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All Journal FIKkeS Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science E-Prodenta Journal of Dentistry Dentin Jurnal Al-Hakim : Jurnal Ilmiah Mahasiswa Studi Syariah, Hukum dan Filantropi Odonto dental journal
Dewi Nurdiana
Department Of Oral Biology, University Of Lambung Mangkurat Banjarmasin, Indonesia
Religion Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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THE CORRELATION OF OROMOTOR DYSFUNCTION TO ORAL HEALTH-RELATED QUALITY OF LIFE IN CHILDREN WITH DOWN SYNDROME Nurdiana Dewi; Adhytya Suryo Kelana; Juliyatin Putri Utami
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18867

Abstract

Background: The genetic condition known as Down syndrome (DS) is brought on by chromosome 21 trisomy. Children with DS frequently have oromotor dysfunctiont. Oromotor dysfunction in children with Down syndrome can lead to oral health issues and lower the oral health-related quality of life. Studies on the relationship between oromotor dysfunction and quality of life related to dental health in children with Down syndrome are still lacking, nevertheless. Objective: To analyze the correlation between oromotor dysfunction and oral health-related quality of life in children with DS. Methods: Total respondents used in this research was 30 children with DS and the parents in Banjarmasin Special Schools. Oromotor dysfunction was determined using the Oral Motor Assessment Scale (OMAS) and oral health-related quality of life was determined using the Modified Parent-Caregiver Perception Questionnaire (P-CPQ). The Spearman correlation test was used to analyze the correlation between oromotor dysfunction and oral health related quality of life in Down syndrome children.  Results: The Spearman correlation test showed that there was a significant correlation between oromotor dysfunction and oral health-related quality of life in children with DS with a significance value of 0.000 (p <0.05) with the correlation coefficient of 0.637. Conclusion: There was a positive and strong correlation between oromotor dysfunction and oral health-related quality of life in children with DS. The weaker the oromotor function in children with Down syndrome is, the worse the oral health-related quality of life will be.Keywords: Down syndrome, oral health-related quality of life, oromotor dysfunction. 
TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT ON KIDNEY HISTOPATHOLOGY GLOMERULAR HYPERTROPHY AND HYDROPIC DEGENERATION Gusti Erysa Nur Tsaniya; I Wayan Arya Krishnawan Firdaus; Nurdiana Dewi; Juliyatin Putri Utami; Bambang Setiawan
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20403

Abstract

Background: Ironwood bark extract (Eusideroxylon zwageri) has antioxidant properties such as tannins, phenolics, flavonoids, saponins and alkonoids. Most compounds in the ironwood bark extract were phenolics (31.28 mg GAE/g), flavonoids (30.48 mg CE/g), and proanthocyanidins (183.30 mg PE/g). These can be used as alternative herbal medicines, but also has toxic effects, so a toxicity test is necessary. Toxicity tests can be seen through histopathological parameters based on glomerular hypertrophy and hydropic degeneration. Purpose: To determine the toxic effect of ironwood bark extract administration at doses of 1,250 mg/kg, 2,750 mg/kg, and 4,750 mg/kg orally on the kidneys of Wistar rats based on histopathological appearance of glomerular hypertrophy and hydropic degeneration. Methods: Pure experimental study with a posttest-only with control design, consisting of 4 groups with 3 treatment groups given ironwood bark extract at doses of 1,250 mg/kg, 2,750 mg/kg, and 4,750 mg/kg, and 1 control group was given distilled water 2x1 ml every 24 hours orally for 14 days. Results: In administration of ironwood bark extract at doses of 2,750 mg/kgBW and 4,750 mg/kgBW, glomerular diameter was found increased. The histopathological hydropic degeneration showed a score of 1 in all dose groups. The research data were analyzed using the One Way Anova and Kruskal Wallis tests. Both tests showed no significant differences between groups. Conclusion: There was no toxic effect of ironwood bark extract at doses of 1,250 mg/kg, 2,750 mg/kg, and 4,750 mg/kg on the kidneys of Wistar rats based on histopathological appearance of glomerular hypertrophy and hydropic degeneration.
NANO-HYDROXYAPATITE AND HYDROXYCHAVICOL'S COMBINED EFFECT IN Streptococcus mutans GROWTH Nurdiana Dewi; Beta Widya Oktiani; Deby Kania Tri Putri; Aura Amelia; Aisyah Nur Zahra
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22207

Abstract

Background: Early childhood caries is an aggressive form of dental caries that affects children under six years old. The increasing prevalence of ECC caused by Streptococcus mutans highlights the need for effective antimicrobial agents. Objective: To evaluate the antibacterial activity of a combination of nanohydroxyapatite (nHAp) and hydroxychavicol (HC) against S. mutans. Methods: 100 mg/mL nHAp was combined with HC at 0.125, 0.25, 0.5, and 1 mg/mL concentrations. DMSO 5% was used as the negative control. S. mutans ATCC 25175 was cultured in Brain Heart Infusion (BHI) media. Minimum Inhibitory Concentration (MIC) was determined using a UV-Vis spectrophotometer to measure absorbance differences. Minimum Bactericidal Concentration (MBC) was established by plating onto BHI agar and counting the colony count.  Results: The results showed that MIC occurred at a combination of nHAp 100 mg/mL + HC 0.125 mg/mL, while MBC was achieved at nHAp 100 mg/mL + 1 mg/mL HC, where no bacterial colonies were observed. Statistical analysis using ANOVA and Bonferroni post-hoc tests revealed significant differences in both absorbance reduction and colony counts between groups (p < 0.05), confirming the dose-dependent antibacterial efficacy of the nHAp-HC combination. Conclusion: These findings indicate that the synergistic action of nHAp and HC offers a promising strategy for controlling ECC, particularly by targeting the growth of S. mutans. Further, in vivo studies are recommended to explore clinical applicability and long-term safety.
EFFECT OF GALAM LEAF EXTRACT AND TRI-CALCIUM SILICATE CEMENT ON NEUTROPHIL CELLS IN WISTAR RAT PULP Fedriko Gamaliel Putra; Sherli Diana; Nurdiana Dewi; Yusrinie Wasiaturrahmah; Amy Nindia Carabelly
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20409

Abstract

Background: Pulp capping is a method of sealing the pulp chamber in teeth with cavities that extend to the pulp. Direct pulp capping involves applying a material directly onto the exposed pulp tissue. Tri-calcium silicate cement (Ca3SiO5) is commonly used due to its nanoparticle mineral composition, but it can cause continued inflammation. Galam leaf (Melaleuca cajuputi) is known for its anti-inflammatory properties, owing to secondary metabolites like alkaloids, flavonoids, polyphenols, and saponins, potentially compensating for the drawbacks of tri-calcium silicate cement. Purpose: To determine the effect of combining Galam leaf extract (Melaleuca cajuputi subsp. Cumingiana (Turz) Barlow) with tri-calcium silicate cement as a direct pulp capping material on neutrophil cell count in the pulp of Wistar rats (Rattus norvegicus). Methods: This pure experimental study used a posttest-only control design. Thirty-six Wistar rats were divided into nine groups: one received a combination of 100% Galam leaf extract and tri-calcium silicate cement; one positive control group received tri-calcium silicate cement alone; and one negative control group received direct placement with glass ionomer cement (GIC). The neutrophil cell count was assessed on days 1, 2, and 3. Results: Two-way ANOVA results indicated a significant effect based on treatment and time (p < 0.05). Further analysis with the Post Hoc Bonferroni test (p < 0.05) revealed differences in neutrophil cell counts across nearly all groups on days 1, 2, and 3. Conclusion: The combination of 100% Galam leaf extract and tri-calcium silicate cement significantly reduced neutrophil cell counts compared to both positive and negative control groups on days 1, 2, and 3, indicating anti-inflammatory effect.
ANTIBACTERIAL ACTIVITY OF PAPUYU FISH SCALES CHITOSAN (Anabas testudineus) AGAINST Enterococcus faecalis Ninda Andrea Haliza; Muhammad Yanuar Ichrom Nahzi; Alexander Sitepu; Nurdiana Dewi; Deby Kania Tri Putri
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22196

Abstract

ABSTRACTBackground: Papuyu fish is widely consumed by Kalimantan people. Papuyu fish scales chitosan has antibacterial potential because it contains amino polysaccharides and enzyme lysozyme which inhibits the growth of root canal bacteria, specifically Enterococcus faecalis. Purpose: The purpose of this experimental is to analyze the antibacterial activity of papuyu fish (Anabas testudineus) scales chitosan against Enterococcus faecalis. Methods: This is a true experimental study with post-test only with a control group design using 15 samples of papuyu fish (Anabas testudineus) scales chitosan grouped into 5 treatment groups and 3 samples repetitions. The treatment groups consisted of papuyu fish (Anabas testudineus) scales chitosan concentrations of 25%, 50%, 75%, 100%, and distilled water (negative control). Absorbance calculation using a UV-Vis Spectrophotometer 722 for minimum inhibitory concentration (MIC) and Enterococcus faecalis colonies are visualized with a colony counter for minimum bactericidal concentration (MBC). Results: The MIC value of papuyu fish (Anabas testudineus) scales chitosan were obtained at 25% concentration and the MBC value were obtained at 100% concentration. The results of One-Way ANOVA test for MIC and Kruskal Wallis for MBC of papuyu fish scales chitosan concentrations of 25%, 50%, 75%, and 100% obtained significant results of p<0,05 and showed a significant difference between treatments. Conclusion: These are differences in the effectiveness of MIC and MBC papuyu fish (Anabas testudineus) scales chitosan concentrations of 25%, 50%, 75%, 100% and distilled water. Papuyu fish scales chitosan 100% concentration is the most effective concentration as an antibacterial against the growth of Enterococcus faecalis.
Co-Authors Adhytya Suryo Kelana Ahda Ahda Annisa Ahmad Syaify, Ahmad Aisyah Nur Zahra Akhmad Akhdiannoor Ramadhan Al Supartinah Alexander Sitepu Alfia Fitriani Alfia Fitriani, Alfia Amy Nindia Carabelly Ana Azizah Ansari Anita Diana Putri Ardi Siswanto Asnawati Asnawati Asnawati Asnawati Aspriyanto, Didit Aulia Azizah Aura Amelia Baehaqi Bambang Setiawan Beta Widya Oktiani Debby Saputera, Debby Devi Puspita Handayani Dewi Puspitasari Diana Wibowo Fedriko Gamaliel Putra Feryra Putri Ayu Suma Feryra Putri Ayu Suma, Feryra Putri Firdaus, I Wayan Arya Krishnawan Fuady, Ridwan Ichshalul Gusti Erysa Nur Tsaniya Gusti Wina Ayu Hazarisa Hamdani, Riky Haryanto Adi Nugroho Hasvina Sofrullah Hatta, Isnur Hilda Ayu Setyawati Hilda Ayu Setyawati, Hilda Ayu Husnul Khatimah I Wayan Arya Krishnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Ika Kustiyah Oktaviyanti Ika Kusuma Wardani Ivan Arie Wahyudi Khatimah, Husnul Lena Rosida Lena Rosida Lia Yulia Budiarti Lisda Hayatie, Lisda Maharani Laillyza Apriasari Maulida Rahmaniah Melinda Hairi Melinda Hairi, Melinda Muhammad Yunanda Anhar Naura Ifthinan Luthfiana Ninda Andrea Haliza Nisa Azaria Nita Herlina Nita Herlina, Nita Noryunita Rahmah Noryunita Rahmah, Noryunita Nurrahman, Tri Phradina Fili Septishelya Raharja, Suka Dwi Rahmad Arifin Rahmadella, Afifah Renie Kumala Dewi Renita Renita Rahmad Renita Renita Rahmad, Renita Riska Nisaul Karimah Riski Agustin Riski Agustin, Riski Rosihan Adhani, Rosihan Salma Humaira Sari, Galuh Dwinta Setyawardhana, Raden Harry Dharmawan Sherli Diana Sinaga, Udur Siti Almira Rahma Siti Bale Sri Rantinah Sonia Dewi Maharani Suka Dwi Raharja Sunjaya Tunggala Sunjaya Tunggala, Sunjaya Tri Putri, Deby Kania Utami, Juliyatin Putri Wahyuni A Wahyuni A, Wahyuni Yasmina Aulia Yusfarani, Mirza Fitria Yusrinie Wasiaturrahmah Zainatun Nadhira