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All Journal VALENSI Medali Jurnal : Media Dental Intelektual Dentika Dental Journal Jurnal Teknosains The Indonesian Journal of Dental Research Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Material Kedokteran Gigi Jurnal Abdi Masyarakat Indonesia JURNAL PENGABDIAN PENDIDIKAN MASYARAKAT (JPPM) Odonto dental journal Journal Center of Excellent : Health Assistive Technology (CoE)

Siti Sunarintyas

Universitas Gadjah Mada, Daerah Istimewa Yogyakarta, Indonesia

Author-ID : 392662

Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Pengaruh Implantasi Subkutan Logam Kobalt Kromium sebagai Bahan Alternatif Mini Screw Orthodontics terhadap Reaksi Jaringan Kelinci Albino Ananto Ali Alhasyimi; Siti Sunarintyas; Marsetyawan HNE Soesatyo
Majalah Kedokteran Gigi Indonesia Vol 1, No 1 (2015): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Mini screw orthodontics merupakan alat yang digunakan dalam perawatan ortodonsia untuk kasus yang membutuhkan absolute anchorage. Mini screw yang tersedia terbuat dari logam nikel titanium atau stainless steel yang pada beberapa pasien menyebabkan reaksi pada jaringan. Uji implantasi adalah uji yang dilakukan untuk menentukan biokompatibilitas medical device yang berkontak langsung dengan jaringan hidup. Respon jaringan terhadap jejas pasca implantasimempengaruhi derajat pembentukan jaringan granulasi, reaksi benda asing, dan fibrosis. Penelitian ini bertujuan untuk mengetahui efek lokal implantasi kobalt kromium sebagai alternatif bahan mini screw orthodontics terhadap jaringan subkutan kelinci albino. Subjek penelitian berupa 20 ekor kelinci jantan albino yang digunakan untuk 2 kelompok(perlakuan dan kontrol negatif). Kobalt kromium dibuat lempengan diameter 10 mm dan ketebalan 1 mm. Pada kelompok perlakuan, material diimplankan pada jaringan subkutan dorsum kelinci dengan insisi sampai terbentuk poket subkutan, dasar poket tidak lebih dari 10 mm dari garis awal insisi dan dilakukan suturing. Kelompok kontrol hanya dilakukanincisi kemudian disuturing. Secara makroskopis 24 jam pasca implantasi, daerah implan diamati terjadinya edema, hematoma, enkapsulasi dan tanda-tanda inflamasi. Evaluasi secara mikroskopis pada hari ke 14 pasca implantasi, diamati perubahan histopatologis infiltrasi sel-sel inflamasi, kemudian rerata hasil diuji dengan uji independent samplet-test untuk mengetahui apakah ada perbedaan jumlah sel-sel inflamasi pada kelompok perlakuan dan kontrol. Hasil pengamatan makroskopis, kelompok perlakuan maupun kontrol hanya terlihat tanda inflamasi ringan berupa eritema. Rerata dan Simpangan baku jumlah PMN, limfosit, sel plasma, makrofag, giant cell, neovaskularisasi, fibrosis kobalt kromium dan kontrol berturut turut yaitu (0,6 ± 0,49; 0,7 ± 0,48); (0,9 ± 0,87; 1,0 ± 0,67); (0,6 ± 0,24; 0,6 ± 0,21); (1,4 ± 0,84; 0,9 ± 0,74); (0,5 ± 0,27; 0); (0,6 ± 0,33; 0,7 ± 0,48); (0,5 ± 0,27; 0,1 ± 0,02). Hasil t-test menunjukkan perbedaan yang tidak signifikan (p>0,05) pada 6 parameter inflamasi sedangkan parameter giant cell menunjukkan perbedaan yang signifikan (p<0,05). Kesimpulan penelitian ini adalah implantasi subkutan logam kobalt kromium menyebabkan reaksi jaringan berupa infiltrasi giant cell selama 14 hari pasca implantasi sebagai respon tehadap benda asing. Effect Of Subcutaneous Implantation Of Cobalt Chromium As An Alternative Material For Mini Screw Orthodontics Against Albino Rabbit’s Tissue. Mini screw orthodontics is an instrument which is used in orthodontic treatment for some cases that require absolute anchorage. Available mini screws are made of nickel titanium or stainless steel alloy which in some patients may cause a reaction to the tissues. Implantation test is a test performed to determine the biocompatibility of medical devices that are directly contacted to the living tissue. Tissue response to injury after implantation affects the degree of formation of granulation tissue, foreign body reaction, and fibrosis. The aim of this study is to determine the local effect of implantation of cobalt chromium as an alternative material for mini screw orthodontic against the subcutaneous tissue of albino rabbits. The subjects of study were 20 male albino rabbits divided into two groups (treatment and negative control groups). Cobalt chromium was made in the form of discs with 10 mm in diameter and 1 mm in thickness. In the treatment group, the material was implanted in the subcutaneous tissue of the dorsum of the rabbits with an incision to form a subcutaneous pocket. The pocket base was not more than 10 mm from the initial line of incision then suturing was performed. The control group only had incision then sutured to maintain aseptic conditions. Macroscopically 24 hours after implantation, the implant area was observed related to the occurrence of oedema, haematoma, encapsulation and signs of inflammation. The evaluation on day 14 post-implantation shows the histopathologic changes observed by the infiltration of inflammatory cells types. The average of the results was analyzed using independent sample t-test. The results of the macroscopic observation shows that the treatment and control group were only seen of mild inflammatory signs included erythema. The mean and standard deviation of the amount of PMN, lymphocyte, plasma cells, macrophage, giant cell, neovascularisation, and fibrosis from cobalt chromium and control groups were (0.6 ± 0.49; 0.7 ± 0.48); (0.9 ± 0.87; 1.0 ± 0.67); (0.6 ± 0.24; 0.6 ± 0.21); (1.4 ± 0.84; 0.9 ± 0.74); (0.5 ± 0.27; 0); (0.6 ± 0.33; 0.7 ± 0.48); (0.5 ± 0.27; 0.1 ± 0.02). The results of t-test show a significant difference in giant cell (p<0.05), while the six others did not (p>0.05). The conclusion of this study is that the cobalt chromium alloy can affect the subcutaneous tissue by inducing giant cell infiltration on day 14 post-implantation as the result of foreign body reactions.

Pengaruh Jenis dan Volumetrik Fiber terhadap Kekuatan Transversal Reparasi Plat Resin Akrilik Pramudya Aditama; Siti Sunarintyas; Widjijono Widjijono
Majalah Kedokteran Gigi Indonesia Vol 1, No 1 (2015): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Resin akrilik merupakan bahan yang sering digunakan dalam pembuatan basis gigi tiruan. Kelemahan resin akrilik adalah mudah patah. Salah satu cara untuk mengatasi masalah tersebut adalah dengan menambahkan polyethylene (PE) atau glass fiber. Tujuan dari penelitian ini untuk mengetahui pengaruh jenis dan volumetrik fiber terhadap kekuatan transversal reparasi plat resin akrilik. Penelitian ini menggunakan dua puluh lima plat resin akrilik kuring panas berukuran 65 x 10 x 2,5 mm. Subjek dipreparasi untuk membuat jarak 3 mm dan sudut bevel 45o. Subjek dibagi menjadi 5 kelompok, masingmasing kelompok terdiri dari 5 subjek. Kelompok 1 (kontrol) tanpa penambahan fiber, kelompok II dengan penambahan 3,7% v/v PE fiber, kelompok III dengan penambahan 7,4% v/v PE fiber, kelompok IV dengan penambahan 3,7% v/v E-glass fiber, dan kelompok V dengan penambahan 7,4% v/v E-glass fiber. Seluruh plat direndam dalam air destilasi selama satu hari pada suhu 37oC. Pengujian kekuatan transversal plat resin akrilik dengan menggunakan Universal Testing Machine dan data yang didapat dianalisis menggunakan ANAVA dua jalur dengan tingkat kepercayaan 95%. Rerata kekuatan transversal (MPa) reparasi plat resin akrilik yang diperkuat fiber: 3,7% v/v PE fiber (67,77±3,34); 7,4% v/v PE fiber (80,37±8,42); 3,7% v/v E-glass fiber (96,72±5,43); 7,4% v/v E-glass fiber (109,44±4,98); sedangkan reparasi plat resin yang tidak diperkuat fiber menghasilkan kekuatan transversal 56,27±4,7 MPa. Hasil analisis menggunakanANAVA dua jalur menunjukkan variabel jenis dan volumetrik fiber memberikan pengaruh signifikan (p<0,05), sedangkan interaksi antara jenis dan volumetrik fiber tidak berpengaruh signifikan (p>0,05). Uji post hoc Tukey menunjukkan perbedaan signifikan (p<0,05) untuk seluruh kelompok perlakuan. Penambahan E-glass fiber dalam reparasi plat resinakrilik mampu meningkatkan kekuatan transversal lebih tinggi dibandingkan dengan menggunakan PE fiber. Peningkatan volumetrik fiber dapat meningkatkan kekuatan transversal reparasi plat resin akrilik. Effect Of Type And Volumetric Fiber On Transverse Strength Of Acrylic Resin Plate Repair. Acrylic resin is the most common denture base material. A disadvantage of acrylic resin is that it is easily fractured. One way to resolve this problem is by adding polyethylene (PE) or glass fibers. The purpose of this research is to find out about the effect of type and volumetric fiber on transverse strength of acrylic resin plate repaired. The experiment involved twenty five plates of heat cured acrylic with the dimensions of 65 x 10 x 2.5 mm. The speciments were prepared to create a 3 mm gap and 45° bevel. The subjects were divided into 5 groups; each group consisted of 5. Group I (control) was without fiber reinforcement, group II reinforced with 3.7% v/v PE fiber, group III reinforced with 7.4% v/v PE fiber, group IV reinforced with 3.7% v/v E-glass fiber, and group V reinforced with 7.4% v/v E-glass fiber. All plates were soaked in distilled water for one day at 37° C temperature. The plates were tested for transverse strength with Universal Testing Machine and all data obtained were analyzed with two way ANOVA at 95% confidence level. The mean of transverse strength (MPa) of the acrylic resin plate repair reinforced with fiber: 3.7% v/v PE fiber was (67.77±3.34); 7.4% v/v PE fiber (80.37±8.42); 3.7% v/v E-glass fiber (96.72±5.43); 7.4% v/v E-glass fiber (109.44±4.98); while the transverse strength of the acrylic resin plate with no fiber reinforced was 56.27±4.7 MPa. Two way ANOVA analysis shows that type and volumetric fiber had significant effect (p<0.05), while the interaction between type and volumetric fiber had no significant effect (p>0.05). Tukey post hoc test shows significant difference (p<0.05) for all groups. The addition of E-glass fibers in the acrylic resin plate repaired increased the transverse strength higher than that with PE fibers. The increase in volumetric fibers might improve the transverse strength of the acrylic resin plate repaired.

Non-Dental glass fiber impregnation on flexural strength of fiber reinforced composite Nilasary Rochmanita Suparno; Siti Sunarintyas; Muhammad Kusumawan Herliansyah
Majalah Kedokteran Gigi Indonesia Vol 4, No 1 (2018): April
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

The availability of dental E-glass fibers for Fiber Reinforcement (FRC) restoration is limited in Indonesia with relatively high cost.Therefore, non-dental glass fibers have been used as an alternative material. The composition of non-dental glass fibers is almost the same with dental E-glass fibers. An important parameter responsible for the strength of FRC is the impregnation of the fibers with resin. Reinforcing fibers are difficult to impregnate with the resin systems of high viscosity. The aim of study is to assess the effect of non-dental glass fibers impregnation using bis-GMA and TEGDMA resin on the flexural strength of FRC. The materials used in the study were non-dental glass fibers (CMAX, China), resin bis-GMA (Sigma-Aldrich, USA) and TEGDMA (Sigma-Aldrich, USA). Three groups of samples consisted of FRC with non-impregnated fibers, FRC with impregnated fibers (bis-GMA:TEGDMA=4:1) and FRC with impregnated fibers (bis-GMA:TEGDMA=1:1). The three groups were tested to determine flexural strength according to ISO 10477. The samples were stored in aquadest at 37 °C for 24 hours prior to flexural strength test. The results were analyzed by one way ANOVA with LSD post hoc test. The results of study showed that the lowest mean of flexural strength (116.16 ± 15.87MPa) was FRC with non-impregnated fiber and the highest mean (151.32 ± 23.74 MPa) was FRC with impregnated fiber (bis-GMA:TEGDMA=1:1). The statistical analysis showed that fiber impregnation had a significant effect (p< 0.05). It can thenbe concluded that non-dental glass fiber impregnation using bis-GMA and TEGDMA resin could increase the flexural strength of FRC and FRC with the impregnated fibers (bis-GMA:TEGDMA=1:1) that had the highest mean of flexural strength.

Effect of Bombyx mori silk-fiber volume on flexural strength of fiber-reinforced composite Aria Fransiska; Siti Sunarintyas; Rini Dharmastiti
Majalah Kedokteran Gigi Indonesia Vol 4, No 2 (2018): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Dental glass fiber is one of dental synthetic fibers that are widely used in dentistry as a dental resin reinforcement, such as in dentin replacement material. The availability of glass fiber is limited in Indonesia because it must be imported and relatively expensive. Bombyx mori silk-fiber is one of the strongest natural fiber derived from silkworm cocoon processing. Silk-fiber is used in medical applications as a post-surgical sutures, scaffolds for tissue engineering and drug delivery. The purpose of this study was to evaluate the effect of Bombyx mori silk-fiber volume on the flexural strength of fiber-reinforced composite (FRC). We used Bombyx mori silk-fiber (Perhutani Pati, Central Java, Indonesia) and flowable composite (Charmfil flow, Denkist, Korea) in this study. The FRC samples were divided into 4 groups consisting of fiber volumes of 0%, 5%, 10% and 15% (n = 4). Tests of flexural strength were performed according to ISO 4049. The results were analyzed using one way ANOVA (p<0.05). The study showed that the means of the flexural strength (MPa) of Bombyx mori silk-fiber FRC for volume of 0%, 5%, 10% and 15% were 149.2 ± 5.5; 127.6 ± 3.8; 110.9 ± 3.5; 71.2 ± 4.2. One-way ANOVA test showed that the means of FRC flexural strength on the four groups’ silk-fiber Bombyx mori volumetric were significantly different (p<0.05). This study concluded that Bombyx mori silk-fiber volumetric influences the flexural strength of fiber- reinforced composite. An increase in Bombyx mori silk-fiber volume decreases the flexural strength of FRC because there is a small gap due to the weak interfacial bonds between dental flowable composite and Bombyx mori silk-silk-fiber.

The effect of silk concentration on the flexural strength of FRC as a Bone Graft Rifki Moechtar; Siti Sunarintyas; Muhammad Kusumawan Herliansyah
Majalah Kedokteran Gigi Indonesia Vol 4, No 2 (2018): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Bone fractures are mostly caused by trauma and disease. In the therapeutic process of bone healing which often meets some constraints, bone graft is mainly used to ensure that the healing process takes place. A fiber reinforced composite (FRC) is a popular bone graft material that is made to resemble bone properties. FRC is normally comprised of polymer matrix, hydroxyapatite filler, and fiber. Hydroxyapatite is a bioactive material widely used as a bone graft. Silk fiber is known as a reliable material to increase mechanical strength of the FRC. On this basis, this study aims to determine the effect of silk fiber concentration on the flexural strength of FRC. Fiber reinforced composite made of Bis-GMA/TEGDMA/ UDMA resin (CharmFil®, DenKist, Korea), hydroxyapatite (Bioceramic Laboratory, DTMI UGM) and silk fiber (Perhutani, Pati) were divided into three groups. Each group contained different silk fiber concentrations which were 1%, 5% and 10%. The flexural strength test was performed with 3-point bending test according to ISO 10477. The result showed that FRC with silk fiber 1%, 5% and 10% respectively had flexural strength of 61.21 ± 8.43 MPa, 62.97 ± 3.92 MPa and 85.01 ± 7.71 MPa. The result of one way ANAVA analysis showed that mean of FRCs flexural strength were significantly different between one treatment group to another. Thus, it is conclusive that silk fiber has a significant effect on FRCs flexural strength. The addition of 10% concentration of silk fiber is proven to increase FRCs flexural strength.

Effect of immersion time in mouthwash on the flexural strength of polyethylene fiber-reinforced composite Syazwani Akmal; Widowati Siswomihardjo; Siti Sunarintyas
Majalah Kedokteran Gigi Indonesia Vol 6, No 1 (2020): April
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.40194

Fiber-reinforced composite (FRC) fixed dentures are exposed to various oral environments. One of the ways in maintaining good oral condition is by using mouthwash. Questions have been araised about the safety of prolongeduse of mouthwash towards FRC. The aim of this study was to evaluate the effect of immersion time in mouthwash on the flexural strength of polyethylene FRC. The specimens used were polyethylene FRC (Construct, KerrLab, USA) and flowable composite resin (Master Flow Biodinamica, Brazil). Block shaped specimens (2x2x25 mm) was light cured (n=12). Specimens were divided into threek groups of immersion: Group 1 (without immersion); Group 2 (24 hour immersion); Group 3 (48 hour immersion). The mouthwash used was Listerine Multi-Protect (Johnson & Johnson, Indonesia) (21.6% alcohol content). Flexure strength was measured by Universal Testing Machine. The results showed the average strength value (MPa) for Group 1 was 91.318 ± 12.466, Group 2 was 62.253 ± 8.027, and Group 3 was55.033 ± 3.373. Statistical analysis (ANOVA) showed that immersion time in mouthwash influenced the flexural strength of polyethylene FRC (p<0.05). LSD0.05 showed there were significant differences of flexural strength between Group1-Group 2, Group 1-Group 3 but not for Group 2-Group 3. In conclusion, the flexural strength of polyethylene FRC were decreased by the immersion time in mouthwash.

Effect of 35% sodium ascorbate on calcium and phosphorus loss in dentin bleached by 35% hydrogen peroxide Tunjung Nugraheni; Nuryono Nuryono; Siti Sunarintyas; Ema Mulyawati
Majalah Kedokteran Gigi Indonesia Vol 7, No 1 (2021): April
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.46946

Post bleaching procedures often have free radicals trapped in dentin tubule and interprismatic enamel, leading to demineralization and denaturation. Sodium ascorbate is an antioxidant substance known to bind residual free radicals to stop demineralization and denaturation. The purpose of the study was to assess the calcium and phosphorus loss from the dentin surface following bleaching by 35% hydrogen peroxide and reversal by 35% sodium ascorbate andthe surface structure of the dentin. Six sound premolars were divided into their crown and root sections, with the crown subsequently being cut into four equal parts to obtain 24 samples. The calcium and phosphorus contents as well as the surface structure of the dentin were assessed using SEM-EDX. These were then divided into four groups, each containing six samples. Group A (control): the samples were bleached by 35% hydrogen peroxide, immersed in an artificial saliva, stored in an incubator at 37 °C for seven days. Group B: the samples were bleached by 35% hydrogen peroxide followed by the application of 35% sodium ascorbate for 5 minutes (once). Group C: the samples were bleached by 35% hydrogen peroxide followed by the applications of 35% sodium ascorbate (twice). Group D: the samples were bleached by 35% hydrogen peroxide followed by the applications of 35% sodium ascorbate (threetimes). The calcium and phosphorus contents as well as the surface structure of the dentin were re-assessed using SEM-EDX at the same locations. The results of one-way ANOVA indicated a difference in the calcium loss in the four treatment groups (p<0.05), but there was no difference in the phosphorus loss. An LSD test showed that there was a difference in the calcium loss between group A and groups C and D or between group B and groups C and D. The dentin tubules in group A were larger than group B, C and D. The frequency of 35% sodium ascorbate application had an effect on the calcium loss and the surface structure in the dentin bleached by 35% hydrogen peroxide.

ROLE OF COMBINATION CASEIN AND LACTOFERRIN BOVINE’S COLLOSTRUM AS A PULP CAPPING ON MACROPHAGE EXPRESSION IN MALE WISTAR RATS Endah Ariyati Eko Ningtyas; Oedijani Santoso; Udadi Sadhana; Siti Sunarintyas
ODONTO : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.8.2.156-164

ABSTRACTBackground: Inflammatory and/or non-inflammatory processes play a role in stimulating pulp repair and the formation of hard tissue, namely reparative dentin. Macrophages play a role in the pathogenesis and chronic inflammatory disorders. The combination casein lactoferrin of bovine colostrum as an immunomodulator has therapeutic potential. This study aims to determine the therapeutic effect and duration of application of the combination of casein lactoferrin of bovine colostrum, on the expression of macrophages as pulp capping.Method: This study was a true experimental laboratories post test only control group design, consisting of three groups of 60 male wistar rats with 4 observation times, namely day to day 7, 14, 21 and 28 each of 5 mice. The maxillary 1st molars were prepared until the roof of the pulp was exposed. Three groups, namely the combination of casein and lactoferrin bovine colostrum (CKL) and calcium hydroxide (K1) and the untreated group (K0). Each group was filled with glassionomer as a permanent restoration. The tissue was made histological preparations with hematoxylin-eosin staining and the number of macrophages were counted, then analyzed by two way ANOVA and post hoc LSD tests.Result: The results showed that the therapeutic effect and duration of application of the combination of casein and lactoferrin bovine colostrum on the expression of macrophages as pulp cappingConclusion: The combination of casein and lactoferrin of bovine colostrum as capping material can increase the number of macrophages in the healing process of dental pulp.

EFEK APLIKASI SERICIN PADA HIDROKSIAPATIT TERHADAP PERLEKATAN SEL OSTEOBLAS Siti Sunarintyas; Yeni Yustisia; Alva Edy Tontowi
Jurnal Teknosains Vol 1, No 1 (2011): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/teknosains.3989

Hydroxyapatite (HA) is often used as a human bone graft. Modification of HA surface is developed to increase osseointegration process which is influenced by cells attachment surrounded the tissue. Sericin has polar side groups which accelerate cells attachment. The aim of this research was to determine the effect of sericin application over HA surface on the attachment of osteoblast cells. The research used HA synthesized from gypsum (Kulon Progo, Yogyakarta). Sericin was extracted from silkworm cocoons of Bombyx mori. Sericin of 0.01, 0.05, 0.1% were applied over HA discs surface (10 mm in diameter, 3 mm thick). The discs were inserted into osteoblast cells culture of MC3T3E1 for attachment test. The data were analyzed by ANOVA and LSD. The result showed that the amount of osteoblast cells attached to HA (7.60±0.42) was significantly difference (p<0.05) with HA + sericin 0.01% (10.30±0.52), HA + sericin 0.5% (10.63±0.70), HA + sericin 0.1% (10.67±0.87). Variation of sericin concentrations applied over HA did not influence any significant difference on the amount of cells attachment (p>0.05). In conclusion, sericin application over HA surface increased the amount of osteoblast cells attachment. Concentrations of sericin application over HA (0.01, 0.05, 0.1%) did not influence osteoblast cells attachment.

Karakteristik Toksisitas Hidroksiapatit yang Disintesis dari Kalsit Terhadap Rattus norvegicus Siti Sunarintyas dan Isti Rahayu Suryani
Jurnal Teknosains Vol 2, No 1 (2012): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/teknosains.5987

The use of synthetic hydroxyapatite (HA) in biomedical application is well warranted. It has shown to havean excellent biocompatibility in human tooth and bones. The present study was conducted to know the toxicitycharacteristics of hydroxyapatite synthesized from Mojokerto calcite in Rattus norvegicus. In this study 30Rattus norvegicus were used as experimental animals. The animals were divided into 3 groups (n=10) to be givenHA-calcite, HA-200 (Waco, Japan), and aquadest (control) orally. The animals were observed 7 days and thenwere analyzed for: fatality rate and clinical behavior, hematology test, organ morphology, and histopathologyappearance. The result showed that there was not any animal death during 7 days observation. None of the animalexhibited any noteworthy findings in clinical behavior, hematology test, organ morphology, and histopathologyappearance. In conclusion, HA-calcite did not show any acute toxicity characteristic; therefore, it was potential tobe used as an alternative material for bone substitution.

Co-Authors Abdulghani Ali Khalil Afra Hatim Ahmad Syaify, Ahmad Akmal, Syazwani Alizatul Khairani Hasan Alva Edy Tontowi Ananto Ali Alhasyimi Archadian Nuryanti Aria Fransiska Asam Khalifa Mohammed Asam Khalifa Mohammed Dahlia Herawati Dea Cahyani, Yessica Dedi Sumantri Dewi Agustina Dian Noviyanti Agus Imam Dita Ayu Mayasari, Dita Ayu Dyah Anindya Widyasrini Dyah Irnawati Ema Mulyawati Ema Mulyawati Ema Mulyawati Endah Ariyati Eko Ningtyas Fery Setiawan Harsini Harsini ,, Harsini Hasna Syifa Yuniva Helmi Fathurrahman, Helmi Heni Susilowati Hilda Mutia Hanum I Dewa Gde Mayun Permana Iwa Sutardja, Iwa Iwa Sutardjo Iwa Sutardjo, Iwa Jukka Pekka Matinlinna Juni Handajani Karina Larasati Khuzaimah, Ismi Lisdrianto Hanindriyo Lukis, Prima Agusti Margareta Rinastiti Mariyam Mariyam Marsetyawan HNE Soesatyo Marsetyawan HNE Soesatyo Marsetyawan HNES Mochammad Imron Awalludin Mohammad Khafid Muhammad Kusumawan Herliansyah N Nuryono Nilasary Rochmanita Suparno Nuryono Nuryono Nuryono Nuryono Nuryono Nuryono Nuryono Nuryono Oedijani Oedijani, Oedijani Paramarta, Sagita Pradnya Pinandi Sri Pudyani Prakosa, Basma Rosandi Pramudya Aditama Prisca Dhyaning Dentiana R. Rachmat A Sriwijaya Rahma Syarafina Maharani Rahman, Friska Ani Raymund Octavius Kusuma Buwana Rifki Moechtar Rini Dharmastiti Rosyida, Niswati Fathmah Sana Mohammed Alrefae Sri Budi Barunawati Sri Kavi Subramaniam Sudarsono Sudarsono Sudibyo Martono Sumantri, Dedi Suparyono Saleh Suryono Suryono , Syazwani Akmal Tunjung Nugraheni Udadi Sadhana, Udadi Verani, Dhea Maurilla W. Widjijono Wayan Tunas Artama Widowati Siswomihardjo Widowati Siswomiharjdo Widowati Siswomiharjo Widowati Widowati Widya Asmara Widya Asmara Widya Puspita Sari Widya Puspita Sari Yasnawi, Mohammad Imanuddin Yeni Yustisia Yoga, I Gede Krisna Merta Yosi Bayu Murti Yuliatun, Leny Yulita Kristanti

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