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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kesehatan Andalas Global Medical and Health Communication Biomedical Journal of Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Window of Health : Jurnal Kesehatan Majalah Kedokteran Andalas Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Majalah Kedokteran Neurosains Human Care Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ners Science Midwifery Nusantara Hasana Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Journal of Pharmaceutical and Sciences. Neurona Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Yuliarni Syafrita
Department Of Neurology, Faculty Of Medicine, Universitas Andalas, Padang, Indonesia.
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Journal : Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan

 1 
PENGARUH TRIGLISERIDA TERHADAP KADAR LEPTIN PADA USIA LANJUT DENGAN GANGGUAN KOGNITIF Syafrita, Yuliarni; Eryanti, Lusi
Jurnal Ilmiah Manuntung Vol 7 No 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.425

Abstract

There are some relationships between cognitive impairment with elevation of triglycerides and reduction of leptin concentration in elderly. The elevation of serum triglycerides concentration leads to leptin resistance resulting in impairment of leptin ability to cross blood brain barrier and decrease leptin concentration in brain. The aim of this study is to determine the correlation between triglycerides serum concentration towards leptin concentration in elderly with cognitive impairment. This was a cross sectional study conducted at Neurology Clinic Dr. M. Djamil Hospital. Cognitive function was assessed by using MoCA-Ina, concentration of triglycerides was measured by using enzymatic GPO-PAP method and concentration of leptin was measured by using ELISA. The correlation between two variables was analyzed by using Mann-Whitney test and correlation between triglycerides concentration with leptin was analyzed by using Spearman test. The p value ≤ 0.05 was statistically significant. There are mean triglycerides differences between elderly groups with cognitive impairment (160 (54 – 397)) and elderly groups with normal cognitive function (107 (53 – 249)) with p= 0.005. There are no leptin concentration differences between elderly with cognitive impairment (8,6 (0,96-36,92)) and elderly with normal cognitive function (11,73 (0,71 -36,66 )) with p= 0.45. There are negative correlations between triglycerides concentration with leptin concentration in groups with cognitive impairment, but the correlation is weak (r=0,347, p=0,134). There is negative correlation between triglycerides concentration with cognitive function. There is no correlation between leptin concentration in elderly with cognitive impairment.
Co-Authors Adang Bachtiar Afriyeni Sri Rahmi Ahmad, Baihaqi Alya Ramadhini Andi Fadilah Yusran Andy, Marfri Anggi Anugerah Basir ATTIYA ISTARINI Basjiruddin Ahmad Cintya Agreayu Dinata Darwin Amir Darwin Amir Darwin Amir, Darwin Dedi Sutia Dhiang Mulia Syofiadi Djong Hon Tjong Dwi Sri Rejeki Dwitya Elvira, Dwitya Elsi Rahmadhani Hardi Elvia Fataya Ennesta Asri Erdanela Setiawati Eryanti, Lusi Eva Chundrayetti Eva Decroli Fadel Muhammad Fadrian, Fadrian Fanny Adhy Putri Fitra Ermila Basri Gunawan Septa Dinata Haiga, Yuri Harun Harnavi Hauda El Rasyid Hendra Permana Husni Minanda Fikri Indra, Syarif Iqbal Al Rasyid Istiqomah Jabbar, Ridho Ahmad Karina Prasasti Helhid Kurniawan, Yoga Setia Lydia Susanti Lydia Susanti Lydia Susanti Lydia Susanti Lydia Susanti, Lydia M Hasan Machfoed Marfri Andy Marliana, Lesti Meldayeni Busra Mubarak, M. Dzaky Muhammad Farhan Khadaffi Mustafa Noer Nailatul Fadhilah Nela Novita Sari Netti Suharti Nora Fitri Nora Fitri Novi Yudia Nur Indrawati Lipoeto Nur Indrawaty Lipoeto Nurhayati Nurhayati Nurvalinda, Nurvalinda Pitra, Dian Ayu Hamama Putri, Fanny Adhy Rahmi Ulfa Rasyid, Hauda El Ratna D Siregar Rauza Sukma Rita Reno Bestari Reno Bestari Restu Susanti Rika Susanti Rika Susanti Rini Gusya Liza, Rini Gusya Rizanda Machmud Rizki Muhammad Rananda RR. Ella Evrita Hestiandari Russilawati, Russilawati Salmiah Agus Sukri Rahman Susila Sastri Susila Sastri Sutia, Dedi Syahrul, Muhammad Zulfadli Syarif Indra Syarif Indra Trya Mia Intani Widia Rahmawati Yantri Maputra Yanwirasti Yanwirasti Yaumi Faiza Yoga Setia Kurniawan Yulia Trisna