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All Journal Majalah Kedokteran Bandung BERITA BIOLOGI Jurnal Penelitian Kesehatan Suara Forikes Media Ilmu Kesehatan JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Health Information : Jurnal Penelitian Jurnal Kefarmasian AKFARINDO Science Midwifery Indonesian Journal of Global Health research Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Multidisiplin Madani (MUDIMA) Formosa Journal of Multidisciplinary Research (FJMR) Jurnal Farmasi Sains dan Praktis Jurnal Kesehatan Tropis Indonesia Journal of Health Management and Pharmacy Exploration (JOHMPE) International Journal of Global Sustainable Research Jurnal Sains dan Kesehatan Strada Jurnal Ilmiah Kesehatan (SJIK)

Opstaria saptarini

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Author-ID : 371349

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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AKTIVITAS ANTIMIKROB FRAKSI EKSTRAK ETANOL BUAH PINANG (ARECA CATECHU L) PADA BAKTERI METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS Nursidika, Perdina; Saptarini, Opstaria; Rafiqua, Nurul
Majalah Kedokteran Bandung Vol 46, No 2 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1639.673 KB)

Infeksi merupakan penyakit penyebab kematian di Indonesia. Salah satu penyebab perkembangan penyakit infeksi di Indonesia adalah resistensi bakteri terhadap antibiotik standar. Methicillin resistant Staphylococcus aureus (MRSA) merupakan penyebab utama infeksi nosokomial dan komunitas.Telah dilakukan uji aktivitas antimikrob fraksi dari ekstrak etanol buah pinang (Areca catechu L) pada bakteri MRSA. Penelitian dilaksanakan di Laboratorium Mikrobiologi Stikes Jenderal Achmad Yani Cimahi, Laboratorium Farmakologi Institut Teknologi Bandung, dan Laboratorium Pusat Penelitian dan Pengembangan Geologi Kelautan Bandung pada Mei?Juni 2011. Aktivitas antimikrobekstrak dan fraksi diuji menggunakan metode broth microdilution, bioautografi, dan scanning electron microscope (SEM). Hasil pengujian menunjukkan bahwa fraksi yang paling efektif ialah fraksi air dengan minimum inhibitory concentration (MIC) 256 µg/mL. Hasil bioautografi menunjukkan bercak kromatogram kromatografi lapis tipis (KLT) yang memberikan hambatan terhadap bakteri uji adalah bercak dengan Rf 0,6. Bercak ini diduga merupakan senyawa fenolat karena memberikan hasil positif dengan penyemprotan FeCl3. Hasil SEM menunjukkan bakteri uji yang telah dipapar dengan tanaman uji diduga mengalami kerusakan pada membran atau bagian yang lebih dalam, sehingga sel bakteri menciut dan bergelembung hingga rusak.Simpulan, ekstrak etanol buah pinang dapat menghambat pertumbuhan bakteri MRSA. [MKB. 2014;46(2):94?9]Kata kunci: Aktivitas antimikrob, Areca catechu, microdilution, MRSA, SEM Antimicrobial Activity of Betel Nut Ethanolic Extract Fractions in Methicillin Resistant Staphylococcus aureusInfection is the major cause of death in Indonesia. Antibiotic resistant is responsible for this progression. Methicillin resistant Staphylococcus aureus (MRSA) is known as the main cause of nosocomial and community infections.The antimicrobial activity of ethanolic extract fractions of betel nut (Areca catechu L) was studied on MRSA. The research was performed at the Microbiology Laboratory, School of Health Sciences, Jenderal Achmad Yani University, Cimahi, the Pharmacology Laboratory of Bandung Institute of Technology, and Research and Development of Ocean Geology Laboratory in May?June 2011.The antimicrobial activities of the extract and fraction were tested by microdilution broth method, bioautography and scanning electron microscope (SEM). The most effective result showed by water fraction with minimum inhibitory concentration (MIC) was 256 µg/mL. Bioautography result showed a spot on thin layer chromatography (TLC) chromatogramof water fraction which inhibited the bacterial growth, which was the spot with Rf 0.6. The spot was suggested as a phenolic substance due to positive result to FeCl3. The electron microscope image showed the breakdown of membrane cell/inner site of bacteria which was exposed by betel nut extract and fractions in which the bacteria was shrinked, bubbled and broken.In conclusion, betel nut ethanolic extract has the ability to inhibit MRSA. [MKB. 2014;46(2):94?9]Key words: Antimicrobial activity, Areca catechu, microdillution, MRSA,SEM DOI: 10.15395/mkb.v46n2.280

PENDEKATAN LEAN HOSPITAL UNTUK MENGIDENTIFIKASI WASTE KRITIS PELAYANAN OBAT DI INSTALASI FARMASI RAWAT JALAN RSUD X MANNA TAHUN 2020 Rahayu, Dinda Sri; Sunarni , Titik; Saptarini, Opstaria
MEDIA ILMU KESEHATAN Vol 9 No 3 (2020): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v9i3.509

Background: Lean Hospital is needed in order to hospital can fulfill patientâ€™s needs optimally, can give health service as much as possible to the patient. This research has a purpose for identifying medicine service, waste and the root cause of waste, so than we give reparation suggestion to medicine service that happens in Outpatient Pharmacy Installation of Regional Public Hospital. Objective: Respondent In this study, patients or their families and pharmacy Methods: This research is study case research with qualitative approach. The research stages are doing observation of service processâ€™s flow which is made in value stream mapping, distributing questionnaires of patientâ€™s value and waste, doing interview by 5 why method for knowing the root cause and waste critical. The proposed of improvements is obtained from Head of Hospital Pharmacy Installation. Results: The research result showed that the service medicine process of pharmacy installation has been lean. Waste critical that is obtained, is waste motion 21,1%. Conclusion: The root cause of waste motion is manually, there is a space that separates between rooms, Emergency Installation/ IGDâ€™s service, Outpatient and Inpatient has not been done separately yet. Adding visual management, rearranging the layout of the room is a suggestion for improvements to eliminate waste.

Aktivitas Antibiofilm Ekstrak dan Fraksi-Fraksi Biji Pinang (Areca catechu L.) Terhadap Staphylococcus aureus ATCC 25923 Tobi, Claudius Hendraman B.; Saptarini, Opstaria; Rahmawati, Ismi
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 7, No 1 (2022)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v7i1.43698

Biofilm merupakan kumpulan dari sel-sel mikrobial yang melekat secara ireversibel pada suatu permukaan dan terbungkus dalam matriks EPS (Extracellular PolymericSubstances). Salah satu bakteri infeksius yang memproduksi biofilm adalah S. aureus. Biji pinang diketahui mengandung flavonoid, alkaloid dan tanin yang memiliki mekanisme antibiofilm dan antibakteri. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antibiofilm ekstrak dan fraksi biji pinang terhadap bakteri S. aureus. Ekstraksi biji pinang dilakukan dengan metode maserasi, fraksinasi dilakukan dengan metode ekstraksi cair-cair menggunakan pelarut air, etil asetat dan n-heksan. Aktivitas penghambatan dan degradasi biofilm dilakukan dengan metode pewarnaan kristal violet yang dibaca pada panjang gelombang 595 nm. Persen peghambatan dan degradasi yang diperoleh dianalisis menggunakan uji statistik ANAVA dua arah. Persen penghambatan dan degradasi tertinggi ditunjukkan oleh ekstrak etanolyaitu secara berturut-turut 70,17% dan 54%dengan nilai IC50 secara berturut-turut yaitu -0,4 mg/ml dan 5,9 mg/ml. Hasil uji statistik menunjukkan setiap kelompok sampel dan konsentrasi memberikan pengaruh yang signifikan pada persen penghambatan dan degradasi biofilm.

Pendekatan Lean Hospital untuk Meminimalkan Waste di Instalasi Farmasi Rawat Jalan di Rumah Sakit Umum Daerah Pandan Arang Boyolali Tria Yuganingsih; Gunawan P Widodo; Opstaria Saptarini
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 12 (2021): Nomor Khusus November 2021
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf.v12i0.1396

Lean Hospital is needed so that in the hospital can fulfill patient's need optimally to give healthy service as much as possible by reducing waste which finally will create added value for the hospital. The purpose of this research is to identify waste and the cause of waste that happen in Outcare Pharmaceutical Installation Regional Public Hospital Pandan Arang, Boyolali.The method of this research is case study research with qualitative approach. The sequence of the research are Chart observation of service process in the form of value stream mapping, The distribution of Value Patient questionnaire and waste, doing interview by 5 Why Method to know the cause and critical waste. The results showed that the critical waste in the form of overproduction waste was 63.33%, waste waiting was 23.07% and waste inventory was 39.35%. The root cause of waste overproduction is inefficient information related to prescription service flow, the root cause of waste waiting is limited human resources, the root cause of waste inventory is doctor's practice hours that are not in accordance with the predetermined hours causing buildup. The proposed improvement for waste overproduction is to add acrylic information from service providers who are more effective at registration counters, queue collection counters. The proposed waste waiting improvement is done by leveling employees to create a middle system by requiring additional human resources. The proposed improvement in waste inventory is to arrange a doctor's practice schedule or a shift system.Keywords: critical waste; lean hospital; pharmaceutical installation; service improvementABSTRAKPendekatan lean adalah untuk meningkatkan efisiensi dan efektivitas organisasi dengan meningkatkan nilai, mempercepat waktu pelayanan dan meningkatkan kualitas dengan menghapus pemborosan dalam semua proses pelayanan di suatu instalasi. Tujuan penelitian ini untuk mengidentifikasi waste dan akar penyebab waste yang terjadi di dalam Instalasi Farmasi Rawat Jalan RSUD Pandan Arang Boyolali. Metode penelitian ini adalah penelitian studi kasus dengan pendekatan kualitatif. Tahapan penelitian yaitu observasi alur proses pelayanan yang dibuat dalam bentuk value stream mapping, penyebaran kuesioner value pasien dan waste, melakukan wawancara dengan metode 5 why untuk mengetahui akar penyebab dan waste kritis. Hasil penelitian menunjukan bahwa waste kritis berupa waste overproduction sebesar 63,33%, waste waiting sebesar 23,07% dan waste inventory sebesar 39,35%. Akar penyebab dari waste overproduction adalah informasi yang kurang efisien terkait alur pelayanan resep, akar penyebab dari waste waiting adalah keterbatasan sumber daya manusia, akar penyebab dari waste inventory adalah jam praktek dokter yang tidak sesuai dengan jam yang telah ditentukan sehingga menyebabkan penumpukan. Usulan perbaikan untuk waste overproduction adalah menambahkan akrilik keterangan petugas pemberi pelayanan yang lebih efektif pada loket pendaftaran, loket pengambilan nomor antrian. Usulan perbaikan waste waiting adalah dilakukan levelling pegawai membuat sistem middle dengan memerlukan tambahan sumber daya manusia. Usulan perbaikan waste inventory adalah mengatur jadwal praktik dokter atau dibuat sistem shift.Kata kunci: waste kritis; lean hospital; instalasi farmasi; perbaikan pelayanan

PENGARUH MINYAK ATSIRI DAUN JERUK PURUT (Citrus hystrix) TERHADAP DINDING SEL BAKTERI Staphylococcus aureus Opstaria Saptarini; Ismi Rahmawati
BERITA BIOLOGI Vol 20, No 1 (2021)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v20i1.3976

Kaffir lime leaves essential oil has activity to inhibit bacterial growth. The mechanism of the inhibition is thought to be located in thebacterial cell wall. This study aimed to determine the antibacterial work location of kaffir lime leaf essential oil against Staphylococcus aureus ATCC 25923. Kaffir lime leaves were distilled by steam distillation, essential oils obtained were identified by organoleptic quality, evaporation, solubility in alcohol, refractive index and specific gravity. The results were compared under with the literature. The results of essential oils were made with various concentrations of 100, 50, 25, 12.5, 6.25, 3.13, 1.56, 0.73, 0.39, and 0.20%. The results of the concentration series were tested for antibacterial activity with the macrodilution method followed by the determination for the location of bacterial growth inhibition using the Scanning Electron Microscope (SEM). The yield of kaffir lime leaf essential oil was 0.82%. The observation of organoleptic essential oil has a light yellow color, the distinctive odor of kaffir lime, a liquid form, and distinctive lime taste. Refractive index examination resulted 1.454; specific gravity 0.8317, and soluble in 70% ethanol with a ratio of 1:1. The Minimum BactericidalConcentration (MBC) obtained from the antibacterial activity test was 6.25%. Kaffir lime leaves essential oil mechanism occurred in the cell walls and cell membranes of Staphylococcus aureus.

PEMBERDAYAAN IBU-IBU PKK MELALUI PELATIHAN DAN PENDAMPINGAN PRODUKSI MINYAK ANGIN AROMATERAPI Fransiska Leviana; Wiwin Herdwiani; Opstaria Saptarini
ABDIMAS ALTRUIS: Jurnal Pengabdian Kepada Masyarakat Vol 2, No 2 (2019): Oktober 2019
Publisher : Universitas Sanata Dharma

The use of aromatherapy was very well known in the community. The best-selling and quickly accepted product was aromatherapy oil. The benefits of aromatherapy were not only for health, but also for calming the mind and relaxation. Empowerment of PKK as members of the community and still classified as productive workforce was very important to do, aiming to foster awareness and independence in doing business, while expanding employment to increase family income in an effort to achieve a happy and prosperous family. In relation to efforts to foster and develop the potential of families and regions, it can be done through various alternative activities, including training in making aromatherapy oil product. The purpose of this community service program was to empower mothers and women through training and assistance in aromatherapy oil production. The target of this activity was PKK RW 04 Mojosongo Village, Jebres District, Surakarta City. The output of this activity was improving the skills of the community to produce aromatherapy wind oil and motivating business opportunities for PKK mothers. The method used in this service was training and assistance in aromatherapy oil production.

Studi Aktivitas Antibakteri Ekstrak Etanolik, Ekstrak Metanol dan Infus Daun Bayam Duri (Amaranthus spinousus) dan Herba Cakar Ayam (Sellaginella doederleinii Hieron) terhadap Bakteri Penyebab Pneumonia Opstaria Saptarini
Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Pneumonia is a respiratory system disease which the alveoli become inflamed and have fluid accumulation. Pneumonia is a serious infection that affects many children and adults in a fundamental way around the world. There are many bacteria that cause diseases such as pneumonia, among others, are used in this test are Streptococcus pneumonia, Klebsiella pneumonia, Streptococcus haemolyticus alpha and beta. Plants used in this study are bayam duri leaves and cakar ayam herbs. Mikrodilusi methods used for testing antibacterial activity. The test is performed to extract ethanol, methanol extracts and infusions of leaves patikan kebo and herbaceous rumput mutiara with the same concentration with the largest concentration is 1024 ug / ml following concentration by dilution continued until the third column will have the smallest concentration. Plates were incubated at 37 Â° C for 24 h and then observed the clear (no microbial growth). The smallestconcentration at which no visible microbial growth defined as the MIC (NCCLS, 2003). Based on the testing of antibacterial activity of the infusion, methanol extract and ethanol extract of leaves of bayam duri leaves and cakar ayam herbs, with the broth method microdillution, it appears that the most active extracts were ethanolic extract of bayam duri leaves and ethanolic extract cakar ayam herbs on the bacteria Streptococcus pneumoniae, Streptococcus haemolyticus alpha and Streptococcus haemoyiticus beta, and Klebsiella pneumonia although the effect is lower than the standard drug tetracycline.

Uji Aktivitas Antibakteri Ekstrak Etanolik Daun Patikan Kebo (Euphorbia hirta Linn) dan Herba Rumput Mutiara ( Hydeotis carymbosa L) terhadap Bakteri Penyebab Pneumonia Opstaria Saptarini
Jurnal Farmasi Indonesia Vol 8 No 2 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Pneumonia merupakan penyakit sistem pernapasan dimana alveoli mengalami peradangan dan terjadi penimbunan cairan. Pneumonia merupakan infeksi serius yang banyak diderita oleh anak anak dan orang dewasa secara fundamental yang terjadi di seluruh dunia. Ada banyak bakteri penyebab penyakit pneumonia antara lain seperti yang digunakan dalam pengujian ini adalah Streptococcus pneumonia, Klebsiella pneumonia, Streptococcus haemolyticus alpha dan beta. Tanaman yang digunakan dalam penelitian ini adalah herba rumput mutiara, dan daun patikan kebo. Metode mikrodilusi digunakan untuk pengujian aktivitas antibakterinya. Pengujian ini dilakukan terhadap ekstrak etanol, ekstrak metanol dan infuse dari daun patikan kebo dan rumput mutiara dengan konsentrasi yang sama dengan konsentrasi terbesar adalah 1024 Î¼g/ml konsentrasi berikutnya berdasarkan pengenceran terus dilakukan sampai pada kolom ketiga yang akan memiliki konsentrasi terkecil. Pelat diinkubasi pada suhu 37Â°C selama 24 jam kemudian diamati bagian yang jernih (tidak ada pertumbuhan mikroba). Konsentrasi terkecil di mana tidak terlihat pertumbuhan mikroba ditetapkan sebagai MIC (NCCLS, 2003). Berdasarkan pengujian aktivitas antibakteri terhadap infus, ekstrak metanol dan ekstrak etanol daun patikan kebo, dan herba rumput mutiara, dengan metode broth microdillution, terlihat bahwa ekstrak yang paling aktif adalah ekstrak etanol daun patikan kebo dan ekstrak etanolik herba rumput mutiara pada bakteri, Streptococcus Pneumonia, Streptococcus haemolyticus alpha dan Streptococcus haemoyiticus beta dan Klebsiella pneumonia meskipun efeknya lebih rendah dibandingkan dengan obat standart tetrasiklin.

Uji Aktivitas Antijamur Kombinasi Berbagai Tanaman terhadap Pityrosporum ovale Ismi Rahmawati; Opstaria Saptarini; Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

One cause of tinea versicolor is a fungal Pityrosporum ovale which colonizes on the skin. Previous research has examined the red betel leaves, beluntas leaves and cabbage leaves as antifungal against Pityrosporum ovale. This study aims to determine the effectiveness of the above herbs in the form of single or various combinations to inhibit the growth of the fungus Pityrosporum ovale by in vitro method. The extraction method was performed by infudation on the red betel leaf powder, beluntas leaves and cabbage leaves. The results of infudation are then made in a combination of (1:1), (1:3) and (3:1). The antifungal test with dilution method was then performed on the single and the combination extract. Dilution method was performed by making a series of dilutions in concentrations of 50%, 25%, 12.5%, 6.25%, 3.13%, 1.56%, 0.78%, 0.39%, 0.19%, 0.09%. The results showed that the MKC (minimum killing concentration) of red betel leaves, beluntas leaves and cabbage leaves, combination of red betel leaves and beluntas leaves (1:1), (1:3) and (3:1), combination of red betel leaves and cabbage leaves (1:1), (1:3) and (3:1) were 50%, 25%, 25%, 25%, 12.5%, 50%, 50%, 12.5%, 25% respectively. The best combination were red betel leaves and beluntas leaves infusions with a ratio of (1:3) and the combination red betel leaves and cabbage leaves infusions with a ratio of (1:3).

Pemanfaatan Daun Belimbing Wuluh (Averrhoa bilimbi L) dalam Bentuk Infusa dan Sediaan Celup terhadap Penurunan Berat Badan Inaratul Rizkhy Hanifah; Suhartinah Suhartinah; Opstaria Saptarini
Jurnal Farmasi Indonesia Vol 11 No 2 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Obesity is excess weight due to the accumulation of fat cells. The adverse effects of obesity are high chances for the spread of degenerative diseases and in terms of aesthetic body look unattractive. This research was aimed to use bilimbi leaves as weight loss with varying doses in two dosage forms, namely infusion and tea bag. The test animals used were female white rats were grouped into: negative control group were given 0.5% CMC; positive control group were given xenicalÂ® a dose of 2.16 mg / 200 g BB rats; and a test group with a dose preparations bilimbi 5.0 mg/200 g BW, 10 mg/200 g BW, and 20 mg/200 g BW. The treatment were given for 30 days and observed weight. At the end of the treatment, animals dissected after anesthetized. Fats contained around abdominal weighed and the results recorded and compared. Results this study were the bilimbi leaves that has been made in the form of infusions and steeping tea bags in which both had effect as a weight loss in female rats wistar strain.

Co-Authors Andintias, Mohammad Febry Claudius Hendraman B. Tobi Daniel Happy Putra Dewi Natalia Dinda Sri Rahayu Endang Sri Rejeki Faelga Sara Fradine, Chossy Fransiska Leviana Gunawan P Widodo Gunawan Pamudji Gunawan Pamudji Widodo Ibnu Nugroho Saputra Ika Purwidyaningrum Ilham Kuncahyo, Ilham Inaratul Rizkhy Hanifah Intan Sofia Irsa Aulia Ismi Rahmawati Ismi Rahmawati Ismi Rahmawati Ismi Rahmawati Ismi Rahmawati Jason Merari Peranginangin Kurniasari, Fitri Lina Susanti Mariyo Jane Sanggel Muhammad Alviyan Shutiawan Munawi Munawir Munawir Munawir Mustika Endah Pratiwi Najiyyah, Trias Durrotun Nia Azzahra Nurul Rafiqua Perawati Perdina Nursidika Priska Juanita Pakingki Putri, Luluk Aniqoh Meliana R.A. Oetari RA Oetari Rahayu, Dinda Sri Rahmawati, Ismi Rakhmi Hidayati Sabda Wahab santi dwi astuti Sri Devi Nur Rahma Suherman Suhartinah Suhartinah Sunarni , Titik Syahputra, Rizka Wahyu Titik Sunarni Titik Sunarni Tri Wijayanti Tri Wijayanti Tria Yuganingsih Veronica Bella Lupita Wiwi Kartiwi Wiwin Herdwiani Yerri Hartanto Yohanes Dwi Putra Agung Embu Yovi Pranata

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