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All Journal USU LAW JOURNAL MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Abdi Dosen : Jurnal Pengabdian Pada Masyarakat El-Wasathiya: Jurnal Studi Agama Iuris Studia: Jurnal Kajian Hukum Narra J Locus Journal of Academic Literature Review AKSONA Counselia: Jurnal Bimbingan Konseling Pendidikan Islam Jurnal Muara Olahraga Jurnal Kedokteran Hewan DECODING: Jurnal Mahasiswa KPI Neoclassical Legal Review: Journal of Law and Contemporary Issues Landraad Journal of Islamic Economics, Banking, and Social Finance
Muhammad Hamdan
Program Studi Magister Ilmu Hukum Fakultas Hukum Universitas Sumatera Utara
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Journal : Narra J

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Motor improvement in Parkinson’s disease patients receiving caffeine adjuvants: A double-blind randomized controlled trial in Indonesia Hamdan, Muhammad; Suharto, Ade P.; Nugraha, Priya; Islamiyah, Wardah R.
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.826

Abstract

Parkinson's disease (PD) manifests as a movement and brain function disorder characterized by symptoms such as resting tremors, rigidity, bradykinesia, and postural instability, leading to disability among patients. The use of psychostimulants such as caffeine has been associated with the improvement of motor symptoms in PD patients; however, studies regarding the effect of caffeine adjuvant therapy on motor function among PD patients in the Indonesian population are lacking. The aim of this study was to evaluate motor improvement as measured by the change in scores of the Movement Disorder Society - Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS-III) among PD patients receiving caffeine adjuvant. A double-blind randomized controlled trial (RCT) was conducted among PD patients at Dr. Soetomo General Academic Hospital and Universitas Airlangga Hospital, Surabaya, Indonesia, from April to August 2023. A total of 27 patients were enrolled and randomly assigned to an intervention (receiving caffeine adjuvant, n=15) and control group (receiving placebo, n=12). Motor improvement was measured using the UPDRS III score prior to intervention and three weeks after. The Chi-squared test was used to analyze the difference in UPDRS III scores between the two groups. Motor improvement, as demonstrated by a reduction in the UPDRS III score, was observed in patients receiving caffeine adjuvant compared to those receiving placebo (80.0% vs 16.7%; p=0.004). Regarding the safety profile, only four out of 15 (26.6%) patients treated with caffeine reported minor adverse events. These conditions improved over time during the intervention. None of the 12 patients in the placebo reported adverse events. This study provides valuable insights into the initial dosage of caffeine that improves motor function in PD patients with minimum adverse effects.
Associations between plasma beta amyloid and cognitive decline: A systematic review and meta-analysis Cynthia, Cynthia; Nugraha, Jusak; Hamdan, Muhammad; Dharma, Rahajuningsih; Lumempouw, Silvia F.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.2268

Abstract

Alzheimer’s disease is a leading neurodegenerative disorder characterized by progressive cognitive decline. Early prediction is crucial for enabling timely interventions. Plasma amyloid β-peptides (Aβ), particularly the Aβ-42/Aβ-40 ratio, have been proposed as potential non-invasive biomarkers for cognitive decline and Alzheimer’s disease risk. However, conflicting findings and methodological variability have hindered consensus regarding their clinical utility. The aim of this study was to evaluate whether the plasma Aβ levels predict dementia, Alzheimer’s disease, and cognitive decline. Studies were eligible for inclusion if they measured at least one plasma Aβ species (Aβ-40, Aβ-42, or the Aβ-42/Aβ-40 ratio) and reported outcomes related to dementia, Alzheimer’s disease, or cognitive change. Only human studies published in peer-reviewed journals were included. A comprehensive search of six databases (PubMed, PMC, SSRN, Scopus, BioRxiv, and MedRxiv) was conducted up to December 1, 2024. Risk of bias was assessed using the ROBINS-E tool, and pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using a random-effects meta-analysis. A total of 25 studies were included in the systematic review, with four contributing to the meta-analysis. Lower plasma Aβ-42/Aβ-40 ratio was not significantly associated with Alzheimer’s disease risk (pooled HR=0.8; 95%CI: 0.62–1.04), and substantial heterogeneity was observed (I²=70%, p=0.02). Individual studies varied in their findings: while some reported that lower Aβ-42/Aβ-40 ratio predicted increased Alzheimer’s disease risk, others found no association or even opposing trends. Methodological heterogeneity—including differences in sample handling, measurement techniques, and study designs—likely contributed to these inconsistencies. Overall, this review suggests that plasma Aβ-42/Aβ-40 ratio is not reliable predictors for the onset of Alzheimer’s disease or dementia. However, the substantial heterogeneity observed underscores the need for further research to clarify the potential of plasma Aβ as a preclinical biomarker.
Co-Authors Abdul Aziz Alsa, Abdul Aziz Aca Surya Putra Zai Adilah, Mujahidah Afif, Tansri Riziq Hilman Aldi Pramana Alia, Safia Alvi Syahrin Amelia, Elena Ghentilis Fitri Andi Rian Djajadi Andi Supratman Anggara Suryanagara Anjani, Nur Dwi atika Azbilia, Siti Fatma Baisa, Hidayah Barry Sugiarto Bismar Nasution Bobbi Sandri Budi Bahreisy Budi Utomo Cynthia Cynthia Cynthia Dedi Harianto Des Boy Rahmat Eli Zega Dienanta, Savira Edi Yunara Ediwarman Ediwarman Edy Ikhsan Ekaputra, Mohammad Elok Budi Retnani Eva Syahfitri Nasution, Eva Syahfitri Fadilah Khoirinnisa Harahap Fahmi Tanjung Fahmi, Achmad Faisal Akbar Nasution Ferry Sandra Fhytta Imelda Sipayung Fuji Sasmita Gerry Anderson Gultom Hana Oktaviana Fahlevi Hanawi Aananda Putra Sitohang Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** HARIYANTO HARIYANTO Hasim Purba Henry Sucipto Sanjaya Sirait Huda Shalahudin Darusman Huda, M. Muchlish Ica Karina Imami, Nabilah Hasna Iman Azahari Ginting Immanuel Colia Immanuel P Simamora Irianto Irianto Islamiyah, Wardah R. Jelly Leviza Jhon Tyson Pelawi Julieta Santi Simorangkir Jusak Nugraha Jusmadi Sikumbang Jusnizar Sinaga Keke Wismana Purba Kesita Eva Lestina Lumban Tobing Kusuma, Yohanna Lestari Victoria Sinaga Lestari, Diayanti Tenti Lidya Rahmadani Hasibuan Lumempouw, Silvia Machin, Abdulloh Madiasa Ablisar Madiasa Ablisar Mahmud Mulyadi MAHMUL SIREGAR Maria Margaretta Sitompul Marlina, Marlina Mathilda Chrystina Katarina Mazmur Septian Rumapea Mirza Nasution Muhammad Ekaputra Muhammad Hykna Kurniawan Lubis Muhammad Iqbal Lubis Muhammad Muchlish Huda, Muhammad Muchlish Mujita Sekedang Munthe, Hasanuddin Nanang Tomi Sitorus Nara Palentina Naibaho Nelson Syah Habibi S. NINGRUM NATASYA SIRAIT Ningrum, Emilna Mega Noviana, Rachmitasari Nugraha, Priya Nurrani Mustika Dewi, Nurrani Mustika Panca Hutagalung Paulus Sugianto, Paulus Perdana Eliakhim Manalu Polin Pangaribuan Pukovisa Prawiroharjo, Pukovisa Pulungan, Juli Julaiha Puti, Nazla Ananda Rachmi Putri Rumondang Siagian Putri, Indah Aprianti Rahajuningsih Dharma Rahmarini, Edfina Ramsi Meifati Barus Rani Angela Gea Rehatta, Nancy Margarita Ricky T. A Pasaribu Rina Melati Sitompul Risna Oktaviyanti Utami Rizky Novia Karolina Rizma, Fachrien Robinson Sihombing Roland Tampubolon Samsul Aripin Silitonga Sarimonang B Sinaga Sensusiati, Anggraini Dwi SILMI MARIYA Silvia F. Lumempouw Siregar, Khoiruddin Manahan Siti Maimana Sari Ketaren SOETJIPTO . Songidan, Junaidi Suhaidi Suhaidi Suharto, Ade P. Sunarmi, Sunarmi Syafruddin Kalo Syafrudin Kallo Syaiful . Syamsul Arifin Syawal Saputra Siregar Tarigan, Yos Arnold Tedi Franggoes Andri Siburian Themis Simaremare Turchan, Agus Utari Maharany Barus Utary Maharani Barus Utary Maharany Barus UUS SAEPULOH Wilson Raja Ganda Tambunan Yohana Yohana Zikrul Hakim