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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology IDJP (Indonesian Journal of Pharmaceutics) Jurnal SOLMA Community Empowerment Medimuh : Jurnal Kesehatan Muhammadiyah Medical Sains : Jurnal Ilmiah Kefarmasian Gemakes: Jurnal Pengabdian Kepada Masyarakat Sciences of Pharmacy Jurnal Pengabdian Pada Masyarakat Medimuh : Jurnal Kesehatan Muhammadiyah Medical Sains : Jurnal Ilmiah Kefarmasian Baktimu : Jurnal Pengabdian Kepada Masyarakat Medimuh : Jurnal Kesehatan Muhammadiyah
Lela Sulastri, Lela
Sekolah Tinggi Farmasi Muhammadiyah Cirebon
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Local food-based education: Utilization of moringa leaves (Moringa oleifera, l.) for stunting prevention Amelia, Renny; Suharyani, Ine; Rizikiyan, Yayan; Lestari, Trisna; Sulastri, Lela; Supriyadi, Yadi; Azzahra, Siti; Ningsih, Widia; Mutmainah, Iin; Maryam, Diana Dwi; Shadrina, Ghesani Nur; Yasmin, Yasmin; Nurhidayah, Sri; Adiibah, Siti
Community Empowerment Vol 10 No 4 (2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.12302

Abstract

Stunting, a condition of impaired growth in children due to chronic malnutrition, is a significant public health problem. This community service aimed to increase the knowledge of the community, particularly pregnant women, regarding the potential of Moringa oleifera leaves as a healthy snack alternative in stunting prevention. This activity employed a pre-test post-test design with an intervention of counseling and training on making chicken nuggets fortified with Moringa oleifera leaves. The target participants were pregnant women with low upper arm circumference and mothers with stunted children. Evaluation of participants' understanding of stunting and the benefits of Moringa oleifera leaves was conducted before and after the intervention. The evaluation results showed an increase in participants' understanding of stunting and the benefits of Moringa oleifera leaves, as indicated by an increase in the average score of correct answers in the post-test compared to the pre-test. A hedonic test on the chicken nuggets fortified with Moringa oleifera leaves showed a very high level of liking for taste and color, and a high level of liking for aroma and appearance. The texture of the nuggets was identified as an aspect requiring further improvement.
The Development of Nano-mist Spray Propolis as Antioxidant Suryaman, Ine Suharyani; Sulastri, Lela; Rizikiyan, Yayan; Wathoni, Nasrul; Suhandi, Cecep; Noviani, Lusy; Rahmasari, Yuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.52433

Abstract

Propolis is a lipid-based compound from honeybees composed of plant wax, resin, and pollen. Due to its poor water solubility, its application is limited to lipid-based formulations with low bioavailability. This study aimed to develop a water-based propolis nano-mist spray with improved dispersion and evaluate its antioxidant activity. The nano-mist formulation was prepared using soy lecithin and Tween 80 in a phosphate buffer base. Evaluations included organoleptic characteristics, pH, particle size, zeta potential, and antioxidant activity by DPPH method. The propolis extract contained flavonoids, alkaloids, and tannins. The resulting spray showed a light brown color, a pH of 6.87 ± 0.03, particle size of 272.13 ± 4.25 nm, and zeta potential of -0.433 ± 0.35 mV. Antioxidant testing revealed moderate activity with an IC₅₀ value of 83.63 ± 11.88 ppm. This study supports the potential of nano-mist spray as a promising delivery system for propolis with antioxidant properties suitable for cosmetic and pharmaceutical applications.
NLP Analysis of Mannan-Based Drug Delivery Trends Pratama, Reza; Cabellon-Semense, Daisy Jane; Sulastri, Lela; Arifka, Mia; Rizikiyan, Yayan
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403339

Abstract

Mannan, a polysaccharide derived from various sources, has gained attention for its biocompatibility and potential in targeted drug delivery. Since its initial use in 1911 as an ointment base, mannan has been applied in cancer therapy, vaccine development, and as an antimicrobial agent. However, research is still largely dominated by in vitro and preclinical studies, with few clinical trials conducted to date. This study aims to provide an overview of mannan's advancements, its uses in drug delivery, the mechanisms involved, the research gaps, and the underexplored areas with significant potential. This study analyzed 321 peer-reviewed articles selected from Scopus (2000-2024), employing natural language (NLP) and bibliometric mapping to identify key materials, application areas, and research trends. Mannan’s flexible molecular structure allows for copolymerization with polymers such as chitosan, alginate, polyacrylate, and polycaprolactione, enabling improved targeting, mucoadhesion, and controlled drug release. Chitosan emerged as the most frequently used co-polymer, particularly in nanogel formulations for cancer and inflammatory diseases. Keyword impact analysis also revealed growing interest in mannans role in post-COVID-19 cytokine storm mitigation and vaccine enhancement, despite limited representation in clinical pipelines. Optimization of polymer ratios, crosslinker use and formulation strategies, remains essential to improving translational outcomes. Future research should also focus on clinical trials to demonstrate its effectiveness. In conclusion, this study underscores mannans role as promising biomaterial for next-generation drug delivery systems, while identifying gaps in clinical validation, mechanistic insight, methodological consistency. To advance toward commercial and clinical applications, future research should integrate machine learning models for predicting formulation parameters and drug release profiles. This findings offer a roadmap for the design, standardization, and eventual commercialization of mannan-based delivery platforms.
Pometia pinnata in Pharmaceutical Research: Bioactivity, Mechanisms, and Formulation Prospects Sulastri, Lela; Sugihartini, Nining; Efiana, Nuri Ari
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403331

Abstract

A literature review was conducted to gather information on the pharmacological properties and pharmaceutical dosage forms made from the Matoa plant (Pometia pinnata). The review aimed to provide a basis for further research and explore the potential of Matoa in the health sector. The method involved searching electronic media platforms, specifically Google Scholar, PubMed, and Open Knowledge Maps, using targeted keywords such as "Matoa,” "Pometia pinnata,” "Matoa preparation formulation,” "Pometia pinnata pharmaceutical preparation,” "Preparation of Pometia pinnata," and "Function of Pometia pinnata." The inclusion criteria included original research, full-text articles, and open-access journals, all published within the last 10 years, in both Indonesian and English. After screening, 64 articles were identified from the 185 search results. The review revealed that various parts of the Matoa plant, including leaves, fruit, stem bark, fruit peel, and roots, possess pharmacological properties such as antibacterial, analgesic, antioxidant, sunscreen, anticancer, antidiarrheal, anti-HIV, anti-obesity, diuretic, nephrotoxic, and antihypertensive activities. Additionally, various pharmaceutical dosage forms containing Matoa were studied, including topical preparations such as lotions, creams, liquid soap, and body scrubs, as well as oral preparations like effervescent powders, herbal drinks, and jelly candies. The review suggests that numerous research opportunities remain to further explore the potential of Matoa in the pharmaceutical and healthcare fields, as well as to develop innovative dosage forms for optimal results.
Review: Isolation of Gelatin from Several Types of Fish Suryaman, Ine Suharyani; Sulastri, Lela; Astuti, Enih Nindi; Delviyanti, Elis; Senja, Rima Yulia; Tomi, Tomi
Indonesian Journal of Pharmaceutics Vol 7, Issue 1, Jan - April 2025
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v7i1.58575

Abstract

Indonesia is a country with the largest fishery waste, one of which is fish bones as a source of gelatin. Gelatin is the main protein that makes up skin and bone tissue in animals. This review was compiled to compare the results of isolating gelatin from bone waste in various types of fish. Articles were collected from the website https://scholar.google.co.id/ with "gelatin, gelatin content, gelatin in fish bones, viscosity, pH" in the 2015–2022 period, and 11 journals were obtained. In this literature study, a method for isolating gelatin from fish bone waste will be discussed, followed by an evaluation of the gelatin obtained, including its yield and its physical properties. It is hoped that the results of this review will provide information regarding a new source for gelatin isolation so that gelatin can be widely used by the food, pharmaceutical, cosmetic, and photographic industries, particularly in the pharmaceutical and food industries, which currently require gelatin as a stabilizer and emulsifier so that it can make and maintain the emulsion system.
Penyuluhan Pemanfaatan dan Pembuatan Teh Celup Daun Salam (Syzygium polyanthum) di Desa Bode Lor Hidayati, Nur Rahmi; Indawati, Iin; Setyaningsih, Indah; Sulastri, Lela; Indriaty, Sulistiorini; Ahidin, Didin; Nabila, Syakira Putri
Jurnal SOLMA Vol. 14 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i2.18902

Abstract

Pendahuluan: Hipertensi merupakan salah satu penyakit tidak menular dan termasuk penyakit kardiovaskular, yang dapat terjadi pada orang dewasa maupun lansia, sehingga membutuhkan pengobatan yang tepat untuk mencegah terjadinya komplikasi. Pengobatan alternatif dapat dilakukan dengan menggunakan produk herbal. Daun salam merupakan salah satu tanaman obat keluarga yang mudah didapat, biasa digunakan sebagai bumbu masakan. Daun salam memiliki banyak khasiat diantaranya dapat digunakan untuk membantu menurunkan tekanan darah. Studi ini bertujuan untuk memberikan pengetahuan kepada masyarakat Desa Bode Lor tentang pemanfaatan dan pembuatan teh daun salam sebagai alternatif pengobatan hipertensi. Metode: Pretest, penyampaian materi, sesi tanya jawab, dan postest. Hasil: Adanya peningkatan pemahaman peserta dimana rata-rata persentase pretest peserta sebesar 67% meningkat menjadi 90% pada saat postest. Kesimpulan: Pelaksanaan penyuluhan pemanfaatan dan pembuatan teh daun salam di Desa Bode Lor dapat terlaksana dengan baik, dengan hasil akhir menunjukkan peningkatan pengetahuan yang signifikan.
IN VITRO ANTIBACTERIAL ACTIVITY OF CARICA PAPAYA LEAF EXTRACT-LOADED ACNE PATCHES AGAINST Propionibacterium acnes Indriaty, Sulistiorini; Rizikiyan, Yayan; Gianto, Vinie Regina Putri; Karlina, Nina; Hidayati, Nur Rahmi; Sulastri, Lela; Firmansyah, Deni
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1673

Abstract

Acne vulgaris is a prevalent skin condition that is characterized by inflammatory lesions. Propionibacterium acnes is a key bacterium implicated in its pathogenesis. This study aimed to investigate the antibacterial potential of Carica papaya leaf extract against P. acnes and its efficacy when formulated into acne patches. Ethanolic extracts of C. papaya leaves were prepared at concentrations of 20%, 25%, and 30%. These extracts were incorporated into acne patch formulations and evaluated for antibacterial activity using the paper disc diffusion method. Clindamycin 1% was used as a positive control and 70% ethanol was used as a negative control. The results demonstrated that all concentrations of the C. papaya leaf extract exhibited significant antibacterial activity against P. acnes. The 30% concentration demonstrated the largest zone of inhibition, which was comparable to that of the positive control. These findings suggest that C. papaya leaf extract-based acne patches are promising natural alternatives for the treatment of acne vulgaris. Keywords: Papaya leaves (Carica papaya L), Propionibacterium acne, Acne patch, Inhibitory power
FORMULATION AND ANTIOXIDANT ACTIVITY FACE TONER BUTTERFLY PEA FLOWER KOMBUCHA (Clitoria ternatea L.) WITH DPPH METHOD Rizikiyan, Yayan; Hidayat, Salsabila Aulia; Suharyani, Ine; Sulastri, Lela; Indriaty, Sulistiorini; Karlina, Nina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1686

Abstract

Antioxidants can be given to the skin through cosmetics such as face toners. One source of antioxidants is obtained through the fermentation of butterfly pea flower kombucha (Clitoria ternatea L.), which has been proven to have better antioxidant activity than butterfly pea flower extract alone. This study aimed to determine the metabolite compounds in butterfly pea flower kombucha and create a facial toner formulation with good antioxidant activity. The butterfly pea flower kombucha was fermented for 6 days at room temperature. Facial toners were made with concentrations of 5%, 7,5% and 10%. Evaluation of the face toner includes organoleptic, homogeneity, pH, specific gravity, and viscosity tests. The antioxidant activity test used the DPPH (1,1-diphenyl-2-pycrilhydrazil) method, with vitamin C as a positive control. The results showed that there were alkaloids, flavonoids, saponins, and terpenoid compounds in butterfly pea flower kombucha. Face toners with concentrations of 5%, 7.5%, and 10% could be prepared and met all evaluations (organoleptic tests, homogeneity, pH, specific gravity, and viscosity). Antioxidant test results on formula 1 IC50 50,21±SD 0,01 (strong), formula 2 IC50 44,32±SD 0,02 (very strong) and formula 3 IC50 38,62±SD 0,03 (very strong). The higher the concentration of butterfly pea flower kombucha, the higher the antioxidant activity. Butterfly pea flower kombucha (Clitoria ternatea L.) which is formulated as a face toner preparation has strong to very strong antioxidants, and the increasing concentration of active ingredients had an effect on antioxidant activity.  Keywords: face toner, butterfly pea flower kombucha, DPPH method, antioxidant activity
Pemanfaatan Minyak Jelantah UMKM di Desa Tuk Kedawung Kabupaten Cirebon Sebagai Lilin Aromaterapi Didi Rohadi; Lela Sulastri; Yadi Supriyadi; Jasmine, Aurellia; Amelia Nurfauziyah; Mima Elistya Utami; Nonok Bunga Enjeli; Ifa Nabila; Ira Dwi Apriliyanti Mugianto Putri; Luqman Alhakim Budiarto; Dzohirul Jabar
BAKTIMU : Jurnal Pengabdian Kepada Masyarakat Vol 4 No 4 (2024)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/bm.v4i4.1618

Abstract

Mengkaji pemanfaatan limbah minyak jelantah dari UMKM di Desa Tuk, Kecamatan Kedawung, Kabupaten Cirebon, sebagai bahan baku untuk pembuatan lilin aromaterapi. Minyak jelantah, yang merupakan produk limbah dari proses penggorengan, dapat menimbulkan dampak negatif bagi kesehatan dan lingkungan jika dibuang sembarangan. Terdapat 95 pelaku UMKM yang terdaftar di data Desa Tuk 2022. Dengan memanfaatkan limbah ini, kegiatan ini yang dihadiri oleh 18 peserta bertujuan untuk menawarkan solusi ramah lingkungan serta meningkatkan potensi ekonomi masyarakat setempat. Metode yang digunakan meliputi simulasi, sosialisasi, dan demonstrasi. Evaluasi kegiatan ini dilaksanakan dengan memberikan kuesioner diawal (pretest) dan diakhir (post test) penyuluhan. Sosialisasi dilakukan untuk meningkatkan pengetahuan mengenai manfaat lilin aromaterapi, sementara simulasi dan demonstrasi bertujuan untuk mengajarkan teknik pembuatan lilin. Program ini dilaksanakan pada tanggal 22 Agustus 2024 di Desa Tuk, dengan peserta yang terdiri dari ibu-ibu PKK setempat. Hasil dari pelatihan menunjukkan adanya peningkatan pengetahuan peserta tentang lilin aromaterapi, dengan 70% peserta menunjukkan peningkatan pengetahuan yang signifikan setelah kegiatan. Kesimpulan dari program ini adalah bahwa pemanfaatan minyak jelantah untuk pembuatan lilin aromaterapi tidak hanya mengurangi limbah lingkungan tetapi juga memberikan peluang pendapatan tambahan bagi masyarakat. Disarankan untuk melanjutkan pengembangan metode pembuatan dan pemasaran lilin aromaterapi agar dapat dijual lebih luas baik secara offline maupun online Kata kunci : Minyak Jelantah, Lilin Aromaterapi
Co-Authors Aan Kunaedi Adiibah, Siti Amelia Nurfauziyah Ananda, Rega Arief Syarifudin Arifka, Mia Astuti, Enih Nindi Ayu, intan Azzahra, Siti Berliani, Fadiyah Romadhona Cabellon-Semense, Daisy Jane Cahyani, Mufida Cantika, Citra Dhea Delviyanti, Elis Deni Firmansyah Didi Rohadi Didin Ahidin Dimas, Gilang Dzohirul Jabar Ewit Lestari Ewit Lestari Fajri, Laika Zulfahnur Falya, Yuniarti Farhat Fadhilah, Muhammad Fariz, Rizal Miftah Fatikhatussa'adah, Intan Fitriah, Aulia Gianto, Vinie Regina Putri Grantika Putri, Adelia Hafidah, Nurul Hamidan, Azmi Hapsari, Dinda Alifia Herliningsih, Herliningsih Hidayat, Salsabila Aulia Ifa Nabila IIN INDAWATI Indah Setyaningsih Indriaty, Sulistioriny Intan Intan Iqbal Bagus Prayogo Ira Dwi Apriliyanti Mugianto Putri Ishadi, Syaiful Latif Jasmine, Aurellia Khofifah Lestari, Trisna Luqman Alhakim Budiarto M. Yani Zamzam Maryam, Diana Dwi Mas'ud, Ibnu Maulidiyani, Roqmah Milhah, Mila Zainatul Mima Elistya Utami mutmainah, iin Nabila, Syakira Putri Nasrul Wathoni Nia Murni Asih Nina Karlina Nina Karlina Nina Karlina Nining Sugihartini Nonok Bunga Enjeli Noviani, Lusy Nur Rahmi Hidayati, Nur Rahmi Nuraisah, Alvia Nurhidayah, Sri Nuri Ari Efiana Pradita Putri Suratman Pradita Putri Suratman Pratama, Reza Puna Lati Putri Amalia Putri, Maisya Mauliana Insani Alifa Rahmadina, Putri Rahmasari, Yuni Ramdhani, Arief Syarifudin Renny Amelia Renny Amelia Rima Yulia Senja, Rima Yulia Risa Deviani Azzahra Rizal Miftah Fariz Rizki Nurbaeti Rury Dwi Lestari Salma Audhita Santana Sela Jovita Amanda Selawati, Anis Setiadi, Encu Asep Setyaningsih, Indah Shadrina, Ghesani Nur Shely Taurhesia Siti Fauziyah Siti Fauziyah Siti Pandanwangi TW Sri Asih Suci Naluriah Suci Riyanti Suhandi, Cecep Suharyani, Arikhatuzzahro Suharyani, Ine Sulistiani Sulistiorini Indriaty Sulistioriny Indriaty Suryaman, Ine Suharyani Syarifudin, Arief Taurhesia, Shelly Taurhesia, Shely Teguh Prasetyo Teti Indrawati Teti Indrawati Teti Indrawati Tomi Tomi . Tomi, Tomi Trisna Lestari Ussya'adah, Nida Wahyuni, Popi Sri Widia Ningsih, Widia Winda Sari Winda Sari Yadi Supriyadi Yasmin Yasmin Yayan Rizikiyan Zamzam, M. Yani