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Rahma Triyana
Universitas Baiturrahmah, Padang
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UNEXPECTED EXTRAPYRAMIDAL REACTION: ACUTE TARDIVE DYSKINESIA FOLLOWING SHORT-TERM METOCLOPRAMIDE USE IN A PATIENT WITH DIABETES AND CHRONIC KIDNEY DISEASE Helmizar, Roland; Yuri Haiga; Vina Tri Septiana; Nana Liana; Ruhsyahadati Ajisman; Rahma Triyana; Muhammad Rizki Saputra
Nusantara Hasana Journal Vol. 5 No. 7 (2025): Nusantara Hasana Journal, December 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i7.1781

Abstract

Tardive dyskinesia (TD) is a potentially irreversible extrapyramidal movement disorder characterized by involuntary, repetitive movements, predominantly affecting the orofacial region. Although most commonly associated with prolonged exposure to dopamine receptor–blocking agents, TD may also arise following the use of gastrointestinal prokinetics such as metoclopramide. Female sex, diabetes mellitus, advanced age, and renal impairment are recognized risk factors that increase susceptibility, yet TD remains underrecognized outside psychiatric settings. A 49-year-old woman with poorly controlled type 2 diabetes mellitus presented with nausea, vomiting, and generalized weakness. Laboratory findings demonstrated normocytic anemia, uncontrolled hyperglycemia (HbA1c 9.2%), and acute-on-chronic kidney disease (eGFR 22 mL/min/1.73 m²). She received standard supportive therapy, including intravenous metoclopramide. Within 24 hours, she developed repetitive tongue protrusion and orofacial dyskinesia. Neuroimaging and electrolyte evaluation were unremarkable, and there was no history of prior neuroleptic exposure. Metoclopramide was promptly discontinued, leading to gradual improvement and complete resolution of symptoms within two weeks. Antiemetic therapy was switched to ondansetron. This case underscores that acute TD may occur after short-term metoclopramide use, particularly in patients with diabetes and renal dysfunction. Heightened clinical awareness and cautious prescribing are essential to prevent this potentially disabling adverse effect.
GAMBARAN KLINIKOPATOLOGI KARSINOMA PAYUDARA DI RSUP DR. M. DJAMIL PADANG TAHUN 2023 Muhammad Rifki; Nana Liana; Irwan Triansyah; Roland Helmizar; Lismawati Lismawati; Desi Aliefia; Muhammad Rizki Saputra; Ruhsyahadati Ruhsyahadati; Rahma Triyana
Nusantara Hasana Journal Vol. 5 No. 12 (2026): Nusantara Hasana Journal, May 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i12.2046

Abstract

Background: Breast cancer is a malignancy originating from epithelial cells of the breast ducts or lobules. Clinicopathological characteristics are important in determining prognosis and treatment. Understanding these features is essential to support early detection and improve management strategies. Objective: This study aimed to describe the clinicopathological features of breast cancer patients at RSUP Dr. M. Djamil Padang in 2023. Methods: This descriptive observational study used a cross-sectional design with secondary data. A total of 114 samples were collected using the total sampling technique. Data were analyzed using univariate analysis with Statistical Product and Service Solution (SPSS) version 25. Results: Among 114 breast cancer patients, the most common age group was 35–44 years, accounting for 37 patients (32.5%). The predominant histopathological subtype was Mixed Infiltrating Duct NST with Lobular Carcinoma in 37 patients (32.5%). Histopathological grading was most commonly grade 2 in 79 patients (69.3%). Positive lymphovascular invasion was identified in 76 patients (66.7%). The most frequent molecular subtype was Luminal B, found in 51 patients (44.7%). Conclusion: Breast cancer was most prevalent in patients aged 35–44 years. The dominant histopathological subtype was Mixed Infiltrating Duct NST with Lobular Carcinoma, with grade 2 and positive lymphovascular invasion most frequently observed. Luminal B was the predominant molecular subtype. Increasing awareness of early detection through breast self-examination is recommended.
Co-Authors Adelin, Prima Akbar, Resti Rahmadika Alief Dhuha Alif Dhuha Anandia Putriyuni Anggraini, Debie Annisa Lidra Maribeth Betty Fitriyasti1 Desi Aliefia Dhuha, Alief Dian Ayu Hamama Pitra Dian Puspita Dinda Muthia Efriza Febianne Eldrian Fionaliza Haiga, Yuri Helmizar, Roland Heru Herbianto Irma Primawati Irwadi, Irwadi Irwan Triansyah Kendall Malik Kendall Malik Laura Zeffira Lismawati Lismawati Malik, Rifkind Melya Susanti Meta Oktora MHD NURHUDA MUHAMAD IVAN Muhammad Ivan Muhammad Riandi Muhammad Rifki Muhammad Rizki Saputra Muhammad Rizki Saputra Muhammad Rizki Saputra, Muhammad Rizki Mutiara Anissa Nana Liana Nana Liana Nirmala Nirmala, Nirmala Nurwiyeni, Nurwiyeni Rahmaddian, Tosi Rinita Amelia Roland Helmizar Roland Helmizar Rosmaini Rosmaini, Rosmaini Ruhsyahadati Ajisman Ruhsyahadati Ajisman Ruhsyahadati Ruhsyahadati Ruhsyahadati, Ruhsyahadati Salmi Salmi Sri Wahyuni Suharni Suharni Thesa Andria Putri Utari Felia Anggaraini Vina Tri Septiana Wisda Widiastuti Yolanda Rahma Donni Yuni Handayani Yusti Siana YUSTI SIANA