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All Journal Majalah Kedokteran Bandung Medula Juke Indonesian Journal of Cancer Jurnal Aplikasi Teknologi Pangan Jurnal Pengabdian Pada Masyarakat Jurnal Aplikasi Teknologi Pangan Jurnal Ilmu Kedokteran dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Jurnal Mandala Pengabdian Masyarakat Jurnal Kesehatan Tambusai MAHESA : Malahayati Health Student Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research JURNAL AGROINDUSTRI HALAL JUSTICIA SAINS: Jurnal Ilmu Hukum Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Sains Medisina JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai BEGAWI: Jurnal Pengabdian Kepada Masyarakat Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Asep Sukohar
Department Of Pharmacology; Faculty Of Medicine; Universitas Lampung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Medula

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daun Daun Salam (Syzygium Polyanthum) Sebagai Penurun Kadar Kolesterol Dalam Darah Aditya Ramadhon Islami Sakaganta; Asep Sukohar
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.146

Abstract

Coronary Heart Disease (CHD) is a major health problem in developed or developing countries. CHD is classified as a degenerative disease related to lifestyle, and socio-economic community. In 2008 it was estimated that 17.3 million deaths were caused by cardiovascular disease. The prevalence of hypercholesterolemia in Indonesia according to riset kesehatan dasar (riskesdas) in 2013 was obtained by Indonesians with higher than normal cholesterol levels higher in women by 39.6% when used with men by 30%. The full scientific bay leaf plant has the Latin name Eugenia polyantha Wight and has another scientific name, namely syzygium polyantha wight and eugenia lucidula miq. This plant belongs to the myrtaceae tribe. Bay leaf contains essential oils of 0.17%, citral, eugenol, tannin, flavonoids, and metal cavikol. Substances that are significant in lowering cholesterol are flavonoids and tannins. How flavonoids work in reducing cholesterol occurs when the hydroxyl group on cholesterol is considered with the ketone group on flavonoids forming hemiasetal. The carbonyl group in flavonoids will choose the hydroxyl group in cholesterol to determine the hydrogen bond. Tannins work quickly in binding and shrinking proteins. Tannin works as an antioxidant, astringent, and hypocholesterolemic. Tanninakan with mucous protein and intestinal epithelial cells so it needs to prevent fat.
Hubungan Antara CT Value pada Test RT-PCR Terhadap Parameter Klinis Pasien COVID-19 Josi Jeremia Manurung; Asep Sukohar
Medula Vol 11 No 1 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i1.190

Abstract

Detection of SARS-CoV-2 by reverse transcription-PCR (RT-PCR) test on nasopharyngeal swab specimens is the main diagnostic method for COVID-19, usually reported qualitatively as positive or negative using a defined cut-off, either based on the CT value. or integrated with an automated algorithm that interprets different parameters of the potential amplification. The CT value was inversely related to the number of viruses in the sample. Consequently, the CT value could indirectly indicate the level of viral replication activity, which affects SAR-CoV-2 infectivity in patients, but this does not differentiate between infectious and non-infectious viruses. Several studies stated that there was no correlation between CT values and severity, in the pneumonia and non-pneumonia groups, symptomatic and asymptomatic patients, the presence or absence of olfactory or tasting dysfunction, as well as on leukocytes, neutrophils, lymphocytes, platelets and C-reactive protein. Many factors that influence the CT value such as the timing of sample collection, method of collection of the sample, the kit used, and the skills of the health worker are biased which can affect the CT value. Further research is needed on the correlation of CT values in COVID-19 patients.
LITERATUR REVIEW: TRIKIASIS Gerliandi, Egi Oktarian; Mustofa, Syazili; Lisiswanti, Rika; Sukohar, Asep
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1008

Abstract

Trichiasis is a pathological disorder characterized by the abnormal growth of eyelashes towards the eyeball, resulting in irritation, pain, and potential harm to the eye. This research utilizes a method of sear Trichiasis is a pathological disorder characterized by the abnormal growth of eyelashes towards the eyeball, resulting in irritation, pain, and potential harm to the eye. The pathophysiology of trichiasis originates with alterations in the structure of the eyelashes and eyelids. Trichiasis is classified into six categories according to the source and location of abnormal eyelash development. The clinical presentation of trichiasis differs according on the extent of the condition. Trichiasis can be diagnosed by assessing the patient's medical history and doing a thorough physical examination. The history encompasses the patient's medical background, record of medication usage, past eye surgical procedures, and the patient's reported symptoms. The physical examination encompasses assessments of visual acuity, biomicroscopic inspection, evaluation of eyelid margins, and the administration of the Schirmer test. The treatment for trichiasis is determined by the extent of eyelash involvement, which includes factors such as the Soft Contact Lense Base Curve. Treatment options may include eyelash removal and surgical procedures, depending on the specific form of trichiasis that the patient is suffering. ching for articles on Google Scholar, PubMed, and NCBI. The search is limited to a specific year range determined by the researcher. The search is conducted using keywords such as trichiasis, etiology of trichiasis, pathophysiology of trichiasis, classification of trichiasis, clinical manifestations of trichiasis, diagnosis of trichiasis, and management of trichiasis. The study's findings revealed that the cause of trichiasis remained unknown, however it was hypothesized to be a result of infection. The pathophysiology of trichiasis originates with alterations in the structure of the eyelashes and eyelids. Trichiasis is classified into six categories according to the source and location of abnormal eyelash development. The clinical presentation of trichiasis differs according on the extent of the condition. Trichiasis can be diagnosed by assessing the patient's medical history and doing a thorough physical examination. The history encompasses the patient's medical background, record of medication usage, past eye surgical procedures, and the patient's reported symptoms. The physical examination encompasses assessments of visual acuity, biomicroscopic inspection, evaluation of eyelid margins, and the administration of the Schirmer test. The treatment for trichiasis is determined by the extent of eyelash involvement, which includes factors such as the Soft Contact Lense Base Curve. Treatment options may include eyelash removal and surgical procedures, depending on the specific form of trichiasis that the patient is suffering.
Literature Review: Faktor-Faktor Penyebab Kejadian Rehospitalisasi Pada Pasien Congestive Heart Failure (CHF) Kylalona, Gracylia; Suri, Nurma; Aulia Ramdini, Dwi; Sukohar, Asep
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1039

Abstract

Congestive Heart Failure (CHF) is a health disorder with a poor prognosis due to functional or structural heart defects that interfere with ventricular filling or blood ejection into the systemic circulation. CHF remains a significant global health concern with high rates of morbidity and mortality. The number of diagnosed CHF leading to frequent rehospitalization or re-admission due to symptom recurrence. Patients who experience readmitted to the hospital after initial admission have a risk of mortality, with about 50% dying within 6 months and 25-35% passing away within 12. In this review focuses on exploring the factors contributing to rehospitalization among CHF patients. The methodolgy involved analyzing electronic database for relevant studies published over the past decade. Factors identified as leading to rehospitalization in CHF patients include a history of hypertension, non-compliance with taking medication, and an unhealthy lifestyle. Pharmacists play an important role in providing education to patients and helping to fulfill patient medication compliance.
REVIEW ARTIKEL : UJI EFEK ANTI AGING DARI BERBAGAI EKSTRAK TUMBUHAN SECARA IN VIVO DAN IN VITRO Febriyanti, Triana; Sukohar, Asep; Pardilawati, Citra Yuliyanda; Adjeng, Andi Nafisah Tendri
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1041

Abstract

The outermost and largest organ in our body is the skin. Skin can experience aging when exposed to sunlight. Sunlight contains ultraviolet. Exposure to ultraviolet (UV) radiation causes damage to the skin and can lead to photoaging. Photoaging can be prevented with antioxidant compounds. Many plant extracts or synthetic compounds act as anti-aging agents. These plant extracts become active ingredients that can be formulated into pharmaceutical preparations. Plant extracts that have anti-aging potential include red cabbage, kepok banana peel, red pomegranate, moringa leaves, butterfly pea flower, black cumin seeds and libo fruit. To prove this, a test was carried out. The testing carried out can be in the form of in vivo and in vitro testing methods. This research was carried out using the article review method and obtained several journals from online literature, local journals and international journals, namely electronic searches with the keywords anti-aging, in vitro, in vivo on the website, namely Google Scholar. The number of journals used in this review was 11 journals spanning the last eight years. The results of the article review study showed that several methods used were UV-VIS spectrophotometer, DPPH method, anti-elastase, as well as tests on rats, mice and guinea pigs. From the results of the review of articles on plant extracts, most of them use in vivo tests on experimental animals.
Kejadian Reaksi Obat yang Tidak Diinginkan Asidosis Tubulus Ginjal Pada Penggunaan Ibuprofen Sebagai Obat Over the Counter Alifah, Ghina Nur; Pardilawati, Citra Yuliyanda; Kurniawati, Evi; Sukohar, Asep
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1061

Abstract

Ibuprofen is an analgesic drug that can be obtained easily by patients because it is an over the counter (OTC) drug.  Ibuprofen when used can risk the lives of patients who consume it incorrectly.  Ibuprofen is a drug that causes damage to the kidneys or is nephrotoxic.  In large doses ibuprofen has been reported to cause hypokalemia, rhabdomyolysis and renal tubular acidosis Article searches with data sources from either journals or books with keywords used to facilitate searches. Journal articles used through case reports collect case reports of renal tubular acidosis due to the use of ibuprofen. In some of the case reports found, the use of ibuprofen had exceeded the dose set for OTC treatment. Patients with an average age of 41 years and reports ranged in age from 33 years to 63 years. Female patients has dominated the reported cases. The use of ibuprofen that caused the adverse drug reaction event belongs to type C, which is Chronic for continuous and long-term use of the drug. Non-pharmacological therapy that can be done is diet by limiting acid-producing foods and increasing alkaline-producing foods. Handling carried out on patients can be in the form of fluid resuscitation, electrolyte replacement through alkaline therapy, and supportive therapy according to the patient's clinical condition. Alkaline therapy using NaHCO3 and KHCO3 can be a fluid replacement and correct acidosis and hypokalemia.
Review Article: Tatalaksana Hipertensi Pada Kehamilan Santika, Mesi; Oktafany, Oktafany; Damayanti, Ervina; Sukohar, Asep
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1090

Abstract

Hypertension is an increase in blood pressure exceeds normal limits i.e. blood pressure ≥140/90 mmHg. Hypertension in pregnancy consists of four categories, namely preeclampsia/eclampsia, chronic hypertension, superimposed preeclampsia with chronic hypertension and gestational hypertension. Hypertension in pregnancy should be managed appropriately to reduce maternal and fetal morbidity and mortality rate, i.e. by preventing women from getting the risks of increased blood pressure, preventing disease progression and preventing the development of seizure and considering termination of pregnancy in life threatening situation for maternal and fetal health. The purpose of this literature review is to determine the management of hypertension in pregnancy. The method used is a literature review, i.e. by searching for both international and national literature using the google scholar and pubmed databases with the keyword "Management of hypertension in pregnancy". There are two categories of antihypertensive drug use in pregnancy, i.e. antihypertensive drugs that can be safely used in pregnancy and antihypertensive drugs to avoid in pregnancy. Antihypertensive drugs that are safe to use are labetalol, nifedipine, methyldopa, hydralazine, magnesium sulfate and prazosin. Antihypertensive drugs that should be avoided are angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, diuretic, beta blocker (except labetalol) and calcium-channel blocker (except nifedipine and diltiazem).
Potensi Beberapa Tumbuhan Sebagai Anti Inflamasi di Indonesi Mutiara, Sephia Aruma; Damayanti, Ervina; Wardhana, M. Fitra; Sukohar, Asep
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1096

Abstract

Inflammation is a biological response of the immune system that can be triggered by various factor including pathogens, physical trauma and toxic compounds. Prolonged consumption of NSAID as an anti-inflammatory can caused some serious side effects for the body. As a result, many people has switched to using plants as therapy. Another reason for choosing therapy with plants is more affordable, as well as family traditions trust in the efficacy of a plant. The purpose of this review article is to provide information about several medicinal plants that have anti-inflammatory  activity. The method in this study was a systematic literature review which is traced through database, Google Scholar and Pubmed. The literature used was published in 2019 to 2024 and 11 journals were obtained as primary data. Some plants studied as anti-inflammatory are red spinach (Amarathus tricolor L.), Beligo (Benincasa hispida (Thunb.) Cogn.), Pineapple (Ananas Comosus (L.) Merr.), Kecapi (Sandoricum koetjape (Burm.f. ) Merr., Sesewanua (Clerodendrum squamatum Vahl.), Turmeric (Curcuma domestica Val.), Aloe vera (Aloe vera L), Tamarind (Tamarindus indica L.), Green grass jelly (Cyclea barbata Miers.) and Galangal (Kaempferia galangal L.). In research on the anti-inflammatory activity of several plants studied, it was proven to be able to improve several inflammatory parameters, but at different doses because it depended on the response of the test animals and the secondary metabolite content of each plant.
Association Of Triple Negative Breast Cancer (TNBC) With BRCA-1 Mutation And Ethnicity Permana, Km. Allan Wahyu; Permana, M. Agung Yudistira; Nisa, Sayyidatun; Sukohar, Asep
Medula Vol 9 No 3 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i3.1109

Abstract

Breast cancer is the most common cancer suffered by women in the world, 15-20% is a subtype of triple negative breast cancer (TNBC). TNBC is a subtype of breast cancer that does not express genes for estrogen receptors (ER), progesterone receptors (PR) and HER2 overexpression, which is clinically more aggressive and unresponsive to standard therapy, thus it can worsen the prognosis. It suggests that TNBC is associated with BRCA-1 gene mutation, moreover in African-Americans. So this study aims to determine the association of TNBC with BRCA-1 gene mutation and ethnicity. International journal literature review. BRCA-1 gene mutations increased 45%-85% of the risk of breast cancer growth and 15% -25% of TNBC have BRCA-1 gene mutations which resulted in activation inefficiencies of the HR DNA repair pathway. TNBC occurred in 60% of the black race, disproportionate incidence of TNBC greater in African ethnicity compared to other ethnic groups in the world and has the worst prognosis among all races. There is asignificant association between TNBC with BRCA-1 gene mutations and ethnicity especially in African-Americans.
Terapi Non-Farmakologi pada Pasien Insomnia: A Literature Review Putri, Meilani; Daulay, Suryani Agustina; Carolia, Novita; Sukohar, Asep
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1262

Abstract

Insomnia is a condition characterized by difficulty initiating sleep despite having adequate time and opportunity. Globally, the majority of insomnia sufferers are women, with approximately 10% of the world’s population estimated to experience severe insomnia. The management of insomnia typically begins with the principles of Consultation, Information, and Education (CIE). In cases of severe insomnia, further intervention often involves pharmacological therapy through medication. The primary class of drugs prescribed for insomnia patients generally belongs to the benzodiazepine group, which acts as a central nervous system depressant, muscle relaxant, and sedative. However, pharmacological treatment should always be complemented with non-pharmacological therapy. Notably, non-pharmacological interventions serve as the first-line treatment for patients with mild to moderate insomnia. This review article aims to evaluate the effectiveness of various non-pharmacological therapies for managing insomnia, which is recognized as the most prevalent sleep disorder worldwide. The literature review was conducted by searching databases such as PubMed, Google Scholar, and ScienceDirect using the keywords “Insomnia,” “Therapy,” and “Non-Pharmacological.” Based on the search results, seven relevant articles were selected for review. The findings from these studies indicate that effective non-pharmacological interventions for insomnia management include Cognitive Behavioral Therapy for Insomnia (CBT-I), hypnotherapy, audiovisual stimulation, aerobic and endurance exercises, acupuncture, and Pre-Sleep Dim Light Therapy (LT).
Co-Authors Aditya Ramadhon Islami Sakaganta Afriyana, Regi Afriyani Afriyani Aghesna Rahmatika Kesuma Ahmad Fitri, Ahmad Akbar, Muhammad Zakky Putra Ali, Nur Fitriana Muhammad Alifah, Ghina Nur Ambarwati, Endah Aminuyati Andi Nafisah Andi Nafisah, Andi Anisa Nuraisa Jausal Anita Febrina, Anita Arianti, Tanti Arief B Witarto Ariyati, Retno Desy Arli Suryawinata Arli Suryawinata Arsyad Sobby Kesuma Aulia Ramdini, Dwi Aulian Mediansyah Bainah Sari Dewi Betta Kurniawan, Betta Christine Wulandari Damayanti, Ervina Daulay, Suryani Agustina Dharmesti, Rizky Aleyda Dyah Indriana Kusumastuti Elisa, Syavira Endah Ambarwati Endah Setyaningrum, Endah Endro Prasetyo Wahono Fala, Arzety Rifda Febriyanti, Triana Fibra Nurainy Fitria Saftarina Fredison, Fredison Gerliandi, Egi Oktarian Hanna Mutiara, Hanna Hardito, Joni Hatimi, Fahmi Ilham Hendra Tarigan Sibero HENING HERAWATTI, HENING Herri S. Sastramihardja Ida Nurhaida Ihsanti Dwi Rahayu Indri Windarti Jausal, Anisa Nuraisa Josi Jeremia Manurung Junando, Mirza Karima, Nisa Kaskoyo, Hari Kurniawaty, Evi Kylalona, Gracylia L.P, Eka Ananda LP, Eka Ananda Mallarangeng, Andi Nafisah Tendri Adjeng Mediansyah, Aulian Morfi, Chicy Widya Muhammad Fitra Wardhana Sayoeti Muhammad Iqbal Muhammad Iqbal Ramadhan Muhartono Muhartono Muhartono Muhartono Muhartono Mukhlis Imanto Mutiara, Sephia Aruma Nisa, Sayyidatun Noverman Duadji Noviani, Erina Novita Carolia Novita Herdiana Novita Tresiana NUR AFRIYANI Nurmasuri, Nurmasuri Oktafany, Oktafany Oktoba, Zulpakor Pardilawati, Citra Yuliyanda Permana, Km. Allan Wahyu Permana, M. Agung Yudistira Puteri, Vadiyani Fricillya Putri Idrus, Indrayati Putri, Asyifa Adinda Putri, Meilani Putri, Meilani Dwi Putri, Oka Mahila Gustia Ramadhan Triyandi Ramadhina, Farrasyifa Ramdini, Dwi Aulia Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Ratna, Maya Ganda Rika Lisiswanti Rizqa Atina Safitri, Nara Said, Feriany Salam, Deby Mipa Samsu Udayana Nurdin Samsu Udayana Nurdin Samsul Bakri Samsul Rizal Santika, Mesi Sepriyadi Adhan S Setiawan, Gigih Shinta Mayasari Slamet Budi Yuwono Sofyan Musabiq Wijaya Sofyan Musyabiq Wijaya Subeki Suharmanto Suharyani Suharyani Suharyani Sumekar, Diyah Suri, Nurma Suryadi Islami Suryawinata, Arli Sutarto Sutarto Sutarto Sutarto Syazili Mustofa Thahir, Salsabila Anggraini Trijayanthi, Winda Triyandi, Ramadhan Wahdah, Annisa Shohifatul Wardani, Farah Dwi Wardhana S, Muhammad Fitra Wardhana, M. Fitra Wijaya, Sofyan Wijaya, Sofyan Musabiq Winda Trijayanthi Utama, Winda Trijayanthi WS, Muhammad Fitra Yofita Sulfiana Sundari Zeta, Nathasya Karren