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All Journal Majalah Kedokteran Bandung Medula Juke Indonesian Journal of Cancer Jurnal Aplikasi Teknologi Pangan Jurnal Pengabdian Pada Masyarakat Jurnal Aplikasi Teknologi Pangan Jurnal Ilmu Kedokteran dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Jurnal Mandala Pengabdian Masyarakat Jurnal Kesehatan Tambusai MAHESA : Malahayati Health Student Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research JURNAL AGROINDUSTRI HALAL JUSTICIA SAINS: Jurnal Ilmu Hukum Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Sains Medisina JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai BEGAWI: Jurnal Pengabdian Kepada Masyarakat Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Asep Sukohar
Department Of Pharmacology; Faculty Of Medicine; Universitas Lampung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Potensi Beberapa Tumbuhan Sebagai Anti Inflamasi di Indonesi Mutiara, Sephia Aruma; Damayanti, Ervina; Wardhana, M. Fitra; Sukohar, Asep
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1096

Abstract

Inflammation is a biological response of the immune system that can be triggered by various factor including pathogens, physical trauma and toxic compounds. Prolonged consumption of NSAID as an anti-inflammatory can caused some serious side effects for the body. As a result, many people has switched to using plants as therapy. Another reason for choosing therapy with plants is more affordable, as well as family traditions trust in the efficacy of a plant. The purpose of this review article is to provide information about several medicinal plants that have anti-inflammatory  activity. The method in this study was a systematic literature review which is traced through database, Google Scholar and Pubmed. The literature used was published in 2019 to 2024 and 11 journals were obtained as primary data. Some plants studied as anti-inflammatory are red spinach (Amarathus tricolor L.), Beligo (Benincasa hispida (Thunb.) Cogn.), Pineapple (Ananas Comosus (L.) Merr.), Kecapi (Sandoricum koetjape (Burm.f. ) Merr., Sesewanua (Clerodendrum squamatum Vahl.), Turmeric (Curcuma domestica Val.), Aloe vera (Aloe vera L), Tamarind (Tamarindus indica L.), Green grass jelly (Cyclea barbata Miers.) and Galangal (Kaempferia galangal L.). In research on the anti-inflammatory activity of several plants studied, it was proven to be able to improve several inflammatory parameters, but at different doses because it depended on the response of the test animals and the secondary metabolite content of each plant.
Association Of Triple Negative Breast Cancer (TNBC) With BRCA-1 Mutation And Ethnicity Permana, Km. Allan Wahyu; Permana, M. Agung Yudistira; Nisa, Sayyidatun; Sukohar, Asep
Medula Vol 9 No 3 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i3.1109

Abstract

Breast cancer is the most common cancer suffered by women in the world, 15-20% is a subtype of triple negative breast cancer (TNBC). TNBC is a subtype of breast cancer that does not express genes for estrogen receptors (ER), progesterone receptors (PR) and HER2 overexpression, which is clinically more aggressive and unresponsive to standard therapy, thus it can worsen the prognosis. It suggests that TNBC is associated with BRCA-1 gene mutation, moreover in African-Americans. So this study aims to determine the association of TNBC with BRCA-1 gene mutation and ethnicity. International journal literature review. BRCA-1 gene mutations increased 45%-85% of the risk of breast cancer growth and 15% -25% of TNBC have BRCA-1 gene mutations which resulted in activation inefficiencies of the HR DNA repair pathway. TNBC occurred in 60% of the black race, disproportionate incidence of TNBC greater in African ethnicity compared to other ethnic groups in the world and has the worst prognosis among all races. There is asignificant association between TNBC with BRCA-1 gene mutations and ethnicity especially in African-Americans.
Protein Digestibility and Protein Efficiency Ratio of Herbal Rice by Rats Given High Fat Diet Fitri, Ahmad; Nurdin, Samsu Udayana; Sukohar, Asep; Subeki; Rizal, Samsul
JURNAL AGROINDUSTRI HALAL Vol. 9 No. 2 (2023): Jurnal Agroindustri Halal 9(2)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/jah.v9i2.8239

Abstract

Herbal rice made from white rice by adding a mixture of turmeric, cinnamon and guava leaves during cooking, reducing cholesterol levels in hypercholesterolemia. This study was aims to evaluate the protein digestibility and protein efficiency ratio of herbal rice by rats given high fat diet. This study used 28 male Spangue dawley rats aged 12 weeks divided into four treatment groups (7 rats per group). The control group (P0) was given standard diet AIN-76 without high fat diet induction, the treatment group (P1) was containing plain rice flour with high fat diet induction, the treatment group (P2) was containing cooked rice flour 1 bag of mixed herbs with high fat diet induction, and the treatment group (P3) was containing cooked rice flour 2 bags of herbal mixture with high fat diet induction. The results showed that the body weight of each rat treatment group increased during the 28 days of the experiment. The type of ration given had a significant effect (p<0.05) on the value of protein digestibility, but had no significant effect (p<0.05) on the value of the protein efficiency ratio (PER). Result evaluation of body weight, protein digestibility and PER of herbal rice obtained, it can be concluded that herbal rice has better protein quality than plain white rice.
Tinjauan Hukum Strategi Optimalisasi Kebijakan untuk Mengatasi Tantangan Dalam Pengelolaan Limbah Padat Medis Said, Feriany; Wulandari, Christine; Bakri, Samsul; Sukohar, Asep; Sumekar, Diyah
JUSTICIA SAINS - Jurnal Ilmu Hukum Vol 9, No 2 (2024): JUSTICIA SAINS: Jurnal Ilmu Hukum
Publisher : Universitas Sang Bumi Ruwa Jurai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24967/jcs.v9i2.3167

Abstract

Solid medical waste management is a crucial issue in the health system. RSUD Menggala of Tulang Bawang Regency is responsible for ensuring orderly and efficient waste management. However, challenges in solid medical waste management often arise, including limited resources and policy changes. A qualitative approach was used as a way to conduct descriptive research, and it was found that Menggala Regional Hospital has not fully complied with regulations according to Permenkes RI Number 7 of 2019 concerning Hospital Environment. Some optimisation strategies that can be proposed include increasing awareness, strengthening resources, strict supervision, external cooperation, and increasing HR capacity. With the right steps, RSUD Menggala can ensure regulatory compliance, reduce environmental risks, and improve patient and health worker safety. This research serves as a basis for RSUD Menggala in formulating more effective policies in solid medical waste management
BNPB Performance in Disaster Management in Indonesia: Follow-up Recommendations Mayasari, Shinta; Wulandari, Christine; Sukohar, Asep; Bakri, Samsul
JUSTICIA SAINS - Jurnal Ilmu Hukum Vol 9, No 2 (2024): JUSTICIA SAINS: Jurnal Ilmu Hukum
Publisher : Universitas Sang Bumi Ruwa Jurai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24967/jcs.v9i2.3188

Abstract

Law Number 24 of 2007 concerning Disaster Management is the main legal basis for disaster management in Indonesia. BNPB as one of its products has the functions of prevention, preparedness, emergency response, as well as disaster rehabilitation and reconstruction. A qualitative narrative approach was used to analyze BNPB's performance and produce follow-up recommendations. Its effectiveness also still varies due to differences in potential and challenges in various regions in Indonesia. A number of follow-up recommendations are provided in this article to improve BNPB's performance in disaster management in Indonesia. BNPB's performance in recent years has been quite good and needs to be appreciated. BNPB has succeeded in reducing the trend in the number of fatalities due to disasters, but it needs to improve in SPD technology through the CSR program. BNPB has succeeded in establishing Destana, but needs to look for more fundings such as from village fund allocations and encourage disaster education as local content in school curriculum. BNPB's performance in its emergency response has not optimal, overlapping regulations between the central and regional governments needs to be clarified. Meanwhile, disaster rehabilitation and reconstruction performance is more focused on short-term infrastructure and economic recovery. BNPB can coordinate with health services provided by BPJS Health which provides psychological and mental health services for long-term recovery of the social and psychological aspects of disaster victims.
Analisis Hukum Implementasi Kebijakan Terkait Pencemaran Udara Dalam Upaya Mitigasi Penyakit Infeksi Kesuma, Aghesna Rahmatika; Wulandari, Christine; Bakri, Samsul; Sukohar, Asep; Kesuma, Arsyad Sobby
JUSTICIA SAINS - Jurnal Ilmu Hukum Vol 9, No 2 (2024): JUSTICIA SAINS: Jurnal Ilmu Hukum
Publisher : Universitas Sang Bumi Ruwa Jurai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24967/jcs.v9i2.3156

Abstract

Environmental protection is becoming increasingly important in the face of the negative impact on human health. This article reviews the role of living environmental laws in regulating environmental pollution to prevent the spread of infectious diseases. Air pollution can cause many infectious diseases that are dangerous to the community. International regulations such as the Stockholm Convention as well as national laws such as Law No. 32 of 2009 in Indonesia, and are linked to the Omnibus Law on Job Creation No. 11 of 2020 thus providing a framework for controlling pollutants and mitigating the risk of disease infection. Case studies show how violations of the environmental laws have caused an outbreak of infectious diseases in a region. Measures such as tighter law enforcement, to maintain a safe and healthy environment, the use of environmentally friendly technologies and raising public awareness are needed. With proper implementation, habitat legislation can be an effective instrument in preventing the spread of infectious diseases through environmental pollution
Terapi Non-Farmakologi pada Pasien Insomnia: A Literature Review Putri, Meilani; Daulay, Suryani Agustina; Carolia, Novita; Sukohar, Asep
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1262

Abstract

Insomnia is a condition characterized by difficulty initiating sleep despite having adequate time and opportunity. Globally, the majority of insomnia sufferers are women, with approximately 10% of the world’s population estimated to experience severe insomnia. The management of insomnia typically begins with the principles of Consultation, Information, and Education (CIE). In cases of severe insomnia, further intervention often involves pharmacological therapy through medication. The primary class of drugs prescribed for insomnia patients generally belongs to the benzodiazepine group, which acts as a central nervous system depressant, muscle relaxant, and sedative. However, pharmacological treatment should always be complemented with non-pharmacological therapy. Notably, non-pharmacological interventions serve as the first-line treatment for patients with mild to moderate insomnia. This review article aims to evaluate the effectiveness of various non-pharmacological therapies for managing insomnia, which is recognized as the most prevalent sleep disorder worldwide. The literature review was conducted by searching databases such as PubMed, Google Scholar, and ScienceDirect using the keywords “Insomnia,” “Therapy,” and “Non-Pharmacological.” Based on the search results, seven relevant articles were selected for review. The findings from these studies indicate that effective non-pharmacological interventions for insomnia management include Cognitive Behavioral Therapy for Insomnia (CBT-I), hypnotherapy, audiovisual stimulation, aerobic and endurance exercises, acupuncture, and Pre-Sleep Dim Light Therapy (LT).
KAJIAN LITERATUR : FAKTOR-FAKTOR YANG MEMENGARUHI KEBERHASILAN TERAPI PASIEN TUBERKULOSIS PARU Putri, Oka Mahila Gustia; Oktarlina, Rasmi Zakiah; Suri, Nurma; Sukohar, Asep
Jurnal Kesehatan Tambusai Vol. 6 No. 1 (2025): MARET 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i1.42725

Abstract

Tuberkulosis paru merupakan penyakit infeksi yang masih menjadi tantangan kesehatan global dengan angka kesembuhan yang belum mencapai target pemerintah sebesar 90%. Keberhasilan terapi pasien dipengaruhi oleh berbagai faktor termasuk karakteristik individu, dukungan keluarga, serta peran tenaga kesehatan. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang memengaruhi keberhasilan terapi tuberkulosis paru melalui kajian literatur yang diperoleh dari Google Scholar dengan kata kunci “keberhasilan terapi pasien tuberkulosis paru”. Seleksi artikel dilakukan berdasarkan kriteria inklusi dan eksklusi yang telah ditetapkan, dari 14.200 artikel yang ditemukan diseleksi kembali hingga diperoleh 10 artikel yang relevan. Hasil kajian menunjukkan beberapa faktor utama yang berkontribusi terhadap keberhasilan terapi pasien meliputi sosiodemografi, pengetahuan, sikap, motivasi, kepatuhan dalam mengonsumsi obat, keteraturan pengobatan, peran pengawas minum obat, dukungan keluarga, dukungan tenaga kesehatan serta kategori pengobatan.
Infeksi Cryptosporidium pada Manusia: Patogenesis, Diagnosis dan Terapi Hatimi, Fahmi Ilham; Mutiara, Hanna; Islami, Suryadi; Sukohar, Asep
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1261

Abstract

Cryptosporidium is a zoonotic protozoan parasite capable of infecting humans and animals, primarily transmitted through contaminated water or food. This infection is a leading cause of moderate to severe diarrhea, particularly in children from low-income regions and immunocompromised individuals, contributing to significant global morbidity and mortality. The pathogenesis of Cryptosporidium involves the invasion of intestinal epithelial cells, resulting in mucosal damage, villous atrophy, and increased intestinal permeability, leading to watery diarrhea. Local inflammatory responses exacerbate symptoms, while immunocompromised individuals often experience chronic infections with serious complications. Diagnosis relies on microscopy, immunofluorescence, and molecular techniques such as PCR, which offer high sensitivity and specificity. Supportive care is the mainstay of treatment, with nitazoxanide being the preferred therapeutic option for selected patients. For immunocompromised individuals, management is more complex and may involve immune restoration therapies, such as antiretroviral treatment for HIV/AIDS patients. However, resistance to conventional treatments remains a significant challenge, necessitating further research into novel therapeutic agents, such as KDU731, which has shown promising efficacy in preliminary studies. This review provides a comprehensive analysis of the pathogenesis, diagnostic methods, and therapeutic strategies for Cryptosporidium infections. Additionally, it highlights the importance of prevention measures, including improved access to clean water and public health education. Enhanced control efforts are crucial to mitigating the global health impact of this infection, particularly among vulnerable populations such as children and immunocompromised individuals.
Article Review: Analisis Kuantitatif Penggunaan Antibiotik Pada Pediatrik Di Indonesia Menggunakan ATC/DDD Thahir, Salsabila Anggraini; Junando, Mirza; Pardilawati, Citra Yuliyanda; Sukohar, Asep
Sains Medisina Vol 3 No 5 (2025): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v3i5.739

Abstract

Penggunaan antibiotik yang tidak tepat menjadi salah faktor pendorong utama terjadinya resistensi yang saat ini masih menjadi ancaman kesehatan global yang semakin mendesak. Di Indonesia, data mengenai pola penggunaan antibiotik pada anak masih terbatas. Di negara berkembang diperkirakan terdapat 30-80% kasus infeksi yang mendapatkan perawatan dengan antibiotik di rumah sakit dan 20-65% penggunaan antibiotik tersebut dinilai kurang tepat. Di Indonesia, sebagai negara dengan populasi besar dan beragam, tantangan dalam mengendalikan penggunaan antibiotik menjadi lebih kompleks, terutama pada populasi pediatri yang rentan. Literature review ini bertujuan untuk mengkaji secara komprehensif literatur yang ada terkait penggunaan metode ATC/DDD sebagai pilihan yang paling banyak digunakan dalam evaluasi kuantitatif penggunaan antibiotik pada pasien pediatri di Indonesia. Metode yang digunakan dalam menyusun articel review ini adalah metode tinjauan pustaka pada artikel yang terbit dalam 10 tahun terakhir dan telah memenuhi kriteria. Dari tinjauan literatur ini, ditemukan bahwa seftriakson, ampisilin, amoksisilin, dan kombinasi ampisilin-sulbaktam merupakan antibiotik yang paling sering diresepkan pada populasi pediatri di Indonesia. Pola peresepan dan penggunaan, serta total konsumsi antibiotik, menunjukkan variabilitas di beberapa fasilitas pelayanan kesehatan yang dikaji. Metode ATC/DDD terbukti menjadi alat yang berguna untuk menganalisis dan membandingkan penggunaan antibiotik secara kuantitatif.
Co-Authors Aditya Ramadhon Islami Sakaganta Afriyana, Regi Afriyani Afriyani Aghesna Rahmatika Kesuma Ahmad Fitri, Ahmad Akbar, Muhammad Zakky Putra Ali, Nur Fitriana Muhammad Alifah, Ghina Nur Ambarwati, Endah Aminuyati Andi Nafisah Andi Nafisah, Andi Anisa Nuraisa Jausal Anita Febrina, Anita Arianti, Tanti Arief B Witarto Ariyati, Retno Desy Arli Suryawinata Arli Suryawinata Arsyad Sobby Kesuma Aulia Ramdini, Dwi Aulian Mediansyah Bainah Sari Dewi Betta Kurniawan, Betta Christine Wulandari Damayanti, Ervina Daulay, Suryani Agustina Dharmesti, Rizky Aleyda Dyah Indriana Kusumastuti Elisa, Syavira Endah Ambarwati Endah Setyaningrum, Endah Endro Prasetyo Wahono Fala, Arzety Rifda Febriyanti, Triana Fibra Nurainy Fitria Saftarina Fredison, Fredison Gerliandi, Egi Oktarian Hanna Mutiara, Hanna Hardito, Joni Hatimi, Fahmi Ilham Hendra Tarigan Sibero HENING HERAWATTI, HENING Herri S. Sastramihardja Ida Nurhaida Ihsanti Dwi Rahayu Indri Windarti Jausal, Anisa Nuraisa Josi Jeremia Manurung Junando, Mirza Karima, Nisa Kaskoyo, Hari Kurniawaty, Evi Kylalona, Gracylia L.P, Eka Ananda LP, Eka Ananda Mallarangeng, Andi Nafisah Tendri Adjeng Mediansyah, Aulian Morfi, Chicy Widya Muhammad Fitra Wardhana Sayoeti Muhammad Iqbal Muhammad Iqbal Ramadhan Muhartono Muhartono Muhartono Muhartono Muhartono Mukhlis Imanto Mutiara, Sephia Aruma Nisa, Sayyidatun Noverman Duadji Noviani, Erina Novita Carolia Novita Herdiana Novita Tresiana NUR AFRIYANI Nurmasuri, Nurmasuri Oktafany, Oktafany Oktoba, Zulpakor Pardilawati, Citra Yuliyanda Permana, Km. Allan Wahyu Permana, M. Agung Yudistira Puteri, Vadiyani Fricillya Putri Idrus, Indrayati Putri, Asyifa Adinda Putri, Meilani Putri, Meilani Dwi Putri, Oka Mahila Gustia Ramadhan Triyandi Ramadhina, Farrasyifa Ramdini, Dwi Aulia Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Ratna, Maya Ganda Rika Lisiswanti Rizqa Atina Safitri, Nara Said, Feriany Salam, Deby Mipa Samsu Udayana Nurdin Samsu Udayana Nurdin Samsul Bakri Samsul Rizal Santika, Mesi Sepriyadi Adhan S Setiawan, Gigih Shinta Mayasari Slamet Budi Yuwono Sofyan Musabiq Wijaya Sofyan Musyabiq Wijaya Subeki Suharmanto Suharyani Suharyani Suharyani Sumekar, Diyah Suri, Nurma Suryadi Islami Suryawinata, Arli Sutarto Sutarto Sutarto Sutarto Syazili Mustofa Thahir, Salsabila Anggraini Trijayanthi, Winda Triyandi, Ramadhan Wahdah, Annisa Shohifatul Wardani, Farah Dwi Wardhana S, Muhammad Fitra Wardhana, M. Fitra Wijaya, Sofyan Wijaya, Sofyan Musabiq Winda Trijayanthi Utama, Winda Trijayanthi WS, Muhammad Fitra Yofita Sulfiana Sundari Zeta, Nathasya Karren