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All Journal JURNAL PENELITIAN SAINTIKA Jurnal Pendidikan Biologi Indonesia Biology, Medicine, & Natural Product Chemistry Jurnal Florea Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Perspektif Jurnal Pembelajaran dan Biologi Nukleus Best Journal (Biology Education, Sains and Technology) IJOEP : International Journal of Ecophysiology JURNAL BIOSHELL Bioscientist : Jurnal Ilmiah Biologi Continuous Education : Journal of Science and Research INVENTION: Journal Research and Education Studies Journal of Learning Improvement and Lesson Study Biocaster : Jurnal Kajian Biologi Jurnal Kedokteran Hewan Journal of Pharmaceutical and Sciences. BIO-CONS: Jurnal Biologi dan Konservasi Biodik: Jurnal Ilmiah Pendidikan Biologi AR-RUMMAN: Journal of Education and Learning Evaluation
Melva Silitonga
Department of Biology, State University of Medan
Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : AR-RUMMAN: Journal of Education and Learning Evaluation

 1 
Literature Study: Cortisol Hormone to DHEA-S Ratio as an Indicator of HPA Axis Activity in Chronic Stress and Insulin Resistance Sinaga, Odor Debora Pita Uli; Gultom, Febry Yeni; Sihite, Judika Adventist Maleakhi; Solin, Naomi Putri Chelsea; Silitonga, Melva
AR-RUMMAN: Journal of Education and Learning Evaluation Vol 2, No 1 (2025): Juni 2025
Publisher : CV. Rayyan Dwi Bharata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57235/arrumman.v2i1.6010

Abstract

Chronic stress can disrupt the regulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis, causing dysregulation of cortisol secretion and an imbalance in the ratio of cortisol to dehydroepiandrosterone sulfate (DHEA-S), which is implicated in the development of insulin resistance and Type 2 Diabetes Mellitus (T2DM). Cortisol, as an insulin antagonist, increases hepatic glucose production and reduces peripheral glucose uptake, while DHEA-S has a protective effect on glucose metabolism. This literature review aims to evaluate the evidence related to the role of the cortisol/DHEA-S ratio as a potential biomarker in the relationship between chronic stress and insulin resistance. The method used is a critical synthesis of previous studies on the mechanism of the HPA axis, the impact of stress on glucose metabolism, and the clinical significance of the cortisol/DHEA-S ratio. The results of the analysis indicate that an imbalance in the cortisol/DHEA-S ratio due to chronic stress contributes to impaired insulin sensitivity, reinforcing the importance of this biomarker approach in the management of T2DM risk. This study highlights the need for further research to validate the use of the cortisol/DHEA-S ratio as a predictive tool and therapeutic intervention.
Literature Study: Cortisol Hormone to DHEA-S Ratio as an Indicator of HPA Axis Activity in Chronic Stress and Insulin Resistance Sinaga, Odor Debora Pita Uli; Gultom, Febry Yeni; Sihite, Judika Adventist Maleakhi; Solin, Naomi Putri Chelsea; Silitonga, Melva
AR-RUMMAN: Journal of Education and Learning Evaluation Vol 2, No 1 (2025): Juni 2025
Publisher : CV. Rayyan Dwi Bharata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57235/arrumman.v2i1.6010

Abstract

Chronic stress can disrupt the regulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis, causing dysregulation of cortisol secretion and an imbalance in the ratio of cortisol to dehydroepiandrosterone sulfate (DHEA-S), which is implicated in the development of insulin resistance and Type 2 Diabetes Mellitus (T2DM). Cortisol, as an insulin antagonist, increases hepatic glucose production and reduces peripheral glucose uptake, while DHEA-S has a protective effect on glucose metabolism. This literature review aims to evaluate the evidence related to the role of the cortisol/DHEA-S ratio as a potential biomarker in the relationship between chronic stress and insulin resistance. The method used is a critical synthesis of previous studies on the mechanism of the HPA axis, the impact of stress on glucose metabolism, and the clinical significance of the cortisol/DHEA-S ratio. The results of the analysis indicate that an imbalance in the cortisol/DHEA-S ratio due to chronic stress contributes to impaired insulin sensitivity, reinforcing the importance of this biomarker approach in the management of T2DM risk. This study highlights the need for further research to validate the use of the cortisol/DHEA-S ratio as a predictive tool and therapeutic intervention.
Co-Authors Abdila, Alya Nur Afdhannisa, Daffa Amanda, Putri anliana Apriliani, Indah Rizka Arda, Gladys Mutia Ashar Hasairin Ayu Putri Ningsih Ayu Wulandari Azhari, Nabilah Syahirah Batubara, Astrida J.A Binari Manurung, Binari Br Barus, Sari Apriani Daulae, Abdul Hakim Fauziyah Harahap Fitriyani, Dina Frisillia, Unikhe Ginting, Aminata Gultom, Febry Yeni Gultom, Novayanti Hariyadi, Itra Hasibuan, Hasni Periadi Hasruddin Hutapea, Helen Veronita Karinanta Sembiring, Surya Kurniawan, Rizal Eko Limbong, Forentina Lumbangaol, Adriana Yulinda Dumaria Maida Pardosi Manalu, Mentari Marpaung, Mieky Grasiaella Martina Restuati Matanari, Ninta Dumaria Mufti Sudibyo, Mufti Muhammad Azhari Nababan, Novia Christy Nainggolan, Junister Nasution, Irma Riavael Nasution, Marina Azzahra Naura Kamila, Aryediutami Niswatun Hasanah Nora, Putri Panguhutan Sitorus, Henry Pardede, Lastiar H Pasar Maulim Silitonga Pasaribu, Tania Valentina Patresia, Indri Pehulisa, Rensiva Ray Pranoto, Hendro Pribadi, Koko Purba, Greace Enita Rajagukguk, Nia Anggelina RISKA WAHYUNI Rosmanta Aritonang, Frince Winda Rumapea, Lusiana Ruth Susanty, Revi Saif, Annisa Hazrina Saragi, Shela Estica Selvia Dewi Pohan Selvia Selvia Sembiring, Gres Anjelia Sianturi, Stephanie Agustin Sidabutar, Efimah Sihite, Judika Adventist Maleakhi Sihotang, Wahyu Frans Sinaga, Erlintan Sinaga, Odor Debora Pita Uli Sipahutar, Feimmy Ruth Pratiwi Siregar, Suci Asda Mutia Sitohang, Mohonia Sabarito Sitohang, Odelia Nova Maria Br. Situmeang, Juwita Cristina Situmorang, Berri Situmorang, Elisa Rauli Situmorang, Imelda Situmorang, Rany Solin, Naomi Putri Chelsea Sumbayak, Mika Canthika Amelia Suriwahyuni Suryani, Cicik Syahmi Edi Tambunan, Diana Putri Kamila Tarigan, Cania Yekholia Ujung, Siti Nuraisah Asma Windah, Putri Witin, Theresia Adhellia