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All Journal PROSIDING SEMINAR NASIONAL Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Biomedika Pharmacon Pharmascience Jurnal Farmasi Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Indonesian Community Journal Abdi Geomedisains Jurnal Farmasi Sains dan Praktis SWARNA Urecol Journal. Part C: Health Sciences Prosiding University Research Colloquium Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat Panacea Usadha Journal of Pharmacy SWARNA: Jurnal Pengabdian Kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia
Arifah Sri Wahyuni
Universitas Muhammadiyah Surakarta
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Pharmacon

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Narrative Review : Aktivitas Antidiabetes Tanaman Tradisional Di Pulau Jawa Cita Primada Hari Anugrahini; Arifah Sri Wahyuni
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PD IAI JATENG 2021
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.14999

Abstract

Diabetes mellitus merupakan gangguan metabolisme karbohidrat yang ditandai dengan hiperglikemi yaitu kadar glukosa plasma 2 jam setelah Tes Toleransi Glukosa Oral (TTGO) ≥ 200 mg/dL dan glukosa darah puasa ≥ 126 mg/dL, terjadi karena tubuh kekurangan hormon insulin absolut maupun relatif. Saat ini obat tradisional telah banyak digunakan oleh masyarakat karena mahalnya atau tidak tersedianya obat modern/sintetis dan kepercayaan bahwa obat tradisional lebih aman. Masyarakat Pulau Jawa telah memanfaatkan tanaman tradisional untuk mengobati berbagai macam penyakit, termasuk diabetes mellitus. Penyusunan narrative review ini dengan pencarian artikel dari database google schoolar menggunakan kata kunci “antidiabetic and rats and ethanol and java” dan “plants and secondary metabolites and antidiabetic”. Kriteria inklusi yang ditetapkan adalah artikel yang dipublikasi pada tahun 2014 – 2020 membahas uji in vivo tanaman antidiabetes di Pulau Jawa, senyawa metabolit sekunder yang bertanggung jawab terhadap aktivitas antidiabetes dan dapat diunduh full text. Hasil skrining literature didapatkan 15 tanaman yang memiliki aktivitas antidiabetes karena adanya senyawa metabolit sekunder golongan alkaloid, flavonoid, fenolik, glikosida, dan poliketida yaitu aloe-emodin, aloin, annonaine, artoflavon, asiaticoside, brazilin, charantin, curcumin, dihydromyricetin, epigallocatechin-3-O-gallate, eugenol, kaempferol, momordicin, morindone, moringine, quercetin-3-O-glucosidase, quercetin-3-O-α-L-arabinofuranoside, quercetin-3-rhamnoside dan 6-gingerol. Senyawa tersebut memiliki mekanisme antidiabetes melalui penghambatan enzim α-glukosidase dan α-amilase, penghambatan enzim DPP-IV, dan peningkatkan translokasi GLUT-1 dan GLUT-4.
PENGARUH EKSTRAK ETANOL JAMUR LINGZHI (Ganoderma lucidum) TERHADAP KADAR HDL (High Density Lipoprotein) PADA TIKUS DISLIPIDEMIAPENGARUH EKSTRAK ETANOL JAMUR LINGZHI (Ganoderma lucidum) TERHADAP KADAR HDL (High Density Lipoprotein) PADA TIKUS DISLIPIDEMIAP Arifah Sri Wahyuni
Pharmacon: Jurnal Farmasi Indonesia Vol 12, No 1 (2011)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v12i1.41

Abstract

Jamur lingzhi (Ganoderma lucidum) termasuk dalam family Polyporaceae yang diketahui memiliki banyak manfaat untuk pengobatan. Penelitian ini merupakan penelitian eksperimental (pretest-postest control group design) dengan rancangan acak lengkap pola searah dan ditujukan untuk mengukur pengaruh ekstrak etanol Ganoderma lucidum pada tingkat HDL pada tikus dislipidemia. Terdapat 4 kelompok perlakuan masing-masing kelompok terdiri dari 5 ekor tikus yaitu kelompok kontrol normal, kontrol negatif, dosis 1 dan dosis 2. Kelompok kontrol normal diberi pakan standar sedangkan kelompok kontrol negatif, dosis 1 dan dosis 2 diberi diet tinggi lemak selama 4 minggu dan ekstrak etanol jamur lingzhi masing-masing 200 mg/kgBB (dosis 1) dan     400 mg/kgBB (dosis 2) selama 2 minggu secara per oral. Data yang diperoleh dianalisis dengan uji Anava taraf kepercayaan 95%. Hasil penelitian menunjukkan bahwa ekstrak etanol jamur lingzhi (Ganoderma lucidum) dosis 200 mg/kgBB dan 400 mg/kgBB tidak mampu meningkatkan kadar HDL pada tikus dislipidemia Kata Kunci: Dislipidemia, kadar HDL, ekstrak etanol jamur lingzhi (Ganoderma lucidum)
Uji Aktivitas Antikolesterol Kombinasi Ekstrak Teh Oolong, Buncis Dan Kayu Manis Ahmad Fauzi; Tanti Azizah Sujono; Azis Saifudin; Arifah Sri Wahyuni
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 1 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i1.18193

Abstract

Hyperlipidemia has an important role in the occurrence of cardiovascular, cerebrovascular, and peripheral vascular diseases. High cholesterol and LDL levels in the blood are at risk of causing various diseases such as atherosclerosis, pancreatic dysfunction and kidney disorders. Meanwhile, high triglyceride levels can cause impaired liver, pancreas and kidney function. Green bean, oolong tea and cinnamon are plants that can lower cholesterol levels. Oolong tea contains catechins, Green Bean contain phytosterols and cinnamon contains cinnamaldehyde. Determination of secondary metabolite levels of extracts was carried out using the Liquid Chromatography – Mass Spectroscopy (LC-MS) method. The activity test was carried out with 30 Wistar white rats which were divided into 6 test groups. The normal control group was treated with CMC-Na without feeding hypercholesterolemia, the positive control group was treated with simvastatin 0.4 mg/KgBW, the negative control group was treated with CMC-Na, the test groups 1, 2 and 3 were treated with cinnamon extract, oolong tea and green bean, respectively (150:50:50 mg/KgBW), (50:150:50 mg/KgBW) and (50:50:150 mg/KgBW). The detected metabolite content was cinnamaldehyde in cinnamon up to 10%, catechins in oolong tea up to 12% and stigmasterol in beans as much as 3.4%.The results obtained by test group 1 and test group 2 can reduce cholesterol and triglyceride levels (p0.05). All test groups had no significant effect on HDL and LDL levels.
Vol 20, No 1 (2023) Arifah Sri Wahyuni
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 1 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i1.22887

Abstract

Immunomodulatory Activity of Kasumba Turate (Carthamus tinctorius L.) Extract Against Non-Specific and Specific Immune Responses in Mice Arini Fadhilah; Anisa Dwi Parwati; Cita Hanif Muflihah; Arifah Sri Wahyuni
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 1 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i1.22629

Abstract

Immunomodulators are compounds that can regulate the immune system with the objective of normalizing or helping to optimize the immune system. People tend to back to nature by utilizing various plants to be used as medicine, one of which is kasumba turate (Carthamus tinctorius L.) which is thought to be efficacious as an immunomodulator in increasing the activity and capacity of macrophages. This study aims to determine the immunomodulatory activity of kasumba turate ethanol (CTEE) extract against non-specific and specific immune responses in mice. Non-specific immune response tests using the carbon clearance method were carried out on mice with 3 dose ratings. Specific immune response tests were carried out by the hemagglutination test method to determine antibody titers. The results of the carbon clearance test showed that the CTEE dose 50 mg/KgBW was a moderate immunostimulant with a phagocytic index of 1.41, while doses of 100 and 200 mg/KgBW were strong immunostimulants with phagocytic index of 1.57 and 1.82 respectively. While the results of the hemagglutination test method, the antibody titers value is determined from the highest serum dilution value that still indicates hemagglutination. The results show an increase in humoral immune response with the highest primary and secondary antibody titer values of 1:256 and 1:1024 for doses of 100 mg/KgBW, and 1:512 and 1:1024 for doses of 200 mg/KgBW. Phytochemical screening results of CTEE proved to contain alkaloid group compounds, flavonoids, saponins, tannins and triterpenoids. Based on the results obtained, it was concluded that the administration of CTEE showed immunostimulant activity.
Vol 20, No 2 (2023) Wahyuni, Arifah Sri
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23493

Abstract

Co-Authors AA Sudharmawan, AA Abdellah, Yousra Nait El Haj Adha, Dinda Caesaria Adha, Dinda Caesaria Adha Afny Al Fath Inaszahira Afrizal Maulana Agita Dyah Ayu Kusumaningtyas Ahmad Azka Mahasin Ahmad Fauzi Ainur Tri Hapsari Al Fawwaz, Zulfa Kamila Alida Rahmalia Damayanti Alifia Jasmina Putri Alvita Marshanda Purnama Puteri Amalia, Nastity Zhahwa Amani, Khalisa Dhiya Ana Riolina Andi Suhendi Anggun Dwi Ayu Fandirah Anisa Dwi Parwati Anita Sukmawati Annisa Nur Lathifah Amanda Putri Annisa Nur Lathifah Amanda Putri Ar Rafi’ Kusuma Hardila Wardoyo Putri Aria Wirabima Aria Wirabima Arini Fadhilah Assyifa Putri Saffira Asti Arum Sari Astrina Dewi Ratnaningrum Astrina Dewi Ratnaningrum, Astrina Dewi Astuti, Devi Dwi Audi Ahmad Rikardi Aulia Fitri Sabilla Azis Saifudin Azizah, Rauhillah Nurul Bakar, Fazleen Izzany Abu Bakhtiar, Muhammad Candrika, Nasha Lulut Chandrika, Nasha Lulut Cita Hanif Muflihah Cita Primada Hari Anugrahini Damayanti, Alida Rahmalia Denny Vitasari DESY KURNIAWATI Desy Kurniawati Devana Inaja Arifin Devana Inaja Arifin Dewi Safitri Dinda Mentariningrum Diski Wahyu Wijayanto Eky Wahyu Novarista Em Sutrisna Erindyah Retno Wikantyasning Fadhilah , Arini Fadhilah, Arini Fadhilah, Arini Fadhilah Faiza Layyana Putri Farah Salsabila Fauzi Ahmad Muda Fawwaz, Zulfa Kamila Al Firda Ayu Fadila Rahmawati Firda Novia Aurum Ghossani, Qisti Fida Gunawan Setyadi Gunawan Setyadi, Gunawan Hamimatusalma Alkautsar Haryati, Resti Dwi Haya Nabilah Utama Heni Mirawati Hidayah Karuniawati Husna Amalia Halwa Ibrohim Hanif Abdulloh Ika Retno Wulandari Ika Trisharyanti Dian Kusumowati Jessica Rosalinda Jihan Jihan, Jihan Julianti, Tri Budi Juwita Rahmawati Kafita Salma Khairani Kamila, Rossy Destriana Katarina Lulu Widyanti Khairani, Kafita Salma Kharisma Aulia Husna Kholifatus Sa’diyah Lathif, Elmasrini Lilla Prapdhani Agni Hajma Lusi Nuryanti Maharani, Yasmin Nida Maulana, Fahmi Alief Muhammad Azmi Nur Asykaruddin Muhammad Da'i Muhammad Da'i Muhammad Haqqi Munajat Tri Nugroho Mursalina Nanda Aurum Mutiara Nurul Fatimah Nadya Tiara Putri Nasywa, Nabila Luthfiana Niam, Muhammad Labib Qotrun Nibrasa, Lauda Aurynava Nida’ Nur Jannah Niken Dyaharesti Ningrum, Nur Faizah Setya Nisrina Hanun Iftadi Novita Sari Novita Sari Nur Faizah Setya Ningrum Nur Muhammad Arrizky Nurazizah, Tazkia Nurul Tri Anggraini Oksaputra, Amar Khoiri Paramita, Heldiyana Ellisia Peni Indrayudha Permata Ashfi Raihana Persada, Tashila Zahra Putri, Annisa Nur Lathifah Amanda Putri, Nastity Zhahwa Amalia Putri, Vanessa Ardelia Indira Rahmadhani, Ajeng Rahmallia, Ega Ramadhan, Muhammad Reza Ramarohasina, Mika Notahiana Ranatri Puruhita Ratih Amelia, Ratih Ratsimandresy, Neciah Fahombiazana Rima Munawaroh Riza Maulana Rizakh, Faizah Siti Rizky Ainun Fitriani Rosa Sayentina Amin Rosa Sayentina Amin Rosita Melannisa Rosita Melannisa, Rosita Sabar Narimo Santhyami Santhyami Sari, Aisah Kensar Nawang Wulan Septyana Dewi Kumara Setyo Nurwaini Shinta Puti Aryanti Shinta Putri Aryanti Suhaimah, Insyiroh Sukamto, Dandi Febrian Sulistyarini, Sulistyarini Suryani - Tanti Azizah Sujono Teguh Imanto Tista Ayu Fortuna Tri Yulianti Tri Yulianti, Tri Ukhtufina, Naila Najwa Utama, Haya Nabilah Wahyu Utami Widagdo, Fathin Fadhilla Wijianto, Diski Wahyu Windarti, Septiana Wulandari, Febri Yeni Mulati Yuniasti, Lainisah Purna Zahidah, Fairus