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All Journal Majalah Kedokteran Bandung BERITA BIOLOGI Jurnal Penelitian Kesehatan Suara Forikes Media Ilmu Kesehatan JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Health Information : Jurnal Penelitian Jurnal Kefarmasian AKFARINDO Science Midwifery Indonesian Journal of Global Health research Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Ilmiah Kesehatan (JIKA) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Multidisiplin Madani (MUDIMA) Formosa Journal of Multidisciplinary Research (FJMR) Jurnal Farmasi Sains dan Praktis Jurnal Kesehatan Tropis Indonesia Journal of Health Management and Pharmacy Exploration (JOHMPE) International Journal of Global Sustainable Research International Journal Of Public Health Jurnal Sains dan Kesehatan Strada Jurnal Ilmiah Kesehatan (SJIK)
Opstaria saptarini
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Immunomodulatory Activity of Ethanol Extract and Kabau (Archidendron Bubalinum) Leaf Fractions on the Macrophage Phagocytosis Index in Male White Rats (Rattus Novergicus) Aulia, Intan Sofia Irsa; Wijayanti, Tri; Saptarini, Opstaria
Jurnal Multidisiplin Madani Vol. 4 No. 6 (2024): June 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i6.9588

Abstract

Immunomodulators are substances that have the ability to balance and restore a dysfunctional immune system, reduce the body's immune response due to excessive immune activity and stimulate leukocyte cells, especially macrophages, to form a strong immune system. The aim of this study was to determine the immunomodulatory activity of kabau leaves (Archidendron bubalinum) in male white rats in terms of the phagocytosis index, number of leukocyte cell types and spleen histopathology. This research design used 35 mice as test animals and then divided them into 6 groups, namely negative control, positive control (Stimuno dose 50 mg), kabau leaf extract 20 mg, n-hexane fraction 6.66 mg, ethyl acetate fraction 4 mg, water fraction 6.66 mg, each group consisted of 5 male rats. Immunomodulatory activity was seen from the phagocytosis index and the number of leukocyte cell types at 10 and 15 minutes. The results showed that the 6 treatments had significantly different immunostimulatory activities with a significant value of less than 0.05. The results of the phagocytosis index calculation showed that the highest value was Stimuno at 3.33, then the 6.66 mg n-hexane fraction was 2.49, the 4mg ethyl acetate fraction was 1.63, the 20 mg extract was 1.26, and the water fraction was 6.66 mg. 1.27. From these results it can be concluded that kabau (Archidendron bubalinum) leaf extracts and fractions have immunostimulant activity
Antibacterial and Antibiofilm Activity of Papaya Leaf Fractions (Carica Papaya L.) Against Staphylococcus Aureus ATCC 25923 Pranata, Yovi; Rahmawati, Ismi; Saptarini, Opstaria
Jurnal Multidisiplin Madani Vol. 4 No. 6 (2024): June 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i6.9879

Abstract

The research on papaya leaves was aimed at determining antibacterial activity, antibiofilm activity, K+ and Ca2+ metal ion parameters, as well as the morphology of S.aureus bacteria from papaya leaf fractions and extracts. The average value of the test results for the diffusion method at 50% concentration was 20.66 ± 0.57 and the test results for the dilution method for Minimum Inhibitory Concentration at a concentration of 12.5%. Antibiofilm formation inhibitor test results at a concentration of 50 mg/ml with an average value of 72.37 ± 0.65, a concentration of 25 mg/ml 64.75 ± 0.83 and a concentration of 12.5 mg/ml with an average value of IC50 of 0.975 ± 0.012. Biofilm degradation testing at a concentration of 50 mg/ml resulted in an average value of 60.43 ± 1.11, a concentration of 25 mg/ml with an average value of 50.05 ± 0.87 and a concentration of 12.5 mg/ml with an average value -mean 35.86 ± 1.05. The average EC50 value was 26.731 ± 1.1874. Tests using AAS on K+ metal ions showed ion leakage or cell contents coming out was 1,805 mg/L, Ca2+ metal ions resulting from this leak were 3,884. Morphological observations using SEM showed that the samples experienced shrinkage and reduced size from being perfectly round to oval to S.aureus bacteria in samples with water fraction
Effect of Ethanol Extract and Fractions of Saluang Balum Root Lavanga Sarmentosa (Blume) Kurz) on Aphrodisiac Activity and Spermatogenesis in Hyperglicemia Rats Dwiannur, Febriandi Ramadhan; Peranginangin, Jason Merari; Saptarini, Opstaria
Jurnal Ilmiah Kesehatan (JIKA) Vol. 6 No. 2 (2024): Volume 6 Nomor 2 Agustus 2024
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v6i2.848

Abstract

High blood glucose levels or hyperglycemia can increase reactive oxygen species (ROS). Complications of secondary diabetes mellitus in the form of sexual dysfunction and impaired fertility in men. This is one of the causes of decreased sexual desire and sperm count, which can cause infertility in men. Saluang balum root (Lavanga sarmentosa (Blume) Kurz) with flavonoid, steroid, and tannin compounds is a traditional medicine that has the potential as an aphrodisiac and spermatogenesis. The purpose of this study was to obtain a histological picture of the seminiferous tubules, a decrease in blood glucose levels, aphrodisiac activity, and spermatogenesis. This study used 35 male wistar rats which were divided into 7 groups, normal group, negative control (CMC Na 1%), positive control (pasak bumi), ethanol extract of saluang balum root at a dose of (225 mg/kgBW), n-hexane fraction. (19.81 mg/kgBW), ethyl acetate fraction (64.5 mg/kgBW) and water fraction (140.67 mg/kgBW). All of these groups were induced by alloxan (100 mg/kgBW), except the normal group. The extracts and fractions were given for 14 days, then observed a decrease in blood glucose levels, aphrodisiacs, spermatogenesis and histological features in the seminiferous tubules. The results showed that the extract and fractions of saluang balum root had reduced blood glucose levels, aphrodisiac and spermatogenesis in hyperglycemic rats.
Analysis of Drug Distribution and Utilization Processes Using the Lean Hospital Method in the Outpatient Pharmacy Installation of Karanganyar Regency Hospital Kresensia Stasiana Yunarti; Opstaria Saptarini; Ika Purwidyaningrum
International Journal of Public Health Vol. 2 No. 4 (2025): December : International Journal of Public Health
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijph.v2i4.573

Abstract

Improving service quality is a primary priority in hospital management. Service quality can be improved by reducing the percentage of non-value added activities through the Lean Hospital approach. This study aims to identify activities and analyze the root causes of critical waste in the drug distribution and utilization processes at the Outpatient Pharmacy Installation of Karanganyar Regency Hospital. This study is a non-experimental research with a qualitative descriptive design. Critical waste was obtained through the distribution of a waste weighting questionnaire assessed by all personnel involved in the drug distribution and utilization processes. The results show that the Value Stream Mapping calculation for the drug distribution process obtained a lead time of 147.41 minutes and a VAR value of 36%, while in the drug utilization process, compounded prescription service obtained a lead time of 128.53 minutes and a VAR of 24%, and non-compounded prescription service obtained a lead time of 75.8 minutes and a VAR of 26%. The critical waste questionnaire calculation using the Borda method in the drug distribution process showed overproduction 60%, inventory 53.33%, and waiting 43.33%, while in the drug utilization process, waiting 43.75%, overproduction 42.85%, and defect 39.70%. The 5S method, a Lean method, was used to eliminate waste in the service process at the Outpatient Pharmacy Installation of Karanganyar Regency Hospital.
Optimization Of Extraction Conditions For Total Phenols, Flavonoids, And Antioxidant Activity Of Avocado Seeds (Persea Americana Mill.) Using Simplex Lattice Design tomi, rizqika bastian; Iswandi, Iswandi; Saptarini, Opstaria
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.691

Abstract

Avocado pits contain a diverse array of bioactive substances, such as procyanidins, phenolic compounds, triterpenoids, acetogenins, fatty amino acids, and mild acids, all exhibiting antioxidant properties. Antioxidants function by preventing oxidation, reducing the formation of harmful compounds, and protecting against aging, inflammation, and cancer. This research centers on assessing the impact of solvent proportions, pinpointing the ideal solvent mixture, and measuring the overall phenolic and flavonoid levels, along with the antioxidant capacity, of the top-performing solvent applied for extracting compounds from avocado seeds. The research method used the SLD (Simplex Lattice Design) Design Expert method. The extract formula was prepared using sonication, with the results showing 17 formulas for three solvents: acetone, distilled water, and 70% ethanol. Test parameters included phytochemical screening tests, specific and non-specific parameter tests, total phenol tests, total flavonoid tests, and antioxidant activity tests using the DPPH method. Statistical data analysis was performed using Design Expert with ANOVA (Analysis of Variance) output according to the designed experimental design. The results obtained based on the research are the 12th run formula with a solvent ratio of acetone, distilled water, and 70% ethanol (100:0:0) has an extract yield of 3.25%, total flavonoids of 17.302 mgQE/g extract, total phenols of 46.274 mgGAE/g extract, and antioxidant activity of 81.68 ppm, the optimisation results show that the optimum solvent composition is 100% Acetone, without a mixture of 70% Ethanol or Distilled Water.
Analisis Pengendalian Persediaan Dan Strategi Perbaikan Di Instalasi Farmasi RSUD dr.Soehadi Prijonegoro Sragen Tahun 2021 Hutasoit, Melyanti Magdalena; Purwidyaningrum, Ika; Saptarini, Opstaria
Health Information : Jurnal Penelitian Vol 17 No 3 (2025): September-Desember
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v17i3.1667

Abstract

Latar Belakang: Pengendalian persediaan obat yang tidak optimal menyebabkan kekosongan atau kelebihan stok di rumah sakit, sehingga diperlukan sistem analisis yang komprehensif untuk meningkatkan efisiensi biaya dan mutu pelayanan. Tujuan: Menganalisis pengendalian persediaan obat menggunakan metode ABC-VEN, EOQ, ROP, ITOR dan merumuskan strategi perbaikan melalui analisis SWOT di RSUD dr.Soehadi Prijonegoro Sragen tahun 2021. Metode: Penelitian deskriptif dengan data kualitatif dan kuantitatif yang dikumpulkan secara retrospektif periode Januari-Desember 2021. Hasil: Analisis ABC-VEN mengidentifikasi 68 item kategori AE bernilai Rp6.095.836.400 yang memerlukan prioritas pengendalian ketat. EOQ menunjukkan jumlah pemesanan optimum tertinggi 113.332 unit dengan ROP bervariasi hingga 1.271 unit. Nilai ITOR sebesar 4,34 kali/tahun menunjukkan perputaran obat masih di bawah standar ideal 8-12 kali. Matriks IFE (3,04) dan EFE (2,81) menempatkan rumah sakit pada kuadran IV dengan strategi pengembangan. Simpulan: Implementasi metode EOQ-ROP pada kategori AE berpotensi menghemat 25% biaya persediaan. Saran: Diperlukan integrasi sistem informasi manajemen, monitoring ITOR bulanan, dan pelatihan berkala staf farmasi
Co-Authors Andintias, Mohammad Febry Aulia, Intan Sofia Irsa Claudius Hendraman B. Tobi Daniel Happy Putra Dewi Natalia Dinda Sri Rahayu Dwiannur, Febriandi Ramadhan Embu, Yohanes Dwi Putra Agung Endang Sri Rejeki Faelga Sara Fradine, Chossy Fransiska Leviana Gunawan P Widodo Gunawan Pamudji Hutasoit, Melyanti Magdalena Ibnu Nugroho Saputra Ika Purwidyaningrum Ilham Kuncahyo, Ilham Inaratul Rizkhy Hanifah Ismi Rahmawati Ismi Rahmawati Ismi Rahmawati Ismi Rahmawati Iswandi Iswandi Jason Merari Peranginangin Kartiwi, Wiwi Khairunnisa, Rizky Dila Kresensia Stasiana Yunarti Kurniasari, Fitri Lina Susanti Mariyo Jane Sanggel Muhammad Alviyan Shutiawan Munawi Munawir Munawir Munawir Mustika Endah Pratiwi Najiyyah, Trias Durrotun Nia Azzahra Nurul Rafiqua Pamudji, Gunawan Perawati Perdina Nursidika Priska Juanita Pakingki Putri, Luluk Aniqoh Meliana R.A. Oetari, R.A. RA Oetari Rahayu, Dinda Sri Rahmawati, Ismi Rakhmi Hidayati Sabda Wahab santi dwi astuti Suhartinah Suhartinah Suherman, Sri Devi Nur Rahma Sunarni , Titik Syahputra, Rizka Wahyu Titik Sunarni Titik Sunarni tomi, rizqika bastian Tri Wijayanti Tri Wijayanti Tria Yuganingsih Veronica Bella Lupita Wiwin Herdwiani Yerri Hartanto Yohanes Dwi Putra Agung Embu Yovi Pranata