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Ovarian Malignant Brenner Tumor Romi Alfianto; Alphania Rahniayu; Indra Yuliati
Majalah Obstetri dan Ginekologi Vol. 26 No. 3 (2018): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (502.173 KB) | DOI: 10.20473/mog.V26I32018.135-142

Abstract

Objectives: To report one malignant Brenner tumor (MBT) case in Dr. Soetomo Hospital, Surabaya, Indonesia, that underwent therapy from August 2016 to August 2017.Case report: A woman aged 62 years underwent total abdominal hysterectomy and bilateral salphingo-oophorectomy surgery with histopathologic results of malignant Brenner Tumor. From immunohistochemical examination the expression of p63 was positive. The patient had been treated with Paclitaxel carboplatin chemotherapy for 5-cycles, with the results of the last post-chemotherapy evaluation showing no recidive mass.Conclusion:There was only one case of malignant ovarian Brenner Tumor in Dr Soetomo Hospital, Surabaya, Indonesia, in 2014- 2016. The diagnosis can only be based on anatomic pathology examination. The specific tumor markers for malignant Brenner tumors have so far not been found.  
The Role of HIF-1alpha in Regional Lymph Nodes Metastasis in Colorectal Adenocarcinoma Ladyna Rumapar; Sjahjenny Mustokoweni; Alphania Rahniayu
Folia Medica Indonesiana Vol. 54 No. 1 (2018): March
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.187 KB) | DOI: 10.20473/fmi.v54i1.8042

Abstract

Colorectal carcinoma has high morbidity and mortality rate worldwide, in which over 90% are adenocarcinoma. Colorectal carcinoma is one of the most cancer that metastasize to the lymph node. Angiogenesis have an important role in tumor growth and metastasis. Hypoxia is the trigger factor for angiogenesis. Hypoxia induced factor-1 (HIF-1) is one critical protein directly reacting to hypoxia. HIF-1alpha, a HIF-1 subunit, is an important regulator of angiogenesis. This study analyzed HIF-1a expression in colorectal adenocarcinoma with and without regional lymph node metastasis. This study was to prove that HIF-1a has a role in regional lymph node metastasis in colorectal adenocarcinoma. An analytical observational study was conducted on thirty formalin fixed paraffin-embedded colorectal adenocarcinoma tissues from Anatomic Pathology Laboratory of Dr. Soetomo Hospital. Detection of HIF-1alpha expressions were performed with immunohistochemistry method, using HIF-1alpha antibody. It were statistically analyzed using Mann-Whitney and Kruskal- Wallis methods. There were no significant differences in the expression of HIF-1alpha in colorectal adenocarcinoma with or without lymph node (LN) metastasis (p>0.05). As a conclusion, this study showed that HIF-1alpha has no role in LN metastasis in colorectal adenocarcinoma.
Distribution of Human Papilloma Virus (HPV) in Cervical Adenocarcinoma and Adenosquamous Carcinoma Gondo Mastutik; Alphania Rahniayu; Nila Kurniasari; Anny Setijo Rahaju; Budi Harjanto
Folia Medica Indonesiana Vol. 57 No. 2 (2021): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.667 KB) | DOI: 10.20473/fmi.v57i2.26473

Abstract

Approximately 20-30% of all cervical cancer cases are adenocarcinoma and adenosquamous carcinoma. Around 70% of all of these types of cancer are related to infection of Human Papillomavirus (HPV). This study evaluated the distribution of HPV genotype in cervical adenocarcinoma and adenosquamous carcinoma. A cross-sectional study was conducted at the Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January to December 2015. The sample were 22 formalin-fixed paraffin-embedded (FFPE) of cervical adenocarcinoma tissues and adenosquamous carcinoma tissues. FFPE was used for DNA extraction and followed with HPV genotyping to detect 40 genotypes of HPV, including low risk (LR) and high risk (HR) HPV. The histopathological types of adenocarcinomas were adenocarcinoma NOS and mucinous adenocarcinoma, while the adenosquamous carcinoma types were adenosquamous carcinoma and adenosquamous carcinoma glassy. All of the specimens were infected by HPV. In cervical adenocarcinoma, the infection was by HPV 6, 11, 16, 18, 31, 45, 68B, and 72, and in adenosquamous carcinoma by HPV 6, 16, 18, 45, and 59. HPV 18 was predominant, which was found in 13/22 (59.1%) in adenocarcinoma and 19/22 (86.4%) in adenosquamous carcinoma. Single infection and multiple infections in adenocarcinoma were 13/22 (59.1%) and 9/22 (40.9%), while in adenosquamous carcinoma were 21/22 (95.5%) and 1/22 (4.5%) respectively. The most common HR HPVs found in this study were HPV 18, HPV 45, HPV 16 and LR HPV are HPV 11, HPV 6.
Distribution Genotype High Risk (HR) And Low Risk (LR) Human Papillomavirus (HPV) at Condyloma Acuminata Gondo Mastutik; Alphania Rahniayu; Dwi Murtiastutik; Afria Arista; Trisniartami Setyaningrum; Nabiha Missaoui; Suhartono Taat Putra
Biomolecular and Health Science Journal Vol. 4 No. 1 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i1.26250

Abstract

Introduction: Condyloma acuminata that is also known as genital warts are one of the most common sexually transmitted that caused by infection of Human papillomavirus (HPV). Persistent infection of Low Risk (LR) or High risk (HR) HPV is a risk factor for progress into benign or malignant cancer. The objective is to analyze distribution of genotype LR-HPV and HR-HPV at condyloma acuminata in anogenital region. Methods: A cross sectional study using were 36 lesions from men and women of condyloma acuminata patients. All subject signed the informed consent and ethic obtained from our institution, number 382/Panke.KKE/V/2016. The specimen was used to histopathological examination and to identified 40 genotypes of HPV using a reverse line blot assay.Results: The All patients were diagnosed as condyloma acuminata, some with focus dysplasia and koilocytosis. All patients were positive for HPV, including LR-HPV were HPV 6, 11, 42, 54, 61, 81,87,89 and HR-HPV were HPV 18, 26, 45, 51, 52, 66, 67, 68B, 69, 82. The single infection of LR-HPV was 44.4%, multiple infection LR/LR-HPV was 13,9% and the multiple infection of LR/HR-HPV was 41.7%. The LR-HPV infected 70,6% and HR-HPV infected 29,4%.  Conclusion: LR-HPV is the major infection of condyloma acuminata, in single infection or multiple infection with HR-HPV. The most common infections were HPV 11, followed by HPV 6, HPV 18, HPV 51, and HPV 82. The determination of genotype of HPV can be used to predict the malignant transformation.
CHARACTERISTIC AND HISTOPATHOLOGICAL FEATURES OF PATIENTS WITH PERFORATED PEPTIC ULCER WHO UNDERWENT OPEN SURGERY THERAPY AT DR.SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA Alfi Nureta Rachmani; Mamiek Dwi Putro; Alphania Rahniayu
Majalah Biomorfologi Vol. 31 No. 2 (2021): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v31i2.2021.70-74

Abstract

Background: Perforated peptic ulcer is a form of complications from peptic ulcer and one of the most common emergency conditions in medicine. Objective: To describe the characteristic and histopathological features of patients with perforated peptic ulcer who underwent open surgery therapy in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Materials and Methods: This study was a descriptive study by observing patients’ data from medical records (secondary data) at Medical Record Center of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in 2016. Data obtained were analyzed descriptively. Results: Forty-six patients were identified (34 male, 12 female), most of them were between 56-65 years old for male and ≥66 years old for female. Majority of the subjects had a history of herbal medicine consumption (54%) as risk factors for developing perforated peptic ulcer and the most frequent comorbid diseases were diabetes and hypertension. The histopathological features found mostly were inflammation (100%), necrosis (44%), fibrosis (36%), granulation (17%) and  positive Helicobacter pylori (6%). Conclusion: Majority of the subjects were male, mostly between 56-65 years old for male and ≥66 years old for female. The histopathological features showed that all subjects had inflammations.
THE MUTATION STATUS OF KRAS GENE CODON 12 AND 13 IN COLORECTAL ADENOCARCINOMA (Status Mutasi Gen Kras Kodon 12 dan 13 di Adenocarcinoma Kolorektal) Gondo Mastutik; Alphania Rahniayu; Anny Setijo Rahaju; Nila Kurniasari; Reny I’tishom
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1177

Abstract

Kanker kolorektum merupakan salah satu kanker yang tersering di dunia. Target molekuler untuk pengobatan kanker kolorektumyaitu Epidermal Growth Factor Receptor (EGFR) dengan pemberian antibodi monoklonal anti-EGFR. Pemberian pengobatan ini tidakdapat memberikan efek dampak di pasien dengan status gen KRAS bentuk mutan, sehingga perlu dilakukan pemeriksaan status mutasigen KRAS. Telitian berupa deskriptif dengan pendekatan potong lintang yang bertujuan untuk mendapatkan data status mutasi genKRAS kodon 12 dan 13 di pasien adenocarcinoma colorectal. Deteksi mutasi KRAS dilakukan dengan teknik Polymerase Chain ReactionRestriction Fragment Length Polymorphism (PCR RFLP) yang dikonfirmasi dengan sekuensing. Sampel telitian adalah 30 blok parafinyang diperoleh dari Rumah Sakit Dr.Soetomo Surabaya masa waktu Januari-Desember 2013. Setelah dilakukan ekstraksi DNA terdapat21 sampel yang dapat digunakan untuk pemeriksaan lanjutan. Hasil PCR RFLP menunjukkan terdapat 7/21 mutasi pada kodon12 dan tidak terdapat mutasi gen KRAS pada kodon 13. Mutasi pada kodon 12 yaitu GGT>GCT, GGT>GGA dan GGT>GAT yangmenyebabkan perubahan asam amino Gly12Ala, Gly12Gly dan Gly12Asp. Simpulan telitian ini adalah mutasi gen KRAS kodon 12 padaadenocarcinoma colorectal di Rumah Sakit Dr. Soetomo Surabaya sebanyak 33%.
EARLY DETECTION OF BREAST AND CERVICAL CANCER OF THE RESIDENTS OF PROPPO PAMEKASAN DISTRICT Dyah Fauziah; Alphania Rahniayu; Nila Kurniasari; Anny Setijo Rahaju; Etty Hary Kusumastuti; Gondo Mastutik; I Ketut Sudiana
Jurnal Pengabdian Masyarakat Dalam Kesehatan Vol. 3 No. 1 (2021): APRIL 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpmk.v3i1.21584

Abstract

Introduction: Breast cancer and cervical cancer are common cancers in females. Both of these cancers can be detected early. Early detect vion can reduce cancer morbidity and mortality. The community outreach activities are required to increase knowledge about breast cancer and cervical cancer, in addition to screening as preventive efforts for these two cancers.Methods: The activity of raising knowledge about the prevention and early detection of breast cancer and cervical cancer was carried out through community counseling to 94 females who were members of the PKK and young females in the Kecamatan Proppo, Kabupaten Pamekasan. Pre and post tests were given before and after the community counseling. After the community counseling, 86 participants were screened for breast cancer by clinical palpation and 46 participants were screened for cervical cancer using the pap smear method.Results: The result of the post test showed a 27.53% increase in knowledge. The results of the pap smear examination on participants showed 96% concluded as Papanicolau Class II, 2% Class I, and 2% Class IV. The patient with class IV results was referred to an obstetrician.Conclusion: Community counseling about breast self examination (BSE) and Pap smear can increase people's knowledge about early detection of breast cancer and cervical cancer.
Role of CXCR4 and MMP-9 Expressions with Regional Cervical Lymph Nodes Metastatic Status in Papillary Thyroid Carcinoma Etty Hary Kusumastuti; Nurdhani Hi Djafar; Alphania Rahniayu
Indonesian Journal of Cancer Vol 15, No 2 (2021): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1561.271 KB) | DOI: 10.33371/ijoc.v15i2.771

Abstract

Background: Papillary thyroid carcinoma (PTC) that has metastasized has a higher risk because of the poor prognosis, ranging from decreased quality of life of the patient to death. There is a need for markers that can understand the image of the tumor so that it can predict earlier the level of aggressiveness and the ability of tumor cells to metastasize. Tumor cells that proliferate excessively will cause CXCR4 expression. Activation of CXCR4 will increase MMP-9 via the MAPK/ ERK line. MMP-9 will degrade the extracellular matrix causing tumor cell metastasis. This study is aimed to analyze the correlation of CXCR4 and MMP-9 expressions with lymph node metastasis (LNM) in PTC.Methods: This cross-sectional analytic observational study was conducted in 43 PTC samples taken from the Anatomical Pathology Laboratory of Dr. Soetomo Hospital from January 2011 to December 2018. The samples were divided into 2 groups based on the regional cervical LNM status. Immunohistochemical staining was used to assess the expression of CXCR4 and MMP-9. Spearman test was used to analyze the correlation of CXCR4 and MMP expression with cervical LNM status.Results: The expression of CXCR4 and MMP-9 was higher in the papillary thyroid carcinoma group with cervical regional LNM (p = 0.007 and p = 0.030). There was a significant positive relationship between CXCR4 and MMP-9 expressions with regional LNM status with rs = 0.468 and p = 0.001 (p < 0.05). Conclusions: Expression of CXCR4 and MMP-9 was proven to correlate with regional cervical LNM status in papillary thyroid carcinoma. Both can be used as predictive markers for metastasis in papillary thyroid carcinoma.
Perbedaan Ekspresi Foxp3+ dan Cd8+ Tumor Infiltrating Lymphocytes Karsinoma Payudara pada Berbagai Stadium T Anisia Indiralia; Alphania Rahniayu; Sjahjenny Mustokoweni
Indonesian Journal of Cancer Vol 12, No 1 (2018): Jan - Mar
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1269.433 KB) | DOI: 10.33371/ijoc.v12i1.549

Abstract

Background: Breast carcinoma, the most common malignancy in women, are often accompanied by tumor infiltrating lymphocytes (TIL) which has controversial clinical relevance. TIL is thought to reflect the host’s immune response to malignant tumors. FOXP3, specific biomarker of Treg, is an important transcription factors that develops and functions in the maintenance of self tolerance, including inhibition of CD8+ cytotoxic T cell function. Aim: To analyze the differences and the correlation between FOXP3+ and CD8+ TIL in breast carcinoma with different T staging. Methods: An analytical observational research, performed on 44 paraffin block of breast carcinoma of various stages T (AJCC 7th ed) in anatomical pathology installation of RSUD Dr. Soetomo, used FOXP3+ and CD8+ antibodies. The immunoexpression are evaluated on stromal area, then analyzed statistically, period January 1, 2014 – December 31, 2016. Result: Showed significant differences in FOXP3+ expression between T1-T4, T2-T3, T2-T4, T3-T4. There were significant differences in CD8+ expression between T2-T3, T2-T4. There is a correlation between the expression of FOXP3+ and CD8+ in T1 and all T (p < 0.05). Conclusion: There was significant difference in FOXP3+ and CD8+ TIL of breast carcinoma with increasing T stage. There was correlation between FOXP3+ and CD8+ TIL expression of breast carcinoma at all T and T1 stage. ABSTRAKPendahuluan: Karsinoma payudara adalah keganasan terbanyak wanita dan sering didapatkan adanya tumor infiltrating lymphocytes (TIL) dengan relevansi klinis yang masih kontroversial. TIL sering dianggap mencerminkan respon imun inang terhadap tumor ganas. FOXP3, biomarker spesifik Treg, merupakan faktor transkripsi yang penting dalam perkembangan dan berfungsi dalam pemeliharaan self tolerance, termasuk penghambatan fungsi sel T sitotoksik CD8+. Metode: Penelitian observasional analitik terhadap 44 sampel blok parafin karsinoma payudara berbagai stadium T (AJCC edisi ketujuh) di instalasi Patologi Anatomi RSUD Dr. Soetomo Surabaya menggunakan antibodi FOXP3 dan CD8, dihitung pada area stroma tumor, kemudian dilakukan uji statistik periode 1 Januari 2014 – 31 Desember 2016. Hasil: Terdapat perbedaan bermakna ekspresi FOXP3+ antara T1 dan T4, T2 dan T3, T2 dan T4, T3 dan T4. Terdapat perbedaan bermakna ekspresi CD8+ antara T2 dan T3, T2 dan T4. Terdapat korelasi antara tingginya ekspresi FOXP3+ dengan tinginya ekspresi CD8+ pada T1 dan semua T (p < 0,05). Kesimpulan: Terdapat perbedaan bermakna ekspresi FOXP3+ dan CD8+ TIL karsinoma payudara dengan meningkatnya stadium T. Terdapat korelasi antara ekspresi FOXP3+ dan CD8+ TIL karsinoma payudara pada semua stadium T dan T1.
PENYULUHAN TENTANG TANDA AWAL DAN DETEKSI DINI TUMOR GANAS PAYUDARA PADA WARGA DI PUSKESMAS SEMEMI KECAMATAN BENOWO KOTA SURABAYA Nila Kurniasari; Gondo Mastutik; Dyah Fauziah; Etty Hary Kusumastuti; Alphania Rahniayu; Anny Setijo Rahaju
Jurnal Layanan Masyarakat Vol. 6 No. 2 (2022): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v6i2.2022.251-258

Abstract

Kanker payudara merupakan keganasan paling sering dan penyebab kematian tertinggi. Di Indonesia, kanker payudara juga merupakan kanker paling sering dan penyebab kematian kedua setelah kanker paru. Hal ini tejadi karena kanker payudara sering terdiagnosis pada stadium lanjut sehingga menyebabkan kegagalan pengobatan dan kematian. Kejadian kanker payudara stadium lanjut ini dapat dicegah dengan deteksi dini, namun masyarakat masih mempunyai pengetahuan yang rendah tentang tanda awal kanker payudara. Tujuan dari kegiatan ini adalah untuk memberikan penyuluhan tentang tanda awal dan deteksi dini tumor ganas di payudara. Kegiatan dilaksanakan pada 11 November 2020, diikuti oleh 91 orang ibu PKK di wilayah kerja Pusat Kesehatan Masyarakat (Puskesmas) Sememi, Kecamatan Benowo Kota Surabaya. Kegiatan diawali pre-test dan pengisian kuisioner faktor risiko, kemudian dilanjutkan dengan pemberian penyuluhan melalui aplikasi zoom meeting dan diakhiri dengan post-test. Evaluasi dilakukan dengan membandingkan hasil pre-test dan post-test. Hasil kuisioner menunjukkan terdapat peningkatan pemahaman tentang tanda awal dan deteksi dini kanker payudara sebesar 6,96%. Faktor risiko peserta menderita kanker payudara menunjukkan bahwa sebagian besar peserta penyuluhan tidak berisiko menderita kanker payudara karena tidak merokok (100%), tidak mempunyai riwayat benjolan pada payudara (97,14%), menyusui lebih dari 6 bulan (88,57%), tidak terpapar radiasi sinar X (88,57%), mempunyai anak (85,71%), tidak mempunyai riwayat keluarga yang pernah menderita tumor atau kanker (71,43%), rutin berolah raga (60%), namun terdapat 97,14% yang berusia lebih dari 25 tahun sehingga masih mempunyai faktor risiko menderita kanker payudara. Kesimpulan. Terdapat peningkatan pengetahuan masyarakat sebesar 6.96% dan sebagain besar peserta penyuluhan tidak memiliki faktor risiko untuk terjadi kanker payudara.
Co-Authors Afria Arista Afria Arista, Afria Alfi Nureta Rachmani Anggoro, Adhitri Anisia Indiralia Anny Setijo Rahaju, Anny Setijo Ariadna Anggi Pasang Ariani, Grace Bilqis Inayatillah Budi Harjanto David Setyo Budi Dewi Sartika A. W. Dhamayanti, Hanifa Erlin Djuanda, Stephanie N. Dwi Murtiastutik DYAH FAUZIAH, DYAH Edi Suyanto Endang Joewarini Evy Ervianti Fetty Fatimah Fira Soraya Fitria Kusumastuti Gatot Soegiarto Gondo Mastutik Gunawan, Vania A. HERAWATI, LILIK Heriyawati, Heriyawati Heru Fajar Trianto Heru Purwanto I'tishom, Reny Ifadah, Hanna Aulia Ilmiah, Khafidhotul Imam Susilo Indiralia, Anisia INDRA YULIATI, INDRA Irwadi, Irfiansyah Isnin Anang Marhana Khafidhotul Ilmiah Khafidhotul Ilmiah Kusumastuti , Etty Hary Kusumastuti, Etty H. Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Ladyna Rumapar Lefi, Achmad Lestari, Neviana Fitri Lilihata, Jilientasia G. Linda Dewanti Lutfi, Delfitri Maharani, Andi RK. Mamiek Dwi Putro Marhana, Isnin A. Meyta Riniastuti Mochamad Amin Mohammad Fathul Qorib Muhammad Alim Ananto Muhammad Alim Ananto Nabiha Missaoui Nadya Kelfinta Hanani Nila Kurniasari Nila Kurniasari Nugraha, Ricardo A. Nugroho, Gilang MS. Nurdhani Hi Djafar Priangga Adi Wiratama Qonitatillah, Ana Rahaju, Anny S. Rahmi Alia Rahmi Alia Rahmi Alia, Rahmi Ramadhani, Amelia Safitri Raniah Baswedan Renny I’tishom Ridholia Ridholia, Ridholia Rinjani, Lalu GP. Romi Alfianto Rosyid, Alfian N. S.Pd. M Kes I Ketut Sudiana . Sari, Aditya Sita Sari, Eny Wulan Sawitri, Brihastami Semedi, Bambang P. Setiawan, Hayuris Kinandita Sjahjenny Mustokoweni, Sjahjenny Stella Agatha Widjaja Suhartono Taat Putra Supriadi Supriadi Tamam Jauhar Tomy Lesmana Trianto, Heru Fajar Trisniartami Setyaningrum Ummi Maimunah Vira Yasmina Ramadhani Wahyu, Dwi Willy Sandhika Wira Santoso Ongko Wiratama, Priangga A. Wiratama, Priangga Adi Yandi, I KR. Yudith Meityana Hernandita Zamzam, Ramadhani Rizki Zuhria, Ismi