Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Borneo Journal of Pharmacy

Tyrosinase Inhibition Activity and Phytochemical Screening of Melaleuca leucadendron L. Leaves Munawarohthus Sholikha; Ainun Wulandari
Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i3.3694

Abstract

Melaleuca leucadendron L. is a plant whose almost all parts (bark, leaves, twigs, and fruit) can be used as medicine, such as antioxidants, antifungals, sedative effects, and anti-hyaluronidase. This research was conducted to determine tyrosinase inhibition activity and compound content of M. leucadendron leaves. Maceration of M. leucadendron leaves was done in methanol, then carried out liquid-liquid fractionation with n-butanol, chloroform, and water. Methanol extract, butanol fraction, chloroform fraction, and water fraction were tested for phytochemical screening and tyrosinase inhibition using L-DOPA substrate with an ELISA plate well reader. The results of the tyrosinase inhibition activity test at concentrations of 100, 1000 and 10000 μg/mL respectively showed that methanol extract 29.532%, 55.227%, 89.583%; butanol fraction 29.313%, 59.174%, 94.737%, chloroform fraction 21.820%, 24.671%; 53.765%; water fraction 24,086%, 47.661%, 91.118%. Inhibition of the tyrosinase enzyme is shown through the IC50 value from methanol extract, butanol fraction and water fraction, and kojic acid as a positive control, respectively 645.438 μg/mL, 517.935 μg/mL, 669.403 μg/mL, 50.064 μg/mL. Phytochemical screening showed that the extract and fraction contained tannins, flavonoids, saponins, terpenes, and steroids. These results indicate that the butanol fraction is more potent as an anti-tyrosinase agent than the others.
Co-Authors Aditya Fitriasari Aditya Fitriasari Adnan Adnan Adrully El Fienda Ahamd Syaifil Iman Akhatik, Nurul Alladin, Dwi Amalia Khoirunnisa Aminudin, Iwan Andini, Issri Mila Nova Ardhianingsih, Vira Ari Fahimatussyam Putra Nusantara Arum, Fitria Diah Dea Selia Dienillah, Qonita Dini Juliana Diny Auliya Mawarni Djuhariah, Yayah Siti Dwi Okta Mellya Edy Meiyanto Erham Erwi Putri Setyaningsih Ester Marintan Purba Fadly, Iqbal Faraidlika Fara Diana Dewi Fathin Hamida Febriani, Amelia Fiandani, Afifah Fina Aryani Goenadi Fina Aryani Goenadi, Fina Aryani Firdha Aprilya Utami Firmanto, Taufik Fitria Rahayu Fitria Yustisiani Gufran, Gufran H Herdini Herdini Hervianti Nurfitria Nugrahani Heryanto, Anas Hindrayani, Woro Hutagaol, Sartika Ika Maruya Kusuma Iksan, Iksan ILHAM Illahi, Sakinah Ayu Ilyas Ilyas sarbini Indra Wani Irawansah, Didik Januarto, Daniel Jaya, Rendy Indra Jerry, Jerry Jessica Khairunnisa Kartika Dyah Palupi Kartika Dyah Palupi Kartin Aprianti Kasmar , Kasmar Khairiah, Ardian Kholid Alfan Nur Kholid Alfan Nur Khulqiyah, Husnul Kinanthi Kusumawardhani Krisnawati, Indah Kusuma, Ika Maruya Lestiana, Elina Lidia Anggita Ramadhani Lili Musnelina Loamena, Raisul Amin M. Farhan Syauki M. Yahya Madhani, Suci Marsa Falihah Masrin, Masrin Maulana, Arif Andy Maulana, M. Rizky Mira Permata Miskun, Miskun Muh Asad Imaduddin Muh. Faris Hidayat Muhammad Amin Mulandita Munawarohthus Sholikha Munawarohthus Sholikha Munawarohthus Sholikhah Nasrullah Nasrullah Nastion, Nastion Ni’matul Khoeriyah Nopianti, Hermila Nugrahani, Hervianti Nurfitria Nurul Akhatik Oktari, Anggi Irma Yani Pontoan, Jenny Pratiwi Ally Florentina Putra, Anis Fuady Surya Putri , Elvina Triana Putri, Clarisya Pramirusanti Putri, Elvina Triana Rachmatiah, Tiah Rahmawardany, Claudia Y Ramadhani, Lidia Anggita Ratna Nilam Cahya Refdanita Refdanita Refdanita Refdanita, Refdanita Resi Sukma Melati Rianty, Ira Ridwan Ridwan Ridwan, Ridwan Risma Eka Putri Ritha Widyapratiwi Rivita, Maisya Rogahang, Preisilia Rosario Trijuliamos Manalu Sahidah, Sahidah Saiful Bahri Saiful Bahri Saputri, Ika Septiyani Monalisa Setiadi, Fandy Rezha Shella Utami Siregar, Tahoma Siswati Siswati Siti Fadila Azahra Sonia Mutiara Subaryanti Subaryanti, Subaryanti Suci Tiara Sukirman Sukirman Syafriana, Vilya Teodhora, Teodhora Teti Indrawati Teti Indrawati Tiah Rachmatiah Tongat Tongat Tri Soehartati Vahlevi, Rizky Reza Veriyanti , Putu Rika Veryanti, Putu Rika Welisa, Selfina Junita Widyapratiwi, Ritha Winahayu, Neng Esti Windiarto, Henriko Suryo Wiwik Handayani Yayah Siti Djuhariah Yunisa Simehete Yunita Kartini Zabitha Zahwa Zaini, Jamal Zuhrah