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All Journal Dentino: Jurnal Kedokteran Gigi Dentin Prosiding Konferensi Nasional PKM-CSR
Beta Widya Oktiani
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Humanities Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Environmental Science Nursing Public Health Social Sciences

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TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT BASED ON LIVER HISTOPATHOLOGY HYDROPIC DEGENERATION AND NECROSIS Dhiya Salma Azminida; I Wayan Arya Krishnawan Firdaus; Juliyatin Putri Utami; Beta Widya Oktiani; Erida Wydiamala
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20400

Abstract

Background: Ironwood bark extract contains antioxidant properties such as flavonoids, phenolics, and proanthocyanidins, which can stabilize ROS in the body and help accelerate wound healing. The liver plays a role in nutrient metabolism, detoxification, and ROS production. The lack of antioxidants to neutralize excess ROS makes the liver vulnerable to damage. Purpose: This study aimed to determine that there was no toxic effect of giving ironwood bark extract (Eusideroxylon zwageri) doses of 1.250 mg/kg, 2.750 mg/kg, and 4.750 mg/kg on the liver of Wistar rats based on histopathological features of hydropic degeneration and necrosis. Methods: Pure laboratory experimental quantitative (true experimental) with a post-test-only research design with control group design and One Way Anova statistical test. Treatment was given to 4 groups, namely group (K) was given aquadest control, group (T1) was given ironwood bark extract at a dose of 1.250 mg/kgBW, group (T2) was given ironwood bark extract at a dose of 2.750 mg/kgBW, and group (T3) given ironwood bark extract at a dose of 4.750 mg/kgBW. Results: The results showed no significant difference between the four treatment groups based on the average percentage of hydropic degeneration and necrosis. Conclusion: There was no toxic effect of giving ironwood bark extract doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW on the liver of Wistar rats based on histopathological appearance of hydropic degeneration and necrosis for 14 days.
ANTIBACTERIAL EFFECTIVENESS OF LIME PEEL (Citrus hystrix) EXTRACT GEL ON Porphyromonas gingivalis BACTERIES M. Rizky Nuari Asmik Ara; Beta Widya Oktiani; Ika Kusuma Wardani; Renie Kumala Dewi; Fransiska Uli Arta Panjaitan
Dentino: Jurnal Kedokteran Gigi Vol 10, No 2 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i2.24167

Abstract

Background: Periodontitis is an inflammation of the tooth-supporting tissues caused by microorganisms, especially Porphyromonas gingivalis. Porphyromonas gingivalis has resistance to many antibiotics. Kuit lime peel has potential as an antibacterial with the most compound content is triterpenoid. Objective: To measure and analyze the effectiveness of antibacterial gel of kuit lime peel extract (Citrus hystrix) on the growth of Porphyromonas gingivalis bacteria. Methods: This study is a laboratory experimental study with post test with control group design, using seven treatment groups, namely 5%, 10%, 20% kecapi leaf extract, and metronidazole positive control with 7 repetitions of each treatment. Antibacterial effectiveness uses the disc diffusion method which is seen from the diameter of the inhibition zone formed on Mueller Hinton Agar media. Results: Based on the results of Kruskal-Wallis and Post hoc Mann Whitney tests, there were significant differences between concentration groups of 5%, 10%, 20%, and metronidazole. Conclusion: Lime peel extract gel (Citrus Hystrix) concentrations of 5%, 10%, and 20% have antibacterial potential against Porphyromonas gingivalis bacteria. Keywords: kuit lime peel extract, antibactery, porphyromonas gingivalis
ANTIBACTERIAL EFFECTIVENESS TEST OF KECAPI LEAVES EXTRACTS (Sandoricum koetjape) AGAINST THE GROWTH OF Porphyromonas gingivalis Novita Nanda Fitria; Beta Widya Oktiani; Aulia Azizah
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18855

Abstract

Background: Chronic periodontitis is a disease of the oral cavity that is influenced by the presence of plaque bacteria caused by Porphyromonas gingivalis which can cause chronic infection of the periodontal tissue. Kecapi leaf (Sandoricum koetjape) extract contains active compounds in the form of flavonoids, saponins, alkaloids, steroids, phenolics, and triterpenoids which function as antibacterial against the growth of Porphyromonas gingivalis. Kecapi leaf extract is used as an alternative to using herbal gluconate to prevent infection caused of Porphyromonas gingivalis. Purpose: To determine the antibacterial effectiveness of kecapi leaf extract against bacterial growth of Porphyromonas gingivalis. Methods: This study used a pure experimental research (true experimental) with post-test only with control design, consists of 7 treatment groups, including: concentrated kecapi leaf extract 5%, 10%, 15%, 25%, 50%, chlorhexidine gluconate 0.2% as positive control, and distilled water as negative control. It was repeated 7 times, the antibacterial effectiveness was assessed from Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) on BHIB and NA media by dilution method. Results: MIC on kecapi leaf extract at a concentration of 5% showed the smallest result of -0.147 and the MBC value at a concentration of 50% did not show the growth of bacterial colonies. Conclusion: Kecapi leaf extract with concentrations of 5%, 10%, 15%, 25%, 50%, and positive control was effective in inhibiting and killing bacterial growth of Porphyromonas gingivalis. Keywords: Antibacterial, Kecapi leaf extract, Porphyromonas gingivalis
Co-Authors Adela Tamara Agung Satria Wardhana Aisyah Nur Zahra Anisa Novia Farrasti Anugrah Qotrunnada Hakim Aqshall Ilham Safatullah Aspriyanto, Didit Aulia Azizah Aura Amelia Az Zahra Khairinisa Bimo Gondo Arum Brachmedio Barito Syech Erlangga Candra Candra Debby Saputera, Debby Della Isnadya Noor Dewi Nurdiana Dhiya Salma Azminida Duhan Kanzu Balad Dwi Kurniawan, Fajar Kusuma Dyah Setyorini Eka Dwita Natasya Fitri Siregar Elsa Ayu Amanda Erida Wydiamala Fransiska U.A Panjaitan Fransiska Uli Arta Panjaitan Galuh Dwita Sari Hatta, Isnur Hilyatul Auliya I Wayan Arya K. Firdaus I Wayan Arya Krishnawan Firdaus Ika Kusuma Wardani Irnamanda D.H., Irnamanda Juli Harnida Purwaningayu Khairunnisa Puspita Sari Laili Nurul Islami M. Ridhotama Wibowo M. Rizky Nuari Asmik Ara Maharani Laillyza Apriasari Makfiyah Saidah Melati Ainun Nisa Melisa Budipramana, Melisa Miftakhu Rizkiyah Nabila Nabila Noor Khalishah Novita Nanda Fitria Nur Alam Prilly Sonya Puteri Rahmad Arifin Renie Kumala Dewi Rini Rahmiyati Riznika Riznika Rosihan Adhani, Rosihan Sarifah, Norlaila Setyawardhana, Raden Harry Dharmawan Sherli Diana Siti Khairiah Stevani Stevani Tri Putri, Deby Kania Utami, Juliyatin Putri Veren Yosi Erinda Yusrinie Wasiaturrahmah