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All Journal E-Jurnal Medika Udayana Jurnal Kesehatan Andalas Sari Pediatri Paediatrica Indonesiana AcTion: Aceh Nutrition Journal Jurnal Kesehatan Reproduksi Majalah Kedokteran Andalas Human Care Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Penyakit Dalam Indonesia Jurnal Ilmu Keperawatan dan Kebidanan Jurnal Kesehatan
Yusri Dianne Jurnalis
Faculty Of Medicine, Andalas University, Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Faktor Risiko Kejadian Laringomalasia pada Anak dengan Stridor Inspirasi yang Dilakukan Fiberoptic Laryngoscopy di Rumah Sakit M. Djamil Padang Mukhti, Karina Astarini; Yani, Finny Fitry; Lestari, Rahmi; Mariko, Rinang; Jurnalis, Yusri Dianne; Ihsan, Indra; Novialdi, Novialdi
Sari Pediatri Vol 27, No 6 (2026)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp27.6.2026.393-400

Abstract

Latar belakang. Laringomalasia merupakan penyebab tersering stridor inspirasi pada bayi dan anak, dan sering dikaitkan dengan usia muda, jenis kelamin laki-laki, prematuritas, berat badan lahir rendah, malnutrisi, serta komorbiditas neurologis maupun kongenital. Data lokal diperlukan untuk memahami faktor risiko yang berperan pada populasi setempat.Tujuan. Mengetahui faktor risiko kejadian laringomalasia pada anak yang menjalani fiberoptic laryngoscopy (FOL) di RSUP Dr. M. Djamil, Padang.Metode. Studi retrospektif kasus–kontrol pada anak usia 1 bulan–5 tahun periode 2019–2023. Sebanyak 36 kasus laringomalasia dibandingkan dengan 72 kontrol. Data diperoleh dari rekam medis meliputi usia, jenis kelamin, berat badan lahir, usia gestasi, status gizi, dan komorbiditas. Analisis menggunakan uji chi-square/Fisher dan odds ratio (OR) 95%.Hasil. Seratus delapan anak yang dilakukan FOL, 36 (33,3%) memenuhi kriteria laringomalasia. Mayoritas berusia <2 tahun, laki-laki, lahir cukup bulan, dan memiliki berat lahir normal, dan gizi baik. Komorbiditas ditemukan pada 94,4% kasus. Tidak terdapat hubungan bermakna antara variabel yang diteliti dengan kejadian laringomalasia (p>0,05), meskipun terdapat kecenderungan peningkatan risiko pada usia <2 tahun (OR 2,42), jenis kelamin laki-laki (OR 1,26), dan usia gestasi < 37 minggu (OR 2,20).Kesimpulan. Tidak ditemukan hubungan signifikan dalam penelitian ini. Usia < 2 tahun, laki-laki, dan usia gestasi < 37 minggu berpotensi menjadi faktor risiko. Studi multisenter dengan sampel yang lebih besar diperlukan untuk memvalidasi temuan ini.
Histamine-2 Receptor Antagonist for Gastric Bleeding Prophylaxis in Low-Risk Critically Ill Children: A Randomized Trial of Ranitidine Sylvetri Lestari; Mayetti; Yusri Dianne Jurnalis; Eva Chundrayetti; Rusdi; Rahmi Lestari; Rinang Mariko
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1397

Abstract

Background: The utility of stress ulcer prophylaxis (SUP) in critically ill children is a subject of ongoing debate, particularly in patients who do not present with classic high-risk features for stress-related mucosal disease (SRMD). This study aimed to evaluate the efficacy of ranitidine for preventing gastric bleeding in a heterogeneous cohort of critically ill children. Methods: A single-center, prospective, open-label, randomized controlled trial was conducted in a tertiary Pediatric Intensive Care Unit (PICU) in Indonesia. Children aged 1 month to 18 years admitted to the PICU were randomized to receive either intravenous ranitidine (1 mg/kg/dose twice daily) or standard care without prophylaxis for five days. The primary outcome was the incidence of overt gastric bleeding. Post-hoc power analysis and multivariable logistic regression were performed to contextualize the findings. Results: From 243 patients screened, 60 were randomized (30 per group). The cohort was predominantly composed of infants (60.0%) with respiratory distress. Overt gastric bleeding occurred in 1 of 30 patients (3.3%) in the ranitidine group versus 3 of 30 patients (10.0%) in the control group. This difference was not statistically significant (Relative Risk [RR] 0.33; 95% CI 0.04–3.11; p=0.612). After adjusting for a baseline imbalance in age, the odds of bleeding remained non-significantly lower in the ranitidine group (Adjusted Odds Ratio [aOR] 0.29; 95% CI 0.03–3.20). The study was found to be severely underpowered (16% power), and none of the bleeding events were clinically significant. Conclusion: In this small, underpowered trial of predominantly low-risk critically ill children, ranitidine did not significantly reduce the incidence of overt gastric bleeding. These findings, while limited by significant methodological weaknesses, do not support the routine use of SUP in similar pediatric populations and underscore the critical need for larger, more definitive trials to inform evidence-based risk-stratification strategies.
High-Dose Sucralfate as a Mucosal-Protective Cornerstone in the Organ-Sparing Management of Pediatric Grade 2A Corrosive Gastroduodenitis: A Case Report and Pathophysiological Review Wely Wahyura; Yusri Dianne Jurnalis; Ade Nofendra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1416

Abstract

Background: Accidental corrosive ingestion is a formidable pediatric emergency that can lead to severe gastrointestinal injury and long-term sequelae. Sulfuric acid, a common agent, induces coagulative necrosis, primarily affecting the stomach. The optimal management for moderate-grade injuries (Zargar Grade 2A) is debated, with a focus on preventing stricture formation. This report details a case managed with an aggressive pharmacotherapeutic protocol centered on high-dose sucralfate. Case presentation: A 2-year-10-month-old boy was admitted following accidental ingestion of battery acid. His presentation was atypical, with vomiting but no oropharyngeal lesions. Initial investigations revealed a significant systemic inflammatory response (leukocytosis: 19,220/mm³; thrombocytosis: 581,000/mm³) and aspiration pneumonitis. Despite a 12-day delay in endoscopy due to parental refusal, an aggressive conservative regimen was initiated upon admission. This protocol included high-dose, frequent-interval sucralfate (80 mg/kg every 2 hours), intensive intravenous acid suppression (omeprazole and ranitidine), and prophylactic antibiotics. The endoscopy on day 12 confirmed Zargar Grade 2A burns in the gastric fundus, pylorus, and proximal duodenum, with the esophagus spared. The patient improved rapidly, tolerated an oral diet by day 11, and was discharged on day 14. Conclusion: Follow-up endoscopy at 6 weeks and 6 months confirmed complete mucosal healing without any evidence of stricture or gastric outlet obstruction. This case suggests that an immediate, aggressive, non-surgical protocol featuring high-dose sucralfate can be effective in managing pediatric Grade 2A corrosive gastroduodenal burns, promoting complete healing and preventing long-term complications. The findings underscore the potential of this pharmacotherapeutic strategy and warrant further investigation.
Unmasking Organic Pathology in Pediatric Recurrent Abdominal Pain: Diagnostic Yield, Histopathological Discordance, and the Asian Enigma in a Tertiary Indonesian Setting Doni Andika Putra; Yusri Dianne Jurnalis
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 3 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i3.1527

Abstract

Background: Recurrent abdominal pain (RAP) in children presents a complex diagnostic dichotomy between functional disorders and organic pathology. In Southeast Asia, this challenge is compounded by the Asian Enigma of variable Helicobacter pylori prevalence. This study evaluated the diagnostic yield of Esophagogastroduodenoscopy (EGD) and the correlation between macroscopic and histopathological findings in an Indonesian tertiary pediatric cohort. Methods: A retrospective, analytical cross-sectional study was conducted on 108 pediatric patients aged 1 to 18 years fulfilling Rome IV criteria for RAP between January 2022 and July 2025. EGD was performed, with biopsies taken based on macroscopic abnormalities or clinical suspicion (n=65). Diagnostic yield was calculated, and H. pylori prevalence was subjected to sensitivity analysis to account for non-biopsied patients. Multivariate logistic regression identified predictors of organic findings. Results: The cohort was predominantly female (65.7%) and adolescent (48.1%). The overall diagnostic yield for macroscopic abnormalities was 77.8%, dominated by macroscopic gastritis (39.8%). H. pylori infection was confirmed in 26.9% of the total cohort, rising to 44.6% (95% Confidence Interval: 32.5%–57.3%) among biopsied patients. Sensitivity analysis estimated the true prevalence range between 26.9% and 48.0%. Notably, in a subset of patients with normal macroscopic mucosa (n=10), 30% exhibited microscopic inflammation, indicating endoscopic-histologic discordance. Independent predictors of organic pathology included age over 10 years (adjusted Odds Ratio 2.41) and vomiting (adjusted Odds Ratio 3.12). Conclusion: EGD reveals a high burden of organic disease in Indonesian children with RAP, challenging the functional paradigm in this setting. The significant rate of H. pylori and potential microscopic inflammation in normal-appearing mucosa suggest that biopsy should be considered routine rather than targeted to avoid verification bias.
Co-Authors A.A. Ketut Agung Cahyawan W Ade Nofendra Ade Rachmat Yudianto Adria Russelly Afdal, . Afriwardi Afriwardi Aisyah Nilakesuma Alfi Maido Alius Alfi Maido Alius Amelia Yendra Amirah Zatil Izzah Andani Eka Putra Andy Darma Ariadi Ariadi As Siddiqi, Abdurrahman Arsyad Aslinar Aslinar Aslinar Aslinar Asrawati Asrawati, Asrawati Asrawati Nurdin Asviandri Asviandri Besri, Hanifa Zahra Christy Venada Delfican Delfican Delfican Delfican Delmi Sulastri Dhina Lidya Lestari Didik Hariyanto Dina Muktiarti, Dina Diyas Anugrah Djusmaini Ismail Doni Andika Putra Edison - Edison Edison Efrida Efrida Endang Purwati RN Eny Yantri Erli Meichory Viorika Eryati Darwin Eti Yerizel Eva Chundrayetti Eva Chundrayetti Fadil Oenzil Farid I Hussein Fatmah Sindi Febianne Eldrian Finny Fitry Yani Fitrina, Dewi Wahyu Fitriyana Fitriyana Gustina Lubis Hafni Bachtiar Hafni Bachtiar Hafni Bachtiar Hamdini Humaira Handre Putra Hirowati Ali Husni Husni Ihsan, Indra Irwan Effendi Iskandar Syarif Iskandar Syarif Jon Efendi Jon Efendi Jon Effendi Julinar Julinar Lestari, Rahmi Liza Fitria Lydia Aswati M Hafiz Nasrulloh Maretha Antya Tamimi Marlia Moriska Marlinda Marlinda Masnadi, Nice Rachmawati Mayetti Mayetti Muhammad Hidayat Mukhti, Karina Astarini Mutiara Annisa Amadea Muzal Kadim Nelvirina Nelvirina Nice Rachmawati Masnadi Nindrea, Ricvan Dana Nolitriani Nolitriani Nolitriani Nolitriani Nolitriani Nolitriani Novialdi . Nurdin, Asrawati Perdana Harmen, Anggia Pradhana Putra, Fajar Prima Julistia Puthisari Zonya Jannata Putri Engla Pasalina Rachmawati Masnadi, Nice Rahmi Lestari Revi Rilliani Riana Youri Rinang Mariko Rinang Mariko, Rinang Rinche Annur Rizka Hanifa Rizqa Fiorendita Hadi Rozetti Rozetti Rusdi Rusdi Rusdi Sari Dewi Selfi Renita Rusjdi Silvia Rane Siti Lestari Sulaiman Yusuf Sylvetri Lestari Tjhin Wiguna Trisna Resti Yanti Utari Gustiany Gahayu Violeta, Vonny Wahyu Damayanti Wely Wahyura Widiasteti Widiasteti Wira Febrisandi Irsan Wiwi Hermy Putri Yanwirasti Yanwirasti Yorva Sayoet Yorva Sayoeti Yorva Sayoeti Yorva Sayoeti Yorva Sayoeti Yorva Sayoeti Yorva Sayoeti Yorva Sayoeti Yorva Sayoeti Yudith Setiati Ermaya Yugatama, Andyan Yulfiwanti, Idha Yuliawati Yusirwan Yusuf Yustini Alioes Zulfahmi Zulfahmi