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All Journal Majalah Kedokteran Bandung BERITA BIOLOGI Jurnal Penelitian Kesehatan Suara Forikes Media Ilmu Kesehatan JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Health Information : Jurnal Penelitian Jurnal Kefarmasian AKFARINDO Science Midwifery Indonesian Journal of Global Health research Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Multidisiplin Madani (MUDIMA) Formosa Journal of Multidisciplinary Research (FJMR) Jurnal Farmasi Sains dan Praktis Jurnal Kesehatan Tropis Indonesia Journal of Health Management and Pharmacy Exploration (JOHMPE) International Journal of Global Sustainable Research Jurnal Sains dan Kesehatan Strada Jurnal Ilmiah Kesehatan (SJIK)
Opstaria saptarini
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FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN SERUM GEL ANTIJERAWAT EKSTRAK ETANOL DAUN KEMANGI (Ocimum basilicum L.)TERHADAP BAKTERI Staphylococcus aureus ATCC 25923 DENGAN VARIASI KONSENTRASI Hydroxyethyl Cellulose (HEC) Ibnu Nugroho Saputra; Opstaria Saptarini; Fitri Kurniasari
Jurnal Kefarmasian Akfarindo Vol 8 No 2 (2023)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.v8i2.206

Abstract

Daun kemangi mempunyai kandungan senyawa flavonoid yang berfungsi sebagai zat antibakteri mampu menghambat penyumbatan bahan keratin pada lapisan pilosebaseus yang dipicu oleh bakteri yaitu Staphylococcus aureus 25923. Penelitian ini bertujuan untuk memformulasikan ekstrak etanol daun kemangi menjadi sediaan serum gel antijerawat dengan memvariasikan konsentrasi Hydroxyethyl Cellulose (HEC) 0,5%, 0,75%, 1% dan menguji mutu fisik serta aktivitas antibakteri terhadap Staphylococcus aureus 25923. Penelitian dilakukan dengan mengekstraksi daun kemangi menggunakan metode maserasi. Uji evaluasi fisik yang meliputi uji organoleptis, pH, viskositas, homogenitas, stabilitas serta uji aktivitas antibakteri pada sediaan serum gel antijerawat dengan variasi konsentrasi Hydroxyethyl Cellulose (HEC), F1 (0,5%), F2 (0,75%), F3 (1%). Metode difusi yang meliputi penyiapan sempel, pembuatan suspensi biakan, pembuatan media lempeng agar, identifikasi bakteri dan pengujian secara difusi. Hasil penelitian menunjukkan bahwa formula dengan variasi konsentrasi Hydroxyethyl Cellulose (HEC), F1 (0,5%), F2 (0,75%), F3 (1%) memiliki aktivitas antibakteri namun pada formula 2 memiliki mutu fisik paling baik dan memiliki diameter zona hambat sebesar 13,00 mm sedangkan pada formula 1 memiliki zona hambat 14,93 mm dan formula 3 memiliki zona hambat sebesar 10,97 mm.
EVALUATION AND DESIGN OF MANAGEMENT INFORMATION SYSTEM DEVELOPMENT IN COMPLETENESS OF RECIPE SCREENING IN AR-RASYID ISLAMIC HOSPITAL PALEMBANG Azzahra, Nia; P, Jason Merari; Saptarini, Opstaria; Wahab, Sabda
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.6233

Abstract

Errors in prescribing and administering drugs are things that often occur in medicine, so in an effort to improve pharmaceutical performance, an evaluation and development of a SIM is carried out to support pharmaceutical services in hospitals. The aim of this research is to evaluate the Management Information System needs at RSI Ar-Rasyid Palembang and continue with the development of a design model. This research is descriptive research conducted through direct observation and documentation. The development of this research system uses a prototype method starting from needs analysis, system design and implementation of the EUCS (End User Computing Satisfaction) framework system, creating a system design using context diagrams, Data Flow Diagrams and Entity Relationship Data, the data analysis method used is qualitative analysis. The results of the research from direct observation on the completeness of the IFRS SIM show that the SIM at RSI Ar-Rasyid in pharmaceutical screening has been fulfilled, but in administrative screening and clinical screening it has not been fulfilled and the results of evaluation using a questionnaire distributed to pharmaceutical installation staff show an average the answer to each statement variable is satisfied. In making a draft design, there are suggestions that include clinical screening of prescriptions, it is hoped that this will help pharmacy installation staff in providing services to avoid medication errors. Based on system design, input design and output design, the patient prescription screening management information system design meets the criteria so it is ready to be implemented into the system.
Minimalisasi Waste di Instalasi Farmasi Rawat Inap Rumah Sakit Umum Daerah Pandan Arang Boyolali melalui Pendekatan Lean Hospital: Minimization Waste in Inpatient Pharmaceutical Installation of Pandan Arang Regional Public Hospital Boyolali with Lean Hospital Approach Yohanes Dwi Putra Agung Embu; Gunawan Pamudji; Opstaria Saptarini; Claudius Hendraman B. Tobi; Mustika Endah Pratiwi
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2224

Abstract

The lean hospital approach is a systematic approach in identifying and eliminating waste through continuous improvement to improve the quality, safety and efficiency of a hospital service process. This study aimed to identified waste, the root cause of critical waste, and provided suggestions for improvement to minimize critical waste in inpatient pharmaceutical installation of Pandan Arang General Public Hospital, Boyolali. Method that used in this research was qualitative research with stages namely observed the service process flow in the form of value stream mapping, distributed questionnaires for waste to got critical waste and conducted interviews with the 5 why method to found out the root cause of the problem. The results showed that on medication service flowhome for class 1, VIP and VVIP patients with critical waste, namely waste defects of 43.34%, waste transportation of 41.67% , and waste inventory of 43.33%. The root cause of waste in the three lines of the service process is human resources that lack discipline. The proposed improvement for waste in the service process is by applying the 5S (Seiri, Seiton, Seiso, Seiketsu, dan Shitsuke) method with the key of success are discipline and consistency applied to service providers.   Keywords:          Lean hospital, Waste, Inpatient Pharmacy Installation, Pandan Arang Boyolali General Public Hospital   Abstrak Pendekatan lean hospital adalah pendekatan sistematik dalam mengidentifikasi dan menghilangkan pemborosan (waste) melalui perbaikan yang berkelanjutan untuk meningkatkan kualitas, keamanan dan efisiensi suatu proses pelayanan di rumah sakit. Tujuan penelitian ini adalah mengidentifikasi waste, akar penyebab waste kritis dan memberikan usulan perbaikan untuk meminimalkan waste kritis di instalasi farmasi rawat inap RSUD Pandan Arang Boyolali. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif dengan tahapan yaitu observasi alur proses pelayanan dalam bentuk value stream mapping, penyebaran kuesioner waste untuk mendapatkan waste kritis serta wawancara dengan metode 5 why untuk mengetahui akar penyebab masalah terjadinya waste. Hasil penelitian menunjukkan bahwa pada alur pelayanan obat pulang untuk pasien kelas 1, VIP, dan VVIP di instalasi farmasi rawat inap RSUD Pandan Arang Boyolali dengan waste kritis yaitu waste defect sebesar 43,34%, waste transportation sebesar 41,67% dan waste inventory sebesar 43,33%. Akar penyebab dari waste pada alur proses pelayanan obat ini adalah pada sumber daya manusia yang kurang disiplin. Usulan perbaikan kejadian waste pada proses pelayanan obat di alur pelayanan obat pulang untuk pasien kelas 1, VIP dan VVIP yaitu dengan menerapkan metode 5S (Seiri, Seiton, Seiso, Seiketsu dan Shitsuke) dengan kunci keberhasilan yaitu disiplin dan konsisten yang diterapkan pada petugas pemberi pelayanan.   Kata Kunci:         Lean hospital, Waste, Instalasi Farmasi Rawat Inap, RSUD Pandan Arang Boyolali
Immunomodulatory Activity of Ethanol Extract and Kabau (Archidendron Bubalinum) Leaf Fractions on the Macrophage Phagocytosis Index in Male White Rats (Rattus Novergicus) Intan Sofia Irsa Aulia; Tri Wijayanti; Opstaria Saptarini
Jurnal Multidisiplin Madani Vol. 4 No. 6 (2024): June 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i6.9588

Abstract

Immunomodulators are substances that have the ability to balance and restore a dysfunctional immune system, reduce the body's immune response due to excessive immune activity and stimulate leukocyte cells, especially macrophages, to form a strong immune system. The aim of this study was to determine the immunomodulatory activity of kabau leaves (Archidendron bubalinum) in male white rats in terms of the phagocytosis index, number of leukocyte cell types and spleen histopathology. This research design used 35 mice as test animals and then divided them into 6 groups, namely negative control, positive control (Stimuno dose 50 mg), kabau leaf extract 20 mg, n-hexane fraction 6.66 mg, ethyl acetate fraction 4 mg, water fraction 6.66 mg, each group consisted of 5 male rats. Immunomodulatory activity was seen from the phagocytosis index and the number of leukocyte cell types at 10 and 15 minutes. The results showed that the 6 treatments had significantly different immunostimulatory activities with a significant value of less than 0.05. The results of the phagocytosis index calculation showed that the highest value was Stimuno at 3.33, then the 6.66 mg n-hexane fraction was 2.49, the 4mg ethyl acetate fraction was 1.63, the 20 mg extract was 1.26, and the water fraction was 6.66 mg. 1.27. From these results it can be concluded that kabau (Archidendron bubalinum) leaf extracts and fractions have immunostimulant activity
Antibacterial and Antibiofilm Activity of Papaya Leaf Fractions (Carica Papaya L.) Against Staphylococcus Aureus ATCC 25923 Yovi Pranata; Ismi Rahmawati; Opstaria Saptarini
Jurnal Multidisiplin Madani Vol. 4 No. 6 (2024): June 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i6.9879

Abstract

The research on papaya leaves was aimed at determining antibacterial activity, antibiofilm activity, K+ and Ca2+ metal ion parameters, as well as the morphology of S.aureus bacteria from papaya leaf fractions and extracts. The average value of the test results for the diffusion method at 50% concentration was 20.66 ± 0.57 and the test results for the dilution method for Minimum Inhibitory Concentration at a concentration of 12.5%. Antibiofilm formation inhibitor test results at a concentration of 50 mg/ml with an average value of 72.37 ± 0.65, a concentration of 25 mg/ml 64.75 ± 0.83 and a concentration of 12.5 mg/ml with an average value of IC50 of 0.975 ± 0.012. Biofilm degradation testing at a concentration of 50 mg/ml resulted in an average value of 60.43 ± 1.11, a concentration of 25 mg/ml with an average value of 50.05 ± 0.87 and a concentration of 12.5 mg/ml with an average value -mean 35.86 ± 1.05. The average EC50 value was 26.731 ± 1.1874. Tests using AAS on K+ metal ions showed ion leakage or cell contents coming out was 1,805 mg/L, Ca2+ metal ions resulting from this leak were 3,884. Morphological observations using SEM showed that the samples experienced shrinkage and reduced size from being perfectly round to oval to S.aureus bacteria in samples with water fraction
Antifertility Activity and Chemical Content of Moringa Oleifera Lam Plant Extract on The Reproductive System of Male and Female White Rats Munawir Munawir; Titik Sunarni; Opstaria Saptarini
Indonesian Journal of Global Health Research Vol 6 No S6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS6.4821

Abstract

Research shows that Moringa extract possesses anti-fertility effects on the reproductive systems of male and female rats. This study investigates Moringa's active chemical compounds and their impact on reproductive parameters such as sperm concentration, motility, morphology, and seminiferous tubule diameter, along with hormone levels (progesterone, LH, FSH), estrogenic activity, and the estrous cycle. The research, a literature review, compiles findings from quality international (Scopus) and national (SINTA) journals, Translation and proofreading: there are 8 articles that meet the research inclusion criteria, selected within a range from the year 2010 to 2024. Key active compounds identified in Moringa include alkaloids, tannins, flavonoids (kaempferol and quercetin), and benzyl isothiocyanate, all of which demonstrate anti-fertility effects. These compounds were observed to reduce sperm concentration, motility, and morphology, and to decrease seminiferous tubule diameter in males, while also impacting hormone levels and the estrous cycle in females. The findings support Moringa’s potential as an anti-fertility agent, highlighting its impact across various reproductive parameters in both genders.
UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL BUAH CABE JAWA (Piper retrovactum Vahl) PADA MENCIT PUTIH JANTAN (Mus musculus L.) DENGAN METODE Forced Swimming Test (FST) Najiyyah, Trias Durrotun; Opstaria Saptarini; Santi Dwi Astuti
Jurnal Kefarmasian Akfarindo Vol 10 No 1 (2025)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.1148

Abstract

Depresi merupakan gangguan kesehatan mental yang disebabkan karena turunnya kadar neurotransmiter di dalam otak. Buah cabe jawa (Piper retrovactum Vahl) memiliki kandungan senyawa utama alkaloid piperidine (piperin) yang dapat digunakan sebagai antidepresan. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antidepresan dan dosis efektif ekstrak etanol buah cabe jawa (Piper retrovactum Vahl). Penelitian ini menggunakan hewan uji yang terbagi dalam 5 kelompok. Terdapat 5 kelompok perlakuan, kontrol negatif Na CMC 0,5%; kontrol positif fluoxetine 1,3 mg/20gBB mencit; ekstrak etanol buah cabe jawa 200; 400; dan 800mg/20gBB mencit. Pengujian antidepresan menggunakan hewan uji mencit putih jantan (Mus musculus L.) dengan metode Forced Swimming Test. Buah cabe jawa sebagai bahan uji disoxhletasi menggunakan pelarut etanol 95%. Hewan uji diinduksi depresi dengan renang paksa 5 menit setiap hari selama 7 hari. Mencit setelah itu diberi perlakuan sampai hari ke-14. Parameter yang diamati adalah immobility time. Data hasil penelitian dianalisis menggunakan One way ANOVA. Hasil dari penelitian menunjukkan bahwa ekstrak etanol buah cabe jawa (Piper retrovactum Vahl) mempunyai aktivitas sebagai antidepresan yang dilihat dari penurunan immobolity time dengan metode forced swimming test. Dosis yang paling efektif untuk menurunkan waktu imobilitas secara signifikan yaitu dosis 400 mg/kg BB mencit dengan % penurunan immobility time sebesar 57,15%. Ekstrak etanol buah cabe jawa (Piper retrovactum Vahl) dengan dosis 200; 400; dan 800 mg/20gBB mencit mempunyai aktivitas sebagai antidperesan.
Effect of Ashitaba Leaf as Antibiofilm Against Pseudomonas aeruginosa and Staphylococcus aureus Luluk Aniqoh Meliana Putri; Ismi Rahmawati; Opstaria Saptarini
STRADA : Jurnal Ilmiah Kesehatan Vol. 14 No. 1 (2025): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v14i1.1236

Abstract

Infection is one of the serious health problems that will continue to grow in Indonesia. Indonesian people have used herbal medicines derived from plants such as ashitaba leaves which contain chemical compounds tannin, alkaloids, flavonoids and saponins to treat several diseases. This study aims to see the potential of extracts and fractions (n-hexane, water and ethyl acetate) to inhibit the formation, destroy biofilms against Pseudomonas aeruginosa and Staphylococcus aureus. The method used is antibacterial testing using the dilution method, observation of bacterial cell morphology using SEM. Results active ashitaba leaf fraction inhibits the formation and degrades Pseudomonas aeruginosa and Staphylococcus aureus biofilms is water. The location of the most active water fraction against Staphylococcus aureus bacteria is on the bacterial cell wall. The water fraction has antibacterial activity against Staphylococcus aureus with an MBC value of 12.5%, the location of the water fraction is on the bacterial cell wall.
Evaluation of Pharmaceutical Services Based on STARKES 2024 Standards Andintias, Mohammad Febry; Saptarini, Opstaria; Wijayanti, Tri
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.7037

Abstract

The 2024 STARKES accreditation standards emphasize the importance of safe, effective, and quality pharmaceutical services and medication use (Pharmaceutical Services and Rational Drug Use - PKPO). Private hospitals often face challenges in meeting these standards, particularly concerning the storage of medicines and medical consumables. This study aims to evaluate the implementation of PKPO at Hospital X in Demak Regency based on STARKES 2024 standards and to identify priority areas for improvement. A mixed methods approach was employed. Quantitative data were collected through a structured questionnaire based on seven key PKPO indicators. Qualitative data were obtained via direct observations and in-depth interviews with the head of the pharmacy department and related staff. Quantitative data were analyzed using percentage compliance calculations, while qualitative data were analyzed thematically. Priority problems were determined using the Hanlon method. The overall PKPO implementation score at Hospital X was 70.15%, below the minimum accreditation threshold of 80%. The highest scoring indicator was PKPO 1 (Organization) at 87.5%, while the lowest scores were observed in PKPO 5 (Dispensing) at 52.5% and PKPO 3 (Storage) at 60%. The main priority issue identified was the security of pharmaceutical and medical consumable storage (PKPO 3, item 1).
PENGENDALIAN PERSEDIAAN OBAT  MENGGUNAKAN METODE ANALISIS ABC-VEN DI INSTALASI FARMASI RS PANDAN ARANG BOYOLALI Syahputra, Rizka Wahyu; Saptarini, Opstaria; Wijayanti, Tri
Jurnal Infokes Vol 15 No 2 (2025): Jurnal Ilmiah Rekam Medis dan Informatika Kesehatan
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/bpd34f40

Abstract

Pelayanan kefarmasian merupakan pelayanan penunjang dan sekaligus menjadi salah satu revenue centre primer, karena lebih dari 90% pelayanan di rumah sakit menggunakan perbekalan farmasi seperti obat-obatan, bahan kimia, bahan radiologi, bahan medis habis pakai, alat kesehatan serta gas medik dan 50% dari semua pemasukan rumah sakit berasal dari pengelolaan perbekalan farmasi. Instalasi Farmasi RSUD Pandan Arang Boyolali mengelola 644 item obat yang terdaftar pada database. Perencanaan obat di RS Pandan Arang Boyolali masih menggunakan metode konsumsi. Penelitian ini bertujuan membuat usulan cara pengendalian perencanaan persediaan agar tidak terjadi stock out di Instalasi Farmasi RSUD Pandan Arang Boyolali. Penelitian ini bertujuan untuk mengetahui pengendalian perencanaan persediaan obat dengan metode ABC-VEN di instalasi Farmasi RS Pandan Arang Boyolali dengan mengambil data persediaan obat yang digunakan untuk menghitung kebutuhan persediaan tahun 2022 dengan metode analisis kombinasi ABC-VEN. Metode yang digunakan yaitu metode ABC (Always, Better, Control), VEN (Vital, Essensial, Non Essensial). Data yang diperoleh pada saat wawancara dengan narasumber, pengamatan dan observasi langsung pada saat penelitian serta data obat pada Instalasi Farmasi RS Pandan Arang Boyolali tahun 2021. Hasil analisis metode ABC-VEN diperoleh data item obat kelompok A 44 item obat kelompok B 159 item obat kelompok C 441 item obat dan dibagi menjadi 9 kategori yaitu : item obat kategori AV 15 item obat AE 24 item obat, AN 4 item obat, BV 26 item obat, BE 105 item obat, BN 28 item obat, CV 20 item obat, CE 289 item obat, CN 132 item obat dari total 644 item obat. Analisis ABC-VEN dapat dijadikan acuan untuk mendapatkan persediaan yang optimal, efektif dan efisien.
Co-Authors Andintias, Mohammad Febry Claudius Hendraman B. Tobi Daniel Happy Putra Dewi Natalia Dinda Sri Rahayu Endang Sri Rejeki Faelga Sara Fradine, Chossy Fransiska Leviana Gunawan P Widodo Gunawan Pamudji Gunawan Pamudji Widodo Ibnu Nugroho Saputra Ika Purwidyaningrum Ilham Kuncahyo, Ilham Inaratul Rizkhy Hanifah Intan Sofia Irsa Aulia Ismi Rahmawati Ismi Rahmawati Ismi Rahmawati Ismi Rahmawati Ismi Rahmawati Jason Merari Peranginangin Kurniasari, Fitri Lina Susanti Mariyo Jane Sanggel Muhammad Alviyan Shutiawan Munawi Munawir Munawir Munawir Mustika Endah Pratiwi Najiyyah, Trias Durrotun Nia Azzahra Nurul Rafiqua Perawati Perdina Nursidika Priska Juanita Pakingki Putri, Luluk Aniqoh Meliana R.A. Oetari RA Oetari Rahayu, Dinda Sri Rahmawati, Ismi Rakhmi Hidayati Sabda Wahab santi dwi astuti Sri Devi Nur Rahma Suherman Suhartinah Suhartinah Sunarni , Titik Syahputra, Rizka Wahyu Titik Sunarni Titik Sunarni Tri Wijayanti Tri Wijayanti Tria Yuganingsih Veronica Bella Lupita Wiwi Kartiwi Wiwin Herdwiani Yerri Hartanto Yohanes Dwi Putra Agung Embu Yovi Pranata