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All Journal Journal of Economic Education Jurnal Fitofarmaka Indonesia JMM (Jurnal Masyarakat Mandiri) Jurnal Analis Kesehatan Journal of Dedicators Community Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati Jurnal Mandala Pharmacon Indonesia JFM (Jurnal Farmasi Malahayati) Jurnal Pengabdian Farmasi Malahayati (JPFM) Jurnal Analis Farmasi Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Ilmiah Wahana Pendidikan Juwara : Jurnal Wawasan dan Aksara Sibatik Journal : Jurnal Ilmiah Bidang Sosial, Ekonomi, Budaya, Teknologi, Dan Pendidikan JAF (Jurnal Analis Farmasi) Jurnal PRIMED:Primary Education Journal atau Jurnal Ke-SD An Balance : Jurnal Akuntansi dan Manajemen Innovative: Journal Of Social Science Research At-Tuhfah : Jurnal Studi Keislaman Journal of Economics and Management Scienties Jurnal Sains Student Research Ghaitsa: Islamic Education Journal JOURNAL OF Pharmacy and Tropical Issues
Tutik Tutik
UNIVERSITAS MUHAMMADIYAH PURWOREJO
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Journal : Jurnal Analis Kesehatan

 1 
Aktivitas Antikanker Ekstrak Aseton Kulit Buah Kakao (Theobroma cacao L.) Terhadap Sel Vero dan MCF-7 Secara In Vitro Chusniasih, Dewi; Tutik, Tutik
Jurnal Analis Kesehatan Vol. 9 No. 2 (2020): JURNAL ANALIS KESEHATAN
Publisher : Department of Health Analyst, Politeknik Kesehatan, Kementerian Kesehatan Tanjungkarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jak.v9i2.2458

Abstract

Sebagian besar pasien pengidap kanker mendapatkan kemoterapi yang melibatkan pemakaian obat antikanker, salah satunya adalah doksorubisin. Namun penggunaan doksorubisin dalam jangka waktu yang panjang bersifat racun bagi organ-organ penting. Oleh karena itu banyak dikembangkan penelitian untuk mencari senyawa antikanker lain yang bersifat alami guna meminimalisir efek samping dari obat antikanker tersebut. Penelitian ini bertujuan untuk menguji aktivitas antiproliferasi ekstrak aseton kulit buah kakao (Theobroma cacao L.) pada sel kanker MCF-7 dan sel vero secara in vitro. Ekstrak kulit buah kakao diharapkan mampu menghambat pertumbuhan sel kanker sehingga dapat dikembangkan untuk pengobatan kanker. Penelitian ini merupakan penelitian eksperimental. Kulit buah kakao diekstraksi menggunakan aseton 80% dan dievaporasi hingga diperoleh ekstrak kental. Uji aktivitas antikanker dilakukan secara in vitro dengan metode MTT assay. Dari hasil pengujian diperoleh nilai IC50 dari analisis regresi dari konsentrasi ekstrak dan persentase inhibisi. Nilai IC50 ekstrak terhadap sel vero yaitu 528,13 ppm, sedangkan Nilai IC50 ekstrak terhadap sel MCF-7 yaitu 24,26 ppm.Simpulan dari penelitian ini adalah ekstrak aseton kulit buah kakao tergolong aktif dalam menghambat pertumbuhan sel kanker payudara MCF-7 dan tidak aktif menghambat pertumbuhan sel normal vero.
Eksplorasi Potensi Antioksidan dan Sitotoksisitas Metabolit Sekunder Ekstrak Kulit Buah Kakao (Theobroma cacao L) Pada Sel WiDr Chusniasih, Dewi; Tutik, Tutik
Jurnal Analis Kesehatan Vol. 11 No. 1 (2022): JURNAL ANALIS KESEHATAN
Publisher : Department of Health Analyst, Politeknik Kesehatan, Kementerian Kesehatan Tanjungkarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jak.v11i1.3144

Abstract

Antioxidant compounds have the ability to inhibit or prevent oxidative damage to target molecules. Oxidative damage is one of the agents that play a role in the development of cancer cells. It is interesting to conduct research to find other anti-cancer compounds in order to minimize the side effects of these anti-cancer drugs.This study aimed to examine the antioxidant activity and cytotoxicity in vitro of acetone extract of cocoa pods (Theobroma cacao L.) on WiDr cells. This research is an experimental study, to see the effect of giving cocoa pod peel extract on the inhibition of free radicals, and WiDr cell death. Samples were extracted using 80% acetone. The antioxidant activity test was carried out using the DPPH method. The anti-cancer activity test was carried out using the MTT assay method. The test results obtained the IC50 value which indicates the cell death rate related to the concentration of the extract using linear regression analysis, as well as the percentage of antioxidant inhibition. Cocoa pod peel extract has an IC50 of 15.41 ppm and is classified as a very strong antioxidant. The IC50 value of the extract for vero cells was 528.13 ppm, while the IC50 value of the extract for WiDr cells was 47.47 ppm. This study showed that cocoa pod peel extract was classified as a very strong antioxidant component and was active in inhibiting the growth of WiDr cells and not actively inhibiting the growth of normal vero cells. 
Co-Authors - Kardoyo Agus Hermanto Ahmad Mansur Alfi Lestari, Alfi Amanda, Sephia Putri Anggraini, Septi Ayu Astuti, Wella Aulia, Tasya Luthfia Awwalina Alfi Ainurrahmi, ‘Asy'fa Azzahra, Maharani Fathiya Cantika, Maria Tri Dewi Chusniasih Diana Putri Dwi Susanti Eka Putra, Ari Subekti Eka Putra, Ari Subki Fitriyanti, Desi Huda, M. Tanwirul Istanti, Fredianaika Istiqomah, Nabila Krisnatalia, Heni Marcelia, Selvi Marcellia, Selvi Mastuti Widianingsih, Mastuti Mentari, Chelsea Cidera MOHAMMAD TSAQIBUL FIKRI Mutiara, Mutiara Oktarima Nihayah, Annis Nurfitriana Nina Mistriani Ningsih, Ni Nyoman setia Nofita, Nofita Octavia, Selvia Oktarima, Mutiara Oktiyaningrum, Ike Pangestika, Maulida Dewi Prameswari, Nabilla Minerva Pratama, Calvin Kurnia Primadiamanti, Annisa Putri Amalia Putri, Melita Regina Putri, Rizka Amaliah Putri, Salma Gustia Rachman, Mohammad Aulia Radho Al Kausar Rai Saputri, Gusti Ayu Ramadhan, Dimas Ray Octafian Rinatha, Elsha Riyanti, Gina Rosita Ambarwati Saddam Husein, Saddam Safitri, Mariska Mulya Salsabilla, Anantha Saputri, Gusti Ayu Rai Sari, Septi Widya Satato, Y.R Savero, M. Aldo Septilia, Riska Setiawan, Muhammad Arif Setiya, Kusumaningtiyas Putra Seto, Deni Gagat Sofyan, Shefira Solichoel, Solichoel Sucihatiningsih Dian Wisika Prajanti Syafitri, Shela Syahputri, Alivia Dela Talakua, Jeane Fransina Diana Trisna, Herman Ulfa Ulfa Ulfa, Ade Maria Umri, Ulfa Nafila Veriyanti, Kirana Nadia Wibowo, Fiko Bradi Winahyu, Diah Astika Wiranata, Neisca Zahro, Hervika Amalia