki risiko mengalami interaksi obat yang dapat menguntungkan atau merugikan bagi penderita. Penelitian ini bertujuan untuk mengkaji tingkat perawatan diri dan menggambarkan kejadian interaksi obat pada penderita gagal jantung di RSUD dr. Soedarso Pontianak. Pengambilan sampel data yaitu teknik purposive sampling dengan jumlah sampel sebanyak 92 pasien. Kriteria inklusi penelitian yaitu pasien yang menderita gagal jantung lebih dari 1 bulan, pasien berusia lebih dari 18 tahun, pasien sedikitnya mendapatkan ≥ 2 terapi pengobatan jantung, pasien yang bersedia mengisi informed consent dan mau diwawancara. Hasil penelitian menunjukkan tingkat perawatan diri pasien dengan rentang baik sebanyak 63 pasien (68,5%), dan buruk sebanyak 29 pasien (31,5%). Potensi interaksi obat dari interaksi farmakodinamika sebanyak 455 kejadian (72,5%), farmakokinetika sebanyak 33 kejadian (5,3%), dan tidak diketahui sebanyak 139 kejadian (22,2%). Kesimpulan dari penelitian ini adalah tingkat perawatan diri pasien terdapat pada rentang baik dan interaksi obat banyak terjadi secara farmakodinamika. Kata kunci : antihipertensi, gagal jantung kongestif, interaksi obat, perawatan diri DOI : 10.35990/mk.v8n1.p25-34
GAMBARAN VISUAL ANALOG SCALE (VAS) PASIEN HIPERTENSI DI PUSKESMAS SIANTAN TENGAH PONTIANAK Putra, Berlian Rizky; Yuswar, Muhammad Akib; Rizkifani, Shoma
Journal Pharmacy Of Tanjungpura Vol 1, No 2 (2024): APRIL
Publisher : Universitas Tanjungpura

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Abstract

Hipertensi merupakan penyakit kronis yang dapat mempengaruhi kualitas hidup pasien hipertensi. Pengukuran rasa sakit merupakan faktor yang penting agar tercapainya keberhasilan terapi dan kualitas kesehatan yang diinginkan. Penelitian ini bertujuan untuk mengetahui gambaran Visual Analog Scale (VAS) pada pasien hipertensi di Puskesmas Siantan Tengah Kota Pontianak. Metode penelitian yang digunakan yaitu observasional kohort. Data didapat dari pasien hipertensi yang memenuhi kriteria inklusi pada bulan Juni-Juli 2021 secara purposive sampling bersifat prospektif dan dikumpulkan dari rekam medis, kuesioner VAS. Hasil yang diperoleh terhadap 50 pasien yaitu pasien didominasi oleh wanita berusia lansia dengan tekanan darah 160 mmHg (Hipertensi Stage II). Selain itu, didapat nilai VAS paling banyak dalam kategori baik sebanyak 43 pasien (86 %) dengan nilai median 70. Kesimpulan mayoritas nilai VAS pasien hipertensi di Puskesmas Siantan Tengah Kota Pontianak adalah kategori baik.
KAJIAN PENGARUH EKSTRAK ETANOL 70% DAUN NANGKA (ARTOCARPUS HETEROPHYLLUS LAM) TERHADAP TIKUS PUTIH (RATTUS NORVEGICUS) GALUR WISTAR Rupiani, Aprias; Rizkifani, Shoma; Wahdaningsih, Sri
Journal Pharmacy Of Tanjungpura Vol 3, No 1 (2025): Oktober
Publisher : Universitas Tanjungpura

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Abstract

Kalimantan Barat mengalami kenaikan jumlah tanaman penghasil nangka (Artocarpus heterophyllus Lam) sehingga daunnya memiliki potensi besar untuk dikembangkan sebagai kandidat obat karena memiliki aktivitas farmakologi. Evaluasi keamanan suatu tanaman obat perlu dilakukan mengingat terdapat beragam senyawa metabolit yang terkandung didalam suatu tumbuhan. Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak etanol daun nangka terhadap berat badan serta aktivitas dan perilaku motorik sebagai parameter penanda awal gejala toksik pada tikus putih (Rattus norvegicus) galur Wistar setelah pemberian oral secara berulang selama 28 hari. Ekstraksi dilakukan melalui metode maserasi dengan pelarut etanol 70%. Hewan uji diklasifikasikan menjadi 6 kelompok berdasarkan jenis kelamin dengan 5 ekor tikus di setiap kelompok. Kelompok kontrol diberikan suspensi CMC-Na 0,5%, kelompok perlakuan diberikan ekstrak dengan dosis 100 mg/KgBB, 400 mg/KgBB, 1000 mg/KgBB dan kelompok satelit kontrol diberikan suspensi CMC-Na 0,5% serta dosis 1000 mg/KgBB untuk kelompok satelit dosis atas. Seluruh kelompok tidak menyebabkan mortalitas dan perubahan baik dari perilaku serta aktivitas motorik, namun terjadi penurunan berat badan signifikan pada kelompok dosis 1000 mg/KgBB yang bersifat reversibel. Kesimpulan dari penelitian ini yaitu pemberian ekstrak etanol daun nangka tidak mempengaruhi berat badan serta aktivitas dan perilaku motorik hewan uji
Co-Authors A.A. Ketut Agung Cahyawan W Abang Raffli Ade Ferdinan Agustriangga, Muhammad Rafly Agvina Felicia Esperanza Ajeng, Melia Alifa Rapaella Fadia Tito Putri Anas Putri Maria Natasya Panamuan Anindia, Winda Ardini, Citra Ayu Aulia Uly Fahmi Bambang WIJIANTO Chang, Samuel Crishanzen Defiga Kasrin Dhenaya Pradina Dwi Wulan Anggraini Eka K. Untari Eka Kartika Untari Eka Kartika Untari Eka Kartika Untari Eka Kartika Untari Elisabeth indah Mulatsih Fahmi, Ayu Aulia Uly Fajar Nugraha Felisitas Feli Filomina Dila Putri Gamayanti, Tasiana Gisela Ghea Egikania Sutanto Hadi Kurniawan Hafrizal Riza Hariyanto IH Husnatika Indriyani, Risa Intan Khairunnisa Khairunnisa, Intan Lestari, Eka Rizki Liza Pratiwi Luluk Mariani Lusi Ariska Triani M Rafly Agustriangga M. Akib Yuswar Mariani, Luluk Meri Ropica Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Rafly Agustriangga Mulatsih, Elisabeth indah Najini, Robby Nera Umilia Purwanti Nera Umilia Purwanti, Nera Umilia Nia Resseda ningsih, yetiutari Nurmainah Nurmainah Nurmainah Nurmainah Nurmainah Nurmainah Nurmainah Oi, San Putra, Berlian Rizky Putri, Arsalna Daersa Rikalia, Rikalia Risa Indriyani Robby Najini Robby Najini Robiyanto, Robiyanto Ronaldo, Ronaldo Ropiqa, Meri Rupiani, Aprias Samuel Crishanzen Chang Saputra, Pinsensius Boni Sarah M. Sasfi Shinta Misdariani Nur Shinta Nia Putri Siti Nani Nurbaeti Sri Wahdaningsih Susanti, Ressi Sutanto, Ghea Egikania Tri Febiani Ulfa Sri Mandasari Utari, Eka Kartika Vanie, Vanie William Rinaldi Yeni Utari Ningsih Yulnalia Mariella Delavega Yuswar, Akib Yuswar, Muhammad Akib