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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Biology, Medicine, & Natural Product Chemistry JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kimia Riset Jurnal Zarah JOPS (Journal Of Pharmacy and Science) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) SANITAS: Jurnal Teknologi dan Seni Kesehatan JURNAL PENDIDIKAN, SAINS DAN TEKNOLOGI Binawan Student Journal Jurnal Farmasi Indonesia Jurnal Ilmiah Farmasi Simplisia Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu
Esti Mumpuni, Esti
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Formulation of facial liquid soap wıth 4-(Dimethylamino) chalcone and virgin coconut oil as antibacterial agents against acne-causing bacteria Wulandari, Putri; Mumpuni, Esti; Mulatsari, Esti; Kartiningsih, Kartiningsih
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1653

Abstract

Acne vulgaris is a multifactorial skin disorder commonly associated with infections caused by Staphylococcus epidermidis and Cutibacterium acnes. This study aimed to develop and evaluate an antibacterial facial liquid soap containing 4-(Dimethylamino) chalcone and virgin coconut oil (VCO). The synthesized chalcone, a flavonoid derivative obtained through the Claisen–Schmidt condensation reaction, was characterized using TLC, melting point analysis, UV-Vis spectrophotometry, and LC-MS/MS. Formulations containing 1.25% and 2.5% chalcone combined with 40% VCO were prepared and tested. Antibacterial activity was evaluated using the agar diffusion method, while physical properties were assessed through organoleptic observation, homogeneity, foaming ability, pH measurement, stability testing, and skin irritation tests. The 1.25% chalcone formulation demonstrated strong antibacterial activity, producing inhibition zones of 19.40±0.39 mm against C. acnes and 18.97±0.45 mm against S. epidermidis. All formulations were stable, homogeneous, and non-irritating. These findings indicate a synergistic antibacterial effect between chalcone and VCO, supporting their potential use as natural active ingredients in anti-acne facial soap formulations.
Andrographis paniculata Burm. F. in-silico analysis compounds that function as an insulin sensitizer therapy for type 2 diabetes via peroxisome proliferator activated gamma receptors (pparγ) receptor activator Pristiyantoro, Pristiyantoro; Siswandono, Siswandono; Mumpuni, Esti
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1651

Abstract

Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, requires safer PPARγ-targeting therapies to overcome the limitations of current thiazolidinediones (e.g., hepatotoxicity of pioglitazone). Andrographis paniculata, a traditional medicinal plant, contains bioactive flavonoids with putative insulin-sensitizing effects, although their PPARγ binding mechanisms remain unexplored. This study conducted in silico screening of eight A. paniculata compounds against PPARγ (PDB:5Y2O) using: (1) molecular docking (Molegro Virtual Docker 2013.6.0.0) to calculate binding affinities (MolDock/Rerank scores) and hydrogen bond interactions; (2) physicochemical profiling (ChemDraw Ultra 22.2/Chem3D Ultra 22.2) for drug-likeness parameters; and (3) ADMET prediction (pkCSM) for pharmacokinetic and toxicity assessment, with pioglitazone as the positive control. The results showed that 5,4'-dihydroxy-7,8,2',3'-tetramethoxyflavone exhibited near-native binding (MolDock: -111.653 vs pioglitazone -137.994) with optimal ligand-receptor stabilization through strong hydrogen bonds (-7.840 kcal/mol) with Ser289, His323, and Tyr473, as well as hydrophobic interactions with Phe282 and Leu330. This compound also demonstrated better aqueous solubility (-3.404 vs -4.309 log mol/L; p<0.05) and a favorable safety profile (non-hepatotoxic, AMES-negative) despite lower Caco-2 permeability (0.141×10⁻⁶ cm/s). This study identifies 5,4'-dihydroxy-7,8,2',3'-tetramethoxyflavone as a lead PPARγ agonist from A. paniculata with enhanced safety and drug-like properties. The HBond score of -7.840 suggests improved target specificity compared to pioglitazone. In vitro validation of glucose uptake modulation is recommended to confirm its therapeutic potential.
Formulation of facial liquid soap wıth 4-(Dimethylamino) chalcone and virgin coconut oil as antibacterial agents against acne-causing bacteria Wulandari, Putri; Mumpuni, Esti; Mulatsari, Esti; Kartiningsih, Kartiningsih
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1653

Abstract

Acne vulgaris is a multifactorial skin disorder commonly associated with infections caused by Staphylococcus epidermidis and Cutibacterium acnes. This study aimed to develop and evaluate an antibacterial facial liquid soap containing 4-(Dimethylamino) chalcone and virgin coconut oil (VCO). The synthesized chalcone, a flavonoid derivative obtained through the Claisen–Schmidt condensation reaction, was characterized using TLC, melting point analysis, UV-Vis spectrophotometry, and LC-MS/MS. Formulations containing 1.25% and 2.5% chalcone combined with 40% VCO were prepared and tested. Antibacterial activity was evaluated using the agar diffusion method, while physical properties were assessed through organoleptic observation, homogeneity, foaming ability, pH measurement, stability testing, and skin irritation tests. The 1.25% chalcone formulation demonstrated strong antibacterial activity, producing inhibition zones of 19.40±0.39 mm against C. acnes and 18.97±0.45 mm against S. epidermidis. All formulations were stable, homogeneous, and non-irritating. These findings indicate a synergistic antibacterial effect between chalcone and VCO, supporting their potential use as natural active ingredients in anti-acne facial soap formulations.
Skrining virtual dan elusidasi moda ikatan senyawa Inhibitor Enzim Elastase dan Hyaluronidase pada beberapa tanaman dengan aktivitas Anti-Aging Mumpuni, Esti; Mulatsari, Esti; Noerfa, Tri Kumala
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 11 No 2 (2019): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5617.764 KB) | DOI: 10.35617/jfionline.v11i2.40

Abstract

Beberapa penelitian mengenai enzim elastase dan enzim hyaluronidase yang berpotensi sebagai anti-aging telah dipublikasi sebelumnya. Mengacu pada berbagai hasil penelitian tersebut, pada penelitian ini dilakukan skrining virtual 30 senyawa bahan alam yang berasal dari 10 tanaman dan elusidasi moda ikatan terhadap senyawa aktif sebagai inhibitor enzim penyebab penuaan. Penelitian ini bertujuan untuk mengetahui mekanisme kerja senyawa penghambat aging pada tanaman dan memodelkan interaksinya. Berdasarkan hasil score ChemPLP dari simulasi docking pada penelitian ini, diperoleh 4 senyawa yang aktif menghambat enzim elastase yaitu dari 2 senyawa dari tanaman jeruk (Citrus aurantium subsp. Amara), 1 senyawa dari bunga lavender (Lavandula angustifolia L.) dan 1 senyawa dari tanaman lengkuas belang (Alpinia zerumbet). Sedangkan pada enzim hyaluronidase diperoleh 11 senyawa yang aktif menghambat enzim hyaluronidase yaitu 2 senyawa dari tanaman lengkuas belang (Alpinia zerumbet), 3 senyawa dari tanaman pinang (Areca catechu L.), 1 senyawa dari tanaman teh (Camellia sinensis Kuntze), 1 senyawa dari bunga mawar (Rosa centifolia L.), 2 senyawa dari tanaman jeruk (Citrus aurantium subsp. Amara), 1 senyawa dari tanaman lavender (Lavandula angustifolia L.) dan 1 senyawa dari rumput laut (Eucheuma spinosum).
SINTESIS SENYAWA 1,5-BIS(3’-ETOKSI-4’-HIDROKSIFENIL)-1,4-PENTADIEN-3-ON (EHP) DENGAN BAHAN BAKU ETIL VANILIN MUTU TEKNIK Mulatsari, Esti; Mumpuni, Esti; Purwanggana, Agus; Rasdianti, Putri
Jurnal Zarah Vol. 9 No. 1 (2021): April, 2021
Publisher : Fakultas Keguruan dan Ilmu Pendidikan, Universitas Maritim Raja Ali Haji

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31629/zarah.v9i1.2184

Abstract

Selama ini, sintesis senyawa 1.5-bis (3'-etoksi-4'-hidroksifenil)-1,4-pentadien-3-on (EHP) menggunakan etil vanillin kualitas pro analisis sebagai bahan baku. Dalam penelitian ini, dilakukan sintesis EHP dengan etil vanilin kualitas teknis sebagai bahan baku. Tujuan dari penelitian ini adalah memperoleh rendemen yang tinggi dengan karakteristik EHP yang sama dengan hasil sintesis menggunakan etil vanillin pro analisis akan tetapi biaya produksi lebih rendah. EHP merupakan senyawa analog kurkumin dengan mengubah gugus metoksi menjadi etoksi dan diketon menjadi monoketon. Metode sintesis menggunakan reaksi kondensasi aldol dengan variasi waktu kondensasi. Karakterisasi dan identifikasi senyawa hasil sintesis dilakukan menggunakan metode spektrofotometri. Hasil penelitian menunjukkan bahwa rendemen optimum yang diperoleh adalah 73,23% dalam waktu kondensasi 7 hari. Proses karakterisasi dan identifikasi menunjukkan bahwa senyawa yang disintesis berwarna hijau kecoklatan dan memiliki aroma aromatik, titik leleh 105,2-109,8 °C, Faktor retardasi (Rf) 0,68 dengan uji Kromatografi Lapis Tipis, serapan maksimum 310 dan 278,50 nm dengan uji kromatografi UV-Vis, vibrasi pada bilangan gelombang 3354,38 cm-1; 2979,82 dan 2931,60 cm-1; 1576.99 cm-1; 1672,51 cm-1; 838,59 dan 631,78 cm-1 dengan uji spektrofotometri Inframerah dan persentase area kemurnian dengan uji densitometri 76,69% dan persentase rendemen 51,16 %. Hasil ini menunjukkan karakteristik dan rendemen yang sama dibandingkan dengan EHP yang disintesis menggunakan etil vanilin kualitas pro analisis sebagai bahan baku dengan persentase rendemen yang lebih rendah.
In Silico Study of Beluntas Leaves (Pluchea indica) on DPP-4, α-Glucosidase, SGLT-2, and PPAR-γ as Antidiabetic Targets Andri Prasetiyo; Simanjuntak, Triviana; Kendok, Edelburga Suryati; Dalo, Matilde Tiwery; Mumpuni, Esti; Esti Mulatsari
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.122-140

Abstract

Background: Diabetes mellitus (DM) is a chronic metabolic disease with a steadily increasing prevalence globally. Long-term use of synthetic antidiabetic drugs is often associated with side effects, making exploration of alternative therapies from natural ingredients important. Pluchea indica L. leaves have been reported as a traditional Indonesian plant empirically used to lower blood sugar levels. Objective: This study aims to explore the potential of active compounds from Pluchea indica L. leaves as candidate multi-target antidiabetic agents through an in silico approach. Methods: An in silico study was conducted using molecular docking with Molegro Virtual Docker (MVD) to evaluate the interaction of four active compounds from beluntas leaves [(+)-Lirioresinol B, β Stigmasterol, (+)-Pinoresinol, and Plucheoside A against diabetes target proteins DPP-4 (PDB: 4FFW), α-glucosidase (PDB: 3L4W), SGLT-2 (PDB: 7VSI), and PPAR-γ (PDB: 5UGM)]. Method validation was performed by re-docking the original ligands (RMSD < 2.0 Å). Lipinski's 5 Rule analysis and ADMET prediction were performed to evaluate the drug-likeness and pharmacokinetic profiles of the compounds. Results: Method validation showed RMSD of 0.31-1.71 Å for all target proteins. Docking results showed that (+)-Pinoresinol had the best affinity as a DPP-4 inhibitor (Rerank score -103.452), (+)-Lirioresinol B as an α-glucosidase inhibitor (-100.173), Plucheoside A as an SGLT-2 inhibitor (-126.555), and β Stigmasterol as a PPAR-γ agonist (-131.023). Lipinski's 5 Rules analysis showed that all compounds most often violated 1 criterion (PSA). ADMET predictions showed an acceptable pharmacokinetic profile with low toxicity. Conclusion: The active compounds from beluntas leaves show potential as multi-target antidiabetic agents with good binding affinity to diabetes target proteins. These findings are still predictive and require further validation through in vitro and in vivo studies to confirm their biological activity, selectivity, safety, and pharmacological relevance as effective antidiabetic candidates in the future.
Co-Authors Achmad Daud, Rizqi Akbar Fandi Aey Fadilah, Yasin Aji, Nur Amalia . Andri Prasetiyo Audrey, Cresentia Budiati, Anarisa Dalo, Matilde Tiwery Dewi, Nidya Luciana Dhani, Muhammad Effionora Anwar Evi Susanti Fadillah, Almufti Fajar, In Rahmi Fatria Hidayat, Andika Muhammad Humaedi, Aji Indriani, Aqilah Idelia intan permata sari KARTININGSIH, KARTININGSIH Kendok, Edelburga Suryati Krismayadi Krismayadi kurnia agustini Martati, Titiek Maryanto, Kenny Mawijaya, Agus Muhammad Luthfi Mulatsari, Esti Mutia Sari Wardana Natthawani, Amitta Noerfa, Tri Kumala Nurmayati, Adi Nursanti, Okta Panca Bayu Chandra, Pra Partomuan Simanjuntak Pristiyantoro, Pristiyantoro Purwanggana, Agus PUTRI WULANDARI Qodriah, Rahmatul R. Sapto Hendri Boedi Soesatyo RAHMAT, DENI Ramadhan, Islami Al-Kaffah Ramadhani, Karina Natasya Rasdianti, Putri Ratumakin, Monika Buka Kopon Raymond R. Tjandrawinata Rhahmadini, Yahdi Thia Sandayu, Feriza Sari Dewi, Rika Shirly Kumala Simanjuntak, Josua Donrio Simanjuntak, Triviana Siswandono, Siswandono Siung, Chris Nicholas Stephanie, Adiva Syabriena, Tarra Syamsi, Lusi Nursilawati Syamsudin Syamsudin Taqwa, Iqbal Ananda Titi Parwati, Titi Utami, Fajar Dwi Utami, Fit Indri Intan WAHYU WIDOWATI Yesi Desmiaty, Yesi Yogaswara, Amira Thufailla Yuliana, Agnes Zahra, Nurulita Az