Article Per Year (5 Year)
p-Index From 2021 - 2026
4.818
P-Index
This Author published in this journals
All Journal Althea Medical Journal Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Health Notions MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Majalah Patologi Indonesia Health and Medical Journal Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Stem Cell Research and Tissue Engineering Jurnal Ners Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology Narra J Indonesian Journal of Cancer Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Journal of Global Research in Public Health Folia Medica Indonesiana
Alphania Rahniayu
Anatomical Pathology Department, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 42 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 42 Documents
Search

 1   2   3   4   5 
EARLY DETECTION OF CERVICAL CANCER AND PAP SMEAR ADEQUACY AT PUSKESMAS PILANGKENCEN, MADIUN DISTRICT Anny Setijo Rahaju; Alphania Rahniayu; Nila Kurniasari; Dyah Fauziah; Etty Hary Kusumastuti; Gondo Mastutik; Dewi Sartika A. W.; Fira Soraya; Khafidhotul Ilmiah
Jurnal Layanan Masyarakat Vol. 7 No. 1 (2023): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v7i1.2023.100-113

Abstract

This study aims to increase understanding about early detection of cervical cancer and pap smear evaluation among residents, as well as to increase the pap smear sampling skills by health workers in Pilangkenceng District, Madiun Regency. This study was a descriptive observational study using a cross-sectional approach which was conducted on 100 women, from the Pilangkenceng Primary Health Center in Madiun Regency, aged 20 to 70 years. Pretest and post test assessments were carried out before and after the education of cervical cancer. Specimen adequacy assessment was carried out on 100 Pap smear samples taken by the health workers based on the Papaniculaou classification and the Bethesda system. Pap smear results were also compared with the results of the visual inspection of acetic acid (IVA) which was done before. Education of cervical cancer to the community can increase people's understanding of cervical cancer by 8.05% to 82.26%, while training for health workers on the technique of pap smear sampling shows an increase in knowledge of 51.62% to 100%. Adequacy of pap smear samples by health workers in Pilangkenceng District, Madiun Regency showed that 99% were adequate and satisfactory. Ten percent of IVA examinations showed positive results and those cases showed signs of inflammation and infection on pap smear examination. Community service activities of early detection of cervical cancer through the pap smear method can increase the understanding of early detection of cervical cancer in the community and the knowledge and sampling skills of health workers, hence the health workers at the Pilangkenceng Primary Health Center are ready to provide pap smear services for the community.   Keywords: adequacy, early detection, pap smear, IVA, cervical cancer.   Abstrak Kegiatan ini bertujuan untuk mengetahui peningkatan pemahaman tentang deteksi dini kanker serviks dan serta evaluasi pap smear pada warga, serta peningkatan kemampuan dalam melakukan pap smear oleh tenaga kesehatan di Kecamatan Pilangkenceng Kabupaten Madiun. Penelitian observasional deskriptif dilakukan dengan metode pendekatan cross sectional yang dilakukan pada 100 wanita, dari wilayah Puskesmas Pilangkenceng Kabupaten Madiun, dengan usia 20-70 tahun. Penilaian pretest dan post test dilakukan sebelum dan sesudah penyuluhan. Penilaian adekuasi spesimen dilakukan pada 100  sediaan  pap smear  yang diambil oleh para tenaga berdasarkan klasifikasi Papaniculaou dan sistem Bethesda. Hasil pap smear juga dibandingakan dengan hasil pemeriksaan inspeksi visual asam asetat (IVA) yang dilakukan sebelumnya. Penyuluhan terhadap masyarakat dapat meningkatkan pemahaman masyarakat tentang kanker serviks sebesar 8,05% menjadi 82,26%, sedangkan pelatihan pada tenaga kesehatan tentang tehnik pengambilan pap smear menunjukkan peningkatan pengetahuan sebesar 51,62% menjadi 100%. Adekuasi sediaan pap smear oleh tenaga kesehatan Kecamatan Pilangkenceng Kabupaten Madiun menunjukkan bahwa 99% adekuat dan memuaskan. Sepuluh persen pemeriksaan IVA menunjukkan hasil positif  dan setelah dilakukan hapusan  pap smear, kasus IVA positif tersebut menunjukkan gambaran proses keradangan dan infeksi. Kegiatan pengabdian masyarakat dapat meningkatkan pemahaman tentang deteksi dini keganasan serviks pada masyarakat dan pengetahuan para tenaga kesehatan tentang deteksi dini kanker serviks melalui metode pap smear, sehingga diharapkan bahwa tenaga kesehatan di Puskesmas Pilangkenceng siap memberikan pelayanan pap smear bagi warga. Kata kunci: adekuasi, deteksi dini, pap smear, IVA, kanker serviks.
Mature Teratoma of The Lung : A Case Report Priangga Adi Wiratama; Alphania Rahniayu; Vira Yasmina Ramadhani
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 10, No 1 (2023): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.10.1.2023.109-116

Abstract

Background:  Mature teratoma is a germinal cell tumor that is commonly found in ovaries and testis. Mature teratoma in the lung region is a rare case. According to the literature there are only 67 cases worldwide starting from 1939 to 2007. There were one cases in Dr. Soetomo general hospital during January 2013 – December 2017.Objective: Mature teratoma in the lung region is a rare case. Presenting in a case report would be beneficial for pathology databaseCase Presentation: A 19 years old man came to hospital with shortness of breath within 3 months ago. It was followed with hemoptysis, trichoptysis and coughing out tooth. CT Scan examination showed an irregular walled cavity with semisolid component and calcification along with a description of "air cresent sign". In thoracotomy tumor excision obtained multilobulated mass size 8.5x6,8x5,6 cm, yellowish-gray white color, and firm consistency. There were also hair and tooth components. The microscopic representation shows pieces of lung tissue with tumor growth coated with squamous epithel with a stroma containing adnexal skin glands, fatty tissue, cartilage tissue, and serous glands (asinar). Discussion: Mature teratoma of the lung is one of the rare tumors, with symptoms of chest pain, hemoptysis, and trichoptysis. Mature teratoma of the lung is generally cystic and multiloculated, but can also be solid, encapsulated. On microscopic examination, shows a picture of various components of ectoderm, mesoderm and endoderm.Conclusion: Mature teratoma of the lung is a rare tumor. Diagnosis was based from clinical findings, radiologic examination, and confirmed with histopathology and immunohistochemistry.
AGE, SEX, AND TYPES OF OCCUPATION WITH HISTOPATHOLOGICAL TYPES IN PATIENTS WITH OCULAR SURFACE SQUAMOUS NEOPLASIA (OSSN) IN A TERTIARY HOSPITAL IN SURABAYA, INDONESIA Stella Agatha Widjaja; Delfitri Lutfi; Linda Dewanti; Alphania Rahniayu; Fitria Kusumastuti
Majalah Biomorfologi Vol. 34 No. 2 (2024): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v34i2.2024.74-82

Abstract

Highlights The histopathological types of OSSN were significantly associated with age and occupation. The study's findings enhance the understanding of OSSN in Indonesia and emphasize the importance of UV exposure, occupation, and age in its development.   Abstract Background:  Ocular Surface Squamous Neoplasia (OSSN) is a spectrum of tumors affecting the conjunctiva and cornea, in which a more invasive type of OSSN has a higher recurrence rate. As a tropical country, Indonesia is constantly exposed to intense ultraviolet (UV) radiation, the main risk factor for OSSN. Despite this, there are very few studies regarding OSSN in Indonesia. Objective:  This study aimed to analyze the association between sociodemographic characteristics such as age, sex, and types of occupation (outdoor and indoor) and histopathological types of OSSN to fill the gap in research and contribute to early diagnostic strategies. Material and Method: Sociodemographic and histopathological data were extracted from the medical records of patients who were histopathologically diagnosed with OSSN at Dr. Soetomo General Hospital from 2017 to 2021. Data from 88 samples that met the inclusion and exclusion criteria were classified and analyzed with descriptive statistics and a two-sided Fisher's exact test using SPSS version 27.0 (IBM Corp., Armonk, N.Y., USA). Result: The exact test results of the two-sided fisher revealed a statistically significant relationship between age (p = 0.0004) and occupation type (p = 0.049) with histopathological types of OSSN. However, no significant association was found between sex and histopathological types of OSSN (p = 0.130). Conclusion: Age and occupation were found to have a significant association with the histopathological types of OSSN, reinforcing the need for further exploration of its strength and nature to be considered by future researchers.
Effect of High-Calorie Diet and Moderate-Intensity Physical Exercise on Gastric Histopathological Features of Mice Zamzam, Ramadhani Rizki; Irwadi, Irfiansyah; Rahniayu, Alphania
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 1 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i1.54573

Abstract

Introduction: Habit of consuming excess calories and sedentary lifestyle can cause oxidative stress which is known to be involved in the pathophysiological process of various diseases including diseases of the gastrointestinal mucosa. Increased Reactive Oxygen Species (ROS) due to a high-calorie diet can damage lipids, proteins, and DNA oxidation of the mucosa and lead to inflammation, apoptosis, damage of mucosal and its barrier. Moderate-intensity physical exercise is known to have health benefits, improve quality of life, reduce the risk of death, and prevent the occurrence of diseases related to oxidative stress. The aim of this study was to analyze the effect of high-calorie diet and moderate-intensity physical exercise on gastric histopathological features of mice.Methods: This research was a true experimental study with posttest only control group design. Female Balb/C strain were randomly assigned into three groups, the control group/K1 (n=12), high-calorie diet group/K2 (n=12), and high-calorie diet and moderate-intensity physical exercise group/K3 (n=9). High-calorie diet in the form of dextrose (D40) was given ad libitum using sonde in a dose of 3-5% of calories or 0.0325 mL/gBW. The moderate-intensity physical exercise was carried out by swimming three times a week for 15 minutes using 6% gBW loading. After 4 weeks of treatment, the mice were sacrificed and their stomach were sampled and prepared for microscopic analysis.Results: The histopathological examination of the gastric mucosa showed the average number of inflammatory cells was 11.60 for K1, 11.25 for K2, and 14.5222 for K3. The Shapiro-Wilk test revealed that the data on inflammatory cells infiltrations were not normally distributed (p<0.05), so a non-parametric difference test was conducted using the Kruskal-Wallis test. Based on the Kruskal-Wallis test results, it was obtained that p>0.05, which means no significant difference was found between the three study groups.Conclusion: There was no effect of a high-calorie diet and moderate-intensity physical exercise on the gastric histopathological features of mice (Mus musculus) in this study
Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19 Maimunah, Ummi; Maharani, Andi RK.; Soegiarto, Gatot; Rahniayu, Alphania; Gunawan, Vania A.; Wiratama, Priangga A.; Djuanda, Stephanie N.; Supriadi, Supriadi; Marhana, Isnin A.; Semedi, Bambang P.; Lefi, Achmad; Kusumastuti, Etty H.; Suyanto, Edi; Lilihata, Jilientasia G.; Anggoro, Adhitri; Rinjani, Lalu GP.; Rosyid, Alfian N.; Wahyu, Dwi; Fauziah, Dyah; Rahaju, Anny S.; Kurniasari, Nila; Ariani, Grace; Nugroho, Gilang MS.; Yandi, I KR.; Nugraha, Ricardo A.
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.463

Abstract

Excessive release of interleukin-6 (IL-6) during the progression of coronavirus disease 2019 (COVID-19) induces cytokine storms, resulting in multi-organ damages including liver injury, similar in nature with mechanism of viral hepatitis. Systemic IL-6 has been associated with the incidence of liver injury among COVID-19 patients; however, studies on IL-6 expression in the liver tissue are completely lacking. The aim of this study was to measure the IL-6 expression in the liver tissues and to determine its correlation with the degree of liver injury in fatal COVID-19 patients. Through this first cross-sectional study, IL-6 expression was measured through immunohistochemical staining and the degree of liver injury was identified based on level of serum alanine aminotransferase (ALT). The Spearman correlation test was used to identify the correlation between IL-6 expression and the degree of liver injury. A total of 47 deceased COVID-19 patients were included and IL-6 expression was observed in all post-mortem liver specimens, ranging from mild to strong expression. Liver injury at various degrees (mild to severe) was found in more than half (59.5%) of the cases. The Spearman correlation analysis suggested a statistically insignificant correlation between liver IL-6 expression and the degree of liver injury (r=0.152; p=0.309). In conclusion, even IL-6 expression was observed in all post-mortem liver specimens, there was an insignificant correlation between IL-6 expression in the liver tissue with the degree of liver injury among fatal COVID-19 patients, suggesting that IL-6 was not the only main factor contributing to liver damage in COVID-19 patients.
EDUCATION ABOUT BREAST CANCER IN THE COMMUNITY AT NGLUYU HEALTH CENTER, NGANJUK Mastutik, Gondo; Fauziah, Dyah; Rahaju, Anny Setijo; Rahniayu, Alphania; Ridholia; Kurniasari, Nila; Kusumastuti, Etty Hari; Ilmiah, Khafidhotul
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 8 No. 3 (2024): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v8i3.2024.422-431

Abstract

Breast cancer is the most common cancer found in the world and this cancer is the second cause of death due to cancer after lung cancer in Indonesia. This high mortality rate can be prevented by carrying out early detection. However, this is still not done well, especially in communities living in remote areas with low to medium economic and educational levels. The aim is to convey knowledge about breast cancer and training in the self-examination of the breast. It was held on Tuesday, 12 September 2023 at the Ngluyu Community Health Center, Nganjuk, from 07.00 to 14.00 WIB and was attended by 111 people. Data on breast cancer risk factors was collected through questionnaires. There were 96 participants who filled out the questionnaire, aged between 22-63 years. Risk factors data showed that 3.13% did not have children, 15.63% breastfed children less than 6 months, 5.21% were exposed to X-rays more than once a year; 1.04% had breast tumors, and 4.17% had family members suffering from cancer. In addition, 89.58% were over 25 years old and 42.71% had doing self-examination of breast. There was an increase in public understanding at the Ngluyu Community Health Center from 77.70% to 84.12%, namely an increase of 6.42%. This can increase public understanding about breast cancer and procedures to self-examination of breast and contribute in early detection of breast cancer as well as reducing the incidence of breast cancer. The results of this counseling can be used as recommendations by health centers in the Nganjuk district area.
Pengukuran Adekuasi Sediaan Papsmear dan Deteksi Dini Kanker Serviks di Ngoro Kabupaten Mojokerto Rahaju, Anny Setijo; Rahniayu, Alphania; Mastutik, Gondo; Kurniasari, Nila; Fauziah, Dyah; Kusumastuti, Etty Hary; Sandhika, Willy; Wiratama, Priangga Adi; Ariani, Grace; Heriyawati, Heriyawati; Sari, Aditya Sita; Ilmiah, Khafidhotul; Qonitatillah, Ana; Ridholia, Ridholia; Sudiana, I Ketut; Susilo, Imam
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 1 (2025): Maret
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i1.2127

Abstract

Penelitian ini bertujuan untuk meningkatkan pemahaman masyarakat tentang deteksi dini kanker serviks dan evaluasi Pap smear, serta meningkatkan keterampilan pengambilan sampel Pap smear pada penyedia layanan kesehatan di Kecamatan Mawaddah, Kabupaten Mojokerto. Studi deskriptif observasional dengan desain cross sectional dilakukan pada 100 wanita berusia 20-70 tahun dari Rumah Sakit Mawaddah. Penilaian dilakukan sebelum dan sesudah pemaparan materi. 100 sampel Pap smear yang dikumpulkan oleh bidan setempat dievaluasi untuk menilai kecukupan spesimen menggunakan sistem Papanicolaou dan Bethesda. Kegiatan ini secara signifikan meningkatkan pemahaman tentang kanker serviks (8,05% menjadi 82,26%), sementara kegiatan pelatihan tenaga medis meningkatkan pengetahuan mengenai pengambilan sampel Pap smear (51,62% menjadi 100%). 99% dari sampel Pap smear yang dikumpulkan oleh tenaga medis di Kecamatan Mawaddah dinilai memadai dan memuaskan. Program pengabdian masyarakat yang berfokus pada deteksi dini kanker serviks melalui Pap smear, secara efektif meningkatkan pemahaman masyarakat, meningkatkan pengetahuan dan keterampilan pengambilan sampel oleh tenaga medis, yang dapat meningkatkan pula efektifitas layanan Pap smear di Rumah Sakit Mawaddah pada masyarakat.
Differences in the Grade of Inflammation in the Liver Tissues of Old White Female Mice (Mus Musculus) due to Weight Bearing and Non-Weight Bearing Exercise Muhammad Alim Ananto; Irfiansyah Irwadi; Alphania Rahniayu
Journal of Global Research in Public Health Vol. 6 No. 2 (2021): December
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/jgrph.v6i2.306

Abstract

Old age causes a decrease in quality of life. Exercise inhibiting the decline in quality of life, however exercise can cause oxidative stress that causes tissue injury including in the liver. There are two types of exercise, weight-bearing and non-weight bearing exercise. It is unknown the type of exercise causes the least injury. This study aimed to analyze the differences in the inflammatory response shown by the degree of inflammation in the liver tissue of old female white mice who performed weight-bearing and non-weight bearing exercise. Thirty-six mice (mus musculus) were divided into 3 groups, control group (12), weight-bearing treatment group (12) and non-weight bearing treatment group (12). The weight bearing treatment consisted of running for 30 minutes, while the non-weight bearing treatment consisted of swimming for 30 minutes. Euthanized on the last day of 4th week. Microscopic evaluation of the degree of inflammation of the liver tissue was carried out according to the Batts and Ludwig method. Statistical analysis used the Kruskal Wallis method to determine whether there were differences in the degree of liver inflammation between groups. Mean value of inflammation degree in control group: 1,50 ± 0.552. Mean value of inflammation degree in weight-bearing exercise group: 1,92 ± 0.515. Mean value of inflammation degree in non-weight bearing exercise group: 1,92 ± 0.669. The Kruskal Wallis statistical test showed the P value 0.139. The results showed that there was no significant difference in the degree of inflammation in the mice liver after receiving weight-bearing and non-weight-bearing exercise treatments.
Program Pengabdian Masyarakat: Edukasi dan Deteksi Dini Kanker Serviks melalui Pemeriksaan Pap Smear di Kecamatan Bangkalan Sari, Aditya Sita; Kurniasari, Nila; Rahaju, Anny Setijo; Rahniayu, Alphania; Mastutik, Gondo; Fauziah, Dyah; Kusumastuti, Etty Hary; Sandhika, Willy; Wiratama, Priangga Adi; Ariani, Grace; Ridholia, Ridholia; Heriyawati, Heriyawati; Sudiana, I Ketut; Ilmiah, Khafidhotul; Qonitatillah, Ana
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 3 (2025): Mei
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i3.2310

Abstract

Kegiatan pengabdia masyarakat ini bertujuan untuk meningkatkan pemahaman tenaga kesehatan dan masyarakat mengenai deteksi dini serta pencegahan kanker serviks. Pelatihan tenaga kesehatan dilakukan agar mereka dapat melakukan prosedur Pap smear dengan benar dan sesuai standar, sementara penyuluhan masyarakat bertujuan untuk meningkatkan kesadaran akan pentingnya deteksi dini dan pencegahan kanker serviks. Studi ini menggunakan metode deskriptif observasional dengan pendekatan cross-sectional, mencakup dua kegiatan utama: pelatihan tenaga medis secara daring dan penyuluhan masyarakat secara langsung. Pelatihan Pap smear diikuti oleh 51 peserta yang terdiri dari perawat, bidan, dan dokter. Evaluasi sebelum dan sesudah pelatihan menunjukkan peningkatan pemahaman yang signifikan, di mana peserta dengan skor 80-100 meningkat dari 58,82% menjadi 82,35%. Penyuluhan kanker serviks diikuti oleh 74 peserta. Sebelum penyuluhan, hanya 12,16% peserta yang memperoleh nilai 80-100, namun setelahnya meningkat menjadi 100%. Sebanyak 62,2% peserta telah menikah, 8,1% memiliki riwayat hubungan seksual sebelum usia 17 tahun, dan 9,5% memiliki lebih dari satu pasangan. Selain itu, 98,6% belum pernah menerima vaksin HPV, dan 78,4% jarang melakukan Pap smear, menunjukkan rendahnya kesadaran pencegahan kanker serviks. Setelah penyuluhan, 60 peserta menjalani skrining kanker serviks. Mayoritas (41,7%) berusia 31-40 tahun. Hasil skrining dengan sistem Bethesda menunjukkan 100% NILM. Berdasarkan klasifikasi Papanicolaou, 88,1% termasuk kelas II (96,2% inflamasi, 1,9% bacterial vaginosis, 1,9% atrofi), dan 11,1% kelas I. Program ini terbukti efektif dalam meningkatkan pemahaman tenaga kesehatan dan masyarakat, serta keterampilan tenaga kesehatan dalam prosedur Pap smear, yang berkontribusi pada peningkatan kualitas layanan deteksi dini kanker serviks di RSIA Hikmah Sawi Bangkalan.
Effect of Moderate-Intensity Continuous Training (MICT) on Pancreatic Islet of Langerhans’ Morphology and Cell Count of Female Rats (Rattus norvegicus) Exposed to High-Calorie Diet Sari, Eny Wulan; Setiawan, Hayuris Kinandita; Rahniayu, Alphania; Herawati, Lilik
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 2 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I22025.102-108

Abstract

Highlights: Moderate-intensity continuous training exercise did not affect the diameter of pancreatic islets of Langerhans in a high-calorie diet subject. Moderate-intensity continuous training exercise did not affect the number of pancreatic islets of Langerhans in a high-calorie diet subject.   Abstract Introduction: Calorie consumption that exceeds normal limits each year can be a risk factor in causing diabetes mellitus (DM). This condition causes the body to be in a state of hyperglycemia, which will trigger changes in the diameter and number of Langerhans islet cells. Moderate-intensity continuous training (MICT) is recommended as a physical exercise method to help prevent DM. Methods: This true experimental study used a randomized post-test-only control group design. Wistar female rats were randomly divided into three large groups: (A) the control group without a high-calorie diet and exercise, (B) the group with a high-calorie diet without exercise, and (C) the group with both a high-calorie diet and exercise (MICT). This experiment lasted for four weeks with an exercise frequency of five times a week. One-way analysis of variance (ANOVA) revealed that group differences in diameter had results of p=0.130 (p>0.05), while the number of islets of Langerhans had results of p=0.068 (p>0.05). Results: There was no significant difference in the islets of Langerhans’ diameter between the three groups (p=0.116). The number of islets of Langerhans also had no significant differences (p=0.068). Conclusion: There was no significant effect of a high-calorie diet and MICT physical exercise on the diameter and number of pancreatic islets of Langerhans cells in female rats (Rattus norvegicus).
Co-Authors , Isnin Anang Marhana Afria Arista Afria Arista, Afria Alfi Nureta Rachmani Anggoro, Adhitri Anisia Indiralia Anny Setijo Rahaju, Anny Setijo Ariadna Anggi Pasang Ariani, Grace Bilqis Inayatillah Budi Harjanto Budi Harjanto David Setyo Budi Dewi Sartika A. W. Djuanda, Stephanie N. Dwi Murtiastutik DYAH FAUZIAH, DYAH Edi Suyanto Endang Joewarini Evy Ervianti Fatimah, Nurmawati Fetty Fatimah Fira Soraya Fitria Kusumastuti Gatot Soegiarto Gondo Mastutik Gunawan, Vania A. Hanifa Erlin Dhamayanti Hanna Aulia Ifadah Harjono, Shella HERAWATI, LILIK Heriyawati, Heriyawati Heru Fajar Trianto Heru Purwanto I'tishom, Reny Ilmiah, Khafidhotul Imam Susilo Indiralia, Anisia INDRA YULIATI, INDRA Irwadi, Irfiansyah Isnin Anang Marhana I’tishom, Reny Khafidhotul Ilmiah Khafidhotul Ilmiah Kusumastuti , Etty Hary Kusumastuti, Etty H. Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Ladyna Rumapar Lefi, Achmad Lestari, Neviana Fitri Lilihata, Jilientasia G. Linda Dewanti Lutfi, Delfitri Maharani, Andi RK. Mamiek Dwi Putro Marhana, Isnin A. Meyta Riniastuti Mochamad Amin MOCHAMAD AMIN Mohammad Fathul Qorib Muhammad Alim Ananto Muhammad Alim Ananto Nabiha Missaoui Nadya Kelfinta Hanani Nila Kurniasari Nila Kurniasari Nugraha, Ricardo A. Nugroho, Gilang MS. Nurdhani Hi Djafar Priangga Adi Wiratama Qonitatillah, Ana Rahaju, Anny S. Rahmi Alia Rahmi Alia Rahmi Alia, Rahmi Ramadhani, Amelia Safitri Raniah Baswedan Renny I’tishom Ridholia Ridholia, Ridholia Rinjani, Lalu GP. Romi Alfianto Rosyid, Alfian N. Rumapar, Ladyna S.Pd. M Kes I Ketut Sudiana . Sari, Aditya Sita Sari, Eny Wulan Sawitri, Brihastami Semedi, Bambang P. Setiawan, Hayuris Kinandita Sjahjenny Mustokoweni, Sjahjenny Stella Agatha Widjaja Suhartono Taat Putra Supriadi Supriadi Tamam Jauhar Tomy Lesmana Trianto, Heru Fajar Trisniartami Setyaningrum Ummi Maimunah Vira Yasmina Ramadhani Wahyu, Dwi Willy Sandhika Wira Santoso Ongko Wiratama, Priangga A. Wiratama, Priangga Adi Yandi, I KR. Yudith Meityana Hernandita Zamzam, Ramadhani Rizki Zuhria, Ismi