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Antibacterial Activity of Etil Acetate Fraction of Chili Leaf Against Streptococcus Pyogenes and Bioautografy Ade Irawan; Nurkhasanah Nurkhasanah; Nanik Sulistyani
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.3002

Abstract

One of the plant that has antibacterial activity is chili leaf (Capsicum frutescens L.). The purpose of this study was to determine the antibacterial activity of ethyl acetate fraction of chili leaf against Streptococcus pyogenes bacteria and conduct bioautography to see compounds that have antibacterial activity. In this study an antibacterial test for ethyl acetate fraction of chili leaf with a concentration of 5%, 10%, 20%, 40%, 80% to Streptococcus pyogenes. From the results of the inhibition zone test 5% ethyl acetate fraction produces an average inhibition zone of 6.3 mm, 10% average inhibition zone 10.3 mm, 20% average inhibition zone of 14 mm, 40% average inhibition zone 18 mm and 80% have 22.7 an average inhibition zone. In the silent phase bioautographic was used test silica gel GF 254 and for the mobile phase was used chloroform : ethyl acetate (3: 7), indicating the presence of inhibition zones on the media which had been inoculated by Streptococcus pyogenes bacteria, namely at RF 0.88. From the research that has been done, the results show that the ethyl acetate fraction of chili leaf has inhibitory zone against Streptococcus pyogenes bacteria and the spotting of compounds which have inhibitory zone has an RF of 0.88.
Public perception of halal medicine certification Zhazha Zetira Utami; Nurkhasanah Nurkhasanah
Journal of Halal Science and Research Vol. 2 No. 2 (2021): September
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (724.185 KB) | DOI: 10.12928/jhsr.v2i2.3176

Abstract

The trend of the halal industry has increased, both in the world and in Indonesia. The development of halal industry trend has developed in all fields, one of which is halal certification of drugs. Drug products are now also a special concern in the halal product category because, in terms of treatment, society demands that the health products used must be of high quality and halal. The purpose of the study was to find out how the public's perception of halal drug certification and whether there was a relationship between the level of knowledge and the perception of drug halal certification. This type of research is an analytic observational research survey section with a cross-sectional approach. Obtained 102 respondents, then the data were analyzed using the SPSS application, both univariate and bivariate analysis. The results showed that the level of knowledge was moderate (63.7%), the level of perception was good (64.7%) and the level of behavior was good (64.7%). Knowledge has a linear relationship (sig value 0.168 > 0.05) significantly (f value 1.557 < 2.20) to respondents' perceptions of halal certification of drugs, and perceptions of drug halal certification also have a linear relationship (sig value 0.119 > 0, 05) significantly (f value 1.805 < 2.31) on the respondent's drug consumption behavior. Public perception of drug halal certification is good (64.7%) and the better the level of knowledge, the better the perception of drug halal certification (significantly linear).
Potential Plants With Antidiabetic Activity In Glut-4 Translocation: A Narrative Review Rabiatul Adawiyah; Ayu Shabrina; Sapto Yuliani; Nurkhasanah Nurkhasanah
Jurnal Ilmu Farmasi dan Farmasi Klinik 2023: [Special Edition] Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v0i1.9344

Abstract

Diabetes Mellitus (DM) is a chronic disease caused by decreased activity of the pancreas in producing insulin. Insulin resistance is characterized by decreased synthesis and translocation of GLUT-4 to cell membranes, GLUT-4 can be found in several tissues, but mainly in muscle and adipose tissue. The purpose of this study was to identify plants that have antidiabetic activity in Glut-4 translocation and further can be used as reference material in research. This research method is Article Review, by searching for articles published in 2013-2023 in the Pubmed, Google Scholar, Proquest, Springer Link, and Science Direct databases. The sample in this study was in the form of research articles that met the inclusion criteria and obtained a total of 15 articles. The results of this study showed that there was significant antidiabetic activity from the administration of Ethanol Extract on 125 mg/kg BW of Salam Leaf, 200 mg/kg BW of Areca Nut, 200 mg/kg of Papaya Seed, 96 mg/kg of Black Cumin, Combination of Sambiloto Leaf and Gotu kola leaves 300 mg/kg BW, 400 mg/kg BW of Adem Ati Bark, 100 mg/kg BW of Artemisia Leaf, 250 mg/kg BW of Coffee Beans, 200 mg/kg BW of Tapak Dara Leaves, 300 mg/kg BW of Puguntano Leaves, 50 mg/kg BW of Ginger, and 200 mg/kg BW of Cinnamon. These plant extracts have antidiabetic activity as GLUT4 translocates to the plasma membrane of muscle cells. The bioactive compounds contained in them which act as antidiabetic activity are flavonoids, saponins and tannins.
PERAN ORANGTUA DALAM MELAHIRKAN GENERASI ULUL ALBAB Nihayati, Nihayati; Nurkhasanah, Nurkhasanah; Arnidha, Yunni; Budiarti, Yesi
Jurnal Dedikasi untuk Negeri Vol 2, No 1 (2023)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat UML

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36269/jdn.v2i1.1877

Abstract

Children are a mandate from God given to parents, children are assets in the afterlife for both parents. Parents are the main teachers in family life, children are like blank paper ready to be drawn and colored. So the purpose of this activity is that parents understand their role in educating, guiding and directing children to become the ulul albab generation in the midst of the onslaught of modern progress in various fields. This activity was carried out at Muhammadiyah Banyuwangi Elementary School, Banyumas, Pringsewu,  with the target being guardians of students from grades 1 to grade 6. This activity used an active participatory method with several stages, namely the stages of observation, coordination with the school and implementation of activities. The result of this activity is that parents understand that current parenting challenges require parenting knowledge. The role of parents in forming the ulul albab generation is to accompany, establish communication, supervise, provide opportunities, provide motivation and direct. This is in line with the principles of parenting, namely good potential in children; exemplary, remind and improve; consistent; need love and patience.
Hubungan Pola Asuh Orangtua dengan Kejadian Pelecehan Seksual Nurkhasanah, Nurkhasanah; Sary, Lolita; Aryastuti, Nurul
Jurnal Kesehatan Komunitas Vol 10 No 2 (2024): Jurnal Kesehatan Komunitas
Publisher : LPPM Hang Tuah Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25311/keskom.Vol10.Iss2.1608

Abstract

Sexual harassment is the misuse of the relationship between a woman and a man that harms one of the parties. Based on data reports on cases of violence in Lampung Province in 2022, there were 41% cases of sexual harassment. One of the factors that influence the incidence of sexual harassment is parenting style. The purpose of this study was to determine the relationship between parenting style and the incidence of sexual harassment at SMP X Pesisir Barat Regency in 2023. This type of research is quantitative with a cross-sectional design. The population in this study were all class VIII teenagers at SMP X Pesisir Barat District with a total of 150 people. The sampling technique used is total sampling. Data collection techniques using a questionnaire. Data analysis using chi-square. The results of this study indicated that there were 38 (25.3%) respondents who had experienced sexual harassment and 112 (74.7%) respondents who had never experienced sexual harassment. The results of the bivariate analysis showed that there was a relationship between authoritarian parenting styles (p=0.001; 0.008), democratic fathers (p=0.024), negligent parenting (p=0.039; 0.029), and spoiling parents (p=0.042; 0.045). with incidents of sexual harassment. Meanwhile, the mother's democratic parenting style (p=0.791) was not related to the incidence of sexual harassment. It is hoped that health workers can be educated about boundaries in sexuality so that adolescents understand boundaries that can be guarded and considered private.
Physico-Chemical, Organoleptic, and Antioxidant Properties of Black Soybean Flour (Glycine soja (L.) Merrit) Flakes with the Addition of Bangle (Zingiber purpureum Roxb.) Kumalasari, Ika Dyah; Nurkhasanah, Nurkhasanah; Sepitriani, Sepitriani
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Flakes are products that are generally made from cereals. In this study, we are interested to use black soybean (Glycine soja (L) Merrit) and bangle (Zingiber purpureum Roxb.) as flakes ingredients. Black soybeans have high antioxidant components, while bangle contains high antioxidant and fiber components, which enables it to capture free radicals. This study aimed to find the most favorable formula with good physical, chemical, and organoleptic characteristics, which also has the highest antioxidant activity. We used the Completely Randomized Design (CRD) method and the variation of formulation used was the ratio of black soybean flour to bangle as follows: T1 (100%:0%), T2 (95%:5%), T3 (90%:10%), T4 (85%:15%), and T5 (80%:20%). The parameters analyzed included physical properties (color, texture, and water absorption), chemical properties (moisture content, ash content, fat content, protein content, carbohydrate content, crude fiber content, and antioxidant activity, as well as total plate count), and organoleptic properties (color, texture, taste, aroma, and overall acceptance). The research data were analyzed using One-Way Analysis of Variance (ANOVA) at a significance level of 5% and Duncan’s multiple range test. The results showed that the best formula for color and texture is T5 L* 54.57, a*-4.22, color b*31.42, hardness 0.74N, and water absorption 30.01%. The best treatment for chemical properties is T5 (moisture: 4.26%, ash: 3.68%, fat: 18.16%, protein: 16.92%, carbohydrate: 56.98%). All formulations meet the total plate count of <2,500. The highest antioxidant activity was in the T5 formulation (49.59 %). The results of the organoleptic properties showed that the most favorable overall organoleptic reception was T1. Flakes based on black soybean flour with the addition of bangle in formulation T5 (80% black soybean flour: 20% bangle) have the potential to be a functional food high in fiber and antioxidants.
UPAYA PENCIPTAAN WIRAUSAHA MAPAN MELALUI SANGGAR ABYAKTA UNTUK PENGUATAN USAHA PADA USAHA RINTISAN DI DESA GENITO KABUPATEN MAGELANG Nurkhasanah, Nurkhasanah; Pramudianti, Ulfa Rahma; Sarifah, Siti; Chasanah, Hikmah Rochimatul; Amini, Nurul Fajar; Maknun, Lu'lu'ul; A'yun, Qurotul; Kautsar, Akhmad; Baroroh, Erli; Ramadani, Cahya; Nugroho, Bondan; Ningsih, Nur Cahyati; Kariza, Alifia Ninda; Anjani, Arlian Sherly; Panjawa, Jihad Lukis
Diklat Review : Jurnal manajemen pendidikan dan pelatihan Vol. 7 No. 2 (2023)
Publisher : Komunitas Manajemen Kompetitif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35446/diklatreview.v7i2.1496

Abstract

Entrepreneurial village as an alternative forum in realizing community welfare through innovation with local resources and potential owned by the village. Business actors in the village are an important element in creating an entrepreneurial village. Start-up entrepreneurs often face the same problems in achieving an established business. The aim of this program is to create established entrepreneurs by strengthening start-up businesses in Genito Village, Magelang Regency. The methods used include outreach and mapping, training and mentoring and expos. The results show that the understanding of start-up entrepreneurs is still at a basic level and has different problems from the mapping results. A forum has been formed in the form of the Sanggar Abyakta to create a pioneering entrepreneurial village. Apart from that, basic management training and assistance, halal certification and marketing have real efforts in strengthening start-up businesses. Expos/exhibitions have an important role in introducing start-up business products. Follow-up is needed regarding information on access to finance and understanding in production capacity in meeting market needs that need to involve other stakeholders.
ANALISIS PENGAKUAN, PENGUKURAN, PENYAJIAN DAN PENGUNGKAPAN PAJAK TANGGUHAN BERDASARKAN PSAK 46 Nurkhasanah, Nurkhasanah; Arfianti, Rizka Indri
Jurnal Akuntansi Vol 13 No 1 (2024): Edisi Februari
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Institut Bisnis dan Informatika Kwik Kian Gie

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46806/ja.v13i1.1053

Abstract

Discrepancies and differences in interests between accounting and taxation require companies to make fiscal corrections or adjustments between commercial financial reports and fiscal financial reports in accordance with tax regulations. The object used for this research is the financial report of PT X in 2021 - 2022, research variables are recognition, measurement, presentation and disclosure of deferred tax PSAK 46. After conducting research, regarding the analysis of the implementation of PSAK 46 deferred taxes at PT X, indicates that the recognition, measurement, presentation and disclosure of deferred tax PSAK 46 has been applied in accordance with the data in the financial statements and notes to the financial statements. The research conclusion is that the recognition of deferred tax according to PSAK 46 has been implemented by recognizing current tax and the benefits of deferred tax.
Phytochemical Screening of Secondary Metabolites, Antioxidant and Antibacterial Activities of Kalangkala Plant (Litsea Angulata): A Review Article Daipadli, Daipadli; Shabrina, Ayu; Yuliani, Sapto; Nurkhasanah, Nurkhasanah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 20, No 2 (2023)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v20i2.9529

Abstract

Litsea angulata, more commonly known as Kalangkala, is a type of plant that belongs to the Lauraceae family. Empirically, the plant has been used traditionally by local people for the treatment of boils, diarrhea, stomachache, dyspepsia, gastroenteritis, diabetes, insect bites, and anti-irritation. This review article aims to find out the results of phytochemical screening of metabolites from parts of Kalangkala plant with various solvents as well as the results of the tests of antioxidant and antibacterial activities that several researchers have carried out. The method used was a literature search on Google Scholar and Pubmed with the keywords kalangkala, Litsea angulata, phytochemical screening, antioxidant, and antibacterial. The results of this review showed that various solvents, such as water, ethanol, methanol, N-hexane, and ethyl acetate in seed, fruit flesh, bark, stem, and leave parts of Kalangakala plant produces different amounts of secondary metabolites. Secondary metabolites such as alkaloids, flavonoids, saponins, and tannins extracted well using etanol as a solvent due to their polarity. The results of the antioxidant activity showed that the part of kalangakala plant such as the bark of the tree, has a very good antioxidant activity of 2.41 ppm when tested using ethyl acetate solvent. Furthermore, the results of the antibacterial activity test show an inhibition of 50 mm on S. mutans bacteria when tested using ethanol solvent. In conclusion, kalangkala plant has secondary metabolites which act as antioxidants and antimicrobials that also potential to developed as traditional medicine.
The Use of Audio-Visual Media in Learning Social Studies to Improve the Learning Outcomes of Grade V Students at Lebak Kepuh 2 Elementary School Karmila, Karmila; Nurkhasanah, Nurkhasanah; Rostika, Rostika
Jurnal Primagraha Vol. 4 No. 01 (2023): MAY
Publisher : LPPM Universitas Primagraha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59605/jp.v4i01.653

Abstract

The purpose of this study was to describe the use of audio-visual media that can improve learning outcomes in social studies learning for student of SDN Lebak Kepuh 2. This type of research is interview research or observation. The subjects in this study all class V grade students SDN Lebak kepuh 2 which totalled 20 people, with 11 men and 9 women. This research procedure uses interview, observation and documentation of data collection techniques used are observation and tests. The data analysis technique uses the presentase (%) formula while the results of this study are using audio-visual media can improve social studies learning achievement in landscape material in grade 5 students at SDN Lebak Kepuh 2, Serang district. In the research result, it was found that the success rate of student learning outcomes achieved a score of >75 by 15 students (75%) and <75 by 5 students (25%). Based on student learning outcomes, there is an increase in student understanding, this was proven after the use of audio-visual media in social studies learning in grade 5 SDN Lebak Kepuh 2.
Co-Authors A'Yun, Qurotul AA Sudharmawan, AA Abdul Rahman Wahid Ade Irawan Adelita, Audrey Adiba, Thoriq Agus Nasihin Ahmad, Aunillah Akrom, Akrom Albab, Farah Qistih Alif Muarifah Amalya Nurul Khairi Amini, Nurul Fajar Anisah, Retnani Anjani, Arlian Sherly Aprilia, Kartini Aryastuti, Nurul Athifah Candra Dewi Ayu Shabrina Baroroh, Erli Carmel Meiden Chasanah, Hikmah Rochimatul Christin Angelina Febriani Daipadli Daipadli Deni Firmansyah Dianingsig, Dianingsih Easter Yanti, Dhiny Elya Zulfa, Elya Farah Qistih Albab Fitri Usfa, Hafiratul Fitrilya Mustikahati Yusuf, Fitrilya Mustikahati Flora Pasaru Gabrilla Yusuf, Ghina Harni, Harni Humaya, Humaya Ika Dyah Kumalasari Ika Kumalasari Imas Juidah Irawati, Riana Jailani, Muhammad Taufiq Bin Mohd Jayadinata, Asep Kurnia Jihad Lukis Panjawa Kariza, Alifia Ninda karmila karmila Kautsar, Akhmad Khairi, Amalya Nurul Laela Hayu Nurani Lola Angelita Lolita Sary Lovrina Rahmi Zulkarmen Mahdi, Lukman Maknun, Lu'lu'ul Meta Safitri Moch. Saiful Bachri Muhammad Syakbani Murinto Murinto Nada, Rafa Nanik Sulistyani Neni Fidya Santi Nihayati, Nihayati Ningsih, Nur Cahyati Nofa Risma Azis Nora Afriza, Zelda Nugroho, Bondan Nur Ahmad, Nur Nurul, Amalya Ofa Suzanti Betha Pramudianti, Ulfa Rahma Puri, Putri Ratna Rabiatul Adawiyah Rahman, Ika Ristia Ramadani, Cahya Ricke Desyratnaputri Rizka Indri Arfianti Rizky H. Mawardi Rostika, Rostika Sabrina Dahlizar Sapto Yuliani Saputri, Ginanjar Zukhruf Sari Manulang, Chanita Sepitriani, Sepitriani Siti Pandanwangi TW Siti Pandawangi TW Siti Sarifah Soedjono Soedjono Tri Yanuarto Tri Yanuarto W, Ratna Kurnia Winata, Nana Triana Wiwin Lismidiati Wulandari, Dita yesi budiarti, yesi Yuni Anggraeni Yunni Arnidha, Yunni Zhazha Zetira Utami Zuniarto, Ahmad Azrul