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All Journal Indonesian Journal of Urology Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Berkala Kedokteran Majalah Obstetri dan Ginekologi Sari Pediatri Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of Maternal and Child Health Jurnal Ilmu Kedokteran dan Kesehatan JURNAL ETIKA KEDOKTERAN INDONESIA eJournal Kedokteran Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Budi Wiweko
Departemen Obstetri Dan Ginekologi, Fakultas Kedokteran, Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVF Pratama, Gita; Agustina, Elizabeth; Yanfaunnas, Atika Mahira; Maidarti, Mila; Harzif, Achmad Kemal; Muharam, R.; Wiweko, Budi
Majalah Obstetri & Ginekologi Vol. 32 No. 3 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I32024.174-180

Abstract

HIGHLIGHTS It was observed that autologous PRP substantially increased endometrial thickness in individuals experiencing infertility linked to a thin endometrium. The elevated clinical pregnancy rate emphasizes the favorable effectiveness of autologous PRP in addressing issues related to a thin endometrium in IVF programs.   ABSTRACT Objective: The objective of this research was to investigate the impact of autologous platelet-rich plasma (PRP) in enhancing endometrial thickness among individuals experiencing infertility associated with a thin endometrium. Materials and Methods: Nine individuals with a thin endometrium who participated in an in vitro fertilization (IVF) program were enrolled in the study. This study was carried out in Yasmin Clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Patients underwent a hormone replacement protocol involving the preparation of the endometrium with estradiol valerate. Treatment with PRP was initiated when the endometrial thickness was less than 7 mm. Autologous PRP was infused into the uterine cavity between the 10th and 12th days after administering estradiol valerate, and the assessment of endometrial thickness was conducted using ultrasound 48 hours later. A second administration of PRP was provided in cases where the endometrial thickness was below 7 mm. Frozen-thawed embryo transfer (FET) was performed if the endometrium reached adequate thickness (minimum 7 mm). Results: Seven of nine patients had adequate endometrial thickness followed by FET. Endometrial thickness was improved in 8 from 9 patients (88.8%). Five patients were improved at the first autologous PRP infusion (62.5%) and three patients (37.5%) at the second PRP infusion. The implantation rate was 33.3-100%, clinical pregnancy was 100%, and ongoing pregnancy rate was 83.3%. Conclusion: The use of autologous platelet-rich plasma (PRP) successfully stimulates endometrial development in individuals with a thin endometrium during frozen-thawed embryo transfer.
Current Trends in Contraceptive Use and Fertility Concerns Among Women of Reproductive Age in Indonesia Muharam Natadisastra, Raden; Christopher Yo, Edward; Nurdya Irzanti, Alisha; Sumapraja, Kanadi; Kemal Harzif, Achmad; Pratama, Gita; Maidarti, Mila; Hari Kurniawan, Riyan; Wiweko, Budi; Hestiantoro, Andon
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2508

Abstract

Abstract Background Family planning remains a key intervention in reducing maternal mortality and creating prosperous families. Assessing the unmet need for family planning allows insight into the progress of family planning programs. On the other hand, there has been much less attention given to the declining fertility rate in Indonesia. To address both the unmet need and declining fertility rate in Indonesia, this study aimed to investigate the most recent trends in contraceptive use in Indonesia as well as evaluate fertility concerns and access to reproductive healthcare service. Methods Women of reproductive age in Indonesia were asked to fill in an online questionnaire. They were asked about sociodemographic characteristics, marital status, pregnancy history, perception towards fertility, and access to healthcare service and information. Descriptive statistics and independent t-test were performed. Results Of 370 women, more than half (57.8%) had used some form of contraception. The most frequently used contraceptive method was natural family planning (30.3%), followed by condom (20%). Women with no prior sexual history, had never been pregnant before, and had not been married cared more about having a child in the future. Internet and social media represented the most popular information source for family planning. Conclusions Many Indonesian women still prefer traditional contraceptive methods over the more effective modern contraceptive methods. Numerous socio-cultural factors are likely to influence the behaviour of reproductive-age women regarding contraceptive use and childbearing in the future. More effort should be put into raising awareness about modern contraceptive methods and addressing fertility concerns. Keywords: contraception; fertility; family planning; awareness; reproduction
Knowledge, Attitude, and Perception Towards Condom Use among Female Sex Workers in North Jakarta: A Mixed-Method Study Harzif, Achmad Kemal; Surya, Raymond; Chiprion, Ariel Timy; Mutia, Heidi Dewi; Puspawardani, Aisyah Retno; Ummah, Nafi'atul; Nurbaeti, Putri; Sayogo, Atikah; Wiweko, Budi
Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Vol. 13 No. 1 (2025): Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Educatio
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpk.V13.I1.2025.83-92

Abstract

Background: HIV/AIDS is a significant global health and social issue, particularly affecting sex workers, who are the second most common high-risk population. Efforts have been attempted to address the challenges, including promoting safer sex and increasing sex workers’ awareness of condom use to reduce sexually transmitted disease (STDs) transmission. Objectives: This study aimed to examine the knowledge, attitude, and perception among FSWs in North Jakarta towards condom use to prevent HIV. Method: Using a validated WHO questionnaire, this cross-sectional community-based study was conducted in pubs and lounges in North Jakarta among 182 FSWs. The questionnaire was translated forward and backward to ensure accuracy. The data were analyzed using SPSS Statistics for Windows and transcription in MS Word for qualitative data. Results: The reliability test for knowledge and attitude were 0.427 and 0.456, respectively. The study found that most participants (75%) had good knowledge about the benefits of condom use, and most agreed that condoms are suitable for casual or established relationships. However, due to cultural barriers in Indonesia, most subjects (68.1%) felt embarrassed about buying condoms.  Conclusion: The study found that FSWs possess a good knowledge and attitude regarding the utilization of condoms to avert STDs, particularly HIV/AIDS. Nonetheless, there is a need to enhance FSWs’ attitudes towards condom use and perceptions of health services, particularly those related to STDs, given their classification as a population at high risk.
Addressing the Global Decline in Total Fertility Rates Wiweko, Budi
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 2 April 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i2.2921

Abstract

N/A
Long COVID in vaccinated women with Polycystic Ovary Syndrome: A retrospective cohort pilot study Muharam, R; Bagastoro, Aswan; Faradina, Anindita Abigail; Yo, Edward Christopher; Irzanti, Alisha Nurdya; Sumapraja, Kanadi; Harzif, Achmad Kemal; Pratama, Gita; Maidarti, Mila; Silvana, Vita; Wiweko, Budi; Hestiantoro, Andon
Majalah Obstetri & Ginekologi Vol. 33 No. 2 (2025): August
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I22025.89-96

Abstract

HIGHLIGHTS Among women with PCOS, many still reported persistent long COVID symptoms such as hair loss and fatigue. COVID-19 vaccination does not exacerbate symptoms of PCOS, which further emphasizes the importance of completing COVID-19 doses for women with PCOS to avoid long COVID sequelae.   ABSTRACT Objective: Long COVID, or the persistence of symptoms after acute COVID-19 illness, can affect individuals with pre-existing health conditions such as polycystic ovary syndrome (PCOS). Long COVID and PCOS may share overlapping pathogenesis which potentially exacerbate one another. The aim of this study was to evaluate the symptoms of long COVID in women with PCOS who have been vaccinated and investigate whether COVID-19 vaccination or infection worsened PCOS symptoms. Materials and Methods: We carried out a retrospective cohort study on 44 women with PCOS who have been vaccinated and previously diagnosed with COVID-19. Questionnaires were distributed to find out the effect of COVID infection and vaccines in these women, as well as the symptoms of long COVID-19. Results: Of all participants, 28 women (70%) continued to report persistent long COVID symptoms, with the highest number of complaints being fatigue and hair loss. The results, using Mann-Whitney test, showed that there was no difference in PCOS symptoms before and after COVID-19 vaccination (p = 0.520) or after COVID-19 infections (p = 0.241). Although this study revealed a substantial prevalence of long COVID symptoms among women with PCOS, an encouraging finding emerged: neither the administration of COVID-19 vaccination nor prior infection with COVID-19 had a significant impact on PCOS-associated symptoms. Conclusion: This study further underscores the importance of vaccination for all individuals, including women with a history of PCOS. Furthermore, the purpose of COVID-19 vaccination is to mitigate symptom severity, thus potentially diminishing the occurrence of long-term COVID-19 symptoms in future cases.
Body Composition Parameters, Adiponectin, Leptin and Adiponectin/Leptin Ratio are Correlated with LH/FSH Ratio in Women with PCOS but not in Women without PCOS Gita Pratama; Wiweko, Budi; Asmarinah; Widyahening, Indah Suci; Andraini, Trinovita; Hartanto Bayuaji; Andon Hestiantoro
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 1 January 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i1.2031

Abstract

Objective: To investigate the correlation between body composition parameters, adiponectin, leptin and the adiponectin/leptin ratio and the LH/FSH ratio in women with polycystic ovary syndrome (PCOS). Methods: A cross-sectional study was conducted at Reproductive Cluster Yasmin, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, with sixty women with PCOS and sixty healthy women as controls (matched for age and BMI). Body composition parameters, including body weight, body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), percent body fat (PBF), visceral fat area (VFA), percent subcutaneous fat (PSF) and skeletal muscle mass (SMM), were measured; levels of fasting glucose, fasting insulin, testosterone, and sex hormone binding globulin (SHBG) were measured; and homeostatic model assessment for insulin resistance (HOMA-IR) values, anti-Mullerian hormone (AMH), free androgen index (FAI), Ferriman-Gallwey (FG) score, adiponectin levels, leptin levels, adiponectin/leptin ratio, LH, FSH and LH/FSH ratio were measured. Results: Body composition parameters (body weight, BMI, WC, WHR, PBF, VFA, PSF, SMM) were not significantly different between women with PCOS and controls. Fasting insulin (P<0.05), HOMA-IR (P<0.05), AMH (P<0.01), FAI (P<0.01), FG score (P<0.01) and LH/FSH ratio (P<0.05) were higher in PCOS women. Adiponectin (P<0.01) was lower in PCOS women, while leptin and the adiponectin/leptin ratio were not significantly different between groups. Most of body composition parameters, adiponectin, leptin and adiponectin/leptin ratio were correlated with HOMA-IR in both groups. SMM was positively correlated with the LH/FSH ratio, while body weight, BMI, WC, PBF, VFA, and PSF were inversely correlated with the LH/FSH ratio in PCOS patients but not in controls. WHR was not correlated in either group. Leptin (r=-0.278; P<0.05) was negatively correlated with the LH/FSH ratio only in the PCOS group. Adiponectin (r=0.394; P<0.01) and the adiponectin/leptin ratio (r=0.413; P<0.01) were also positively correlated with the LH/FSH ratio only in the PCOS group. AMH was correlated with the LH/FSH ratio, whereas testosterone level, FAI, FG score, fasting insulin level and HOMA-IR value were not correlated with the LH/FSH ratio in PCOS women. Conclusion: Most of the body composition parameters, leptin, adiponectin and the adiponectin/leptin ratio were significantly correlated with HOMA-IR in both groups. However, correlations of those parameters with LH/FSH ratio were found only in PCOS but not in women without PCOS. Adiponectin and leptin may play a significant role in the mechanism of neuroendocrine disorders in PCOS, which is characterized by an increased LH/FSH ratio. Keywords: adiponectin, adiponectin/leptin ratio, body composition, HOMA-IR, leptin, LH/FSH ratio, PCOS
Peripheral Serum AMH Level Reflects the Size of the Follicle Pool in a Mouse Model Study Suratih, Ni Made Desy; Wiweko, Budi; Maidarti, Mila; Wuyung, Puspita Eka; Jusuf, Ahmad Aulia; Louisa, Melva; Kekalih, Aria
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.2220

Abstract

Objective: This is to compare peripheral and central serum levels of Anti-Mullerian hormone (AMH) in experimental animals for predicting ovarian reserve. Methods: This is an experimental study involving 20 female Sprague-Dawley rats aged 8–10 weeks with normal estrus cycles as the young control group and 5 female rats aged 28–30 weeks as the old control group (n = 5/group): the young control group, the old control group, the 1x cisplatin group, the 2x cisplatin group, and the 3x cisplatin group. After treatment, tissue collection, histological staining, and blood collection through the retro-orbital bleeding (ROB) and heart were performed. Subsequently, measurements of ovarian weight, follicle counting, and levels of AMH and Follicle-stimulating hormone (FSH) were conducted.Results: The serum AMH levels from ROB in the young control, 1x cisplatin, 2x cisplatin, 3x cisplatin, and the old control groups were 1151, 1818, 2782.96, 1381.352, and 1544 ng/mL, respectively. Cisplatin 2x group was significantly (p<0.005) higher compared to the young control. The average concentrations of serum AMH in the ROB and heart were higher in the 2x cisplatin group compared to the other groups. Meanwhile, cisplatin 3x group decreased in level due to the burn out phenomenon. Conclusion: AMH is a preferred marker compared to FSH. Blood collection through the ROB is considered a less invasive alternative technique in the treatment group, requiring serial observation. Keywords: AMH, follicle pool, ovarian aging, ROB
The Essence of Telemedicine for Bridging the Gap in Health Services Wiweko, Budi; Zakirah, Sarah Chairani; Luthfi, Atha
Kesmas Vol. 16, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study aimed to review the essence of telemedicine in this modern era of technology and innovation, especially in developing countries. It also investigated the regulation aspect as the main component for healthcare services. There were five main categories of telemedicine: revenue stream and technology literacy, health facilities, human resources, data authorization and security, and health protocol. Furthermore, when combined with wearable devices, it enhanced healthcare delivery opportunities. There were two major components of global electronic health, namely telehealth and health informatics, based one-commerce and e-learning systems. The World Health Organization (WHO) has been able to describe the roles of telehealth services in developing countries.However, some related issues were needed to be well managed, such as the patient data security. It was found that the regular training and evaluation of people with poor educational background, low income, and stress were the main reasons most communities attend healthcare services despite mild sickness.Therefore, those need to be enlightened on the roles and importance of telehealth services.
Co-Authors Achmad Aulia Achmad K. Harzif Achmad K. Harzif Achmad K. Harzif Achmad Kemal Achmad Kemal Harzif Ade Jamal Agustina, Elizabeth Ahmad Aulia Aldri Frinaldi Ali Akbar Septiandri Andon Hestiantoro Anto Satriyo Nugroho Aprilia Asthasari Siregar Aria Kekalih Arief Budiono Ario Legiantuko Ariyati, Ira Asmarinah Atha Luthfi Aulia, Achmad Azali, Chairul Nurdin Azharul Yusri Bagastoro, Aswan Bernie Endyarni Medise Bram Pradipta Caroline G. Puspita Chiprion, Ariel Timy Christopher Yo, Edward Cynthia A. Susanto Dewi Ananta Hakim Dewi Friska Diana Sunardi Dwi A. Suryandari Dwi A. Suryandari Dwi Anita Suryandari Eliza Mansyur Endy M. Moegni Erfi Prafiantini Fadlika Harinda Faradina, Anindita Abigail Gita Pratama Hari Kurniawan, Riyan Hartanto Bayuaji Hartanto Bayuaji Herbert Situmorang Herbert Situmorang Huthia Andriyana Huthia Andriyana I Putu Gde Sanjaya, I Putu Indah S. Widyahening Irzanti, Alisha Nurdya Ivan Rizal Sini, Ivan Rizal Joedo Prihartono Judi Januadi Endjun Kanadi Sumapradja Kemal, Achmad Khatimah, Husnul Kurniati, Mala Legiantuko, Ario Luluk Yunaini Luthfi, Atha Mala Kurniati Melva Louisa Mila Maidarti Mohammad Baharuddin Muharam Natadisastra Muharam Natadisastra Muharam Natadisastra, Raden Muharam, R Mushlihani Mushlihani Mutia, Heidi Dewi Nur Rasyid Nurbaeti, Putri Nurdya Irzanti, Alisha Panghiyangani, Roselina Ponco Birowo Prini Diandara Garinasih Pudji Sari Puspawardani, Aisyah Retno Puspita Eka Wuyung Putri Chairani Eyanoer, Putri Chairani R. Muharam Rahmad Mulyadi, Rahmad Raymond R. Tjandrawinata Raymond Surya Retno A. Werdhani Rizki Yusrini Pohan Robert H. Purwaka, Robert H. Sarah Chairani Zakirah Sayogo, Atikah Silvana, Vita Suratih, Ni Made Desy Susanto, Cynthia A. Tita Yuningsih Titis Prawitasari, Titis Trinovita Andraini Ummah, Nafi'atul Veinardi Madjid Vita Silvana Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Wisnu Jatmiko Yanfaunnas, Atika Mahira Yo, Edward Christopher Yurnadi Yurnadi Zakirah, Sarah Chairani