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All Journal Majalah Kedokteran Bandung BERITA BIOLOGI Jurnal Penelitian Kesehatan Suara Forikes Media Ilmu Kesehatan JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Health Information : Jurnal Penelitian Jurnal Kefarmasian AKFARINDO Science Midwifery Indonesian Journal of Global Health research Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Jurnal Ilmiah Kesehatan (JIKA) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Multidisiplin Madani (MUDIMA) Formosa Journal of Multidisciplinary Research (FJMR) Jurnal Farmasi Sains dan Praktis Jurnal Kesehatan Tropis Indonesia Journal of Health Management and Pharmacy Exploration (JOHMPE) International Journal of Global Sustainable Research Jurnal Sains dan Kesehatan Strada Jurnal Ilmiah Kesehatan (SJIK)
Opstaria saptarini
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UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL BUAH CABE JAWA (Piper retrovactum Vahl) PADA MENCIT PUTIH JANTAN (Mus musculus L.) DENGAN METODE Forced Swimming Test (FST) Najiyyah, Trias Durrotun; Opstaria Saptarini; Santi Dwi Astuti
Jurnal Kefarmasian Akfarindo Vol 10 No 1 (2025)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.1148

Abstract

Depresi merupakan gangguan kesehatan mental yang disebabkan karena turunnya kadar neurotransmiter di dalam otak. Buah cabe jawa (Piper retrovactum Vahl) memiliki kandungan senyawa utama alkaloid piperidine (piperin) yang dapat digunakan sebagai antidepresan. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antidepresan dan dosis efektif ekstrak etanol buah cabe jawa (Piper retrovactum Vahl). Penelitian ini menggunakan hewan uji yang terbagi dalam 5 kelompok. Terdapat 5 kelompok perlakuan, kontrol negatif Na CMC 0,5%; kontrol positif fluoxetine 1,3 mg/20gBB mencit; ekstrak etanol buah cabe jawa 200; 400; dan 800mg/20gBB mencit. Pengujian antidepresan menggunakan hewan uji mencit putih jantan (Mus musculus L.) dengan metode Forced Swimming Test. Buah cabe jawa sebagai bahan uji disoxhletasi menggunakan pelarut etanol 95%. Hewan uji diinduksi depresi dengan renang paksa 5 menit setiap hari selama 7 hari. Mencit setelah itu diberi perlakuan sampai hari ke-14. Parameter yang diamati adalah immobility time. Data hasil penelitian dianalisis menggunakan One way ANOVA. Hasil dari penelitian menunjukkan bahwa ekstrak etanol buah cabe jawa (Piper retrovactum Vahl) mempunyai aktivitas sebagai antidepresan yang dilihat dari penurunan immobolity time dengan metode forced swimming test. Dosis yang paling efektif untuk menurunkan waktu imobilitas secara signifikan yaitu dosis 400 mg/kg BB mencit dengan % penurunan immobility time sebesar 57,15%. Ekstrak etanol buah cabe jawa (Piper retrovactum Vahl) dengan dosis 200; 400; dan 800 mg/20gBB mencit mempunyai aktivitas sebagai antidperesan.
Effect of Ashitaba Leaf as Antibiofilm Against Pseudomonas aeruginosa and Staphylococcus aureus Luluk Aniqoh Meliana Putri; Ismi Rahmawati; Opstaria Saptarini
STRADA : Jurnal Ilmiah Kesehatan Vol. 14 No. 1 (2025): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v14i1.1236

Abstract

Infection is one of the serious health problems that will continue to grow in Indonesia. Indonesian people have used herbal medicines derived from plants such as ashitaba leaves which contain chemical compounds tannin, alkaloids, flavonoids and saponins to treat several diseases. This study aims to see the potential of extracts and fractions (n-hexane, water and ethyl acetate) to inhibit the formation, destroy biofilms against Pseudomonas aeruginosa and Staphylococcus aureus. The method used is antibacterial testing using the dilution method, observation of bacterial cell morphology using SEM. Results active ashitaba leaf fraction inhibits the formation and degrades Pseudomonas aeruginosa and Staphylococcus aureus biofilms is water. The location of the most active water fraction against Staphylococcus aureus bacteria is on the bacterial cell wall. The water fraction has antibacterial activity against Staphylococcus aureus with an MBC value of 12.5%, the location of the water fraction is on the bacterial cell wall.
Evaluation of Pharmaceutical Services Based on STARKES 2024 Standards Andintias, Mohammad Febry; Saptarini, Opstaria; Wijayanti, Tri
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.7037

Abstract

The 2024 STARKES accreditation standards emphasize the importance of safe, effective, and quality pharmaceutical services and medication use (Pharmaceutical Services and Rational Drug Use - PKPO). Private hospitals often face challenges in meeting these standards, particularly concerning the storage of medicines and medical consumables. This study aims to evaluate the implementation of PKPO at Hospital X in Demak Regency based on STARKES 2024 standards and to identify priority areas for improvement. A mixed methods approach was employed. Quantitative data were collected through a structured questionnaire based on seven key PKPO indicators. Qualitative data were obtained via direct observations and in-depth interviews with the head of the pharmacy department and related staff. Quantitative data were analyzed using percentage compliance calculations, while qualitative data were analyzed thematically. Priority problems were determined using the Hanlon method. The overall PKPO implementation score at Hospital X was 70.15%, below the minimum accreditation threshold of 80%. The highest scoring indicator was PKPO 1 (Organization) at 87.5%, while the lowest scores were observed in PKPO 5 (Dispensing) at 52.5% and PKPO 3 (Storage) at 60%. The main priority issue identified was the security of pharmaceutical and medical consumable storage (PKPO 3, item 1).
PENGENDALIAN PERSEDIAAN OBAT  MENGGUNAKAN METODE ANALISIS ABC-VEN DI INSTALASI FARMASI RS PANDAN ARANG BOYOLALI Syahputra, Rizka Wahyu; Saptarini, Opstaria; Wijayanti, Tri
Jurnal Infokes Vol 15 No 2 (2025): Jurnal Ilmiah Rekam Medis dan Informatika Kesehatan
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/bpd34f40

Abstract

Pelayanan kefarmasian merupakan pelayanan penunjang dan sekaligus menjadi salah satu revenue centre primer, karena lebih dari 90% pelayanan di rumah sakit menggunakan perbekalan farmasi seperti obat-obatan, bahan kimia, bahan radiologi, bahan medis habis pakai, alat kesehatan serta gas medik dan 50% dari semua pemasukan rumah sakit berasal dari pengelolaan perbekalan farmasi. Instalasi Farmasi RSUD Pandan Arang Boyolali mengelola 644 item obat yang terdaftar pada database. Perencanaan obat di RS Pandan Arang Boyolali masih menggunakan metode konsumsi. Penelitian ini bertujuan membuat usulan cara pengendalian perencanaan persediaan agar tidak terjadi stock out di Instalasi Farmasi RSUD Pandan Arang Boyolali. Penelitian ini bertujuan untuk mengetahui pengendalian perencanaan persediaan obat dengan metode ABC-VEN di instalasi Farmasi RS Pandan Arang Boyolali dengan mengambil data persediaan obat yang digunakan untuk menghitung kebutuhan persediaan tahun 2022 dengan metode analisis kombinasi ABC-VEN. Metode yang digunakan yaitu metode ABC (Always, Better, Control), VEN (Vital, Essensial, Non Essensial). Data yang diperoleh pada saat wawancara dengan narasumber, pengamatan dan observasi langsung pada saat penelitian serta data obat pada Instalasi Farmasi RS Pandan Arang Boyolali tahun 2021. Hasil analisis metode ABC-VEN diperoleh data item obat kelompok A 44 item obat kelompok B 159 item obat kelompok C 441 item obat dan dibagi menjadi 9 kategori yaitu : item obat kategori AV 15 item obat AE 24 item obat, AN 4 item obat, BV 26 item obat, BE 105 item obat, BN 28 item obat, CV 20 item obat, CE 289 item obat, CN 132 item obat dari total 644 item obat. Analisis ABC-VEN dapat dijadikan acuan untuk mendapatkan persediaan yang optimal, efektif dan efisien.
Uji Aktivitas Antibakteri dan Antibiofilm Fraksi Ekstrak Daun Gamal (Gliricidia Sepium (Jacq Walp)) Terhadap Staphylococcus Aureus ATCC 25923 Herman, Herman; Sunarni, Titik; Saptarini, Opstaria
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.484

Abstract

Daun gamal (Gliricidia sepium (Jacq Walp)) di dalamnya terkandung zat flavonoid, alkaloid, tanin, saponin, dan terpenoid. Senyawa dalam daun gamal mempunyai sifat uang antibakteri. Tujuan dari penelitian ini yakni untuk mengetahui bagaimana peran ekstrak serta fraksi n-heksana, etil asetat, serta air terhadap aktivitas antibakteri dengan menghambat pembentukan dan degradasi biofilm. Metode maserasi digunakan untuk mengekstraksi daun gamal menggunakan pelarut etanol 96%. Ekstrak kental dilakukan fraksinasi dengan pelarut n-heksana, air, serta etil asetat. Uji aktivitas antibakteri dilaksanakan melalui metode dilusi dilanjutkan observasi pengaruh kerja melalui uji AAS kebocoran ion. Uji aktivitas antibiofilm menggunakan alat microplate serta pembacaannya dilaksanakan pada panjang gelombang 595 nm. Hasil penelitian bahwa fraksi etil asetat daun gamal teraktif terhadap bakteri S. aureus. Fraksi etil asetat daung gamal  dapat merusak pada membran  sel bakteri. Rata-rata persentase penghambatan pembentukan biofilm terhadap S. aureus terbesara di konsentrasi 50%, yaitu fraksi etil asetat sebanyak 40,69%, ekstrak 37,51%, fraksi n-heksana 28,93% dan fraksi air 30,20%, sedangkan rata-rata persentase degradasi biofilm terlihat yang tertinggi adalah fraksi etil asetat dengan konsentrasi 50% yaitu sebesar 37,27%, ekstrak  34,55%, fraksi air 31,77%, fraksi n-heksan nilai 30,05%. Kontrol positif (Tetrasiklin) memiliki aktivitas dengan nilai 51,66 %.
Antifertility Activity and Chemical Content of Moringa Oleifera Lam Plant Extract on The Reproductive System of Male and Female White Rats Munawir, Munawir; Sunarni, Titik; Saptarini, Opstaria
Indonesian Journal of Global Health Research Vol 6 No S6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS6.4821

Abstract

Research shows that Moringa extract possesses anti-fertility effects on the reproductive systems of male and female rats. This study investigates Moringa's active chemical compounds and their impact on reproductive parameters such as sperm concentration, motility, morphology, and seminiferous tubule diameter, along with hormone levels (progesterone, LH, FSH), estrogenic activity, and the estrous cycle. The research, a literature review, compiles findings from quality international (Scopus) and national (SINTA) journals, Translation and proofreading: there are 8 articles that meet the research inclusion criteria, selected within a range from the year 2010 to 2024. Key active compounds identified in Moringa include alkaloids, tannins, flavonoids (kaempferol and quercetin), and benzyl isothiocyanate, all of which demonstrate anti-fertility effects. These compounds were observed to reduce sperm concentration, motility, and morphology, and to decrease seminiferous tubule diameter in males, while also impacting hormone levels and the estrous cycle in females. The findings support Moringa’s potential as an anti-fertility agent, highlighting its impact across various reproductive parameters in both genders.
The Evaluation of Drug Management and Improvement Strategies Using the Hanlon Method in the Pharmacy Installation of the Bahteramas Hospital Southeast Sulawesi Suherman, Sri Devi Nur Rahma; RA Oetari; Saptarini, Opstaria
Formosa Journal of Multidisciplinary Research Vol. 3 No. 3 (2024): March 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v3i3.8267

Abstract

Drug management is a drug management cycle which includes these stages as follows: selection, procurement, distribution and use. Ineffectiveness and inefficiency may negatively impact hospitals both medically and economically. This study aims to evaluate drug management in the selection, procurement, distribution and use of drugs at the Bahteramas Hospital, Southeast Sulawesi, with Hanlon method as strategic improvement. This study has done with a descriptive method with data collected retrospectively in 2022 and prospectively, both primary (management record) and secondary (interviews). Results of this study about drug management showed there were 4 indicators that do not comply with standards. Meanwhile, other 10 indicators could comply with the standards. The improvement strategy using the Hanlon method in drug management is to prioritize repairing problems sequentially starting from the average percentage of drug waiting time, suitability of the national formulary and hospital formulary, as well as the percentage of dead stock.
Antibacterial and Antibiofilm Activity of Katuk Leaf Fraction (Sauropus androgynus (L.) Merr.) against Bacteria Staphylococcus Aureus ATCC 25923 Khairunnisa, Rizky Dila; Sunarni, Titik; Saptarini, Opstaria
Formosa Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v3i9.11237

Abstract

This study aims to determine the antibacterial and antibiofilm activity of extracts and fractions from katuk leaves against Staphylococcus aureus. Katuk leaves were extracted using the maceration process and fractionated using the liquid-liquid method with solvents such as n-hexane, ethyl acetate, and water. Diffusion and dilution methods were used to measure the antibacterial activity, and crystal violet staining at a wavelength of 595 nm was used to measure the inhibition and biofilm destruction activities. The antibacterial and antibiofilm test results obtained were analyzed using ANOVA statistical test. The results of the diameter of the inhibition zone with a concentration of 75 mg/ml showed that the extract was 11.3 ± 1.02 mm, the ethyl acetate fraction was 18.1 ± 2.46 while the water and n-hexane fractions were 0.0 ± 0.0 mm. The antibiofilm test results showed inhibitory activity against Staphylococcus aureus bacteria with the average IC50 values obtained from extracts, n-hexane, ethyl acetate, and water fractions were 10.248±0.405; 11.799±0.355; 8.332±0.585; and 11.372±0.557. While the average EC50 values obtained from the extract, n-hexane, ethyl acetate, and water fractions were 9.343±0.586; 10.530±0.483; 7.695±0.491; and 8.490±0.954.
Analysis of outpatient service satisfaction in the pharmacy installation of Kendari City Hospital, Southeast Sulawesi Province in 2022 Kartiwi, Wiwi; Oetari, R.A.; Saptarini, Opstaria
Science Midwifery Vol 11 No 6 (2024): February: Midwifery and Health Sciences
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v11i6.1404

Abstract

The quality of service in the hospital is very important to support the quality of the hospital in order to strive to create the best service and treatment for every patient. The purpose of this study was to determine the overall level of outpatient satisfaction with the quality of service and complaint handling at the pharmaceutical installation of Kendari City Hospital. In this study, it is descriptive with qualitative and quantitative approaches. Then the data obtained is processed using gap analysis, custumer satisfaction Index (CSI), and Importance Performance Analysis (IPA) to identify the strengths and weaknesses of the service and determine opportunities to develop strategic planning. The results of the gap analysis show that each dimension of the servqual is at a negative index, which means that the patient is not satisfied with the services provided, namely tangibles -0.24, reliability -0.17, responsiveness -0.22, assurance -0.16, empathy -0.54. The results of the CSI analysis of the servqual dimensions and overall complaint handling have not reached 100% (excellent) but have received a value of 91.75% (excellent). The results of the IPA analysis show that quadrant A is a priority in improvement, namely: the tangibles dimension, namely the availability of drugs and the responsiveness dimension, namely the waiting time for drugs.
Minimalisasi Waste di Instalasi Farmasi Rawat Inap Rumah Sakit Umum Daerah Pandan Arang Boyolali melalui Pendekatan Lean Hospital: Minimization Waste in Inpatient Pharmaceutical Installation of Pandan Arang Regional Public Hospital Boyolali with Lean Hospital Approach Embu, Yohanes Dwi Putra Agung; Pamudji, Gunawan; Saptarini, Opstaria; B. Tobi, Claudius Hendraman; Pratiwi, Mustika Endah
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2224

Abstract

The lean hospital approach is a systematic approach in identifying and eliminating waste through continuous improvement to improve the quality, safety and efficiency of a hospital service process. This study aimed to identified waste, the root cause of critical waste, and provided suggestions for improvement to minimize critical waste in inpatient pharmaceutical installation of Pandan Arang General Public Hospital, Boyolali. Method that used in this research was qualitative research with stages namely observed the service process flow in the form of value stream mapping, distributed questionnaires for waste to got critical waste and conducted interviews with the 5 why method to found out the root cause of the problem. The results showed that on medication service flowhome for class 1, VIP and VVIP patients with critical waste, namely waste defects of 43.34%, waste transportation of 41.67% , and waste inventory of 43.33%. The root cause of waste in the three lines of the service process is human resources that lack discipline. The proposed improvement for waste in the service process is by applying the 5S (Seiri, Seiton, Seiso, Seiketsu, dan Shitsuke) method with the key of success are discipline and consistency applied to service providers.   Keywords:          Lean hospital, Waste, Inpatient Pharmacy Installation, Pandan Arang Boyolali General Public Hospital   Abstrak Pendekatan lean hospital adalah pendekatan sistematik dalam mengidentifikasi dan menghilangkan pemborosan (waste) melalui perbaikan yang berkelanjutan untuk meningkatkan kualitas, keamanan dan efisiensi suatu proses pelayanan di rumah sakit. Tujuan penelitian ini adalah mengidentifikasi waste, akar penyebab waste kritis dan memberikan usulan perbaikan untuk meminimalkan waste kritis di instalasi farmasi rawat inap RSUD Pandan Arang Boyolali. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif dengan tahapan yaitu observasi alur proses pelayanan dalam bentuk value stream mapping, penyebaran kuesioner waste untuk mendapatkan waste kritis serta wawancara dengan metode 5 why untuk mengetahui akar penyebab masalah terjadinya waste. Hasil penelitian menunjukkan bahwa pada alur pelayanan obat pulang untuk pasien kelas 1, VIP, dan VVIP di instalasi farmasi rawat inap RSUD Pandan Arang Boyolali dengan waste kritis yaitu waste defect sebesar 43,34%, waste transportation sebesar 41,67% dan waste inventory sebesar 43,33%. Akar penyebab dari waste pada alur proses pelayanan obat ini adalah pada sumber daya manusia yang kurang disiplin. Usulan perbaikan kejadian waste pada proses pelayanan obat di alur pelayanan obat pulang untuk pasien kelas 1, VIP dan VVIP yaitu dengan menerapkan metode 5S (Seiri, Seiton, Seiso, Seiketsu dan Shitsuke) dengan kunci keberhasilan yaitu disiplin dan konsisten yang diterapkan pada petugas pemberi pelayanan.   Kata Kunci:         Lean hospital, Waste, Instalasi Farmasi Rawat Inap, RSUD Pandan Arang Boyolali
Co-Authors Andintias, Mohammad Febry Aulia, Intan Sofia Irsa Claudius Hendraman B. Tobi Daniel Happy Putra Dewi Natalia Dinda Sri Rahayu Dwiannur, Febriandi Ramadhan Embu, Yohanes Dwi Putra Agung Endang Sri Rejeki Faelga Sara Fradine, Chossy Fransiska Leviana Gunawan P Widodo Gunawan Pamudji Ibnu Nugroho Saputra Ika Purwidyaningrum Ilham Kuncahyo, Ilham Inaratul Rizkhy Hanifah Ismi Rahmawati Ismi Rahmawati Ismi Rahmawati Ismi Rahmawati Jason Merari Peranginangin Kartiwi, Wiwi Khairunnisa, Rizky Dila Kurniasari, Fitri Lina Susanti Mariyo Jane Sanggel Muhammad Alviyan Shutiawan Munawi Munawir Munawir Munawir Mustika Endah Pratiwi Najiyyah, Trias Durrotun Nia Azzahra Nurul Rafiqua Pamudji, Gunawan Perawati Perdina Nursidika Priska Juanita Pakingki Putri, Luluk Aniqoh Meliana R.A. Oetari, R.A. RA Oetari Rahayu, Dinda Sri Rahmawati, Ismi Rakhmi Hidayati Sabda Wahab santi dwi astuti Suhartinah Suhartinah Suherman, Sri Devi Nur Rahma Sunarni , Titik Syahputra, Rizka Wahyu Titik Sunarni Titik Sunarni Tri Wijayanti Tri Wijayanti Tria Yuganingsih Veronica Bella Lupita Wiwin Herdwiani Yerri Hartanto Yohanes Dwi Putra Agung Embu Yovi Pranata