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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia e-GIGI Jurnal Pembangunan Wilayah dan Kota JURNAL GIZI INDONESIA SAINS DAN MATEMATIKA Jurnal Kedokteran Diponegoro Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Urology Journal of Biomedicine and Translational Research Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Media Medika Muda JURNAL PENDIDIKAN TAMBUSAI Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Inovasi Farmasi Indonesia Dinamika Bahari: Journal of Maritime Dynamic TheJournalish: Social and Government Jurnal Ilmiah Wahana Pendidikan Dynamic Management Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Generics: Journal of Research in Pharmacy Berita Kedokteran Masyarakat Jurnal Karya Abdi Masyarakat Depik Jurnal Ilmu-Ilmu Perairan, Pesisir dan Perikanan Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan Generics : Journal of Research in Pharmacy Journal of Transportation and Society Empowerment Indonesian Journal of Nautical Study
Indah Saraswati
Department Of Medical Biology And Biochemistry, Faculty Of Medicine, Universitas Diponegoro, Semarang, Indonesia
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Journal : JURNAL GIZI INDONESIA

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Histopathological changes in pregnant mice's hepar and kidney following exposure to kelor (Moringa oleifera) leaf extract Armalina, Desy; Susilaningsih, Neni; Saraswati, Indah
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 13, No 2 (2025): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.13.2.145-151

Abstract

Background: Moringa provides extra dietary benefits. The immune system is significantly influenced by the nine necessary amino acids, calcium, iron, potassium, magnesium, zinc, and vitamins A, C, E, and B that are included in this food. Previous studies state that moringa causes liver and kidney damage. Another study found that moringa has an abortive effect.Objectives: This study aimed to determine how exposure to kelor (moringa oleifera) leaf extract affected the hepar and kidney in pregnant mice and found the secondary metabolite of the moringa leaves.Materials and Methods: An experimental laboratory design was conducted in 24 pregnant female Balb/c mice. They were randomized into four groups. Group K was not given anything. Group P1-P3 were given moringa leaf extract during pregnancy at days with a dose dose of 10, 20, and 30 mg in 10, 20, and 18 days, and termination was done to take the organs and make the tissue processing.Results: We found no dead mice and no aggression during the experiment. Significant statistics differed between the experimental group in the microscopic appearance of the kidney and hepar. This study found degeneration and inflammation in the hepar and kidney in the treatment group. Qualitative phytochemical tests on leaves contained alkaloids, flavonoids, phenolics, tannins, and steroids.Conclusion: The ethanol extract of Moringa leaf has shown a mild heparin and kidney effect compared to the control.
Co-Authors Achmad Zulfa Juniarto Aditya Amar Mahendra Agus Subagio Alissa, Evalina Amir, Diana Andi Prasetiawan, Andi Anfa Adnia Fatma Anfa Adnia Fatma Anggita, Vinka Dwi Annaafi, Alviona Denti Antari Arlita Leniseptaria Antari, Arlita Leniseptaria Arifin, Moh. Zaenal Arlita Leniseptaria Antari Arummaisya, Sahila Nifa Aryoko Widodo Astika Widy Utomo, Astika Widy Awal Prasetyo Azhar, Talia Sarafina Azizah, Fadia Nur Azka, Milati Choerunisa, Nisrina David Pakaya Desi Kristina Gultom Desy Armalina Dewi, Marzela Dian Wijayanto Dimas Sindhu Wibisono Dwi Retnoningrum Ekawati, Nuraini Endang Mahati Erliyani, Dian Eva Annisa Eva Annisa Eva Annisaa Eva Annisaa Faizah Bafadhal Farmaditya Eka Putra FITRI PUSPITASARI Fitri Wulandari Gabriela Rolanda Gufron, Ahmad Handoyo, Regenio Akira Hardian Hardian Heriawan, Mohammad Sapta Hermawan Istiadi Hosen, Hosen Ibrahim, Natalia P. Ika Pawitra Miranti Ilham Saptia Nugraha Imam Buchori Indranila Kustarini Samsuria Khasan Rowi Kundori Kurniasari, Teny Kusmiyati Tjahjono DK Kusumaningrum, Novi Lusiana Batubara Maulia, Sinta Mentari, Alfitra Akbar Bara Mentari Mochtar, Arufiadi Anityo Muflihatul Muniroh Muhammad Avicenna Abdul Syukur Mulyaningrum, Sri Kris Muslimin Muslimin Najatullah Neni Susilaningsih Nurtari, Rahma Yulia Prabowo, Yoghi B. Pranyoto, Pranyoto Priguna, Tangkas Mukti Rediyanto, Rediyanto Renni Yuniati Robert Kristaung Rohana, Evieta Samsul Huda Sarastri, Darsih Sasikirana, Widyandani Setiawan, Rivaldo Heru Sinna, Najwan Muhammad Stefani Candra Firmanti Sumardi . Sutrisno Anggoro Talitha Salsabila Taufiq, Heydar Ruffa Trimoelyo, Heri Vega Fonsula Andromeda Vega Karlowee Widyandani Sasikirana