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Journal : Medical Laboratory Technology Journal

The Efficacy of Green Grapefruit (Vitis Vinifera L) Extracts on Reducing Blood Glucose in a Diabetic Rat Model Habibah, Nur; Rofi'ah, Lisa Khofidatur; Bekti, Heri Setiyo; Dewi, Ni Nyoman Astika; Wilankrisna, Luh Ade; Posmaningsih, Dewa Ayu Agustini
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.606

Abstract

Diabetes mellitus (DM) is a chronic disease in which the pancreas cannot produce enough insulin hormone or when the body cannot use the insulin hormones properly. Green grapes contain flavonoids, anthocyanins, tannins, phenolic acids, and resveratrol and are high in antioxidants that are beneficial in lowering blood glucose levels. This study aims to determine the effectiveness of green grapefruit (Vitis vinifera L) extract in reducing blood glucose levels in a diabetic rat model. This research is a true experiment with a post-test-only control group design, using 24 male Wistar white rats aged 8-12 weeks and weighing 130-200 grams. The rats were divided into three groups: the positive control (I), green grapefruit extract (II), and normal group (III). The results showed that green grapefruit extract effectively reduced blood glucose levels in experimental animals by a percentage of 98.4%. The Independent T-Test showed a value of ρ>0.05 (0.533), so there was no significant difference in glucose levels between green grapefruit extract and positive control. This study concludes that green grapefruit extract was effective at 98.4% in reducing blood glucose levels in the diabetic rat model, compared to the positive control. The promising results of this study need to be continued by establishing a standardized optimal dose, assessing long-term effects, and implementing clinical trials to evaluate efficacy and safety.
Co-Authors Adi Susanto Agustina Agustina, Praditya Ayu Anak Agung Sri Agung Aryastuti Apdoludin Apdoludin, Apdoludin Aprilia, Indri Ayu Arjani, I A Made Sri Arjani, Ida Ayu Made Sri Arneni, Ni Putu Gita Asma, Maulia Assyfa Ramadhina Aswa, Putri Nadila Balti, Levandra Burhannuddin Cokorda Dewi Widhya Hana Sundari Definingsih Yuliastuti Desak Made Lestari Dewi Dewa Ayu Agustini Posmaningsih Dewi, Kadek Eliana Kesuma Dewi, Ni Km Ayu Kusuma Dewi, Ni Nyoman Astika Dewi, Ni Nyoman Astika Dhea Aura Cindyana Dwi Agustini, Desak Gede Gejir, I Nyoman Gusti Ayu Marhaeni Guswita, Reni Handriyani, Kadek Ayu Tia Surya Heri Setiyo Bekti I Gusti Agung Ayu Dharmawati I Gusti Ayu Sri Dhyanaputri I Nyoman Jirna, I Nyoman I Nyoman Purna I Wayan Jana I Wayan Karta I Wayan Karta I Wayan Mustika I Wayan Suardana Idazufina, Idazufina Indrasari, Dewa Ayu Ratna Putri Kurniawan, Bayu Surya Kurniawan, Surya Bayu Kusumajaya, Anak Agung Ngurah Lely Ika Mariyati Lisa Anjani, Ni Putu Lubis, Rizkika Walda Luh Ade Wilan Krisna Luh Ade Wilankrisna Mahastuti, Shri Ayu Purnami Mastra , Nyoman mastra, nyoman Maulina, Aprilia Mayumi, Ni Kadek Sintya Merdekawati, Fusvita Mochamad Choirul Hadi Nadilla Indriani Nasution Ni Nyoman Suindri Ni Wayan Rika Kumara Dewi Niluwih, Komang Deatriasa Pakerti Noviar, Ganjar Nugraheni, Clarissa Maheswari Setyo Laily Oktavia, Diana Posmaningsih, Dewa Ayu Agustini Pradnya Yasa, Ni Putu Candra Dewi Putra, Anak Agung Ngurah Dwi Tisna Adi Rahmadani, Dela Rahmadani, Najma Meutya Rakhmawati, Aprilia Ratih , Gusti Ayu Made Ratih, Gusti Ayu Made RIDHO KURNIAWAN, RIDHO Ridhoh, Ahmad Rinawati, Luh Putu Rindi, Oktavelendi Dhaneta Graha Rofi'ah, Lisa Khofidatur Savitri, Ni Putu Ayu Dani Sopar Subadra, Oemeria Shitta Sudarmanto, I Gede Sudiantara, Ketut Sujaya, I Nyoman Suryaningsih, Putu Ayu Suyasa, I Nyoman Gede Suyasa, Ida Bagus Oka Swastini, I Gusti Agung Ayu Putu Titik Nurchasanah, Titik Nurchasanah Usiono Usiono Vinenthy, Luh Putu Intan Visva Waldi, Irfa Wardi, Syah Wilankrisna, Luh Ade