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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Jurnal Matematika & Sains Medula Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan INDONESIAN JOURNAL OF PHARMACY Jurnal Sains dan Teknologi Pangan BERITA BIOLOGI Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Mandala Pharmacon Indonesia Berkala Penelitian Agronomi Akubis: Jurnal Akuntansi dan Bisnis Jurnal Mandala Pengabdian Masyarakat Jurnal Kewarganegaraan Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Jurnal Biofiskim: Pendidikan dan Pembelajaran IPA Farmasis: Jurnal Sains Farmasi Makara Journal of Science Jurnal Farmasi Sains dan Praktis Journal of Community Health Provision Molekul: Jurnal Ilmiah Kimia Media Farmasi Borneo Journal of Pharmacy Jurnal Studi Islam dan Sosial International Journal of Islamic Business and Economics (IJIBEC)
Sahidin .
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Sains dan Teknologi Pangan

 1 
PENENTUAN KADAR HAMBAT MINIMUM EKSTRAK ETANOL RIMPANG Etlingera alba (Blume) A. D. Poulsen TERHADAP BAKTERI PENYEBAB DIARE Cronobacter muytjensii DAN PENGEMBANGANNYA DALAM SEDIAAN GRANUL Fristiohady, Adryan; Andriani, Rina; Ramadhani, Rizky Barkah; wahyuni, Wahyuni; Muzuni, Muzuni; Bafadal, Mentarry; Sani, Asrul; Aspadiah, Vica; Sari, Puspita; Sahidin, Sahidin
Jurnal Sains dan Teknologi Pangan Vol 5, No 5 (2020): Jurnal Sains dan Teknologi Pangan
Publisher : JURUSAN ILMU DAN TEKNOLOGI PANGAN, UNIVERSITAS HALU OLEO

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (597.631 KB) | DOI: 10.33772/jstp.v5i5.15099

Abstract

ABSTRACT This study aimed to determine the potential inhibition of ethanol extract of Etlingera alba rhizome against the Cronobacter muytjensiis bacteria and its development in a granule dosage form. Measurement of Minimum Inhibitory Concentration (MIC) using the Broth Microdilution method while granule formulation used the wet granulation method. The results of this study indicate a concentration of 32μg/mL in C. muytjensii as an inhibition of bacterial growth by looking at the absorbance value that was close to 0 and confirmed by spectrophotometric results to see the turbidity of each concentration. This study used 12 extract concentrations, namely 2, 4, 8, 16, 32, 64, 128, 256, 512, 102, and 4096 μg/mL. The granule formulation used 5% gelatin as a binder, Explotab® 4%, 1% magnesium stearate, aerosil PH 101 4%, and lactose ad. 100%. Tablets of ethanol extract of E. alba rhizome qualified for evaluation of weight uniformity and size uniformity evaluation tests.Keywords:Etlingera alba, MIC, granulABSTRAKPenelitian ini bertujuan untuk mengetahui potensi penghambatan ekstrak etanol rimpang Etlingera alba terhadap bakteriCronobacter muytjensiiserta pengembangannya dalam bentuk sediaan granul. Pengukuran Minimum Inhibitory Concentration (MIC) dengan metode Broth Microdilutiondan formulasi granul menggunakan metode granulasi basah.Hasil penelitian ini menunjukkan konsentrasi 32μg/mL pada C. muytjensii sebagai penghambatan pertumbuhan bakteri dengan melihat nilai absorbansi yang mendekati 0 dan dikonfirmasi dengan hasil spektrofotometri untuk melihat turbiditas masing-masing konsentrasi.Penelitian ini menggunakan 12 konsentrasi ekstrak yaitu 2, 4, 8, 16, 32, 64, 128, 256, 512, 102 dan 4096 μg/mL. Formulasi granul menggunakan bahan gelatin 5% sebagai pengikat, Explotab® 4%, magnesium stearat 1%, aerosil PH 101 4% dan laktosa ad. 100%. Tablet ekstrak etanol rimpangE. alba telah memenuhi uji evaluasi berupa keseragaman bobot dan uji evaluasi keseragaman ukuranKata kunci: Etlingera alba, MIC, granul
PENGARUH PENAMBAHAN GELATIN SEBAGAI PENGIKAT TERHADAP STABILITAS FISIK TABLET EKSTRAK ETANOL BUAH WUALAE (Etlingera elatior (JACK) R.M. Smith). Fristiohady, Adryan; Andriani, Rina; Mugiarno, Dita Oktavianti; Asrul Sani, Asrul; Malaka, Muhammad Hajrul; Aspadiah, Vica; Sahidin, Sahidin
Jurnal Sains dan Teknologi Pangan Vol 5, No 6 (2020): Jurnal Sains dan Teknologi Pangan
Publisher : JURUSAN ILMU DAN TEKNOLOGI PANGAN, UNIVERSITAS HALU OLEO

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (589.34 KB) | DOI: 10.33772/jstp.v5i6.15777

Abstract

ABSTRACTThis study aims to determine the effect of adding gelatin as a binder to the granular formula containing theethanol extract of E. elatior. Formulation of tablet containing ethanol extract of E. elatior used wet granulation methodwith various concentration of gelatin as a binder, namely 5%, 7.5% and 10%. The granule mass evaluated included flowvelocity test, angle of repose and the tapped density, while the tablets were evaluaed for weight uniformity and sizeuniformity. The results of the evaluation of the granules have met the requirements except for the flow properties test.The granules were good and there was a significant effect on disintegration time and friability with addition of gelatinconcentration. The tablets fulfilled the evaluation test of weight uniformity and content uniformity.Keywords:Etlingera elatior, gelatin, tablet.ABSTRAKPenelitian ini bertujuan untuk melihat pengaruh penambahan gelatin sebagai pengikat pada formula granullyang mengandung ekstrak etanol E. elatior. Formulasi tablet ekstrak etanol E. elatior ini menggunakan metode granulasibasah dengan variasi konsentrasi gelatin sebagai pengikat yaitu 5%, 7.5% dan 10%. Massa granul yang dievaluasimeliputi ujikecepatan alir, sudut diam dan tapped density sedangkan tablet diuji evaluasi keseragaman bobot dankeseragaman ukuran. Hasil evaluasi granul memenuhi persyaratan kecuali pada uji sifat alir. Granul yang baik danterdapat pengaruh yang signifikan terhadap waktu hancur dan kerapuhan tablet dengan penambahan konsentrasigelatin. Tablet ekstrak etanol E. elatior memenuhi uji evaluasi keseragaman bobot dan keseragaman kandungan.Kata kunci: Etlingera elatior, gelatin, tablet.
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Karim Achmad, SA Ade Dedi Rohayana Adryan Fristiohady Amalia Alfitrianingrum Amir Tajrid Ananda, M Aflahmuna Andriani, Rina Arba, Muh. Arba, Muhammad ARDIANSYAH ARDIANSYAH Ardiansyah Ardiansyah Arfan Arfan Arif Rahman Hakim Asniar Pascayantri Aspadiah, Vica Aspadiah, Vica Aspadiah Asrul Sani Asrul Sani, Asrul Ayu Wulandari Bafadal, Mentarry Baru Sadarun Daud, Nur Saadah Dewi Dewi Din, LB Erfina, Erfina Euis H. Hakim Euis Holisotan Hakim Fadeli Ehsan Hanafi Fadhliyah Malik Fahria Nadiryati Sadimantara Faisal Faisal Fatima, Nur Firdayanti, Firdayanti Fristiohady, Adryan Fusvita, Angriani Hakim, EH Hakini, EuisH Haristan, Haristan Harliani, Harliani Helmia, Wa Ode Nia Hendrawan Tulungi, Wahyu Heriana, Heriana Idhul Ade Rikit Fitra Imam Yahya Indalifiany, Astrid Irnawati Irnawati Jabbar, Asriullah Jalifah Latip Juliawaty, LD Juliawaty, Lia D Kangkuso Analuddin, Kangkuso Karmilah, Karmilah Kuncoro, Shienny Laily Bin Din Latip, J Lia D. Juliawaty Lia Dewi Juliawaty Lubis, Adryan Fristiohady Malaka, Muhammad Hajrul Malaka, Muhammad Hajrul Manggau Marianti Marianti, Manggau Maulana Anwar Mirawanti G, Wa Ode Mugiarno, Dita Oktavianti Muhammad Azhar Muhammad Hajrul Malaka Muhammad Ilyas Yusuf Muhammad Ramadhan Muhammad, Taher Mursanti, Wa Ode Indah Arum Musadar Mappasomba Musdalipah Musdalipah, Musdalipah Muzuni, Muzuni Naimah Naimah Naniar, Naniar Nasution, Ali Napiah Nohong Nohong, Nohong Nordin Hj Lajis Nunuk Hariani Soekamto Nur Illiyyin Akib Nurcahyani, Fitria Nurhayani nurhayani Nurkhalis Bintang Astiasal Parrung, Arsyani Paulina Taba Poko, Feny Rizkia Puspita Sari Putri, Natalia Christiani Putri, Olivia Dicha Raden Arfan Rifqiawan RAHMAT MULIADI, RAHMAT Ramadhan, LOAN Ramadhani, Rizky Barkah Rini Hamsidi Ruslin, Ruslin Rustam HN, Muhammad SADIMANTARA, I GUSTI RAY Saputri, Ulan Mulyani Sarmin, Yuti Sarpan, Lisna Wati Sernita, Sernita Siti Helmyati Sjamsul A. Achmad Sjamsul Arifin Achmad Solly Aryza Solo, Dian Munasari Sunandar Ihsan Supangat Supangat Syah, YM Taher Muhammad Tanzil, Dwi Lestari Khaulani W Wahyuni, W wahyuni wahyuni Wirasmanto, Bayu Wulandari, Rezky Y, Muhammad Ilyas Yana M Syah Yana M. Syah Yana Maolana Syah Yayan Sopyan Yerin Tri Agustina Yodha, Agung Wibawa Mahatva Zubaydah, Wa Ode Sitti