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All Journal Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Sodality: Jurnal Sosiologi Pedesaan MEDIA KONSERVASI Jurnal Manajemen Teknologi OSEATEK Jurnal Pengelolaan Sumberdaya Alam dan Lingkungan (Journal of Natural Resources and Environmental Management) Jurnal Ekonomi Pembangunan: Kajian Masalah Ekonomi dan Pembangunan ANDHARUPA Jurnal Tataloka Proceeding SENDI_U Indonesian Journal of Cancer ETERNAL: English Teaching Journal Paediatrica Indonesiana JFMR (Journal of Fisheries and Marine Research) AL-FALAH : Journal of Islamic Economics Jurnal Bina Praja Jurnal Manajemen Pembangunan Daerah Journal of Regional and Rural Development Planning Jurnal Agroqua: Media Informasi Agronomi dan Budidaya Perairan JURNAL AGRICA Jurnal Kebijakan Sosial Ekonomi Kelautan dan Perikanan Jurnal Agrisistem: Seri Sosek dan Penyuluhan Jurnal Manajemen Retail Indonesia (JMARI) Jurnal Ketenagakerjaan Journal Of World Science Jurnal Agriculture Indonesian Journal of Cancer Jurnal Ilmiah Ilmu Terapan Universitas Jambi Eduvest - Journal of Universal Studies Jurnal Ekonomi dan Pembangunan Indonesia Policy Brief Pertanian, Kelautan, dan Biosains Tropika JOURNAL SAINS DAN TEKNOLOGI BUDIDAYA PERAIRAN (SINTASAN)
Sri Mulatsih
Program Studi Akuntansi Universitas Pancasila
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : Paediatrica Indonesiana

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Cumulative cyclophosphamide dose and serum anti-Mullerian hormone levels in adolescent cancer survivors in Indonesia Mulatsih, Sri; Ayuandari, Sarrah; Rahmawati, Naafi Rizqi; Oktasari, Rizki; Dewanto, Agung
Paediatrica Indonesiana Vol. 63 No. 5 (2023): September 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.5.2023.376-82

Abstract

Background As both the prevalence and survival rates of cancer in children and adolescents has risen, longer-term effects of cancer treatment must be investigated. High-risk gonadotoxic chemotherapeutic agents such as cyclophosphamide may affect the ovarian reserve and impact female adolescent fertility. Anti-Mullerian hormone is a reliable marker to assess ovarian reserve. Objective To assess for a possible correlation between the cumulative dose of cyclophosphamide and serum anti-Mullerian hormone (AMH) levels among adolescent cancer patients. Methods This cross-sectional study included 12-18-year-old adolescent female cancer patients who had experienced menarche and received cyclophosphamide therapy. We recorded the patients’ full history, including menstrual history, computed the cumulative dose of cyclophosphamide received, and measured serum AMH levels. The correlation test was performed to evaluate for a possible correlation between the cumulative dose of cyclophosphamide and ovarian reserve as represented by AMH levels. Results Out of 12 female adolescent cancer patients, three complained of disturbances in their menstrual cycles. Low levels of AMH (<1.5 ng/mL) were noted in five patients. Median cumulative cyclophosphamide dose was 1,000 mg/m2 (range 1,000 to 5,250 mg/m2). Cumulative cyclophosphamide dose was negatively correlated with serum AMH levels, but this correlation was not statistically significant (r=-0.316, P=0.318). Conclusion This study has not been able to show a correlation between cumulative cyclophosphamide dose and serum AMH level. Regular evaluation of fertility and involvement of fertility team is recommended in adolescents receiving high-risk gonadotoxic chemotherapeutic agents.
Co-Authors . Nuva Abdullah, Zaki Adisono, Muhamad Tulodo Aji, Samudra Akhmad Fauzi ALI MUQODDAS Alla Asmara Anak Agung Gede Sugianthara Anisa Rahma, Anisa Annazah, Nur Siti Asfaruddin Asfaruddin Asfaruddin Asti Istiqomah Astuti, Dwi Anggun Ayu, Sakuntala Devi Ayuandari, Sarrah Bambang Juanda Boedi Tjahjono Cinta, Mutiara Dedi Budiman Hakim Desyandri Desyandri Dewanto, Agung Dewi Diniaty Dian Verawati Panjaitan Didy Sopandie Dina, Karina Farkha Eko Sri Wiyono Erika Devi Udayanti Ernan Rustiadi Faletehan, Faroby Farida Aryani Hadikumara, Fikri Hanifah, Atikah Harianto Harianto Hariyadi, Hariyadi Hariyadi, nfn Hartoyo Hartoyo Helmi, Fiora Hermanto Siregar Ida Nur Istina, Ida Nur Ignatius Purwanto Indah Kartika Murni Irfan Syauqi Beik Iwan Dwiprahasto Jabani, Burhan Asril Khalifah Muhamad Ali Khawa, Zenith Yufa Nafilah Komaruddin Idris Kusdiyantoro Kusumawati, Sri Ambar Lala M Kolopaking Laoli, Nilam Cahyani Br. Lestari Agusalim Lestari, Febby Listiana, Yufita Lukytawati Anggraeni Mariana Mariana Mubarok, Huzni Muhammad Al-Jabri Muhammad Firdaus Muhammad Guntur, Muhammad Naafi Rizqi Rahmawati, Naafi Rizqi Ninik Umi Hartanti Nurhayati, Ely Nurjanah , Nurjanah . Oktasari, Rizki Omo Rusdiana Paripurna, Arbi Wardana Pini Wijayanti Pratama, Teguh Aditia PUDJO HAGUNG WIDJAJANTO, PUDJO HAGUNG PURWANTO, DIAN A.P R. Sapto Hendri Boedi Soesatyo Raden Arief Nugroho Rini Dwi Lestari, Rini Dwi Risvan Anwar, Risvan Rivan Danuaji Samodra Laya, Willie Serasiamy Ritonga, Serasiamy SITI AURELIA NURMALASARI, SITI AURELIA Soerjowardhana, Aloysius SOETARYO -, SOETARYO Sofana, Nofi Fitria Sofyan Sjaf Sri Rustianti Rustianti, Sri Rustianti Sri Wahyuni Sudirman Yahya Suhendarwan, Bhakti Sul, Suliamin Kasnar Suroyo Junior, Raden Sonny Susetyowati Sutaman Suyetno, Suyetno SUYONO Syartinilia . Tanti Novianti Teguh Triyono Utami, Neiva Cahya Valentina Widya Suryaningtyas, Valentina Widya Voltri, Fransisca WA’U, DAVID VICTORY Wahju Q. Mugnisjah Widada, Rasyid Widyastutik Wilianto, Aris Yeti Lis Purnamadewi Yudo, Lukman Pranoto Yukiman Yuliani, Meida Z. Karim, Taufik