One of the innovations in developing teaching materials that utilize technology and learning approaches is to modify printed LKPD into electronic form which is prepared using a learning model. This research aims to develop a valid and practical guided inquiry-based E-LKPD on acid and base subject for class XI SMA/MA. The type of research used is design research with a plomp development model. The results of this research show that the E-LKPD developed is valid and practical. The average content validity value of E-LKPD is 0.85 with a valid category and the average construct validity value of E-LKPD is 0.85 with a valid category. The average value of practicality analysis is 92% for teacher practicality in the very practical category and 88% for students' practicality in the very practical category.