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Promosi Gizi dan Kesehatan bagi Wanita Hamil, Wanita Menyusui, dan Ibu Balita dalam Rangka Pencegahan Stunting di Kabupaten Lampung Tengah, Lampung Sutarto Sutarto; Asep Sukohar; Ratna Dewi Puspita Sari; Winda Trijayanthi; Sofyan Musabiq Wijaya
Jurnal Pengabdian Pada Masyarakat Vol 6 No 2 (2021)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/002.202162.572

Abstract

PROMOTION OF NUTRITION AND HEALTH FOR PREGNANT WOMEN, BREASTFEEDING WOMEN, AND MOTHERS TODDLER IN THE CONTEXT OF STUNTING PREVENTION IN LAMPUNG TENGAH REGENCY, LAMPUNG. One of the determining factors for the success of health development is nutritional status. Health promotion efforts to increase awareness, willingness and ability of both individuals, families, groups and communities to live healthy and it is necessary to increase nutrition and health promotion for pregnant women and mothers under five. This activity was carried out in the context of preventing stunting in Tanggamus and Tanggamus Regencies which was carried out by the Service Team of the Faculty of Medicine, University of Lampung. Various health promotion efforts have been made to obtain optimal results through nutrition and health promotion. This activity aims to assist in the success of national health development through improving nutritional status, through increasing public knowledge about clean and healthy living habits in household settings, a balanced nutrition menu in preventing the incidence of stunting in the family. The methods used in carrying out this activity are lectures, focus group discussions, counseling on the portion of my plate, skill practice and food serving competitions for lokal products to improve nutrition for pregnant women and toddlers. Results of nutrition and health promotion activities for pregnant women and mothers under five in the context of preventing stunting in Central Lampung and Tanggamus districts. can assist in the success of national health development through improving nutritional status.
The Ethanolic Extract of Annonaceous sp. to Inhibit Vascular Endothelial Growth Factor (VEGF) as Anticancer Modalities Muhartono Muhartono; Asep Sukohar; Khairun Nisa; Ratna Dewi Puspita Sari; Suharyani; Arli Suryawinata
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 7 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i7.331

Abstract

Introduction: Cancer has become a major public health problem worldwide, with breast cancer is the most common cancer among women and one of the most important causes of death among them. Management of breast cancer have some adverse effects, with many factorx=s shiouln be considered to ordered the therapy. Use of chemotherapy will suppress cell proliferation and trigger apoptosis, but it cannot just focus on cancer cells only, but also would affected on other cells and cause. Objective: This study aim to analyze the inhibition effect of the Annonanceous sp. ethanolic extract to Vascular Endothelial Growth Factor (VEGF) on MCF-7 cells line Material and Methods: This study is an analytic experimental study used Randomized Complete Block Design (RCBD) with three repetitions. The extract was dissolved in 1 ml of DMSO with a concentration of 0.1%. Furthermore, dilution was made with a dose of 0 µg / ml (K); 25 µg / ml (P1); 50 µg / ml (P2); 100 µg / ml (P3); 200 µg / ml (P4). MCF-7 cells line were cultured used RPMI 1640 Medium with 80 – 90% confluent. The ethanolic extract of Annonaceous sp. were exposed to MCF-7 cells for 48 hours. Analyze of VEGF level use ELISA Methods with λ=405 nm. Results: The results of ELISA analyze shows that the ethanolic extract of Annonaceous sp. have potential effect to decreased of VEGF expression on sample with treatment on some concentration (p< 0,05). Conclusion: The ethanolic extract of Annonaceous sp. has shows the potential effect to decreased of VEGF level on MCF-7 cells line
Pemanfaatan Kulit Labu (Cucurbita Moschata Durch) Sebagai Minuman Herbal Pada Masyarakat Desa Negeri Katon-Provinsi Lampung Asep Sukohar; Andi Nafisah Tendri Adjeng; Nur Fitriana Muhammad Ali; Zulpakor Oktoba; Endah Ambarwati; Ihsanti Dwi Rahayu; Afriyani Afriyani; Ramadhan Triyandi
Jurnal Mandala Pengabdian Masyarakat Vol. 3 No. 2 (2022): Jurnal Mandala pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1420.645 KB) | DOI: 10.35311/jmpm.v3i2.101

Abstract

Antioksidan berperan penting dalam melindungi tubuh akibat efek radikal bebas yang menyebabkan menurunnya sistem imun, kanker, dan penyakit degeneratif seperti diabetes dan jantung. Salah satu sumber antioksidan alami adalah kulit Labu (Cucurbita moschata Durch) namun pemanfaatannya belum optimal dan masih sering dianggap limbah. Daerah yang banyak membudidayakan tanaman Labu adalah Desa Negeri Katon Kecamatan Negeri Katon Kabupaten Pesawaran, Provinsi Lampung. Pemanfaatan limbah kulit Labu belum optimal dikarenakan masyarakat tersebut belum memahami kandungan serta manfaat yang bisa diperoleh dari kulit Labu. Kegiatan ini merupakan salah satu bentuk pengabdian yang bertujuan untuk mengoptimalkan penggunaan kulit Labu sebagai sumber antioksidan adalah dengan memanfaatkannya menjadi produk sediaan teh. Melalui Pengabdian Kepada Masyarakat Desa Binaan (PKMDB) ini masyarakat dibimbing untuk meningkatkan pemanfaatan kulit Labu berupa pengetahuan dasar mengenai manfaat kulit labu sebagai antioksidan dalam menangkal radikal bebas, penyiapan bahan baku sampel kulit Labu. Pelaksanaan Kegiatan pengabdian kepada masyarakat menggunakan metode berupa memberi penyuluhan (ceramah dan tanya jawab), Pemberian questionare untuk mengukur efektifitas pengetahuan masyarakat sebelum dan setelah penyuluhan (pre dan post-test). Setelah pemberian materi dan pendampingan pembuatan sediaan teh Kulit Labu hasil kegiatan menunjukkan bahwa pengetahuan warga meningkat saat kembali mengisi kuesioner yang sama dan berbeda cukup besar dibandingkan sebelumnya. Sehingga melalui adaanya kegiatan pengabdian masyarakat ini dapat disimpulkan bahwa Kegiatan Pengabdian Masyarakat Di Desa Negeri Katon Kecamatan Negeri Katon Kabupaten Pesawaran mampu menambah wawasan dan memberi kontribusi mengenai manfaat dan pemanfaatan kulit Labu (Cucurbita moschata Durch).
Pengaruh FKTP (Fasilitas Kesehatan Tingkat Pertama), Kesehatan Lingkungan dan Morbiditas Penyakit Berbasis Lingkungan Terhadap IPM (Indeks Pembangunan Manusia) di Provinsi Lampung dengan Metode Structural Equation Modeling (SEM) Anita Febrina; Evi Kurniawaty; Bainah Sari Dewi; Samsul Bakri; Asep Sukohar; Hari Kaskoyo
MAHESA : Malahayati Health Student Journal Vol 4, No 5 (2024): Volume 4 Nomor 5 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i5.14381

Abstract

ABSTRACT In the JKN-KIS Program, FKTP acts as a gate keeper where FKTP is responsible for providing basic health services and functioning optimally according to its competency standards. The unequal availability of health facilities and very varied geographical conditions give rise to the potential for widening inequality in health utilization. The Human Development Index (HDI) is an important indicator for measuring success in efforts to build the quality of human life (society/population), one of the elements that make up the HDI is health. Good health is supported by health facilities and good environmental health conditions so that it can reduce environmental-based morbidity rates, so that people are able to carry out productive activities. This research uses a quantitative approach with a causal design which aims to explain how the FKTP variable influences changes in mediating variables, namely environmental health and morbidity and its influence on HDI. The research was conducted in the Lampung Province area. The data source used is secondary data from BPS (Central Statistics Agency) Lampung Province and the Lampung Province Health Service for 2018-2022. The data analysis method in this research uses a path analysis model to analyze the pattern of relationships between variables. Based on the research results, there is a significant influence of FKTP on environmental health and environmental-based disease morbidity, and there is a significant influence of FKTP, environmental health and environmental-based disease morbidity on HDI in Lampung Province. Meanwhile, there is no influence of environmental health on environmental-based disease morbidity. Thus, efforts to increase the HDI in Lampung Province as a measure of community welfare can be pursued by carrying out interventions to increase FKTP, environmental health and environmental-based disease control in a representative manner, where FKTP becomes central in health efforts in the region, so that a healthy community will be able to maximum productivity to improve their welfare. Keywords: FKTP, Environmental Health, Morbidity, IPM   ABSTRAK Dalam Program Jaminan Kesehatan Nasional (yang disebut bJKN-KIS), fasilitas Kesehatan tingkat pertama (FKTP) berperan sebagai gate keeper dimana FKTP bertanggungjawab sebagai pemberi pelayanan kesehatan dasar serta berfungsi optimal sesuai standar kompetensinya. Ketidakmerataan ketersediaan fasilitas kesehatan dan kondisi geografis yang sangat bervariasi, menimbulkan potensi melebarnya ketidakadilan pemanfaatan Kesehatan. Indeks Pembangunan Manusia (IPM) merupakan indikator penting untuk mengukur keberhasilan dalam upaya membangun kualitas hidup manusia (masyarakat/penduduk), salah satu unsur yang menyusun IPM adalah kesehatan. Kesehatan yang baik didukung dengan fasilitas kesehatan dan kondisi kesehatan lingkungan yang baik sehingga mampu menekan angka kesakitan berbasis lingkungan, sehingga masyarakat mampu beraktifitas secara produktif. Penelitian ini menggunakan pendekatan kuantitatif dengan desain kausal yang bertujuan untuk menjelaskan bagaimana variable FKTP mempengaruhi atas perubahan-perubahan dalam variabel mediasi, yaitu kesehatan lingkungan dan morbiditas hingga pengaruhnya pada IPM. Penelitian dilakukan di wilayah Provinsi Lampung. Sumber data yang digunakan adalah data sekunder dari BPS (Badan Pusat Statistik) Propinsi Lampung dan Dinas Kesehatan Propinsi Lampung Tahun 2018-2022. Metode analisis data dalam penelitian ini menggunakan model path analysis (analisis jalur) digunakan untuk menganalisis pola hubungan di antara variabel. Berdasarkan hasil penelitian ada pengaruh signifikan FKTP terhadap Kesehatan lingkungan dan morbiditas penyakit berbasis lingkungan, serta ada pengaruh signifikan FKTP, Kesehatan Lingkungan dan Morbiditas Penyakit berbasis Lingkungan terhadap IPM di Propinsi Lampung. Sementara itu, tidak ada pengaruh kesehatan lingkungan terhadap morbiditas penyakit berbasis lingkungan. Dengan demikian upaya peningkatkan IPM di Provinsi Lampung sebagai tolak ukur kesejahteraan masyarakat dapat diupayakan dengan melalukan intervensi pada peningkatan FKTP, kesehatan lingkungan dan pengendalian penyakit berbasis lingkungan secara refresentatif, dimana FKTP menjadi sentral dalam upaya-upaya kesehatan di wilayahnya, sehingga masyarakat yang sehat akan mampu berproduktifitas secara maksimal untuk meningkatkan kesejahteraannya. Kata Kunci: FKTP, Kesehatan Lingkungan, Morbiditas, IPM
Review Artikel: Pemanfaatan Kulit Jeruk Sebagai Antioksidan dalam Sedian-Sediaan Farmasi Wardani, Farah Dwi; Sukohar, Asep; Afriyani, Afriyani; Oktarlina, Rasmi Zakiah
Sains Medisina Vol 2 No 4 (2024): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v2i4.383

Abstract

Kulit jeruk telah lama dikenal mengandung senyawa bioaktif, termasuk antioksidan. Dengan kandungan senyawa antioksidan yang melimpah, seperti fenolik, flavonoid, asam askorbat, polifenol, dan terpene dapat memberikan perlindungan yang efektif terhadap efek negatif radikal bebas dengan cara menetralkan radikal bebas yang menyebabkan stress oksidatif dan merusak DNA serta sel-sel tubuh. Dalam  memanfaatkan senyawa-senyawa yang terkandung di dalamnya maka dibuat sediaan farmasi. Penelitian ini menggunakan metode penelusuran artikel menggunakan basis data ilmiah seperti Pubmed, ScienceDirect, dan Google Scholar dengan kata kunci kulit jeruk, antioksidan, dan sediaan farmasi dengan jurnal terbitan sepuluh tahun terakhir.  Hasil dari studi article review menunjukkan beberapa jenis kulit jeruk yang memiliki aktivitas antioksidan seperti kulit jeruk kalamansi, kulit jeruk nipis, kulit jeruk manis, dan kulit jeruk purut yang mengandung senyawa seperti limonene, flavonoid, β-pinene yang memiliki aktivitas antioksidan sangat kuat yang diuji menggunakan metode DPPH. Dalam memanfaatkan senyawa-senyawa yang terkandung di dalamnya dapat dimanfaatkan dalam formulasi sediaan farmasi, seperti masker gel, lipbalm, serum,  spray gel, lotion, krim, gel, dan splash mask yang memiliki stabilitas sediaan yang baik. Beberapa sediaan juga diuji aktivitas antioksidan dan menggunakan metode DPPH dan pengukuran absorbansi menggunakan spektrofotometer UV-VIS dan didapatkan hasil sediaan  memiliki aktivitas antioksidan dari sedang hingga kuat.
Review Article: Patofisiologi Dan Terapi Farmakologi Diabetes Melitus Tipe 2 Pada Pasien Geriatri Putri, Asyifa Adinda; Junando, Mirza; Oktafany, Oktafany; Sukohar, Asep
Sains Medisina Vol 2 No 5 (2024): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes melitus (DM) adalah gangguan metabolisme pada pankreas yang menyebabkan peningkatan gula darah, atau dikenal sebagai hiperglikemia, akibat penurunan jumlah insulin yang diproduksi oleh pankreas. Menurut International Diabetes Federation (IDF) pada tahun 2021, jumlah pasien dewasa diabetes melitus di Indonesia mencapai 10,8%, setara dengan 19,4 juta orang, dan cenderung meningkat setiap tahunnya. Tujuan penelitian mengetahui patofisiologi dan terapi farmakologi diabetes melitus tipe 2 pada pasien geriatri. Metode dalam penelitian ini menggunakan desain Literatur Review yang dikumpulkan dari basis data Pubmed dan Google Scholar dengan kata kunci “Diabetes mellitus in geriatrics”. Hasil penelitian menunjukkan bahwa penderita diabetes melitus tipe 2 geriatri mengakibatkan peningkatan resistensi dan gangguan sekresi insulin. Perbaikan klinis pada pasien diabetes geriatri lebih sulit dikarenakan adanya penyakit kronis yang menyertainya sehingga dapat meningkatkan risiko komplikasi. Diperlukan perubahan gaya hidup serta terapi farmakologi berupa penggunaan insulin basal dikombinasikan dengan agen noninsulin. Metformin adalah terapi non insulin lini pertama. Obat lainnya yaitu tiazolidindion, sulfonilurea, DPP-4I, SGLT2-I, dan GLP-1. Terapi farmakologi disesuaikan dengan kondisi pasien seperti, komorbit yang diderita, status kognitif dan fisik, serta risiko hipoglikemia.
LITERATUR REVIEW: TRIKIASIS Gerliandi, Egi Oktarian; Mustofa, Syazili; Lisiswanti, Rika; Sukohar, Asep
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1008

Abstract

Trichiasis is a pathological disorder characterized by the abnormal growth of eyelashes towards the eyeball, resulting in irritation, pain, and potential harm to the eye. This research utilizes a method of sear Trichiasis is a pathological disorder characterized by the abnormal growth of eyelashes towards the eyeball, resulting in irritation, pain, and potential harm to the eye. The pathophysiology of trichiasis originates with alterations in the structure of the eyelashes and eyelids. Trichiasis is classified into six categories according to the source and location of abnormal eyelash development. The clinical presentation of trichiasis differs according on the extent of the condition. Trichiasis can be diagnosed by assessing the patient's medical history and doing a thorough physical examination. The history encompasses the patient's medical background, record of medication usage, past eye surgical procedures, and the patient's reported symptoms. The physical examination encompasses assessments of visual acuity, biomicroscopic inspection, evaluation of eyelid margins, and the administration of the Schirmer test. The treatment for trichiasis is determined by the extent of eyelash involvement, which includes factors such as the Soft Contact Lense Base Curve. Treatment options may include eyelash removal and surgical procedures, depending on the specific form of trichiasis that the patient is suffering. ching for articles on Google Scholar, PubMed, and NCBI. The search is limited to a specific year range determined by the researcher. The search is conducted using keywords such as trichiasis, etiology of trichiasis, pathophysiology of trichiasis, classification of trichiasis, clinical manifestations of trichiasis, diagnosis of trichiasis, and management of trichiasis. The study's findings revealed that the cause of trichiasis remained unknown, however it was hypothesized to be a result of infection. The pathophysiology of trichiasis originates with alterations in the structure of the eyelashes and eyelids. Trichiasis is classified into six categories according to the source and location of abnormal eyelash development. The clinical presentation of trichiasis differs according on the extent of the condition. Trichiasis can be diagnosed by assessing the patient's medical history and doing a thorough physical examination. The history encompasses the patient's medical background, record of medication usage, past eye surgical procedures, and the patient's reported symptoms. The physical examination encompasses assessments of visual acuity, biomicroscopic inspection, evaluation of eyelid margins, and the administration of the Schirmer test. The treatment for trichiasis is determined by the extent of eyelash involvement, which includes factors such as the Soft Contact Lense Base Curve. Treatment options may include eyelash removal and surgical procedures, depending on the specific form of trichiasis that the patient is suffering.
Literature Review: Faktor-Faktor Penyebab Kejadian Rehospitalisasi Pada Pasien Congestive Heart Failure (CHF) Kylalona, Gracylia; Suri, Nurma; Aulia Ramdini, Dwi; Sukohar, Asep
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1039

Abstract

Congestive Heart Failure (CHF) is a health disorder with a poor prognosis due to functional or structural heart defects that interfere with ventricular filling or blood ejection into the systemic circulation. CHF remains a significant global health concern with high rates of morbidity and mortality. The number of diagnosed CHF leading to frequent rehospitalization or re-admission due to symptom recurrence. Patients who experience readmitted to the hospital after initial admission have a risk of mortality, with about 50% dying within 6 months and 25-35% passing away within 12. In this review focuses on exploring the factors contributing to rehospitalization among CHF patients. The methodolgy involved analyzing electronic database for relevant studies published over the past decade. Factors identified as leading to rehospitalization in CHF patients include a history of hypertension, non-compliance with taking medication, and an unhealthy lifestyle. Pharmacists play an important role in providing education to patients and helping to fulfill patient medication compliance.
REVIEW ARTIKEL : UJI EFEK ANTI AGING DARI BERBAGAI EKSTRAK TUMBUHAN SECARA IN VIVO DAN IN VITRO Febriyanti, Triana; Sukohar, Asep; Pardilawati, Citra Yuliyanda; Adjeng, Andi Nafisah Tendri
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1041

Abstract

The outermost and largest organ in our body is the skin. Skin can experience aging when exposed to sunlight. Sunlight contains ultraviolet. Exposure to ultraviolet (UV) radiation causes damage to the skin and can lead to photoaging. Photoaging can be prevented with antioxidant compounds. Many plant extracts or synthetic compounds act as anti-aging agents. These plant extracts become active ingredients that can be formulated into pharmaceutical preparations. Plant extracts that have anti-aging potential include red cabbage, kepok banana peel, red pomegranate, moringa leaves, butterfly pea flower, black cumin seeds and libo fruit. To prove this, a test was carried out. The testing carried out can be in the form of in vivo and in vitro testing methods. This research was carried out using the article review method and obtained several journals from online literature, local journals and international journals, namely electronic searches with the keywords anti-aging, in vitro, in vivo on the website, namely Google Scholar. The number of journals used in this review was 11 journals spanning the last eight years. The results of the article review study showed that several methods used were UV-VIS spectrophotometer, DPPH method, anti-elastase, as well as tests on rats, mice and guinea pigs. From the results of the review of articles on plant extracts, most of them use in vivo tests on experimental animals.
Kejadian Reaksi Obat yang Tidak Diinginkan Asidosis Tubulus Ginjal Pada Penggunaan Ibuprofen Sebagai Obat Over the Counter Alifah, Ghina Nur; Pardilawati, Citra Yuliyanda; Kurniawati, Evi; Sukohar, Asep
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1061

Abstract

Ibuprofen is an analgesic drug that can be obtained easily by patients because it is an over the counter (OTC) drug.  Ibuprofen when used can risk the lives of patients who consume it incorrectly.  Ibuprofen is a drug that causes damage to the kidneys or is nephrotoxic.  In large doses ibuprofen has been reported to cause hypokalemia, rhabdomyolysis and renal tubular acidosis Article searches with data sources from either journals or books with keywords used to facilitate searches. Journal articles used through case reports collect case reports of renal tubular acidosis due to the use of ibuprofen. In some of the case reports found, the use of ibuprofen had exceeded the dose set for OTC treatment. Patients with an average age of 41 years and reports ranged in age from 33 years to 63 years. Female patients has dominated the reported cases. The use of ibuprofen that caused the adverse drug reaction event belongs to type C, which is Chronic for continuous and long-term use of the drug. Non-pharmacological therapy that can be done is diet by limiting acid-producing foods and increasing alkaline-producing foods. Handling carried out on patients can be in the form of fluid resuscitation, electrolyte replacement through alkaline therapy, and supportive therapy according to the patient's clinical condition. Alkaline therapy using NaHCO3 and KHCO3 can be a fluid replacement and correct acidosis and hypokalemia.