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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Kimia (Journal of Chemistry) IPTEK The Journal for Technology and Science Alchemy : Journal of Chemistry Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal AgroBiogen Indonesian Journal of Cancer Chemoprevention MPI (Media Pharmaceutica Indonesiana) UNEJ e-Proceeding Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Jurnal Wiyata : Penelitian Sains dan Kesehatan Journal Of Vocational Health Studies Jurnal Kreativitas PKM Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Riayah: Jurnal Sosial dan Keagamaan Jurnal Al-Irsyad: Jurnal Bimbingan Konseling Islam Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal Pharmasci (Journal of Pharmacy and Science) Berkala Penelitian Hayati Jurnal Ilmiah Kesehatan (JIKA) Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan International Journal of Sociology of Religion Jurnal Info Kesehatan Ulul Albab: Journal Dak'wah and Social Religiosity
Sukardiman
Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, UniversitasAirlangga, Surabaya
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Journal : Jurnal Sains dan Kesehatan

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Senyawa Metabolite Sekunder dan Aktifitas Afrodisiak Ekstrak Etanol Cabe Jawa (Piper retrofractum Vahl) Secara In silico: Secondary Metabolite Compounds and Aphrodisiac Activity of Ethanol Extract of Cabe Jawa (Piper retrofractum Vahl) With In silico Methode Taufikurrahman, Taufikurrahman; Widyowati, Retno; Sukardiman, Sukardiman
Jurnal Sains dan Kesehatan Vol. 6 No. 5 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i5.2391

Abstract

Erectile dysfunction is one of the most common sexual problems in men. Drugs available on the market can be used to treat this problem, but the use of these drugs often causes unwanted side effects, the use of natural ingredients as an alternative treatment is increasingly popular, one of which is a herb made from chili jamu (Piper retrofractum Vahl). Metabolite profiling of the chili jamu plant turns out to be different depending on the location of growth, it is thought to result in differences in natural conditions and circumstances which result in differences in aphrodisiac activity. Cabe Jawa extracted with 96% ethanol was analyzed using LC / MS, detected as many as ten secondary metabolites namely, Salsolinol, Quercetin, Caffeoyl putrescin, Diferuloyl putrescine, Feruloyl tyramine, Hydroxychloroquine, Tetrahydropapaveroline, Piperine, N-Oleyl-Leucine, Capsaicin. From the results of in silico tests, it is known that piperine has activity as a phosphodiesterase type 5 (PDE5) inhibitor with binding energy and inhibition constant values of -8.62 kcal/mol and 0.485 uM. Keywords:          Piper retrofractum Vahl, Secondary metabolite, Aphrodisiac   Abstrak Disfungsi ereksi merupakan salah satu masalah seksual yang paling umum terjadi pada pria. Obat yang tersedia di pasaran dapat digunakan untuk mengatasi masalah ini, tetapi penggunaan obat tersebut seringkali menimbulkan efek samping yang tidak diinginkan., penggunaan bahan alami sebagai alternatif pengobatan semakin populer, salah satunya yaitu ramuan berbahan cabe jamu (Piper retrofractum Vahl). Metabolit profiling dari tanaman cabe jamu ternyata berbeda-beda tergantung dari lokasi tumbuhnya, hal tersebut diduga mengakibatkan perbedaan kondisi dan keadaan alam yang berakibat pada perbedaan aktivitas afrodisiak. Cabe jamu yang diekstrak dengan etanol 96% di analisa dengan menggunakan LC/MS, terdeteksi sebanyak sepuluh metabolite sekunder yaitu, Salsolinol, Quercetin, Caffeoyl putrescin, Diferuloyl putrescine, Feruloyl tyramine, Hydroxychloroquine, Tetrahydropapaveroline, Piperine, N-Oleyl-Leucine, Capsaicin. Dari hasil uji in silico diketahui bahwa piperine memiliki aktifitas sebagai penghambat phosphodiesterase type 5 (PDE5) dengan nilai energi ikat dan konstanta inhibisi sebesar -8,62 kkal/mol dan 0,485 uM. Kata Kunci:         Piper retrofractum Vahl, Metabolite sekunder, Afrodisiak
Co-Authors A. Dinar Ambarwati Achmad Fuad Hafid Adam Hermawan Al ‘Amali, Mayla Khayra Aly, M. Ainun Najib Anak Agung Gede Sugianthara Annisa Farida Muti Arie Ika Susanty Ario Imandiri, Ario Aty Widyawaruyanti Awik Puji Dyah Nurhayati Bambang Prayogo Bambang Sugiharto Bambang Tri Purwanto Dewi Hidayati Dini Retnowati Diyah, Nuzul Wahyuning Djoko Agus P. Dwi Ningsih Dwi Riani Oktavia Palupi Edy Listanto Edy Meiyanto Edy Meiyanto Emma Rahmawati Emma Rahmawati Engel, Daniella Elizabeth Eny I. Riyanti Esti Hendradi Faisal Akhmal Muslikh Hadi Poerwono Handayani, Rosita Hardiyanti, Andi Sry Hindiana, Linda I.A.A. Widhiartini Idha Kusumawati Iis Wahyuningsih Isna Rahmayani Isnaeni Istiqamah, Farida Junaidi Khotib Juni Ekowati Kholis Amalia Nofianti Kusmana Kusmana Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Masyrobatin, Masyrobatin Melanny Ika Sulistyowaty Miatmoko, Andang Misgiati, Misgiati Munandar, Tristiana Erawati Noor Erma NS Nur Fadilla Achmad Nurhidayah - Nuri Nuri Oka Adi Parwata Paramita, Angggun Putri Prasetyanti, Intan Kris Pratama, Edo Purwitasari, Neny Putri, Anisa Yustikka Rahmawati, Emma Ramadhani, Firmansyah Ardian Rarastoeti Prastiwi Retno Sari Retno Widyowati Rijal, Agus Syamsur Roihatul Mutiah Samudra, Rizka Putra Shigeru Sasaki Shigeru Sasaki Shobahah, Jauharotus Siti Maimunah Siti Zulaikah Sudjarwo Sudjarwo Sudjarwo Suharjono, Suharjono Sulistiyono, Ilham Robbynoor Sulistyowati, Melanny Ika SUZANA, SUZANA Taufikurrahman Taufikurrahman Taufikurrahman Toto Hadiarto Tri Dewanti W. Tri J. Santoso Tri Sundari Tutik Sri Wahyuni Tutuk Budiati Widiyaningsih, Arum Widyowati , Retno Widyowati, Rr. Retno Wijayanti Pujitono Win Darmanto Wiwied Ekasari Yurika Sastyarina Yurika Sastyarina Yurika Sastyarina Yusuf, Helmy