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All Journal Science and Technology Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) JPP Jurnal Kesehatan Poltekkes Palembang Gema Wiralodra Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Indonesian Journal of Pharmaceutical Education Jurnal Kolaboratif Sains JHTS Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Kesehatan Farmasi Jurnal Multidisipliner Kapalamada Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products Borneo Nursing Journal
Ariani H. Hutuba
Universitas Negeri Gorontalo
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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ANTIOXIDANT ACTIVITY EVALUATION OF CATFISH (CLARIAS SP.) COLLAGEN EXTRACT USING DPPH AND ABTS METHODS Faramita Hiola; Wiwit Zuriati Uno; Mahdalena Sy. Pakaya; Ariani Hutuba
Jurnal Multidisipliner Kapalamada Vol. 4 No. 04 (2025): JURNAL MULTIDISIPLINER KAPALAMADA
Publisher : Pusat Studi Ekonomi, Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/kapalamada.v4i04.1964

Abstract

This study aimed to evaluate the antioxidant activity of collagen extracted from catfish (Clarias sp.) using DPPH and ABTS assays. The research procedures included sample preparation, collagen extraction using an acid-based method, and antioxidant analysis at concentrations ranging from 20–100 ppm. The degree of hydrolysis (DH) was measured to determine the effectiveness of Alkalase in producing bioactive peptides. The results showed that higher enzyme concentrations led to increased DH, with the highest value of 62.42% obtained at 3% Alkalase. Antioxidant activity increased with sample concentration, with maximum inhibition values of 78.57% (DPPH) and 85.00% (ABTS) at 100 ppm. The ABTS assay exhibited higher sensitivity than DPPH. These findings indicate that catfish collagen has strong potential as a safe and natural antioxidant source suitable for further development in food, pharmaceutical, and cosmetic applications.
Formulation and Physical Evaluation of Lavender (Lavandula angustifolia) Essential Oil Aromatherapy Candles Tri Sucianita T. Tama; Nurain Thomas; Ariani H. Hutuba; Mohamad Adam Mustapa
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 2 (2026): Volume 3 Nomor 2 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i2.147

Abstract

Lavender flowers are widely used in aromatherapy because their principal constituents, linalyl acetate and linalool, are associated with relaxing effects. Aromatherapy preparations contain volatile aromatic substances intended to promote calmness and relaxation. This study aimed to formulate and physically evaluate aromatherapy candles containing lavender (Lavandula angustifolia) essential oil. An experimental laboratory design was employed, with lavender essential oil as the active ingredient and variations in beeswax and stearic acid concentrations. Formula I contained 50% soy wax, 50% beeswax, and 25% stearic acid, whereas Formula II contained 50% soy wax, 60% beeswax, and 30% stearic acid. The formulations were evaluated for organoleptic characteristics, burning performance, melting point, and hedonic acceptance. Both formulations met the specified physical-evaluation criteria, demonstrating that lavender essential oil can be successfully incorporated into aromatherapy candle formulations
Evaluation of the Physical Stability of a Grape Seed Oil Nanoemulsion Base Using a Centrifugation Test Siti Ruqaiyah Lakoro; Teti Sutriyati Tuloli; Mohamad Aprianto Paneo; Robert Tungadi; Ariani H Hutuba
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 2 (2026): Volume 3 Nomor 2 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i2.302

Abstract

Nanoemulsions are nanometer-scale dispersion systems used as bases for pharmaceutical and cosmetic preparations because they can improve the solubilization and physical stability of lipophilic ingredients. This study evaluated the physical stability of a grape seed oil nanoemulsion base containing Tween 80, PEG 400, Poloxamer 407, and Transcutol HP using an accelerated centrifugation test. Four formulations with different surfactant and co-surfactant concentrations were prepared and centrifuged at 2,000, 4,000, 6,000, and 8,000 rpm. Homogeneity, clarity, turbidity, and phase separation were assessed visually after each treatment. All formulations remained homogeneous without visible phase separation at 2,000 and 4,000 rpm. At 6,000 rpm, several formulations showed increased turbidity but no phase separation. At 8,000 rpm, the formulations remained homogeneous and showed no visible phase separation. The stability of the system may be associated with Tween 80 reducing interfacial tension, PEG 400 and Transcutol HP supporting solubilization of the oil phase, and Poloxamer 407 providing steric stabilization. These results demonstrate satisfactory physical stability under the applied centrifugation conditions and support further evaluation through droplet-size analysis, polydispersity index, zeta potential, rheology, and long-term storage studies.
Physical Evaluation and Stability of HPMC-Based Bromelain Enzyme Gel Preparation Fira Irianti Umar; Mohamad Aprianto Paneo; Muhammad Taupik; Isha Isa; Ariani H Hutuba
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 2 (2026): Volume 3 Nomor 2 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i2.315

Abstract

Bromelain is a proteolytic enzyme derived from pineapple (Ananas comosus) and has potential as an active ingredient in topical preparations. The development of bromelain in gel form requires a suitable base to produce a preparation with good physical characteristics and stability. Hydroxypropyl methylcellulose (HPMC) was selected as the gel base because it can form a stable, homogeneous gel suitable for topical use. This study aimed to formulate and evaluate the physical characteristics and stability of an HPMC-based bromelain enzyme gel preparation. The study was conducted experimentally by optimizing HPMC gel bases at concentrations of 1%, 2%, and 3%. The selected base was used to prepare bromelain enzyme gel with bromelain concentrations of 2% (F1), 4% (F2), and 8% (F3). The evaluation included organoleptic properties, homogeneity, pH, viscosity, spreadability, adhesiveness, qualitative identification of bromelain, and stability using the temperature stress test method. The optimization results showed that 2% HPMC was the most suitable base, as it produced a homogeneous gel with pH, viscosity, spreadability, and adhesiveness values that met the requirements. The Biuret test was positive in pure bromelain and all gel formulas, indicating that bromelain protein remained detectable after formulation. Physical evaluation showed that all formulas were homogeneous, had a characteristic bromelain odor, and met the requirements for pH, viscosity, spreadability, and adhesiveness. The stability test showed no noticeable organoleptic changes in all formulas. However, pH and viscosity decreased as temperature increased, with the greatest viscosity reduction observed in F3. Based on the results, the HPMC-based bromelain enzyme gel preparation showed good physical characteristics, with 2% HPMC as the most suitable gel base. However, storage temperature should be considered to maintain the physical stability of the preparation.
Pemberian Informasi Penggunaan Obat Antihiperlipidemia Pada Pasien Lansia: Providing Information on Antihyperlipidemia drugs to the elderly Juliyanty Akuba; Fika Nuzul Ramadani; Ariani Hutuba; Sukmaty Damiti; Asral Kelvin Sahrain
Jurnal Kolaboratif Sains Vol. 7 No. 7: July 2024 - Jurnal Kolaboratif Sains (JKS)
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v7i7.5533

Abstract

Hiperlipidemia sering dikenal juga sebagai hiperlipoproteinemia, karena sebelum mengalami sirkulasi dalam darah, lemak harus berikatan dengan protein membentuk lipoprotein. Tujuan dari pengabdian ini adalah untuk memberikan informasi penggunaan obat antihiperlipidemia pada lansia. Tahapan – tahapan yang dilakukan diawali dengan melakukan survey awal kondisi disekitar kelurahan Limba B pada lansia yang mengalami hyperlipidemia selanjutnya diberikan penyuluhan dari rumah ke rumah dengan membagikan brosur. Dengan pengabdian ini diharapkan lebih menambah pengetahuan masyarakat terkait penatalaksanaan untuk penyakit – penyakit hiperlipidemia.
Pencegahan Mata Kering dan Penggunaan Sediaan Tetes Mata Masyarakat Desa Monano: Dry Eye Prevention and Use of Artificial Tears Eye Drops Monano Community Fika Nuzul Ramadhani; Ariani H. Hutuba
Jurnal Kolaboratif Sains (Special Issue) - Jurnal Kolaboratif Sains (JKS) - Oktober 2025
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v8i10.8211

Abstract

Sindrom mata kering atau dry eye syndrome (DES) adalah suatu kondisi penyakit mata yang disebabkan oleh banyak faktor meliputi permukaan okular, ditandai dengan rusaknya homeostasis lapisan air mata dan gejala okular dikarenakan ketidakstabilan lapisan air mata, hiperosmolaritas dan inflamasi permukaan okular, berserta adanya abnormalitas dari neurosensoris. Sosialisasi yang dilakukan dengan tujuan menambah pengetahuan masayarakat agar dapat mengerti pencegahan DES dan tahap-tahap menggunakan obat tetes mata yang baik dan benar, terbukti efektif mencegah terjadinya DES. Hasil studi menunjukkan pemberian edukasi berpengaruh secara signifikan terhadap peningkatan pengetahuan. Berdasarkan observasi yang dilakukan, pengetahuan akan DES serta penggunaan obat tetes pada kelompok masyarakat di Desa Monano masih rendah. Masyarakat Desa Monano juga masih banyak yang mengacuhkan DES yang mengakibatkan komplikasi seperti infeksi mata, kerusakan korena dan gangguan pengelihatan. Program penyuluhan pencegahan DES ini bertujuan untuk mencegah komplikasi DES pada masyarakat dengan membagikan leaflet mengenai pengetahuan untuk pencegahan DES beserta edukasi mengenai cara penggunaan tetes mata. Edukasi dilakukan menggunakan media leaflet dengan menerangkan materi DES, penyebab serta pencegahannya dan cara penggunaan tetes mata. Pengenalan dilakukan dengan menyebutkan tahapan penggunaan sediaan tetes mata. Masyarakat diberikan materi mengenai pencegahan DES serta praktik penggunaan sediaan tetes mata agar dapat mengetahui tingkat pengetahuan masyarakat setelah dilakukan edukasi. Diakhir materi masyarakat quesioner untuk melihat perbedaan sebelum dan setelah pemberian edukasi. Kesimpulan pada kegiatan pengabdian ini adalah program sosialisasi pencegahan mata kering (dry eye) dan penggunaan sediaan tetes mata memberikan gambaran serta informasi mengenai obat-obatan pada masyarakat sehingga masyarakat dapat mencegah DES serta lebih mengetahui cara penggunaan sediaan tetes mata.
Nitrogen dioxide (NO2) levels and health problems in street sellers around Universitas Negeri Gorontalo (UNG) Ayu Rofia Nurfadillah; Ariani Hutuba; Siti Melisawati Djafar
Gema Wiralodra Vol. 14 No. 3 (2023): Gema Wiralodra
Publisher : Universitas Wiralodra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31943/gw.v14i3.550

Abstract

Air is the most critical factor for human survival, which must and must always be maintained for quality. If the air quality changes from normal, the air has been polluted. Transportation activities are one of the contributing factors to air pollution. UNG is one of the largest campuses in Gorontalo Province, which involves students in increasing the number of residents outside the area who have an impact on campus activities and an increase in the number of vehicles. In the UNG area, street vendors sell from 6 in the morning to midnight. This makes street vendors a group at risk of experiencing health problems due to exposure to NO2 from vehicle exhaust emissions. This type of research is observational with a descriptive study design. This research was conducted on Jalan Jendral Sudirman, around the UNG campus. The population in this study were all street vendors selling around the UNG campus, totaling 58 traders. The sampling technique uses the Total Sampling technique; the entire population is used as a sample. The results showed that the average concentration of NO2 around the UNG campus did not exceed the quality standards set by Government Regulation No. 22 of 2021, namely 0.2 mg/m3, and the most common health complaints experienced by respondents were coughing 43 people (74.1%), body aches and headaches 36 people (62.1%), runny nose 32 people (55.2%), sore throat 12 people (20.7%). Moreover, the least experienced was eye irritation in 2 people (3.4%). It is suggested that there should be monitoring of pollutant concentrations, and it is hoped that street vendors will use masks when selling and reduce selling time.
Co-Authors A. Mu'thi Andy Suryadi A. Mu'thi Andy Suryadi A. Mu’thi Andy Suryadi A. Mu’thi Andy Suryadi Abdulkadir, Widi Susanti Andi Makkulawu Andy Suryadi, A. Mu'thi Asral Kelvin Sahrain Ayu Rofia Nurfadillah Datu, Novanza L.M.N Djafar, Lisa Dr. Apt. Hamsidar Hasan S.Si.,M.Si Fika Nuzul Ramadani Fika Nuzul Ramadhani Fira Irianti Umar Grasela Mbae Hiola, Faramita Isha Isa Jauria Julianty Akuba Kaino, Ratni Kostiawan Sukamto, Kostiawan La Ode Aman Lahay, Astiara Madania, Madania Mahdalena Sy Pakaya mahdalena sy. pakaya Maku, Mohamad Aditya Manno, Mohamad Reski Mohamad Adam Mustapa Mohamad Aprianto Paneo Mohamad Reski Manno Muhammad Taupik Nasrun Pakaya Nur Ain Thomas Nur Rasdianah Nurul Istiqomah Payuyu, Alifia Robert Tungadi Safitri Fatikasari Sapiun, Zulfiayu Selvi Marcellia Siti Ruqaiyah Lakoro Sitti Rahmawaty Sisilia Mursidi Sukmaty Damiti Suryadi, A. Mu'thi Andy Teti Sutriyati Tuloli Tri Sucianita T. Tama Widy Susanti Abdulkadir Wiwit Zuriati Uno Yambese, Alpiani Yayah Rachmatiyah Zulkifli B Pomalango