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All Journal Jurnal Kedokteran Syiah Kuala Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Althea Medical Journal Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Jurnal NERS Indonesian Journal of Tropical and Infectious Disease Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Science and Technology Indonesia Journal Of Vocational Health Studies Amerta Nutrition JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology Medicosphere Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

Erwin Astha Triyono

Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia

Author-ID : 508768

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Medical Audit of the Management of Patients with Sepsis in the Intermediate Care Unit of Department Internal Medicine School of Medicine Airlangga University/Dr. Soetomo Hospital Hadi, Usman; Triyono, Erwin Astha
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 1 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

Sepsis and septic shock is one of the highest causes of death in patients treated in hospitals. Research Objectives: to evaluate the quality of the management of sepsis patients in Intermediate Care Unit, Department of Internal Medicine Dr. Soetomo Hospital Surabaya, Indonesia. This study was a retrospective study to re-evaluate the patient medical record. The number of patients treated: 275 patients, sepsis patients: 80 patients, the number of patients who entered the study 50 patients, 30 (60%) female and 20 (40%) men, most age groups aged 60 -70 years (32%), Mean 54 Median 56. Diagnostic accuracy according to the criteria of sepsis 45 (90%) patients, compliance with taking blood culture 2 (4%) patients, appropriate antibiotic selection 49 (98%) patients, the number of patients who should not be given antibiotics (4 patients), but given the antibiotic is 3 (75%) patients, the number of patients who should be given antibiotics (46 patients) but were not given antibiotics 1 (2%) patient. The reason of patients discharged: 27 had died (54%), 13 cured (26%), not yet recovered 10 (20%). The reason of patients discharged forcibly: to feel recovered 2 (20%), the condition gets worse 3 (30%), no cost 2 (20%), not clear 3 (30%). Patients with sepsis remain a big problem, and it still needs to improve the management of sepsis on existing guidelines.

CRYPTOCOCCAL ANTIGENEMIA IN HIV/AIDS PATIENTS USING LATERAL FLOW IMMUNOASSAY DETECTION AT Dr. SOETOMO GENERAL HOSPITAL SURABAYA Widjaja, Sajuni; Triyono, Erwin Astha; Kawilarang, Arthur Pohan; Rohiman, Abu
Indonesian Journal of Tropical and Infectious Disease Vol. 7 No. 1 (2018)
Publisher : Institute of Topical Disease Universitas Airlangga

Cryptococcus infection in HIV / AIDS patients results in cryptococcal meningitis, a major cause of subacute meningitis with 100% mortality if not receiving appropriate antifungal therapy. An examination of cryptococcal antigen will provide risk information for patients who will experience cryptococcal meningitis. Better diagnosis in asymptomatic and symptomatic phases of cryptococcosis are key components to reduce morbidity and mortality. This study aims to determine the proportion of cryptococcal antigenemia in HIV / AIDS patients treated at Intermediate Treatment-Infectious Diseases Unit of Dr. Soetomo General Hospital Surabaya. Cryptococcal antigenemia was examined in HIV / AIDS patients with suspected Cryptococcus infection and CD4+ T cell lymphocyte count <200 cell /Î¼l. The examination used a lateral flow assay diagnostic tool, a simple FDA(Food and Drug Administration)-approved immunochromatographic test system for detection of capsular polysccharide antigens of Cryptococcus species complex (Cryptococcus neoformans and Cryptococcus gattii) in blood. This test meets all of the World Health Organization ASSURED criteria (affordable, sensitive, specific, user friendly, rapid/robust, equipment-free, and delivered). Sensitivity and specifiticy of this method from serum are both 100%. There were 3 positive cryptococcal antigenemia from 41 serum HIV / AIDS patients with suspected cryptococcus infection at Intermediate Treatment- Infectious Diseases Unit of Dr. Soetomo General Hospital Surabaya. All of these patients were male aged over 36 years, had CD4+ T cell lymphocytes <100 cell /Î¼l and had never received antiretroviral therapy before. The proportion of cryptococcal antigenemia in HIV / AIDS patients with suspected Cryptococcus infection at Intermediate Treatment-Infectious Diseases Unit of Dr. Soetomo General Hospital Surabaya was 7.32%.

MICROBIAL PATTERNS OF HOSPITALIZED HIV POSITIVE PATIENTS ADMITTED IN DR. SOETOMO GENERAL HOSPITAL, SURABAYA INDONESIA Tan, Feriawan; Triyono, Erwin Astha; Wahyunitisari, Manik Retno
Journal of Vocational Health Studies Vol. 5 No. 1 (2021): July 2021 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V5.I1.2021.1-11

Background: HIV patients with a weak immune system are very vulnerable to opportunistic infections, can trigger systemic endothelial activation and end up as a condition of sepsis. In Indonesia currently, there is no bacterial epidemiological mapping of the etiology of opportunistic infections in HIV patients. Purpose: To determine the pattern of bacteria that cause opportunistic infections and their antibiotic sensitivity in HIV patients. Method: Prospective observational study design. Data were obtained from medical records of hospitalized patients at RSUD Dr. Soetomo Surabaya from August 2019 - February 2020. Result: Out of 64 patients, 83 specimens were found with the most types of gram-negative bacteria 44.6%, while gram-positive bacteria were 15.7% and a mix of 2.4% and 37.3% negative culture. The highest prevalence of gram-negative bacteria was Klebsiella pneumoniae (35.15), followed by Escherichia coli (10.8%), Pseudomonas aeruginosa (8.1%), and Acinetobacter baumanii (8.1%). The highest prevalence of gram-positive bacteria was Streptococcus mitis / oralis (30.7%), followed by Staphylococcus aureus (23.1%) and Staphylococcus epidermidis (15.4%). Among gram-negative bacteria antibiotic, Cefoperazone-sulbactam showed the greatest sensitivity, following by Amikacin, Gentamycin and Piperacillin-tazobactam; while among gram-positive bacteria are Chloramphenicol, Linezolid, and Vancomycin. Almost all isolates showed resistance to Ampicillin. Conclusion: Bacteria pattern that caused opportunistic infection in RSUD Dr. Soetomo is K. pneumonia as most common gram-negative bacteria followed by E. coli, P. aeruginosa and A. baumanii; while the most gram-positive bacteria found are S. mitis/oralis and S. aureus. Among antibiotic used, Ampicillin showed the lowest sensitivity to almost all bacteria isolates.

EARLY DETECTION OF LOW VISION DETERMINANT FACTORS USING THE E-SIGALON SELF-ASSESSMENT APPLICATION: Deteksi Dini Faktor Determinan Low Vision Menggunakan Aplikasi e-SIGALON Berbasis Pemeriksaan Mandiri Triyono, Erwin Astha; Arini, Merita; Tan, Feriawan; Masyfufah, Lilis; Rachmad, Eka Basuki; Kusumayanti, A.A.Ayu Mas; Kartikawati, Tri; Kartikadewi, Indriani; Novanda, Aisyah Wahyu; Ramadhani, Putri Nabilah
Jurnal Berkala Epidemiologi Vol. 12 No. 3 (2024): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V12I32024.263-272

Background: Low Vision is an end-stage condition that cannot be cured. The best treatment for low vision is the early detection. However, there is still no integrated low vision data in health services, the lack of public knowledge about low vision, the low rate of case discovery, and the lack of optimal referral and treatment mechanisms for low vision are problems that must be addressed at this time. Purpose: This study aims to detect early low vision determinant factors using a self-assessment application. Methods: This study is analytical and quantitative research. Respondents for this research were from five selected populations in East Java who filled out the e-SIGALON application from September to December 2023. The respondents were suspected as having low vision if they had score of 6 or higher. The variables were analyzed using logistic binary regression, the validity and reliability test was also performed. Results: From 446 respondents, there were 237 people (53.14%) suspected of low vision but only 66 people came to referral hospital. The low vision suspect showed 12 of the 15 statistically significant questions (p<0.05). The most common was sitting very close to the television/monitor (48.43%), followed by having difficulties in seeing objects in dim light (44.17%) and difficulties in doing the things they want to do (40.13%). Conclusion: The e-SIGALON application can be a solution in managing low vision. Through this application, people can easily find out and recognize whether they have low vision or not.

Profile of Elderly COVID-19 Patients at Indrapura Field Hospital, Surabaya Mahdian, Haidar; Triyono, Erwin Astha; Handajani, Noor Idha; Kartina, Leny
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 1 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I12025.7-13

Highlights: Elderly patients with comorbidities are more vulnerable to coronavirus disease (COVID-19) because it can cause a higher mortality rate and a poor prognosis. Most of the elderly COVID-19 patients who were given symptomatic treatment were cured. Abstract Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pathogen that causes coronavirus disease (COVID-19). The elderly, especially those with comorbidities, are vulnerable to COVID-19. This study aimed to determine the profile of elderly patients with COVID-19 and to provide valuable data for further research. Methods: This was a retrospective descriptive study of 132 (n=132) elderly COVID-19 patients at Indrapura Field Hospital, Surabaya, between April and October 2021. The clinical profile was determined by collecting medical record data from Indrapura Field Hospital, Surabaya. All statistical data analyses were conducted using the International Business Machines Corporation (IBM) Statistical Package for Social Sciences (SPSS) for Macintosh version 25.0. Results: This study indicated that among 132 (n=132) elderly patients, the predominated age range was 61–63 years old (37.12%), and most of the patients were males (57.6%). The majority of the patients' occupations were private employees, and hypertension was the main comorbidity in elderly patients (52.3%). Most patients experienced mild symptoms (46.2%), with the most common complaint being a productive cough (42.4%). All of the patients had no antiviral, antibacterial, or corticosteroid therapy. There were 73 patients (55.3%) who had been hospitalized for less than 10 days, with most of the patients (78.79%) cured and allowed to go home. Conclusion: The majority of patients at Indrapura Field Hospital, Surabaya, were elderly male patients, with hypertension being the most common comorbidity. Most patients exhibited mild symptoms, mainly a productive cough, and showed significant improvement with symptomatic, isolation, relaxation, nutrition, and observation (SIRNO) therapy, resulting in a high recovery and discharge rate.

Comparison between Exposure of Ciprofloxacin and Cefotaxime on Developing of Escherichia coli ESBL Amin, Muhammad; Wasito, Eddy Bagus; Triyono, Erwin Astha
Folia Medica Indonesiana Vol. 56 No. 2 (2020): June
Publisher : Universitas Airlangga

This study aimed to compare ciprofloxacin and cefotaxime exposure to develop ESBL producing Escherichia coli (E. coli). A total of 16 isolates of cefotaxime sensitive E. coli and ciprofloxacin were exposed to ciprofloxacin and cefotaxime for 14 days using the Kirby-Bauer antibiotic disc diffusion method. Colonies that grew on the edge of the inhibiting zone were exposed each day by the same method. Furthermore, we observed the occurrence of resistance to cefotaxime as ESBL screening test. Isolates were resistant, the following day the ESBL was confirmed by the Modified Double Disk Sinergy Test (MDDST) method using Cefotaxime (CTX), Ceftazidime (CAZ), Aztreonam (ATM), and Amoxilin Clavulanate (AMC) antibiotic discs. From 16 isolates of ESBL producing E. coli exposed to ciprofloxacin, it was obtained 4 (25%) to ESBL E. coli. ESBL production occurred after E. coli was exposed to ciprofloxacin on days 5, 6, 7, and 12. While those exposed to cefotaxime none becomes ESBL E. coli. There was no difference between ciprofloxacin and cefotaxime exposure to develop ESBL producing E. coli (p=0.101; Chi-square).

Factors That Reduce The Incidence of Lung Tuberculosis Other Than Isoniazid Preventive Therapy (IPT) in Latent Igra Positive HIV-TB Patients Shinta Karina Yuniati; Tutik Kusmiati; Erwin Astha Triyono; Aryati
Journal of Diverse Medical Research: Medicosphere Vol. 1 No. 4 (2024): J Divers Med Res 2024
Publisher : Faculty of Medical - UPN Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v1i4.20

Background. One crucial public health measure to stop persons living with HIV (PLWHA) from developing active TB is isoniazid preventative therapy (IPT). Only few hospitals in Indonesia continue to offer IPT. Aim. The purpose of this study was to assess how IPT affected the incidence of TB in patients with latent HIV infection. Method. This study uses a prospective cohort design and is quasi-experimental in design. Samples for the study were obtained by convenience sampling and the study was carried out in the inpatient and outpatient departments of UPIPI Dr. Soetomo Hospital. Latent IGRA positive HIV-TB patients who satisfied the inclusion requirements made up the samples. Result. Of the 59 patients who finished the screening exam, 23 fulfilled the inclusion requirements for this study. Using the ELISPOT method, the IGRA T-SPOT.TB test yields 36 (64.29%) negative findings and 23 (35.18%) positive results. After six months of IPT administration, analysis of the data revealed that the incidence of active pulmonary TB in latent HIV-TB patients was 0% in the IPT group and 0% in the non-IPT group. Antiretroviral medication used for more than four years and a CD4+ T lymphocyte count of more than 200 cells/μL were factors that contributed to the lack of pulmonary tuberculosis in both groups. Conclusion. ARV used for more than four years and CD4+ lymphocyte count more than 200 cells/L contributing significantly in pulmonary tuberculosis incidence.

Pola Penggunaan Levofloxacin pada Pasien HIV dan AIDS di UPIPI RSUD DR. Soetomo Surabaya Pambudi, Rien Esti; Triyono, Erwin Astha; Surdijati, Siti; Jaya, Halim Priyahau
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 2 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i2.2142

HIV is a retrovirus (RNA) that attacks the human immune system. AIDS is a retrovirus disease characterized by immunosuppression which causes opportunistic infectious diseases. Opportunistic infections appear with new forms of infection by other microorganisms or reactivation of latent infections under normal conditions that can be controlled by the immune system so as not to cause manifestations. Opportunistic infections show effects on immunity associated with CD4 cell counts. The therapy used to reduce opportunistic infections is levofloxacin. Based on research, levofloxacin for HIV AIDS patients is often used to reduce opportunistic infections including bacterial pneumonia, tuberculosis and sepsis. This study aims to provide data that includes levofloxacin therapeutic doses, frequency use, old route drugs, prevalence and interaction of qualitative analysis related to medical records in HIV & AIDS patients at UPIPI DR. Soetomo Regional General Hospital Surabaya. The research method used is a retrospective observational study on medical records of patients with HIV & AIDS. Sampling was done by consecutive sampling in the period January 1, 2015 to June 30, 2015. The results obtained from the most relevant types of research, dose, frequency and route were levofloxacin for the treatment of opportunistic infections, especially bacterial pneumonia, tuberculosis, and sepsis. in oral doses and injections at a dose of 500 mg and a frequency of 750 mg 1x1. The use of levofloxacin given to HIV & AIDS patients at UPIPI DR. Surabaya Soetomo Regional General Hospital, related to dosage, route, frequency, interval, and duration of administration is in accordance with existing guidelines.

Pola Penggunaan Ranitidine pada Pasien HIV & AIDS di UPIPI RSUD DR. Soetomo Surabaya Nurohmawati, Weni; Triyono, Erwin Astha; Surdijati, Siti; Jaya, Halim Priyahau
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2182

HIV is a retrovirus that attacks CD4 lymphocyte cells. AIDS is a retrovirus disease caused by infection with retrovirus HIV-1 or HIV-2 which causes opportunistic diseases, secondary neoplasms and neurological abnormalities. In patients with HIV & AIDS often experience gastrointestinal disorders such as nausea and vomiting caused by side effects of the use of antiretroviral or due to other factors. Ranitidine is an H2 inhibitory receptor that will selectively and reversibly reduce excess gastric acid secretion. In this study ranitidine was used as a stress ulcer prophylaxis in hospitalized patients. This study aims to display ranitidine therapy data including type, dose, route of drug administration, prevalence, duration of use and qualitative analysis of interactions associated with medical record data at UPIPI RSUD Dr. Soetomo Surabaya. The research method used was observational prospectively on patient medical record with HIV & AIDS. Sampling was carried out by consecutive sampling period from November 1, 2016 to December 31, 2016. The results of this study give information that ranitidine was most widely used for stress ulcer prophylaxis therapy in hospitalized patients in UPIPI RSUD Dr. Soetomo Surabaya in a dose of 50mg / 2ml with a frequency of 2x1 while for oral ranitidine with a dose of 150mg / tablet with a frequency of 2x1. The use of ranitidine on HIV & AIDS patients in UPIPI RSUD Dr Soetomo Surabaya, related to dosage, route, frequency, interval, and duration of administration is in accordance with the existing guidelines.

Co-Authors Afif Nurul Hidayati Alfadhila Khairil Sinatrya Amos Pongbulaan Anak Agung Ayu Niti Wedayani Anindita Abigail Anisa Lailatul Fitria Aprilawati, Dwi Arini, Merita Armedy Ronny Hasugian Aryati Aryati Aryati Aryati Aryati Audrey Gracelia Riwu Bambang Wiryanto Bramantono Bramantono, Bramantono Brian Eka Rahman Budiono Budiono Christian Yochanan Christina Avanti Cita Rosita Sigit Prakoeswa Djoko Agus Purwanto Djoni Susanto Dwi Murtiastutik Eddy Bagus Wasito Endang Retnowati Endang Retnowati Endang Wahyu Fitriani Erika Marfiani Erna Kristin Eti Nurwening Sholikhah Eva Lydiawati Faiz Murfid Gunawan Feriawan Tan Firdausa, Sarah Firdausiyah Firdausiyah Hafidh Maulana Harianah Harianah Hazreen B Abdul Majid Hermi Indita I Made Sila Darmana Intan Putri Risky Amalia Iskandar Zulkarnain Ivan Hoesada James Hutagalung Jaya, Halim Priyahau JS. Hutagalung Jusak Nugraha Kartikadewi, Indriani Kartikawati, Tri Kartina, Leny kawilarang, Arthur pohan Kusmiati, Tutik Kusumayanti, A.A.Ayu Mas Linda Astari, Linda M Vitanata M. Yulianto Listiawan Mahdian, Haidar Masyfufah, Lilis Muhammad Amin Musofa Rusli MVS Mahanani Nabil Salim Ambar Nabilah Nono Tri Nugroho Noor Idha Handajani Novanda, Aisyah Wahyu Nurohmawati, Weni Oryza Dwi Nanda Pambudi, Rien Esti Pauline Hadisiswoyo Pudji Lestari R. Heru Prasetyo R. Heru Prasetyo Rachmad, Eka Basuki Rahmadewi Rahmadewi Ramadhani, Putri Nabilah Rehatta, Nancy Margarita Rimbun Rimbun Rohiman, Abu Senda Sulvain Rahmaningrat Shinta Karina Yuniati Siti Rahayu Nadhiroh Siti Surdijati, Siti Sulistiawati Sulistiawati Sulvy Dwi Anggraini Syahru Ramadhaan Unzila Tan, Feriawan Tripudi Asmarawati Umiastuti, Pirlina Usman Hadi Usman Hadi Wahyu Dian Pratiwi Wahyunitisari, Manik Retno Widjaja, Sajuni

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