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All Journal Jurnal Teknik Mesin Jurnal Simetris Nadwa : Jurnal Pendidikan Islam Jurnal Pendidikan Ilmu Sosial Universa Medicina Smart Medical Journal Syntax Literate: Jurnal Ilmiah Indonesia MEKANIKA - JURNAL TEKNIK MESIN YARSI Medical Journal Majalah Kesehatan Pharmamedika Jurnal Ilmiah Manajemen Kesatuan Jurnal Pengabdian Masyarakat Khatulistiwa Respiratory Science Journal of Mechanical Engineering, Science, and Innovation Zona Manajerial: Program Studi Manajemen (S1) Universitas Batam Journal of Artificial Intelligence and Digital Business Junior Medical Journal Jurnal AGRISEP: Kajian Masalah Sosial Ekonomi Pertanian dan Agribisnis Current Biomedicine Jurnal Riset Kajian Teknologi dan Lingkungan Ekobisman : Jurnal Ekonomi Bisnis Manajemen Jurnal Ruhul Islam Jurnal Komplikasi Anestesi
Indra Kusuma
Department of Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Ikhtiar Sehat dan Usia Panjang Ditinjau dari Aspek Biomedik dan Islam Riliani, Marisa; Muhammad Astiwara, Endy; Purwaningsih, Endang; Samsul Mustofa, Muhammad; Kusuma, Indra
Jurnal Ruhul Islam Vol 2 No 1 (2024): Jurnal Ruhul Islam
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jri.v2i1.173

Abstract

Agama Islam telah mengajarkan bahwa sehat dan sakit merupakan sunnatullah, karena Allah SWT yang menciptakannya, sehingga apapun yang hendak diberikan-Nya adalah hak mutlak Allah SWT. Seluruh umat manusia di dunia selalu menginginkan kebahagiaan di dunia maupun di akhirat. Hal itu dapat terjadi apabila seseorang dapat melaksanakan kewajiban agama dengan baik, namun untuk dapat melaksanakan kewajiban agama dengan baik maka perlu kondisi fisik dan mental yang sehat. Dunia kedokteran saat ini telah banyak mengalami peningkatan pesat dalam hal ilmu pengetahuan untuk mengobati penyakit maupun untuk mencegah terjadinya penyakit, diantaranya dengan adanya pengobatan berbasis sel punca dan telomer maka harapan hidup manusia semakin lama semakin meningkat. Penelitian ini bertujuan untuk melihat tinjauan Islam dan Biomedik mengenai ikhtiar sehat dan usia panjang umur. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan kajian literatur atau studi pustaka. Hasil penelitian menunjukkan bahwa sehat merupakan rahmat yang sangat besar pemberian dari Allah SWT yang harus dipelajari dan harus dipelihara, serta apabila seseorang sakit maka wajib berikhtiar untuk mencari pengobatan. Sedangkan ikhtiar atau usaha untuk mencari pengobatan menggunakan teknologi kedokteran berbasis sel dan telomer tidak bertentangan dengan ajaran agama Islam selama mengikuti aturan-aturan yang sudah ditentukan. Dan usia yang panjang adalah berkah tak terhingga dari Allah SWT yang patut disyukuri dengan cara banyak berbuat baik dan beramal saleh sehingga menjadi manusia yang bermanfaat di dunia.
DETERMINATION OF WORK FACILITIES, COMPETENCE AND WORK ENVIRONMENT WITH WORK MOTIVATION AS VARIABLES INTERVENING ON PERFORMANCE OF EMPLOYEES IN GENERAL JOB, LAND AND PROVINCE SPACE MANAGEMENT RIAU'S SKILLS Kusuma, Indra; Rumengan, Jemmy; Manjang, Yunazar
Zona Manajerial: Program Studi Manajemen (S1) Vol 9 No 2 (2019): Zona Manajerial: Program Studi Manajemen
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (280.195 KB) | DOI: 10.37776/zm.v9i2.212

Abstract

In this study, researchers used respondents' data, such as gender, age and duration of work of respondents to be able to provide information about the characteristics of respondents. Where from the questionnaire distributed questionnaire as many as 60 respondents using census techniques. Data analysis with parametric and non parametric statistics using SEM-PLS (Structural Equation Modeling-Partial Least Square) regarding research variables, instrument test, normality test, hypothesis test, and discussion of the results of hypothesis testing and Path Path Analysis. This study uses path analysis (path analysis) to test the pattern of relationships that reveal the influence of variables or a set of variables on other variables, both direct influence and indirect influence. The results of the study are as follows: The effect of the X3 variable on X4 has a P-Values value of 0.020 <0.05, so it can be stated that the influence between X3 and X4 is significant. The effect of the X3 variable on Y has a P-Values value of 0.020> 0.05, so it can be stated that the effect between X3 on Y is significant. The effect of the X4 variable on Y has a P-Values value of 0.010> 0.05, so it can be stated that the influence between X4 on Y is significant. The effect of X1 on X4 has a P-Values value of 0.035 <0.05, so it can be stated that the influence between X1 to X4 is significant. The effect of X1 on Y has a P-Values value of 0.007> 0.05, so it can be stated that the influence between X1 and Y is significant. The effect of the X2 variable on X4 has a P-Values value of 0.001 <0.05, so it can be stated that the effect between X2 on X4 is significant. The effect of the X2 variable on Y has a P-Values value of 0.008 <0.05, so it can be stated that the effect between X2 on Y is significant.
Characterization of Fibroblast Secretome: Extracelular Vesicles (EVs) Particle Count, Molecular Size and Total Protein Levels Riliani, Marisa; Kusuma, Indra; Sandra, Yurika; Zakiyah, Zakiyah; Ramansyah, Aditya
Smart Medical Journal Vol 8, No 3 (2025): December
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v8i3.109896

Abstract

Introduction: The secretome of human dermal fibroblasts consists of diverse bioactive molecules including proteins and extracellular vesicles (EVs), playing a key role in skin regeneration and homeostasis. Molecular weight-based fractionation provides insights into the functional heterogeneity of the conditioned medium (CM). This study aimed to characterize size-fractionated CM from fibroblasts to reveal its molecular properties and potential bioactivity.Methods: A descriptive laboratory study was conducted using conditioned medium from passage 5 human dermal fibroblasts cultured in serum-free conditions. Tangential flow filtration (TFF) was applied to fractionate the CM into low (LMW), medium (MMW), and high molecular weight (HMW) components. Nanoparticle tracking analysis (NTA) quantified EV particle concentration and size, while total protein content was assessed by BCA assay. Experiments were performed in triplicate (n=3).Results: Particle concentrations increased with molecular weight, with HMW fractions showing the highest counts but slightly smaller average particle sizes compared to LMW and MMW fractions. Total protein concentration also rose with molecular weight, peaking in HMW fractions, indicating enrichment of larger protein complexes and vesicles. Fractionation maintained consistent particle size distribution across fractions, supporting effective separation.Conclusion: Fibroblast secretome exhibits heterogeneous EV and protein populations distinguishable by molecular weight fractionation. The enriched higher molecular weight fractions contain more EVs and proteins, suggesting distinct biological roles. Combining TFF with further purification steps may enhance separation purity, facilitating therapeutic applications of secretome components.
Co-Authors Agus Sulistiawan Ahmad Sulaeman Ajib Susanto Alida Harahap Alvita, Nini Aridestama, Raihan Aulia Arief Boediono Arief, Ilham Ascobat, Purwantyastuti Asnita, Rika Aufa, Akhdan Aulia, Maila Rizqi Azmi, Sabrina Azzahra, Sabna Bahri, Syukrini Bambang Kiranadi Bambang Purwoko Dewi, Hanik Anggraeni Djoko Sasono, Djoko Edy Supriyadi Eko Poerwanto Elsye Souvriyanti, Elsye Endang Purwaningsih Endy Muhammad Astiwara Erlina Burhan Erlina, Andi Evy Latifah Fachry Abda El Rahman Fadilah, Khonsa Fitri Fahrudin Fahrudin Fajrian, Muhammad Adhif Fasli Jalal Fauzi, Achmad Ma’ruf Fitria Athayya Desvianti Galih Saputra, Galih Gusnanto, Arief Hadi, Restu S. Hambani, Susy Hidayati, Anggi Puspa Nur Hidayati, Nur Ilham Risma Idris, Muthoharoh Jemmy Rumengan Juniarti . Kesumaningtias, Raden Roro Widorini Lating, Noval Ali Lina Lasminingrum Muchtiar, Mulyadi Mulyono, Ibnu Utomo Wahyu Mulyono, Ibnu Utomo Wahyu Noeriwan, Noeriwan Olivia, Prisca Pangestu, Hendri Pelangi Eka Yuwita Pratama, Muhammad Abel Priyono, Harim Putra, Andika Chandra Putri, Pingkan Permata Ramansyah, Aditya Restu Syamsul Hadi Restuti, Ratna Dwi Rianda Dirkareshza Rianto Setiabudy Rifqatussaadah, Rifqatussaadah Rika Bur Rika Yuliwulandari Riliani, Marisa Ros Sumarny Samsul Mustofa, Muhammad Sapto Mei Budiyanto, Sapto Mei Sophie Yolanda Sulistiawati, Indah Syarifah, Lensy Khosinatus Taupiqqurrahman Tjandra Yoga Aditama Trijaya, Dewi Sekarsari Trinovita Andraini Utomo, Ahmad Rusdan H Wening Sari Yati Sumiyati, Yati Yudertha, Andreo Yulia Suciati Yunazar Manjang Yurika Sandra Zakiyah Zakiyah Zannah, Fahma Hayyul