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All Journal Jurnal Sain Veteriner Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional Pharmascience JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal SOLMA Media Farmasi MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Journals of Ners Community FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Cendekia Eksakta KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat Medfarm: Jurnal Farmasi dan Kesehatan SINTA Journal (Science, Technology, and Agricultural) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Farmasi Klinik dan Sains Jurnal Kesehatan dr. Soebandi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia
Sapto Yuliani
Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

 1 
Antihypertensive Activity of Black Garlic Extract in Rats and Its Phytochemical Analysis using GC-MS Estiningsih, Daru; Saiful Bachri, Moch; Hayu Nurani, Laela; Ma’ruf, Muhammad; Yuliani, Sapto; Sofia, Vivi; Prasasti, Dian
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.67-74

Abstract

Background: Hypertension is defined as a medical condition where blood pressure rises above 140/90 mmHg. Black garlic is recognized as a natural remedy that may help lower high blood pressure, primarily due to its abundant antioxidant properties, which are believed to inhibit the function of the angiotensin-converting enzyme (ACE) that is essential for regulating blood pressure. Objective: This study aimed to identify the chemical composition of black garlic using GC-MS and assess its antihypertensive effects in rat models. Methods: This study characterized the chemical composition of black garlic using GC-MS (Agilent 7890A) and evaluated its antihypertensive effects in rats. Hypertension was induced by oral administration of NaCl at a dose of 3.75 g/20 g body weight (BW) from day 0 to day 14. Blood pressure measurements were taken on days 0, 14, and 21. Black garlic extract was administered at three dose levels 4.2 mg/20 g BW, 8.4 mg/20 g BW, and 12.4 mg/20 g BW to evaluate dose dependent antihypertensive responses. Statistical analysis included the Kolmogorov-Smirnov test for normality, homogeneity testing, One-Way ANOVA Results: The GC-MS analysis identified 9-octadecenoic acid as the dominant compound in black garlic, accounting for 34.53% of its total composition. The antihypertensive activity test showed that administering black garlic at a dose of 12.4 mg/20 g BW significantly lowered systolic, diastolic, and mean arterial blood pressure while enhancing nitric oxide levels in hypertensive rats. Conclusion: Black garlic has the potential as an effective herbal treatment to lower blood pressure.
Co-Authors Adhi Gunawan Adi Permadi Adi Permadi, Adi Ainiyah, Nadia Putri Aisha Raihana Anggraeni, Linda Suci Arif Budi Setianto Arsyannur Pratiwi Aspamufita, Nuroh Ayu Shabrina Ayu Wulandari Azali, Aulia Syafadilla Bachri, Mochammad Saiful Botutihe, Lisa Agustina Cendekiawan, Khrisna Daffara Kinanthi Lustikaiswi Daipadli Daipadli Danang Prasetyaning Amukti Dandy Annas Muttaqien Daru Estiningsih Davit Nugraha Desi Ambarwati Desi Iswahyuni Dian Prasasti Didik Yuni Prasetya Dwi Utami Elmi Rahmadani Enti Rikomah, Setya Fitri Rahmawanti Galuh Rista Putri Gina Lestari Gina Lestari, Gina Gunawan, Adhi Handayani, Tiara Rizki Handayani, Tiara Rizki Hartati, Meity Hasana, Siti Nur Ibdal Satar Iis Wahyuningsih Intan Dwi Rahmita Khozanatul Ulwy Khrisna Agung Cendekiawan Kintoko Kintoko Kintoko Kintoko, Kintoko Laela Hayu Nurani Lasanudin, Rindi Ibrahim Leni Setiani Lily Noor Falah Lily Noor Falah Ma'ruf, Muhammad Magfirah Septiani Yusuf Maghfirah, Rahmayani Maysara, Risha Moch Saiful Bachri Moch Saiful Bachri Moch. Saiful Bachri Muhammad Alfian, Muhammad Muhammad Ma'ruf Muhammad Marwan Ramadhan Muhammad Nuh Muhammad Yusron Maulana El-Yunusi Nadia Putri Ainiyah Nadia Selvia Najini, Robby Ningrum, Lailatul Fitria Nining Sugihartini Nur Mahdi Nurkhasanah Nurkhasanah Mahfudh Nurkhasanah Nurkhasanah Nuroh Aspamufita Pelita, Putri Dina Poerwahyuningrum, Neny Putri Dina Pelita Rabiatul Adawiyah Rahmah Annura Rahmah Niar Ulfah Rahmawati, Dhea Ramadhan, Muhammad Marwan Ratih Saridewi Reka Rukmiati Rifka Salsabila Rikadyanti Rikadyanti Risha Maysara Risha Maysara Robby Najini Safira, Rizka Safwan Safwan Saraswati, Yasti Rizkandar Sari, Eka Anisa Satar, Ibdal Sofina Rahmadita Sri Mulyaningsih Suci Kurniati Suwidjiyo Pramono Tiara Rizki Handayani Ulfa Ramdhani M Uswatun Chasanah Vivi Sofia Vivi Sophia Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wardhani, Firda Aprillia Wardhani, Firdha Aprillia