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All Journal Journal of Food and Pharmaceutical Science Jurnal Penelitian Farmasi Indonesia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Science and Technology Indonesia Jurnal Penelitian Farmasi Indonesia Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PENDIDIKAN TAMBUSAI PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Majalah Farmasetika Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Katalisator Journal of Food and Pharmaceutical Sciences Jurnal Manajemen Rekayasa (Journal of Engineering Management) Usadha Journal of Pharmacy Jurnal Medika: Medika Jurnal Bakti Nusantara Medical Sains : Jurnal Ilmiah Kefarmasian
Deni Anggraini
Sekolah Tinggi Ilmu Farmasi Riau
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Edukasi Penggunaan Tanaman Herbal Terhadap Penderita Diabetes di Desa Empat Balai, Kampar Wildan Rasyid; Wirahma Indah Pratiwi; Meiriza Djohari; Deni Anggraini; Enda Mora; M. Almurdani; Ihsan Ikhtiarudin; T. Harpirabi; Jasma Jasma; Tami Tami; Sukma Sukma
Jurnal Medika: Medika Vol. 4 No. 3 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/w8yeem10

Abstract

Diabetes mellitus is a public health problem that continues to increase, especially in rural areas that have limited access to modern health services. The use of herbal plants as alternative therapy is increasingly receiving attention because of its abundant availability and relatively low cost. In order to increase public awareness of the importance of prevention and treatment, especially with herbal ingredients for this degenerative disease, there needs to be ongoing counseling, one of which is through community service. This community service activity aims to provide education on the use of herbal plants that have the potential to lower blood sugar levels to the people of Empat Balai Village, Kuok District, Kampar Regency. The activities include counseling, interactive discussions, and demonstrations of the use of local herbal plants such as insulin leaves (Costus igneus), Moringa leaves (Moringa oleifera), Belimbing Wuluh (Averrhoa bilimbi), Pare (Momordica charantia), sambiloto, and mahkota dewa. The research method uses a qualitative approach with counseling techniques and leaflets given to 50 respondents. The results of the study showed an increase in public knowledge or insight about the use of herbal plants for diabetes sufferers with significance (p <0.5). The results of this Community Service activity show the importance of educating the community about managing diabetes naturally and increasing interest in implementing the use of herbs as a treatment support. Therefore, further efforts need to be made to increase insight and prevention related to Diabetes Mellitus by using herbal plants holistically.
Increased Dissolution Rate of Solid Dispersion Fenofibric Acid PEG 6000 and In Vivo Study Deni Anggraini; Nesa Agistia; Armon Fernando; Amanda Yulia; Dira Repuja
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26376

Abstract

Fenofibrate acid is a fibrate drug with high permeability but low water solubility, resulting in limited bioavailability. Solid dispersion using hydrophilic carriers is one strategy to increase solubility. The objective of this study was to improve the solubility of fenofibric acid by converting it into a solid dispersion system using PEG 6000 as a carrier. Preparation of solid dispersion systems by the melting method. The fenofibric acid PEG 6000 weight ratios were F1 (1:1), F2 (1:3), and F5 (1:5). Physicochemical characterization of the solid dispersions included DSC, PXRD, FTIR, and SEM tests, as well as dissolution and bioavailability tests with the determination of pharmacokinetic parameters. Characterization results show that fenofibric acid with PEG 6000 as a carrier still exhibits a crystalline phase but with reduced intensity, resulting in increased solubility and dissolution rate. Dissolution test show that solid dispersion F3 (1:5) dissolves faster (78.7%) than pure fenofibric acid (53.2%). after 60 minutes. Pharmacokinetic parameter determination tests showed no significant difference between pure fenofibric acid and solid dispersion. Solid dispersion of fenofibric acid with PEG 6000 as a carrier can improve the physicochemical performance and dissolution rate of fenofibric acid but pharmacokinetic parameters did not differ significantly.
OPTIMASI DAN KARAKTERISASI SNEDDS MINYAK BIJI BUNGA MATAHARI MENGGUNAKAN BOX-BEHNKEN DESIGN Rodhia Ulfa; Melzi Octaviani; Aina Novalia; Deni Anggraini; Haiyul Fadhli
Usadha Journal of Pharmacy Vol 5. No 3. (2026) : Agustus
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v5i3.1240

Abstract

Penggunaan minyak biji bunga matahari sebagai zat aktif sekaligus fase minyak dalam Self-Nanoemulsifying Drug Delivery System (SNEDDS) masih memerlukan optimasi formulasi yang terikur untuk menghasilkan sistem dengan karakteristik fisikokimia yang konsisten. Penelitian ini bertujuan untuk mengembangkan dan mengoptimalkan SNEDDS berbasis minyak biji bunga matahari menggunakan Box-Behnken Design (BBD), serta mengevaluasi karakteristik fisikokimianya. Kebaruan penelitian ini terletak pada penerapan optimasi statistik multirespon terhadap minyak biji bunga matahari, Tween 80, gliserol, dan waktu pengadukan, yang diintegrasikan dengan karakterisasi nanoemulsi dan verifikasi eksperimental terhadap formula optimum. Setelah analisis GC-MS dan skrining formulasi awal, formulasi dioptimalkan menggunakan Design-Expert 13 berdasarkan transmitansi dan waktu emulsifikasi sebagai respons kritis. Formula optimum yang diperoleh pada komposisi yaitu 9,09% minyak biji bunga matahari, 83,33% Tween 80, dan 7,57% gliserol, dengan nilai desirabilitas sebesar 0,863. Formula tersebut menunjukkan transmittansi sebesar 99,67 ± 0,25%, waktu emulsifikasi 28,46 ± 0,02 detik, ukuran partikel 13,67 nm, indeks polidispersitas 0,324, dan potensial zeta sebesar −19,76 mV. Hasil verifikasi menunjukkan tidak ada perbedaan yang signifikan antara nilai yang diprediksi dan hasil eksperimen (p>0,05), yang mendukung validitas metode optimasi. Hasil ini menunjukkan bahwa minyak biji bunga matahari dapat diformulasikan menjadi SNEDDS dengan karakteristik nanoemulsi yang baik. Pendekatan berbasis BBD memberikan dasar rasional untuk pengembahangan lebih lanjut pada sistem pengantaran obat berbasis lipid.
Co-Authors Abdul Kadir Adela, Syarifah Nur Adris Ade Putra agistia, nesa Agistia, Nesa Aina Novalia Al-Fadillah, Annsisya Shafira Amanda Yulia Amanda, Denisya Anggraini, Dhiva Anita Lukman Anita Lukman Anita Lukman Anita Lukman Anita Lukman Annisa Annisa Armon Fernando Astaharie, Shinta Angelia Azhar, Gustika Azizah, Nur Rahmi Azli, Echa Saskia Benni Iskandar Delvi Dira Repuja Eliza Fitri Enda Mora Erizal Zaini Ezuela, Deska Z Fathur Rahman Fitri Mulyani, Fitri Furi, Mustika Gressy Novita Gressy Novita Haiyul Fadhli Hilwan Y. Teruna Hulwa Salsabila Idzan, Nur Kamilah Ihsan Ikhtiarudin Indriana, Annisa Chika Ayu Jasma Jasma K, Della Yunita Sary. Kurnia, Lisa Lisa Yunus Kasmawati M Almurdani M. Almurdani Maria Susiladewi Masril Malik Meiriza Djohari, Meiriza Melanie, Claudy Friesta Melzi Octaviani Mia Audina, Mia Musyirna Rahmah Nst N Nurfieftien Nabela, Nabela Nadia, Putri Nani Suhaeni Nofri Hendri Sandi Noveri Rahmawati Novtafia Endri Nurul Elisa Pratiwi, Wulan Iska Prima Aulia Putra Rajeb Fadillah Repuja, Dira Ria Mulyani Rodhia Ulfa Rodhia Ulfa Safitri, Elsa Salman Umar Sandra, Alya Dwi Sandry Eka Saputri Nst Sari, Fatwa Aulia Sinata, Novia Siti Hafsah Suhada, Zikra Sukma Sukma Suwinda, Elia Syarifah Merlina T. Harpirabi Tami Tami Teruna, Hilwan Y. Wildan Rasyid Wira Noviana, Wira Noviana Wirahma Indah Pratiwi Wiwik Sri Rahmides Wulandari, Intan Wulandari, Lydia Tri Yadi, Hervi Yufri Aldi Yulia, Amanda Zalfa Desion, Aufa Zikrinnissa, Zikrinnissa