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All Journal Althea Medical Journal Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Health Notions MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Majalah Patologi Indonesia Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Stem Cell Research and Tissue Engineering Jurnal Ners Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology Narra J Indonesian Journal of Cancer Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Journal of Global Research in Public Health Folia Medica Indonesiana
Alphania Rahniayu
Anatomical Pathology Department, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia
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Effects of Tamarillo (Solanum betaceum) Extract on Glutathione Peroxidase Expression and Inflammatory Reactions in Lead Acetate-Induced Lung Tissue of Mice Harjono, Shella; I’tishom, Reny; Rahniayu, Alphania; Fatimah, Nurmawati
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4460

Abstract

Background: Lead acetate exposure through oral route has a significant impact on lung tissue as lead can induces the formation of reactive oxygen species (ROS), resulting in decreased glutathione peroxidase (GPx) and triggering inflammatory responses. The induction of exogenous antioxidants may prevent this mechanism. This study aimed to evaluate the protective effect of Tamarillo ethanol extract on GPx expression and inflammatory reactions in the lung tissue of mice induced with lead acetate.Methods: This true experimental laboratory study utilized stored formalin-fixed-paraffin-embedded (FFPE) lung tissue  from 30 male mice (Mus musculus). The samples were divided into five intervention groups, each consisting of six mice. Immunohistochemistry and histopathology assessments were performed at 100x and 400x magnification to evaluate the GPx expression using the H-score and to assess inflammatory reactions based on five scoring parameters, which were summed to obtain the total lung injury score.Results: Lead exposure significantly increased inflammatory reactions, particularly in the hemorrhage parameters (p=0.041). A significant increase in GPx expression was observed following lead acetate administration (p=0.027). Administration of Tamarillo ethanol extract at a dose of 400 mg/kgBW increased GPx expression compared with the positive control group (p=0.027).Conclusion: Tamarillo ethanol extract, especially at a dose of 400 mg/kgBW, significantly increases GPx expression in lead acetate-induced lung tissue of mice. This finding highlights the potential role of Tamarillo extract as an antioxidant source to reduce lead-induced lung injury, supporting broader efforts to promote healthy lifestyle practices that protect against environmental toxin exposure.
Co-Authors , Isnin Anang Marhana Afria Arista Afria Arista, Afria Alfi Nureta Rachmani Anggoro, Adhitri Anisia Indiralia Anny Setijo Rahaju, Anny Setijo Ariadna Anggi Pasang Ariani, Grace Bilqis Inayatillah Budi Harjanto Budi Harjanto David Setyo Budi Dewi Sartika A. W. Dhamayanti, Hanifa Erlin Djuanda, Stephanie N. Dwi Murtiastutik DYAH FAUZIAH, DYAH Edi Suyanto Endang Joewarini Evy Ervianti Fatimah, Nurmawati Fetty Fatimah Fira Soraya Fitria Kusumastuti Gatot Soegiarto Gondo Mastutik Gunawan, Vania A. Harjono, Shella HERAWATI, LILIK Heriyawati, Heriyawati Heru Fajar Trianto Heru Purwanto I'tishom, Reny Ifadah, Hanna Aulia Ilmiah, Khafidhotul Imam Susilo Indiralia, Anisia INDRA YULIATI, INDRA Irwadi, Irfiansyah Isnin Anang Marhana I’tishom, Reny Khafidhotul Ilmiah Khafidhotul Ilmiah Kusumastuti , Etty Hary Kusumastuti, Etty H. Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Ladyna Rumapar Lefi, Achmad Lestari, Neviana Fitri Lilihata, Jilientasia G. Linda Dewanti Lutfi, Delfitri Maharani, Andi RK. Mamiek Dwi Putro Marhana, Isnin A. Meyta Riniastuti MOCHAMAD AMIN Mochamad Amin Mohammad Fathul Qorib Muhammad Alim Ananto Muhammad Alim Ananto Nabiha Missaoui Nadya Kelfinta Hanani Nila Kurniasari Nila Kurniasari Nugraha, Ricardo A. Nugroho, Gilang MS. Nurdhani Hi Djafar Priangga Adi Wiratama Qonitatillah, Ana Rahaju, Anny S. Rahmi Alia Rahmi Alia Rahmi Alia, Rahmi Ramadhani, Amelia Safitri Raniah Baswedan Renny I’tishom Ridholia Ridholia, Ridholia Rinjani, Lalu GP. Romi Alfianto Rosyid, Alfian N. Rumapar, Ladyna S.Pd. M Kes I Ketut Sudiana . Sari, Aditya Sita Sari, Eny Wulan Sawitri, Brihastami Semedi, Bambang P. Setiawan, Hayuris Kinandita Sjahjenny Mustokoweni, Sjahjenny Stella Agatha Widjaja Suhartono Taat Putra Supriadi Supriadi Tamam Jauhar Tomy Lesmana Trianto, Heru Fajar Trisniartami Setyaningrum Ummi Maimunah Vira Yasmina Ramadhani Wahyu, Dwi Willy Sandhika Wira Santoso Ongko Wiratama, Priangga A. Wiratama, Priangga Adi Yandi, I KR. Yudith Meityana Hernandita Zamzam, Ramadhani Rizki Zuhria, Ismi