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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Kedokteran Brawijaya Biology, Medicine, & Natural Product Chemistry Biomedika Bioeksperimen: Jurnal Penelitian Biologi Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Kedokteran dan Kesehatan Herb-Medicine Journal Indonesian Journal of Medicine PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Litbang Sukowati : Media Penelitian dan Pengembangan Cermin Dunia Kedokteran Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Medika
Safari Wahyu Jatmiko
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Cermin Dunia Kedokteran

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Peran Mucosal-associated Invariant T-Cells dalam Imunitas terhadap Salmonella typhi Jatmiko, Safari Wahyu
Cermin Dunia Kedokteran Vol 42, No 12 (2015): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.7 KB) | DOI: 10.55175/cdk.v42i12.931

Abstract

Demam tifoid masih menjadi masalah di negara-negara berpenghasilan rendah. Demam tifoid disebabkan oleh bakteri Salmonella typhi yang penularannya terjadi secara fekal oral. Bakteri yang berhasil melewati asam lambung akan menempel kepada sel M dan epitel usus. Invasi ini direspon oleh berbagai sel seperti sel neutrofil, sel makrofag, sel T dan sel B. Sel MAIT sebagai bagian dari sel T yang terletak di mukosa usus mempunyai peran penting dalam usaha eliminasi Salmonella typhi. Sel MAIT mempunyai TCR Vα7.2 yang bisa mengenali produk antara sintesa riboflavin Salmonella typhi yang terikat oleh MR1. Sel MAIT diaktifkan dengan adanya ikatan antara TCR dengan ligannya, ikatan antara molekul asesori CD80 atau CD86 dengan CD28, dan ikatan antara IL-12 dan 18 dengan IL-12R dan IL-18R. Sel MAIT yang aktif mengeliminasi bakteri dengan cara mengeluarkan sitokin, perforin, dan granzim.Typhoid fever is still a problem in low-income countries. Typhoid fever is caused by fecal oral transmission of Salmonella typhi bacteria. Bacteria survived from gastric acid will be attached to M cells and intestinal epithelial cell. This invasion was responded by various cells such as neutrophils cells, macrophages, T cells and B cells. MAIT cell as part of the T cells located in the intestinal mucosa have an important role in the elimination of Salmonella typhi. MAIT cells have Vα7.2 TCR that recognize MR1-bound intermediate product of riboflavin synthesis of Salmonella typhi. MAIT cell is activated by bond between the TCR and ligand, bond between accessory molecule CD28 and CD80 or CD86, and bond between IL-12 and IL-18 with IL-12R and IL-18R. Active MAIT cells eliminate bacteria by secreting cytokines, perforin, and granzyme. 
Co-Authors Affifah, Fathiyya Noor Agustina, Dinda Dwi Ahmad Alrizaldi Alfajri, Asri Alim, Fika Nurul Anam, Ilham Hafizha Maulana Anggitaratri, Zakia Novi Anika Candrasari Annas Syahirul Nugraha Annas Syahirul Nugraha, Annas Syahirul Annisa Maulidia Aprida Putri Aqmarina, Nadia Wdihi Arkan Adi Widiya Arkan Adi Widiya, Arkan Adi Aryanto Asfarina, Fatin Aulia Hanif Azenta, Moch. Tabriz Azhim Rahmawati Azhim Rahmawati, Azhim Brilliantama, Fandy Akbar Devi Usdiana Rosyidah Dodik Nursanto Edi Dharmana Em Sutrisna Erika Diana Risanti Faizah, Ishmah Nur Fauzi, Favian Arriella Shabri Ikmal Fitka Romanda Fitri, Alifah Aulia Graffico Eryza Oldiara Haliza, Sheli Nur Hanif, Aulia Hasna Zahro Iftikhonsa Iin Novita Nurhidayati Mahmuda Kamila, Aulida Azkia Kania, Yulia Intan Kumala, Aswa Arsa Lestari, Nining Listiana Masyita Dewi Lisyani Suromo, Lisyani Mapa, Anna Rochim Marsya, Vitania Maulida, Amira Hasna Muhammad Adha Muhammad Alim Abdulmajid Hidayatulloh Nadia Wdihi Aqmarina Nida Faradisa Fauziyah Nining Lestari Nur Mahmudah Nurhaliza, Sheli Pambudi, Nasrurrofiq Risvana Bayu Pintakasari Widyaningtyas Prasetyo, Andri Sugeng Puspitasari, Metana Putri, Aprida Retno Sintowati - Retno Siryaningsih Retno Siryaningsih, Retno Riandini Aisyah Rochmadina Suci Bestari Rohman, Raihan Fadzlur Salsabiela, Salwa Salsabila, Nabila Mutia Sholeh, Muhammad Dzikru Irfan Sigit Widyatmoko Sri Wahyuni Sulistiyo, Azka Hafiy Supraba, Intan Pratiwi Suryani, Latifah Syahida, Safira Tara , Irmanawati Audhina Nirmala Tri Agustina, Tri Utami, Aurelia Ratna Utami, Indari Wafiq, Muhammad Azzim Wibowo, Haryo Kunto Widyaningtyas, Pintakasari Yunitama, Alifa Agil Dhillu