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All Journal Majalah Kedokteran Bandung BERITA BIOLOGI Jurnal Penelitian Kesehatan Suara Forikes Media Ilmu Kesehatan Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Health Information : Jurnal Penelitian Jurnal Kefarmasian AKFARINDO Science Midwifery Indonesian Journal of Global Health research Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Jurnal Ilmiah Kesehatan (JIKA) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Multidisiplin Madani (MUDIMA) Formosa Journal of Multidisciplinary Research (FJMR) Jurnal Farmasi Sains dan Praktis Jurnal Kesehatan Tropis Indonesia Journal of Pharmaceutical and Sciences. Journal of Health Management and Pharmacy Exploration (JOHMPE) International Journal of Global Sustainable Research International Journal Of Public Health Jurnal Sains dan Kesehatan Strada Jurnal Ilmiah Kesehatan (SJIK) Indonesian Journal of Global Health Research
Opstaria saptarini
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Analisis Pengendalian Persediaan Dan Strategi Perbaikan Di Instalasi Farmasi RSUD dr.Soehadi Prijonegoro Sragen Tahun 2021 Hutasoit, Melyanti Magdalena; Purwidyaningrum, Ika; Saptarini, Opstaria
Health Information : Jurnal Penelitian Vol 17 No 3 (2025): September-Desember
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v17i3.1667

Abstract

Latar Belakang: Pengendalian persediaan obat yang tidak optimal menyebabkan kekosongan atau kelebihan stok di rumah sakit, sehingga diperlukan sistem analisis yang komprehensif untuk meningkatkan efisiensi biaya dan mutu pelayanan. Tujuan: Menganalisis pengendalian persediaan obat menggunakan metode ABC-VEN, EOQ, ROP, ITOR dan merumuskan strategi perbaikan melalui analisis SWOT di RSUD dr.Soehadi Prijonegoro Sragen tahun 2021. Metode: Penelitian deskriptif dengan data kualitatif dan kuantitatif yang dikumpulkan secara retrospektif periode Januari-Desember 2021. Hasil: Analisis ABC-VEN mengidentifikasi 68 item kategori AE bernilai Rp6.095.836.400 yang memerlukan prioritas pengendalian ketat. EOQ menunjukkan jumlah pemesanan optimum tertinggi 113.332 unit dengan ROP bervariasi hingga 1.271 unit. Nilai ITOR sebesar 4,34 kali/tahun menunjukkan perputaran obat masih di bawah standar ideal 8-12 kali. Matriks IFE (3,04) dan EFE (2,81) menempatkan rumah sakit pada kuadran IV dengan strategi pengembangan. Simpulan: Implementasi metode EOQ-ROP pada kategori AE berpotensi menghemat 25% biaya persediaan. Saran: Diperlukan integrasi sistem informasi manajemen, monitoring ITOR bulanan, dan pelatihan berkala staf farmasi
Antifertility Activity and Chemical Content of Moringa Oleifera Lam Plant Extract on The Reproductive System of Male and Female White Rats Munawir Munawir; Titik Sunarni; Opstaria Saptarini
Indonesian Journal of Global Health Research Vol 6 No S6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS6.4821

Abstract

Research shows that Moringa extract possesses anti-fertility effects on the reproductive systems of male and female rats. This study investigates Moringa's active chemical compounds and their impact on reproductive parameters such as sperm concentration, motility, morphology, and seminiferous tubule diameter, along with hormone levels (progesterone, LH, FSH), estrogenic activity, and the estrous cycle. The research, a literature review, compiles findings from quality international (Scopus) and national (SINTA) journals, Translation and proofreading: there are 8 articles that meet the research inclusion criteria, selected within a range from the year 2010 to 2024. Key active compounds identified in Moringa include alkaloids, tannins, flavonoids (kaempferol and quercetin), and benzyl isothiocyanate, all of which demonstrate anti-fertility effects. These compounds were observed to reduce sperm concentration, motility, and morphology, and to decrease seminiferous tubule diameter in males, while also impacting hormone levels and the estrous cycle in females. The findings support Moringa’s potential as an anti-fertility agent, highlighting its impact across various reproductive parameters in both genders.
Evaluation of Pharmaceutical Services Based on STARKES 2024 Standards Mohammad Febry Andintias; Opstaria Saptarini; Tri Wijayanti
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.7037

Abstract

The 2024 STARKES accreditation standards emphasize the importance of safe, effective, and quality pharmaceutical services and medication use (Pharmaceutical Services and Rational Drug Use - PKPO). Private hospitals often face challenges in meeting these standards, particularly concerning the storage of medicines and medical consumables. This study aims to evaluate the implementation of PKPO at Hospital X in Demak Regency based on STARKES 2024 standards and to identify priority areas for improvement. A mixed methods approach was employed. Quantitative data were collected through a structured questionnaire based on seven key PKPO indicators. Qualitative data were obtained via direct observations and in-depth interviews with the head of the pharmacy department and related staff. Quantitative data were analyzed using percentage compliance calculations, while qualitative data were analyzed thematically. Priority problems were determined using the Hanlon method. The overall PKPO implementation score at Hospital X was 70.15%, below the minimum accreditation threshold of 80%. The highest scoring indicator was PKPO 1 (Organization) at 87.5%, while the lowest scores were observed in PKPO 5 (Dispensing) at 52.5% and PKPO 3 (Storage) at 60%. The main priority issue identified was the security of pharmaceutical and medical consumable storage (PKPO 3, item 1).
Drug Management Evaluation with Hanlon Method and Fishbone Diagram Desti Nuryani Sitompul; Opstaria Saptarini; Tri Wijayanti
Indonesian Journal of Global Health Research Vol. 7 No. 6 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i6.284

Abstract

Pharmaceutical management at primary health centers plays an important role in ensuring the availability, affordability, and quality of healthcare services. However, many primary health centers still face challenges in the planning, procurement, and evaluation of medicines, which potentially lowers the quality of services. This study aims to evaluate the quality of pharmaceutical management at Puskesmas X in Karanganyar Regency, determine priority problems using the Hanlon method, and analyze root causes with a Fishbone diagram. The study used an observational design with a qualitative descriptive and analytical approach. Data were collected through observation, interviews with pharmaceutical personnel, and document reviews of medicine management for the period December 2023–December 2024. The collected data were systematically examined through content analysis to identify key themes and patterns related to pharmaceutical management practices. Quantitative scoring of issues was performed using the Hanlon method to prioritize problem areas based on criteria such as magnitude, seriousness, and feasibility. Root cause analysis was conducted by categorizing identified problems into groups using the Fishbone diagram framework, facilitating the identification of underlying factors. The results show that the aspects of planning, procurement, stock, and evaluation did not meet standards, while the aspects of storage and medicine use were in accordance with standards. Hanlon method analysis identified medicine proposals based on FORNAS as the main priority issue, followed by the appropriateness of medicines with FORNAS, DOEN, fund allocation, and disease patterns. Fishbone analysis revealed the main causes as limitations in human resources, absence of SOPs, weak cross-sector coordination, and minimal technological support. The study concludes that improving human resource capacity, developing SOPs, forming proposal teams, strengthening coordination, and utilizing information technology are necessary to improve the quality of pharmaceutical management and ensure medicine availability according to community needs.
Analysis of Drug Distribution and Utilization Processes Using the Lean Hospital Method in the Outpatient Pharmacy Installation of Karanganyar Regency Hospital Kresensia Stasiana Yunarti; Opstaria Saptarini; Ika Purwidyaningrum
International Journal of Public Health Vol. 2 No. 4 (2025): December : International Journal of Public Health
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijph.v2i4.573

Abstract

Improving service quality is a primary priority in hospital management. Service quality can be improved by reducing the percentage of non-value added activities through the Lean Hospital approach. This study aims to identify activities and analyze the root causes of critical waste in the drug distribution and utilization processes at the Outpatient Pharmacy Installation of Karanganyar Regency Hospital. This study is a non-experimental research with a qualitative descriptive design. Critical waste was obtained through the distribution of a waste weighting questionnaire assessed by all personnel involved in the drug distribution and utilization processes. The results show that the Value Stream Mapping calculation for the drug distribution process obtained a lead time of 147.41 minutes and a VAR value of 36%, while in the drug utilization process, compounded prescription service obtained a lead time of 128.53 minutes and a VAR of 24%, and non-compounded prescription service obtained a lead time of 75.8 minutes and a VAR of 26%. The critical waste questionnaire calculation using the Borda method in the drug distribution process showed overproduction 60%, inventory 53.33%, and waiting 43.33%, while in the drug utilization process, waiting 43.75%, overproduction 42.85%, and defect 39.70%. The 5S method, a Lean method, was used to eliminate waste in the service process at the Outpatient Pharmacy Installation of Karanganyar Regency Hospital.
Aktivitas Antibakteri Kombucha Daun Sirsak (Anonna muricata L.) Terhadap Bakteri Escherichia coli Nadia Rahmasari; Ismi Rahmawati; Opstaria Saptarini
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.996

Abstract

Infectious diseases caused by pathogenic bacteria such as Escherichia coli are increasing, especially due to antibiotic resistance. One potential alternative treatment is the use of natural antibacterial compounds, such as those found in soursop leaves (Annona muricata L.). Soursop leaves contain various bioactive compounds, such as flavonoid polyphenols, acetogenins, and tannins, which have antibacterial activity. This study aims to of soursop leaf-based probiotic kombucha fermentation in inhibiting the growth of Escherichia coli. In this study, probiotic kombucha was produced through a fermentation process using Symbiotic Culture of Bacteria and Yeast (SCOBY) with variations in temperature, time, and soursop leaf extract concentration parameters. Activity testing was carried out using the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) methods to assess its antibacterial effectiveness. The results showed that soursop leaf kombucha fermentation had significant antibacterial activity against Escherichia coli. The disc diffusion activity test obtained in this study was 9.1 mm (15% concentration); 5.10 mm (10% concentration); and 2.3 mm (5% concentration) with different concentration variations on the 7th day of fermentation. The resulting inhibition zone diameter for E. coli bacteria indicates that kombucha's antibacterial activity is in the moderate category, as it produced the highest inhibition zone of 9.1 mm. This study demonstrates that soursop leaf kombucha has the potential to be developed as a functional probiotic beverage with effective and natural antibacterial effects.
Co-Authors Aulia, Intan Sofia Irsa Claudius Hendraman B. Tobi Daniel Happy Putra Desti Nuryani Sitompul Dewi Natalia Dinda Sri Rahayu Dwiannur, Febriandi Ramadhan Embu, Yohanes Dwi Putra Agung Endang Sri Rejeki Faelga Sara Fradine, Chossy Fransiska Leviana Gunawan P Widodo Gunawan Pamudji Hutasoit, Melyanti Magdalena Ibnu Nugroho Saputra Ika Purwidyaningrum Ilham Kuncahyo, Ilham Inaratul Rizkhy Hanifah Ismi Rahmawati Ismi Rahmawati Ismi Rahmawati Ismi Rahmawati Jason Merari Peranginangin Kartiwi, Wiwi Khairunnisa, Rizky Dila Kresensia Stasiana Yunarti Kurniasari, Fitri Lina Susanti Mariyo Jane Sanggel Mohammad Febry Andintias Muhammad Alviyan Shutiawan Munawi Munawir Munawir Munawir Mustika Endah Pratiwi Nadia Rahmasari Najiyyah, Trias Durrotun Nia Azzahra Nurul Rafiqua Pamudji, Gunawan Perawati Perdina Nursidika Priska Juanita Pakingki Putri, Luluk Aniqoh Meliana R.A. Oetari, R.A. RA Oetari Rahayu, Dinda Sri Rahmawati, Ismi Rakhmi Hidayati Sabda Wahab santi dwi astuti Suhartinah Suhartinah Suherman, Sri Devi Nur Rahma Sunarni , Titik Syahputra, Rizka Wahyu Titik Sunarni Titik Sunarni Tri Wijayanti Tri Wijayanti Tria Yuganingsih Veronica Bella Lupita Wiwin Herdwiani Yerri Hartanto Yohanes Dwi Putra Agung Embu Yovi Pranata