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Journal : Journal of Pharmaceutical and Sciences.

Drug-Related Problems Pada Penyakit Paru Obstruksi Kronis: Literatur Review Fahmi, Muhammad Zaini; Karuniawati, Hidayah; Ismail, Wan Ismahanisa
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.955

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of global morbidity and mortality, with a continuously increasing health burden. The complexity of long-term therapy in COPD increases the risk of Drug-Related Problems (DRPs), which can affect patient clinical outcomes. This literature review was conducted descriptively by searching articles in the PubMed, Scopus, Google Scholar, and ScienceDirect databases using keywords related to DRPs and COPD. The selection was made on publications from the last 10 years (2015–2025) relevant to the topic and available in full text. Based on studies by Li et al., (2019) and Apikoglu-Rabus et al., (2016), the classification of DRPs according to PCNE V9.0 mainly included aspects of medication safety (54.2%), inappropriate drug selection (up to 8.7%), excessive dosage (19.9%), excessive duration of therapy (17.7%), and errors in the drug use process (up to 63.3%). Patient factors such as non-compliance (25%) and incorrect inhalation techniques were the main contributors to the occurrence of DRPs. Inappropriate use of medications, drug-herb interactions, and lack of therapy monitoring were also consistently found. The findings suggest that DRPs significantly worsen symptom control and increase the risk of exacerbations. Pharmacists are critical in identifying, preventing, and managing DRPs through patient education, therapy review, and ongoing therapy monitoring. DRPs in COPD patients are a serious challenge that requires a multidisciplinary approach. Ongoing education, monitoring of therapy rationality, and collaboration between healthcare professionals are needed to improve patient safety and the effectiveness of COPD treatment.
Kejadian Drug-Related Problems Pada Pasien Rawat Inap dengan Diabetes Melitus Berdasarkan Kriteria PCNE : Literatur Review Febriani, Rizkina Elistya; Karuniawati, Hidayah; Rahman, Anees Ur
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.956

Abstract

Non-communicable chronic diseases such as diabetes mellitus (DM) are a significant health burden worldwide. In the treatment of DM patients, long-term drug use is inevitable and increases the risk of Drug-Related Problems (DRPs). The presence of DRPs can affect the effectiveness of therapy and the risk of side effects in hospitalized DM patients. This review aims to evaluate various studies conducted on DRPs in hospitalized DM patients based on the Pharmaceutical Care Network Europe (PCNE) classification. A systematic search of relevant articles in the last 10 years through the SpringerLink, ScienceDirect, Scopus, and PubMed databases. Irrelevant studies, review articles, and no data on DRP classification using PCNE or outpatients will be excluded. The review found four articles discussing DRP classification using PCNE in hospitalized DM patients. The number of DRPs varied, ranging from 253 to 873 cases. The proportion of patients experiencing at least one DRP was also relatively high, ranging from 48.1% to 84.5%. The most common problem was treatment ineffectiveness (P1.2), which accounted for more than half of the DRPs in the three studies reviewed, namely 62.0%, 79.6%, and 52.7%. The most common cause of DRPs came from the patient-related domain (C7.1) at 71.85%. Other domains that caused DRPs were the Drug use domain (C6.1) at 62.0%, other domains (C9) at 40.9%, the drug selection domain (C1.6) at 26%, and the dose selection domain (C3.5) at 25.9%. The occurrence of DRPs is a significant problem in the management of diabetes mellitus, especially in the hospital environment. The ineffectiveness of therapy is the main problem of DRPs. The high number of DRPs from other domains indicates that many causes of DRPs are not classified explicitly in the PCNE category.
Tingkat pengetahuan dan sikap mahasiswa Fakultas Farmasi Universitas Muhammadiyah Surakarta tentang beyond use date obat Alinda, Oevita Nur; Karuniawati, Hidayah
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.490

Abstract

Beyond Use Date (BUD) is the expiry time of a drug after it is opened from its primary packaging. The aim is to determine the level of knowledge and attitudes regarding BUD, to analyze whether there are differences between sociodemographics and BUD knowledge and attitudes, as well as whether there is a relationship between knowledge and attitudes of students in the Muhammadiyah University of Surakarta Pharmacy study program regarding BUD. This research is descriptive analytical research with observational methods. The data collection method was cross-sectional. Analysis (using Mann-Whitney and Kurskall-Wallis analysis) was carried out to assess differences in mean knowledge and attitude scores. Linear regression analysis was carried out to identify factors related to knowledge and attitudes about BUD. Spearman Rank analysis was used to test the correlation between knowledge and attitudes. The research results showed that respondents had a sufficient level of knowledge at 53,0% and attitude about BUD were classified as good at 68,8%. Statistical analysis shows that knowledge and attitudes about BUD are significantly related to age and generation (p<0,001). The research results also stated that men, respondents aged 17 and 18 years and the class of 2023 had a lower understanding of knowledges and attitude about BUD. Apart from that, there is a correlation between knowledge and attitude (p=0,000).
Co-Authors 'Utsman, Panji A Anifatussaa'dah Abdul Gofir Adiva Tantyas Aurora Adiva Tantyas Aurora, Adiva Tantyas Aflit Nuryulia Praswati Agita Dyah Ayu Kusumaningtyas Ahmad, Farhand Alinda, Oevita Nur Amalya Maulida Ambar Yunita Nugraheni Andi Suhendi Andika Permana Anifatussaa'dah, A Anita Sukmawati Anjani, Rosi Hayyu Ardalia Rinanda Oktaviani Arifah Sri Wahyuni Artamevia, Vanessa Reza Ashari Wahyu Budi Aji Athaillah, Najwa Kayana Auliya, Dhiyahul Basusena, Rahardian Surya Bestari, Mahardika Putri Broto Santoso Burhanudin Ichsan Cholisoh, Zakky Citra, Tia Mella Desti Purnamasari Devi Etivia Purlinda Devi Rahmawati Devi Usdiana Rosyidah Dewi, Meilenia Shinta Kusuma Dewi, Syochi Jannati Pramudya Dewi, Triana Ariska Dian Oktianti Didik Hasmono Dwi Sarbini Dyah Aryani Perwitasari Dzafira, Laila Endang Yuniarti Erindyah Retno Wikantyasning Erna Herawati Erna Herawati, Erna Fahmi, Muhammad Zaini Fahriza Mei Trihatmoko Farida, Rahayu Faridita khoirun Nisa' Febriani, Rizkina Elistya Fidhia Nur Rifaini Fidinillah, Masniar Firda, Fathiyyatu Assadiy Fitriani, Rizki Ainun Fortuna, Tista Ayu Gayuh Ilham Rahmadi Gunawan Setiyadi Hakim, Bilal Rahman Haliza Arzeti Nurseptiria Hanjani, Wildanoor Sekar Haryoto Haryoto Haryoto, H Haya Nabilah Utama Hekmah, Laila Nur Heni Mirawati Hertaliyana, Junita Ayu Hevi Mifta Kumalasari HI, Marsilia Rosa Sinensis Hidajah Rachmawati Ichsan, Burhanudin Ida Maesaroh Ida Maesaroh, Ida Ika Gilar Hapsari Ika Gilar Hapsari, Ika Gilar Ismail, Wan Ismahanisa Karimah, Izqi Keisya, Aulita Khairunnisa, Shafira khusnul khotimah Khusnul Khotimah Kurnia Eryani Kusumastuti, Lina Ayu Laila Dzafira Laila Nur Hekmah Lilla Prapdhani Agni Hajma Lina Ayu Kusumastuti Listiana Masyita Dewi Mahardika Putri Bestari Malik, Muhammad Ihsan Mariska Sri Harlianti Marsilia Rosa Sinensis HI Marsya, Vitania Marwiani Arum Marwiani Arum, Marwiani Maryati Maryati Masniar Fidinillah Maulana, Fahmi Alief Mika Tri Kumala Swandari, Mika Tri Kumala Mufida Alfiana Muhammad Da&#039;i Muhayaroh, Miftah Muhtadi Muhtadi Muhtadi, M Musayyaf, Ahmad Farras Muslihah, Sayyidah Nurul Nisa', Faridita khoirun Nungky Asmaraning Wahyono Nungky Asmaraning Wahyono, Nungky Asmaraning Nur Azizah Nuraini, Filla Rizky Nurseptiria, Haliza Arzeti Nurul Mutmainah Oktaviani, Ardalia Rinanda Oktri Viyanti Panji &#039;Utsman Puteri Santika, Aprilia Raafika Studiviani Rachmalia, Fauniza Marwa Rahardian Surya Basusena Rahma Saritri Cahyani Rahman, Anees Ur Rajali, Ahmad Retno Sintowati - Riandini Aisyah Rif'aini, Fidhia Nur Rifaini, Fidhia Nur Rizki Ainun Fitriani Rizky Wiharti, Irda Rochmadina Suci Bestari Roshitasari, Eva Sakinatul Hayati Salsabela Salsabela Salsabila Salsabila, Aulia Shafa Sanjaya, Muhammad Riyanto Sari, Erlinda Novita Saskia, Adinda Tri Prabandari Sava Salsabila Putri Sayyidah Nurul Muslihah Septi Fatmawati Setyo Nurwaini Sikanaa, Arinaa Manaa Studiviani, Raafika Sulistyarini, Sulistyarini Suprapto Suprapto Suryani - Susilo, Rinto Syahputri, Janies Arly Syaifia, Diska Awal Syam, Ricky Aditya Syifa Imelda Tanti Azizah Tanti Azizah Tanti Azizah Sujono Thalia Fiandra Tia Mella Citra Tista Ayu Fortuna Tista Ayu Fortuna Trihatmoko, Fahriza Mei Trisya Nur Pratiwi Tsaniya, Naura Azka Utama, Haya Nabilah Vitania Marsya Wikantyasning, Erindyah R. Yunika Isnanda Pratiwi Zaenab Zaenab Zaenab Zuhroh Tustika Vieda Zullies Ikawati