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All Journal Medical Journal of Indonesia Universa Medicina Paediatrica Indonesiana Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Neurosains Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indonesia Journal of Physical Medicine and Rehabilitation Indonesia Journal Physical Medicine and Rehabilitation Jurnal Pendidikan Indonesia Gemilang Sriwijaya Journal of Neurology Occupational and Environmental Medicine Journal of Indonesia Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Retno Asti Werdhani
Department Of Community Medicine Faculty Of Medicine Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Platelet-Rich Plasma as a Pharmacopuncture Agent in Cervical Myofascial Pain Nareswari, Irma; Kamal, Achmad Fauzi; Mihardja, Hasan; Yunus, Reyhan Eddy; Jusuf, Ahmad Aulia; Harahap, Alida Roswita; Wahyuni, Luh Karunia; Werdhani, Retno Asti; Handayani, Selfi; Rukmindar, Dion
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.310

Abstract

Chronic cervical myofascial pain (CMP) is a prevalent musculoskeletal disorder characterized by persistent neck pain, inflammation, functional impairment, and altered pain processing. Conventional treatments, including pharmacological therapy and physical rehabilitation, often provide limited and temporary relief. Increasing evidence suggests that chronic CMP involves not only peripheral nociceptive input but also nociplastic pain mechanisms driven by sustained neuroimmune dysregulation and central sensitization. Pharmacopuncture, combining acupuncture point stimulation with localized injection of therapeutic agents, has evolved with the introduction of regenerative biologics such as platelet-rich plasma (PRP). PRP contains concentrated platelets and bioactive growth factors, including VEGF, PDGF, and TGF-β, which exert anti-inflammatory and tissue-reparative effects. Emerging data indicate that PRP pharmacopuncture may reduce pro-inflammatory cytokines (e.g., IL-1β and TNF-α), modulate regulated cell death pathways (e.g., apoptosis and pyroptosis), and promote the restoration of myofascial tissue homeostasis. These mechanisms may contribute to both peripheral tissue repair and attenuation of nociplastic pain processing. This narrative review synthesizes current clinical and experimental evidence on the biological mechanisms and therapeutic potential of PRP pharmacopuncture in chronic CMP. Available studies report meaningful improvements in pain intensity and functional outcomes compared with conventional acupuncture or pharmacotherapy alone. However, substantial methodological heterogeneity may arise from PRP preparation protocols, acupoint selection, and outcome measures, limiting the ability to draw definitive conclusions. High-quality randomized controlled trials incorporating standardized protocols and mechanistic biomarkers are required to establish PRP pharmacopuncture as an evidence-based integrative treatment for chronic CMP.
Application of The JMF 10 Warning Signs for Early Detection of Primary Immunodeficiency among Children with Recurrent Infections in Indonesia Muktiarti, Dina; Hendarto, Aryono; Munasir, Zakiudin; Wulandari, Dewi; Satari, Hindra Irawan; Werdhani, Retno Asti; Wati, Ketut Dewi Kumara
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.318

Abstract

Introduction: Limited awareness and diagnostic resources contribute to delayed recognition of primary immunodeficiency (PID). The Jeffrey Modell Foundation (JMF) 10 warning signs have been widely used for screening. However, their diagnostic performance has not been validated in Indonesia. Objective: To evaluate the diagnostic performance of the JMF 10 warning signs for early detection of PID among children with recurrent infections in Indonesia. Methods: This multicentre cross-sectional study was conducted across 10 hospitals in Jakarta involving 254 children aged 0–18 years who met the severe, persistent, unusual, and recurrent (SPUR) infection criteria. The diagnosis of PID was established based on clinical diagnosis by the European Society for Immunodeficiencies (ESID) Registry Working Definitions. Analysis was performed to determine the sensitivity, specificity, predictive values, and accuracy of the JMF 10 warning signs. Results: Diagnostic performance for PID improved with the number of warning signs, with overall accuracy increasing from 15% (1 sign) to 86.2% (≥5 signs). A total score of ≥3 signs was associated with higher occurrence of PID (PR 2.63; 95% CI 1.23–5.60; p = 0.008), providing an optimal balance of 75.7% sensitivity and 48.9% specificity. The two most specific indicators were recurrent severe sinus infections (99.5%) and ear infections (95%). All PID subjects required IV antibiotics. Conclusion: The JMF warning signs remain a valuable clinical screening tool for early detection of PID among Indonesian children. A threshold of three or more warning signs provides reasonable accuracy for screening and referral of PID in resource-limited settings.
Co-Authors Achmad Fauzi Kamal Achmad Kemal Harzif Adriani, Ance Agus Rizal Ardy Hariandy Hamid, Agus Rizal Ardy Hariandy Agus Sugiharto Agustina, Amilya Ahmad Aulia Akbar, Resti Rahmadika Akmal Taher Amilya Agustina Ampri, Irfan Arieqal Hatta Anandita, Faizal Ablansah Anang Endaryanto Ance Adriani Andy Ardhana Mamahit Ardi Findyartini, Ardi Ari Prayitno, Ari Aria Kekalih Aryono Hendarto Asmarinah Badriul Hegar Cantika, Wastucitra Dewanto, Naomi Esthernita Fauzia Dewi Wulandari Dian Kusumadewi Dina Muktiarti, Dina Elsa P. Setiawati Fajriani, Rosalina Fatima Safira Alatas, Fatima Safira Fedri R. Rinawan Ferry Safriadi Fiastuti Witjaksono Gita Pratama Harahap, Alida Roswita Hartono Gunadi Hasan Mihardja Hindra Irawan Satari, Hindra Irawan Isman Firdaus Ivo Novita Sah Bandar Jenny Bashiruddin Jeo, Wifanto Saditya Juandy Jo Kanadi Sumapradja Ketut Dewi Kumara Wati Khoe, Levina Chandra Koloi, Vican Sefiany Kusuma Dewi, Dian Luh Karunia Wahyuni, Luh Karunia Lusiana, Nadya Mahardika, Abiyyu Ghiyats Malau, Bintang Leonard Mardiastuti H Wahid Maria Melania Muda Maria, Nove Michelle, Michelle Mila Maidarti Muchtaruddin Mansyur Muda, Maria Melania Muhammad Arvianda Kevin Kurnia Nareswari, Irma Nove Maria Nur Indah Lestari Lestari Nur Rasyid Pambudi, Wiyarni Ponco Birowo Pukovisa Prawiroharjo Ramdhani, Aris Ramlan, Andi Ade Retno Wibawanti Retno Wibawanti Reyhan Eddy Yunus Rini Sekartini Rino Alvani Gani Rukmindar, Dion Rusli, Noer Triyanto Salim Harris Savira, Missy Selfi Handayani Setyawati Budiningsih Setyawati Budiningsih Sri Rezeki S. Hadinegoro, Sri Rezeki S. Suharto, Wuryantoro Sulistomo, Astrid Susyana Tamin Talya, Natasha Tanoto, Rodri Tantri, Julietta Theresia Santi, Theresia Tiffany, Tiffany Umi Fahmida Widayat Alviandi Widi Atmoko Widjaja, Lydia Rosalina Widjajalaksmi Kusumaningsih Widjajalaksmi Kusumaningsih Winnugroho Wiratman Wistara, Sevita Sathya Yanfaunnas, Atika Mahira Yefta Moenadjat Yusra, Yusra Zakiudin Munasir