Article Per Year (5 Year)
p-Index From 2021 - 2026
3.11
P-Index
This Author published in this journals
All Journal Biota Journal of Tropical Biodiversity and Biotechnology Indonesian Food and Nutrition Progress JMM (Jurnal Masyarakat Mandiri) Jurdimas (Jurnal Pengabdian Kepada Masyarakat) Royal Biota PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Community Empowerment Narra J Biological Environment and Pollution Jurnal Pengabdian Pada Masyarakat Rumphius Pattimura Biological Journal
Fajar Sofyantoro
Departemen Biologi Tropika, Fakultas Biologi, Universitas Gadjah Mada, Yogyakarta
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

Published : 20 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Biota

 1 
Modulatory Effects of Fucoidan on Paracetamol-induced Hepatic Damage and Histological Alterations in Rasbora lateristriata Sofyantoro, Fajar; Dafa, Maula Haqul; Primahesa, Alfian; Oktaviana, Shintia; Mayani, Olvita; Simanungkalit, Eben Ezer; Prissandi, Anthera Al Firdaus; Nuriliani, Ardaning; Retnoaji, Bambang; Saragih, Hendry T. S. S. G.; Rohmah, Zuliyati; Widiyanto, Slamet; Wijayanti, Nastiti; Septriani, Nur Indah
Biota Vol 12 No 1 (2026): Jurnal Biota 2026
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/biota.v12i1.27845

Abstract

Paracetamol overdose is a well-documented cause of hepatic injury across vertebrate species, including teleost fish. This study aimed to evaluate the hepatoprotective potential of fucoidan, a sulfated polysaccharide derived from brown algae, against paracetamol-induced liver damage in Rasbora lateristriata. Fish were divided into five experimental groups and exposed to paracetamol (3 mg/L), either alone or in combination with fucoidan at concentrations of 50, 100, or 300 µg/mL, for seven days. Histopathological evaluation of liver tissues was performed using hematoxylin–eosin staining, with semi-quantitative scoring focused on hydropic degeneration, nuclear pyknosis, and necrosis. The results demonstrated that paracetamol exposure induced moderate hepatocellular injury, characterized by cytoplasmic vacuolization, apoptotic nuclear alterations, and necrotic lesions. Co-treatment with fucoidan at 300 µg/mL was associated with reduced severity across all histopathological parameters, indicating partial hepatoprotective effects. In contrast, the 50 µg/mL fucoidan group exhibited paradoxically severe hydropic degeneration despite the absence of pyknosis and necrosis, suggesting a delayed or altered injury profile. Intermediate outcomes were observed at 100 µg/mL. Overall, fucoidan exhibited dose-dependent but inconsistent hepatoprotective effects. The observed histological variability across concentrations suggests that protection may be influenced by factors such as bioavailability, cellular uptake, or interactions with intracellular stress pathways. These findings highlight the need for further mechanistic investigations before fucoidan can be considered a reliable hepatoprotective agent in aquatic toxicology.
Co-Authors Abiyyi, Muhammad Hawi Qabus Adania, Baik Aisyah Adelfiani, Adelfiani Aeniah, Siti Allimi, Hayu Swari Almunawar, Muhammad Fikri Ammaru Bisandyaloka Andri Frediansyah Andri Frediansyah, Andri Aphrodita, Adiva Aprilia Sufi Subiastuti Apriliyani, Tia Ardaning Nuriliani Arief Maulana Sabilillah Ariel Hananya Ariesti, Wiwin Ashfiya Hanif Hasnadewi Athira Nur Rahma Azmatun Fildzah Azzahira, Faiha Azka Bambang Retnoaji Chusnul Azhar Dafa, Maula Haqul Dewi, Umi Rosita Dimas, Abimanyu Dwi Eny Djoko Setyono Dwi Sendi Priyono Empra, Desi Eka Putri Fadhlurrohman, Galih Dzaky Ganies Riza Aristya Gizela Aulia Agustin Halim, Shuha Ma’muriyah Hendrix I. Kusuma Hendry Tri Sakti Saragih Hidayat, Rheina Faticha Asyamsa Himarosa, Rela Adi Illiyin, Sirayya Ishana, Aurelia Araya Isra Wahid Joko Nugroho Wahyu Karyadi Karlina, Ina Khoiruddin Anshori Krisdiyanto Krisdiyanto Krisdiyanto, Krisdiyanto Kusuma, Hendrix I. Lathief Al Umami Lisna Hidayati, Lisna Maharesi, Chesa Ekani Marius Rademaker Mataram, Made Bagus Auriva Mayani, Olvita Muhammad Ardillah Rusydan Muhammad Baihaqi Muhammad Budi Nur Rahman Muhammada, Khusnus Syifa Muliawati, Adina Mulyati Mulyati Nareta Defiani Nastiti Wijayanti Nasution, Nurlita Putri Bela Nata Dwi Annisa Nizma Nur Rachman Maulana Nurhidayah, Septika Nuringtyas, Tri R. Oktaviana, Shintia Pertiwi, Anggita Endar Podhi, Felisitas Moli Pradnya Paramita Primadian Adhi Wardana Primahesa, Alfian Prissandi, Anthera Al Firdaus Purwestri, Yekti A. Pusparini, Nur Ainun Oktavia Rademaker, Marius Rahayu, Sekar Rahmi, Sri N. Ramadhani, Gilang Afif Setya Rarastoeti Pratiwi Rela Adi Himarosa Rela Adi Himarosa Rizky Nuryani Rohmah, Zuliyati Rumansara, Papuani Samparisna Sadewo, Imran Saeed, Faisal Safitri, Della Thasya Liona Sandro Vento Saragih, Hendry T. S. S. G. Sari, Ria Vinola Septhya Saribu, Ruth Liananda Citra Dolok Senny Helmiati Sentono, Diva N. Septriani, Nur Indah Septriani, Nur Indah Simanungkalit, Eben Ezer Slamet Raharjo Slamet Widiyanto Sritanjung, Opi Sudarisman Sudarisman Sukirno Sukirno Sularsah, Sais Supraitno, Murtiadi Erlan Syafei, Dio Rachmaputra Syam, Adi Mazdi Ulfa, Siti Zakia Utami, Mia Vento, Sandro Wahyu Aristyaning Putri Wahyu Aristyaning Putri Wahyu Nursehan Wahyudi, Setyanto T. Wulandari, Mutiara Tri Yekti Asih Purwestri Yudha, Donan S. Zusrina, Laili Mufli