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All Journal Althea Medical Journal MAJALAH ILMIAH WIDYA Biology, Medicine, & Natural Product Chemistry Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati YARSI Medical Journal Majalah Kesehatan Pharmamedika Majalah Sainstekes Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Science Midwifery Indonesian Journal of Global Health research Babali Nursing Research Medical Scope Journal (MSJ) JOURNAL LA MEDIHEALTICO Jurnal Locus Penelitian dan Pengabdian JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Info Abdi Cendekia Junior Medical Journal Eduvest - Journal of Universal Studies Jurnal Ruhul Islam Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Diniwati Mukhtar
Faculty Of Medicine, Yarsi University, Jakarta, Indonesia
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PENGARUH STRES OKSIDATIF PADA GINJAL TERHADAP KADAR KLOTHO Endah Purnamasari; Endang Purwaningsih; Diniwati Mukhtar; Astuti Giantini
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 3 (2024): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i3.218

Abstract

Pada stres oksidatif terjadi peningkatan produksi reactive oxygen species (ROS) dan penurunan antioksidan. Akumulasi ROS dan ketidakseimbangan redoks menyebabkan disregulasi dan atau oksidasi protein, asam nukleat, karbohidrat, dan lipid yang semuanya berkontribusi terhadap apoptosis dan nekrosis sel. Stres oksidatif pada ginjal dapat menyebabkan disregulasi yang berlanjut menjadi kerusakan sel tubulus ginjal, terlibat dalam patofisiologi kerusakan ginjal akut maupun kronis, serta bertanggungjawab terhadap progresifitas penyakit ginjal. Klotho adalah protein transmembran single-pass yang diekspresikan terutama di tubulus distal dan sedikit di tubulus proksimal ginjal. Setelah dipecah oleh protease, Klotho dapat ditemukan di dalam darah dan urin. Klotho mempunyai peran perlindungan yang potensial melalui mekanisme anti inflamasi, aktivasi autofagi, meredam stress oksidatif, dan melindungi fungsi mitokondria. Bila sel tubulus ginjal mengalami stres oksidatif, maka kadar Klotho di darah dan urin menurun secara signifikan.
PERITONITIS BAKTERIAL SPONTAN DAN PENGARUH PENGHAMBAT POMPA PROTON PADA PENDERITIA SIROSIS HATI Lelosutan, Syafruddin; Sakura Muhammad Tola; Intan Keumala Dewi; Endah Purnamasari; Diniwati Mukhtar; Muhammad Samsul Mustofa; Himmi Marsiati
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 3 (2024): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i3.224

Abstract

Abstract. Spontaneous bacterial peritonitis (SBP) is an acute infection of ascitic fluid in the abdominal cavity (ACAF - ascitic fluid that accumulates in the abdominal cavity) in patients with portal hypertension who experience ascites and is a serious complication of internal medical emergencies in patients with Liver cirrhosis (SH) and nephrotic syndrome (SN). A pathophysiological condition that may be contaminating, such as contamination of dialysate fluid in patients with chronic renal failure (CKD) who receive peritoneal dialysis (PD) or that stimulates the transmission of germs, such as long-term use of proton pump inhibitors (PPI) in SH sufferers, could be an infectious etiology. The pathophysiology of SBP in SH is an inoculation of bacteria in the form of intestinal organisms in ACAF which most likely (> 90%) comes from bacterial contamination due to transmission of germs from the gastrointestinal tract in the presence of enteric microorganism endotoxin which is a direct transmural migration (DTM) of hollow and solid organ bacteria. stomach (gastrointestinal system / esophago-gastro-duodenalis, small and large intestines and pancreatic-hepato-biliary system / pancreas, liver, gallbladder and its ducts); known as enteric bacterial translocation (EBT). Understanding the pathophysiological process of SBP is generally not paid much attention by clinical practitioners, let alone understanding what types of germs are in ascitic fluid. This can be seen from the rare critical assessment (culture and cytology) of the existing ascitic fluid, perhaps even thinking about the presence or absence of ascites at the start of a case of liver cirrhosis (SH). General results show that SH patients who receive PPI therapy appear to experience SBP more often than those who do not receive PPI therapy in their treatment. This review aims to be a critical review of the use of PPIs in liver cirrhosis sufferers to warn of the risk of germ migration from the gastrointestinal tract to ascitic fluid which might cause SBP. Study and understand the literature relating to the management of SBP and the risks of using PPIs in liver cirrhosis sufferers. Gain an understanding of the risks of using PPIs in liver cirrhosis sufferers.
The Comparative Effects of Almond and Peanut on Adipose Tissue Profile and Blood Sugar Levels in Rats: A Review from an Islamic Perspective prastina sari, Putri Agnia; Mukhtar, Diniwati; Ainur Rahmah, Nunung; Astiwara, Endy Muhammad
Junior Medical Journal Vol. 3 No. 1 (2024): September 2024
Publisher : Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v3i1.4690

Abstract

Type 2 diabetes and cardiovascular disease are associated with high blood sugar and poor lipid profiles. Almonds and peanuts have the potential to reduce these risks. This study aims to evaluate the effects of these two nuts on blood sugar levels and lipid profiles, within the Islamic perspective of halal and thayyib foods. An experimental study was conducted with 4 groups: standard feed (K1), high-fat feed (K2), almond feed (K3), and peanut feed (K4) over 4 weeks. Blood sugar measurements were taken using the GOD-PAP method, and histopathological analysis of adipose tissue was performed using Hematoxylin-Eosin (HE) staining. The results showed that both almonds and peanuts significantly (P<0.05) increased blood sugar levels. When compared to the high-fat feed group, the nut groups were more effective in inhibiting this increase. However, changes in blood sugar levels and lipid profiles were not statistically significant (P>0.05). From the study results, it can be concluded that there are differences in blood sugar and lipid profiles after the consumption of almonds and peanuts, although not significant. The consumption of halal and thayyib foods is recommended in Islam.
Dietary almonds and peanuts improve metabolic health and reduce oxidative stress in wistar rats Mukhtar, Diniwati; Rahmah, Nunung Ainur; Royhan, Aan; Yusnidar, Amirah
Science Midwifery Vol 13 No 1 (2025): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i1.1856

Abstract

Metabolic syndrome characterized by insulin resistance, atherogenic dyslipidemia, and hypertension, is a significant health concern often associated with obesity and Diabetes Mellitus. Regular consumption of nuts has been suggested to mitigate some of these conditions. This study investigates the effects of almond and peanut consumption on oxidative stress, plasma lipids, body weight, glucose, and blood pressure in Wistar rats. Wistar rats were divided into four dietary groups: standard diet (ST), high-fat diet (HF), high-fat diet with almonds (HFA), and high-fat diet with peanuts (HFP). The treatment lasted for 8 weeks, during which body weight was monitored weekly. Blood pressure measurements and retro-orbital blood samples were collected before and after the treatment. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were measured using ELISA and TBARS methods. Blood lipid profiles and glucose levels were analyzed using enzymatic methods. Statistical tests used the oAnova followed by Posthoc LSD. The HF group exhibited significant increases in body weight, blood glucose, cholesterol, triglycerides, MDA, and blood pressure, with reduced SOD levels. Conversely, the HFA and HFP groups showed moderated increases in these parameters compared to the HF group. Both nut-supplemented groups had significantly lower MDA levels and higher SOD activity, indicating reduced oxidative stress and enhanced antioxidative defenses. Almonds and peanuts can reduce body fat, improve lipid profiles, and stabilize blood glucose levels, suggesting their potential role in promoting metabolic health and reducing cardiovascular risk. Further research should explore the long-term benefits and the specific bioactive compounds responsible for these effects.
Hubungan Tingkat Stres terhadap Aktivitas Fisik pada Mahasiswa Fakultas Kedokteran Universitas YARSI Angkata 2021/2022 dan Tinjauannya Menurut Pandangan Islam Melia Puji Pratami; Mukhtar, Diniwati; Arsyad, Muhammad
Junior Medical Journal Vol. 3 No. 2 (2024): October 2024
Publisher : Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v3i2.4347

Abstract

Pendahuluan: Stres di definisikan sebagai respon tubuh yang diakibatkan karena adanya tuntutan dari luar diri individu yang melebihi kemampuan dalam memenuhi tuntutan untuk mengatasi dan menyelesaikan suatu masalah. Aktivitas fisik merupakan serangkaian gerak yang teratur untuk memelihara gerak dan meningkatkan kemampuan gerak. Melakukan aktivitas fisik dengan tujuan mengembangkan aspek jasmani maupun rohani dapat berdampak positif bagi orang yang melakukannya yaitu guna meningkatkan daya tahan tubuh demi meningkatkan aktivitas keimanan, dan mengurangi resiko stres. Sehingga dengan melakukan penelitian, maka seorang muslim mengetahui suatu kebenaran ilmu Allah SWT dan manfaatnya bisa berguna bagi orang lain. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui hubungan tingkat stres terhadap aktivitas fisik pada mahasiswa kedokteran Universitas Yarsi Angkatan 2021 dan 2022. Metodologi: Penelitian ini menggunakan jenis penelitian deskriptif analisis dengan metode cross sectional. Populasi dalam penelitian ini adalah mahasiswa fakultas Kedokteran Universitas Yarsi. Analisis data yang dilakukan dengan analisis univariat dan analisis bivariat. Hasil: Hasil uji univariat menunjukkan terdapat 5 orang (6,7%) mengalami stres ringan, 64 orang (85,3%) mengalami stres sedang, serta 6 orang (8%) mengalami stres berat. Serta terdapat terdapat 30 orang (40%) melakukan aktivitas fisik ringan, 39 orang (52%) melakukan aktivitas fisik sedang, serta 6 orang (8%) melakukan aktivitas fisik berat. Simpulan: Hasil uji chi-square dengan hasil p-value 0,147 (> 0,05) yang menyatakan bahwa hubungan antara tingkat stres terhadap aktivitas fisik tidak terdapat perbedaan yang signifikan.
Faktor Risiko Kematian Pasien Covid-19 Periode September 2021 - 2022 di RS Yarsi dengan Komorbid Diabetes Melitus Serta Tinjauannya Menurut Pandangan Islam Putra Pangraizan, Farel; Mukhtar, Diniwati; Ainur Rahmah, Nunung; Ma'sum, Ali
Junior Medical Journal Vol. 3 No. 3 (2025): Maret 2025
Publisher : Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v3i3.4409

Abstract

KATA KUNCI COVID-19, Diabetes Melitus, Komorbid, Kematian, Faktor Risiko ABSTRAK Penelitian ini dilakukan untuk mengetahui fakor resiko kematian pasien covid 19 periode september 2021-2022 di RS yarsi dengan komorbid diabetes melitus serta tinjauannya menurut pandangan islam. Penelitian ini menggunakan metode kuantitatif dengan desain penelitian kohort retrospektif. Sampel penelitian diambil secara total sampling. Data dikumpulkan melalui data sekunder menggunakan data rekam medis. Pada penelitian ini terdapat 10 Sampel. Analisis dilakukan menggunakan uji Chi Square: Hasil analisis menunjukkan tidak terdapat hubungan yang signifikan antara usia dan jenis kelamin terhadap kematian pasien covid-19 dengaan komorbid diabetes melitus dan komorbid lain karena nilai signifikansi tersebut memiliki nilai yang lebih besar dari 0,05, sehingga H0 diterima.Dalam pandangan islam, kematian dan penyakit dapat dibagi menjadi dua yaitu fisik dan non-fisik. Dalam kasus penelitian ini covid-19 sendiri masuk kedalam penyakit medis atau dalam pandangan islam masuk kedalam penyakit fisik yaitu penyakit badan, penyakit yang tampak dan dapat kita rasakan. KEYWORDS COVID-19, Geriatric, Comorbid, Death, Factor Risks ABSTRACT This research was conducted to determine the risk factors for death of Covid 19 patients for the period September 2021-2022 at Yarsi Hospital with comorbid diabetes mellitus and its review according to Islamic views. This research uses quantitative methods with a retrospective cohort research design. The research sample was taken by total sampling. Data was collected through secondary data using medical record data. In this study there were 10 samples. The analysis was carried out using the Chi Square test: The results of the analysis showed that there was no significant relationship between age and gender on the death of Covid-19 patients with comorbid diabetes mellitus and other comorbidities because the significance value had a value greater than 0.05, so H0 was accepted .In the Islamic view, death and disease can be divided into two, namely physical and non-physical. In the case of this research, Covid-19 itself is a medical disease or in the Islamic view it is a physical disease, namely a bodily disease, a disease that we can see and feel.
The Relationship of Dietary Habits on The Incidence of Hypertension in The Elderly in Rw 07, Sumur Batu District, Central Jakarta and Its Review According to Islamic Views Naila Nur Fauziah; Syarif, Irfan; Mukhtar, Diniwati; Astiwara, Endy M
Junior Medical Journal Vol. 3 No. 4 (2025): Juni 2025
Publisher : Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v3i4.4747

Abstract

Hypertension is a chronic condition commonly experienced by the elderly, with a high prevalence in Indonesia. This condition is caused by structural changes in blood vessels, such as lumen narrowing, stiffening of vessel walls, and reduced elasticity, which lead to increased blood pressure. One of the primary risk factors for hypertension is an unhealthy diet, including high sodium and fat consumption. This study aims to explore the relationship between dietary habits and the incidence of hypertension among elderly individuals in RW 07, Sumur Batu Village, Central Jakarta, from an Islamic perspective. This research employs a quantitative approach with an analytical cross-sectional design. The sample consists of 55 elderly individuals selected through purposive sampling. Data were directly collected through interviews using a dietary habit questionnaire based on the Food Frequency Questionnaire (FFQ) and blood pressure measurements with a sphygmomanometer. Statistical analysis using the chi-square test was conducted to identify the relationship between dietary habits and hypertension incidence. The majority of respondents had irregular dietary patterns, with high salt and fat consumption as dominant factors. The analysis revealed a significant relationship between dietary habits and hypertension (p < 0.05). Elderly individuals with irregular dietary habits were at a higher risk of developing hypertension compared to those with healthy dietary patterns. Adopting dietary practices aligned with the Islamic principles of halalan thayyiban can help prevent hypertension by emphasizing the importance of consuming nutritious and balanced food. Unhealthy dietary habits are significantly associated with hypertension in the elderly. Community-based health education, including religious approaches, is necessary to raise awareness about the importance of healthy eating in preventing hypertension.
Hubungan Kurangnya Asupan Air Putih Terhadap Konsentrasi Belajar Mahasiswa Fakultas Kedokteran Universitas YARSI Angkatan 2022 dan Tinjauannya Menurut Pandangan Islam Dian Noor Aristi; Ferlianti, Rika; Mukhtar, Diniwati; TW, Afrizal
Junior Medical Journal Vol. 3 No. 4 (2025): Juni 2025
Publisher : Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v3i4.4801

Abstract

Air putih adalah komponen penting dalam fungsi fisiologis tubuh, termasuk menjaga konsentrasi belajar. Penelitian ini bertujuan untuk menganalisis hubungan antara kurangnya asupan air putih dengan konsentrasi belajar pada mahasiswa Fakultas Kedokteran Universitas YARSI angkatan 2022. Penelitian ini menggunakan pendekatan kuantitatif dengan desain cross-sectional. Sebanyak 106 responden dipilih dengan metode total sampling. Data dianalisis menggunakan uji chi-square untuk melihat hubungan antara asupan air putih dengan tingkat konsentrasi belajar. Hasil penelitian menunjukkan mayoritas responden (42,5%) mengonsumsi air putih 1000-1500 mL/hari, sementara tingkat konsentrasi belajar tinggi ditemukan pada 63,2% responden. Analisis statistik tidak menemukan hubungan yang signifikan antara asupan air putih dan konsentrasi belajar (p > 0,05). Studi ini menyimpulkan bahwa pola konsumsi air putih tidak secara langsung memengaruhi konsentrasi belajar mahasiswa. Temuan ini menunjukkan pentingnya mempertimbangkan faktor lain yang mungkin memengaruhi konsentrasi belajar.
Identifikasi Parameter Resistensi Moxifloxacin pada Pasien Tuberkulosis Dewi, Intan Keumala; Tunru, Insan Sosiawan; Sudarmono, Pratiwi Pujilestari; Umniyati, Helwiah; Mukhtar, Diniwati
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 10 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i10.5011

Abstract

Tuberkulosis (TBC) tetap menjadi masalah kesehatan global yang serius dan semakin kompleks dengan munculnya resistensi obat, termasuk terhadap moxifloxacin—salah satu antibiotik golongan fluoroquinolone yang digunakan dalam pengobatan TBC resisten obat, seperti MDR-TB dan XDR-TB. Resistensi terhadap moxifloxacin menjadi tantangan besar karena dapat memperpanjang durasi terapi, meningkatkan angka kegagalan pengobatan, serta memperbesar risiko penularan. Penelitian ini bertujuan untuk menganalisis mekanisme resistensi moxifloxacin pada Mycobacterium tuberculosis dengan mengidentifikasi mutasi genetik yang berperan serta mengevaluasi dampaknya terhadap efektivitas terapi. Metode yang digunakan adalah deskriptif laboratorium dengan uji sensitivitas obat (Drug Susceptibility Testing/DST) dan analisis sekuensing gen gyrA dan gyrB dari isolat klinis M. tuberculosis. Hasil penelitian menunjukkan adanya korelasi signifikan antara mutasi pada gen gyrA, khususnya pada kodon 90 dan 94, dengan tingkat resistensi tinggi terhadap moxifloxacin. Sementara itu, mutasi pada gen gyrB ditemukan lebih jarang, namun tetap berkontribusi terhadap resistensi tingkat sedang. Temuan ini menegaskan pentingnya penerapan diagnostik molekuler sebagai pelengkap uji konvensional untuk meningkatkan akurasi dan kecepatan deteksi resistensi. Implikasi penelitian ini menekankan perlunya skrining genotipik rutin dalam program pengendalian TBC agar terapi dapat disesuaikan dengan profil resistensi pasien, serta mencegah penyebaran lebih lanjut dari strain resisten obat. Penguatan surveilans dan deteksi dini resistensi fluoroquinolone menjadi langkah strategis untuk mendukung keberhasilan pengendalian TBC secara global.
NGS-Based Insights into the Oral Microbiome and Glycemic Control in Pediatric Type 1 Diabetes Mellitus: A Literature Review Maharsi, Eri Dian; Sudarmono, Pratiwi Pudjilestari; Mukhtar, Diniwati; Fadilah, Fadilah
Babali Nursing Research Vol. 6 No. 4 (2025): October
Publisher : Babali Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37363/bnr.2025.64513

Abstract

Introduction: Type 1 Diabetes Mellitus (T1DM) in children is associated with significant alterations in the oral microbiome that can influence glycemic control and oral health. This study aimed to synthesize current evidence on the composition of the oral microbiome in children with T1DM using Next-Generation Sequencing (NGS) and its association with glycemic parameters. Methods: A structured literature review was conducted on studies published between 2020 and 2025 that utilized 16S rRNA sequencing to compare the oral microbiome of children with T1DM and healthy controls. Results: Across the included studies, dysbiosis was consistently observed, characterized by increased pathogenic taxa (Prevotella, Veillonella) and decreased protective genera (Streptococcus), which correlated with elevated HbA1c levels and poor metabolic control. These findings suggest that hyperglycemia-driven shifts in the oral microbiome may exacerbate inflammation and oral disease risk, potentially forming a bidirectional relationship between glycemic regulation and microbial imbalance. Conclusion: Oral microbiome profiling shows promise as a non-invasive indicator of glycemic status in children with T1DM. Further standardized, longitudinal studies in local populations, particularly in Indonesia, are recommended to validate these findings and support the integration of oral microbiome monitoring into pediatric diabetes management.
Co-Authors Aan Royhan Afifah Herlianti, Lucy Alqudsi, Hade Irhas Amsaka, Azha Azzuna Anisya Fitriah Astalia Maisya Adhitama Astuti Giantini Dewi, Intan Keumala Dian Noor Aristi Dicky Budiman Dicky Wahyudi Dita Safira Dita Safira Salsabila Endah purnamasari Endang Purwaningsih Endy M Istiwara Endy Muhammad Astiwara Endy Muhammad Istiwara Eri Dian Maharsi Fachry Abda El Rahman Fadilah Fadilah Fadilah Fadilah, Fadilah Farah Zahida Fatimah Eliana Taufik Febri Irwansyah Fenie Oktafiani Budi Ferlianti, Rika Fitriani, Hasna L. Hasna Luthfiah Hasna Luthfiah Fitriani Hasna Luthfiah Fitriani Helwiah Umniyati Himmi Marsiati Himmi Marsiati Intan Keumala Dewi Irfan Syarif Irfan Syarif, Irfan Karina A Ridwan Karina Ajeng Ridwan Lelosutan, Syafruddin Lena Fitriyana Linda Weni M Arsyad Ma'sum, Ali Maharsi, Eri Dian Mahendra Milby Febrian Putra Khaerun Marsiati, Himmi Melasari Marantika Melia Puji Pratami Muhammad Arsyad Muhammad Iqbal Thamrin Muhammad Samsul Mustofa Muren Dhianisa Dzakirah Mustofa, M Samsul nafizha Naila Nur Fauziah Novia Suci Ramadhanti Nunung Ainur Rahmah Nurwijayanti Pd, Fanny Ratnasari prastina sari, Putri Agnia Pratiwi Pudjilestari Sudarmono Pratiwi Pujilestari Sudarmono Putra Pangraizan, Farel Q Qomariyah Qomariah RS Qomariyah Qomariyah Qomariyah Sachrowardi Retno Noviar Dhani Ridwan, Karina A. D. A. Ridwan, Karina Ajeng Sakura Muhammad Tola Samsul Mustofa, Muhammad Siti Helmyati Sudarmono, Pratiwi Pudjilestari Susmiarsih Panjiasih, Tri Taufik, Fatimah Eliana Tiara Anisyah Harahap Tirsa Persila Awairaro Tjandra Yoga Aditama Tunru, Insan Sosiawan Tw, Afrizal Wan Nedra Widiastari, Erina Febriani Yulia Suciati Yusnidar, Amirah