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Arsyad, Muhammad Aryadi
Fakultas Kedokteran, Universitas Hasanuddin
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Pengaruh Pemberian Dehydroepiandrosterone (DHEA) terhadap Aktivitas Peroksidasi Lipid dan Kadar Nitrit Oksida pada Aorta Tikus Wistar Jantan yang Terpapar Asap Rokok Nila Ridhayani; Aryadi Arsyad; Yulia Yusrin Djabir
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol 11, No 2 (2022): September
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/sainsmat112359002022

Abstract

The research aimed to investigate the effect of dehydroepiandrosterone (DHEA) on lipid peroxidation activity and nitric oxide concentration in the aorta of male Wistar rats due to exposure to cigarette smoke. This study was a laboratory experiment using 21 rats that were divided into 3 groups: KN-14 (negative control that is given smoke exposure within 14 days), DHEA-1 (15 mg/kgBW + smoke exposure for 14 days), and DHEA-2 (30 mg/kgBW + smoke exposure for 14 days). The exposure was carried out in 25-45 minutes with 4 cigarettes/day. Surgery was performed in the 15th days to remove the aorta to examine malondialdehyde (MDA) as a biomarker of lipid peroxidation and nitric oxide (NO) concentration using Enzyme-linked Immunosorbent Assay (ELISA). The results showed that a significant increase in MDA concentrations was found in the group administered with DHEA, particularly at a dose of 30 mg/kgBW (p<0.05). Meanwhile, the administration of DHEA at doses of 15 and 30 mg/kgBW did not have a significant effect (p>0,05) on aortic NO concentrations compared to the group KN-14. Therefore, it can be concluded that the administration of DHEA could increase lipid peroxidation activity, as indicated by a significant increase in aortic MDA concentrations, without affecting aortic NO concentrations in rats exposed to cigarette smoke for 14 days.Keyword: Dehydroepiandrosterone (DHEA), MDA, NO, lipid peroxidation, exposure of cigarettes smoke
Pengaruh Pemberian Dehydrepiandrosterone (DHEA) Terhadap Paru-Paru Tikus Wistar Jantan Yang Terpapar Asap Rokok Sri Hardiyanti Asad; Aryadi Arsyad; Yulia Yusrini Djabir
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol 11, No 2 (2022): September
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/sainsmat112359582022

Abstract

This study investigated the effect of dehydroepiandrosterone on the lungs of male Wistar rats exposed to cigarette smoke. A total of 21 male Wistar rats were divided into 3 groups, namely the first group (negative control exposed to cigarette smoke for 14 days), the second group (given DHEA at a dose of 15 mg/kgBW and exposure to cigarette smoke), the third group (given DHEA at a dose of 30 mg/kgBW and exposure to cigarette smoke). DHEA was administered orally through a cannula 30 minutes before exposure to cigarette smoke with an exposure duration of about 25-40 minutes, equivalent to 4 cigarettes/day. After 14 days of experimentation, the rats were euthanized. Right lungs were harvested for malondialdehyde level measurement using the thiobarbituric acid reactive substance method measured by UV-Visible spectrophotometer at a wavelength of 532 nm. The left lungs were also harvested for histopathological examination. This study showed that pulmonary malondialdehyde levels in second and third group tended to be higher than in first group. Meanwhile, histopathological examination showed that the percentage of lung tissue damage in second and third group tended to be lower than in first group. Thus, it can be concluded that DHEA at doses of 15 and 30 mg/kgBW tended to act as a pro-oxidant but might potentially improve lung histology due to cigarette smoke exposure.
Co-Authors A Asrina A. Nilawati Usman A.Wardihan Sinrang A.Wardihan Sinrang Abustani, Muthiah Agustin, Dinah Inrawati Ahmad, Mardiana Al Mukarram H. A. Amir, Muzakkir Andi Nilawati Andi Nilawati Usman Andi Wardihan Sinrang Arief, Nila Ardilla Arif Santoso Ariyandy, Andi Arwan Bin Laeto Budu - Cangara, Husni Desi Dwirosalia Suparman Dewiyana, Srigita Djabir, Yulia Yusrini Djaharuddin, Irawaty Dwi Kartika Sari Dwi P. Wulansari Edy Machmud Elizabeth Catherine Jusuf Enny Nahumuri Eri Hendra Jubhari Gemini Alam H Anwar, St Hadijah Hafsa, Mahmud Hafsah, Amir Mahmud Hasrianti, Hasrianti Hasrimayana Hasrimayana Healthy Hidayanti Idris, Irfan Ika Yustisia Ika Yustisia Ilhamjaya Patellongi Irene E. Rieuwpassa IRFAN IDRIS Ismail, Amirah Febrianti Kasim, Hasim Latifah Rahman Luciana Heidee Christianty Mallisa, Hilda Emma Mardiana Ahmad Mardiana Ahmad Mardiana Ahmad Mardiana Ahmad Masrika, Nur Upik En Massi, Moh Nasrum Muh Tamar Muh. Akbar Bahar Muhammad Aswad Muhammad Husni Cangara Muhammad Husni Cangara Natsir, Rosdiana Nila Ridhayani Nilawati Andi Nuni Rismayanti Nurkalbi Nur Aliya Arsyad Nur Amalia Alif Nur Hayati Saud Nur Partiwi Nurjannah Damis Nurlindah Hamrun Pratiwi, Vira Prihantono, Prihantono Putri, Dwi Anggara Rafiah, Siti Rafikah Hasyim Ramadhani, Sri Risfah Yulianti Risfah Yulianty Riu, Deviana Soraya Rosdiana Natsir Rosdiana Natsir Saidah Syamsuddin Sakinah, Andi Irhamnia Sanaky, Marliyati Seri Pasongli, Seri Sitti Rafiah Sri Hardiyanti Asad Sri Ramadany, Sri St. Raf’iah Stang Stang Veni Hadju Wadi Renah Werna Nontji Werna Nontji, Werna Widyatma Adinda Jubhari Yadul Ulya Yudi Yanto Yulia Y Djabir Yulia Yusrin Djabir Yulia Yusrini Djabir