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Journal : HAYATI Journal of Biosciences

Characterization of SNEDDS Formulated with Single Bulb Garlic and its Anti-Inflammatory Effect on 3T3-L1 Lestari, Sri Rahayu; Sunaryono, Sunaryono; Susanto, Hendra; Rachmawati , Hidajah; Irawanto, Rony; Miasih, Dewi Sekar; El Baroroh, Alif Rosyidah; Annisa, Yuslinda; Djati, Muhammad Sasmito
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.793-804

Abstract

Inflammation is an early symptom of a disease that reduces the level of health. Single-bulb garlic (Allium sativum L.) is used medicinally as a plant with a broad pharmacological effect, especially anti-inflammatory activity. Self-nanoemulsifying drug delivery systems (SNEDDS) have offered opportunities to improve drug delivery. The current study aimed to characterize SNEDDS-single bulb garlic extract (SBGE) and determine its potential as an anti-inflammatory agent in 3T3-L1 cells. SNEDDS was formulated from tween-80, glycerol, canola oil, and SBGE. The formula characterization is done using droplet size, polydispersity index, zeta potential, physical stability test, and antioxidant assay. The cytotoxicity test of SNEDDS-SBGE was evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The anti-inflammatory activity was examined using 3T3-L1 cell methylglyoxal (MG) induction, and the expression of cytokines was measured using immunocytochemistry (ICC). The SNEDDS-SBGE had a nanoemulsion size of 42.30±1.39 nm, 0.6±0.03 for the polydispersion index, and -22.63±0.75 mV for the zeta potential. SNEDDS-SBGE was physically stable and had a high antioxidant level (47.579±8.017 %). SNEDDS-SBGE exhibited no toxic effect on 3T3-L1 cells. The administration of 62.5 µg/ml and 125 µg/ml SNEDDS-SBGE could inhibit (p<0.05) the expression of IL-1β after methylglyoxal induction. Thus, SNEDDS-SBGE may have potential anti-inflammatory properties.
Co-Authors -, Nandang Mufti Abdul Ghofur Achmad Hamdan Achmad Khofiyulloh Agung Witjoro Ahmad Taufiq Ahmad Taufiq Aisyah, Dahniar Nur Akhmad Jufriadi Al Ihsan, Rifqi Annisa, Yuslinda Apriani, Tia Ari Gunawan Arif Hidayat Aripriharta - Audisty Prana Hardayu Aulanni’am, Aulanni’am Avrilia, Annisa B. Anggit Wicaksono, B. Anggit Baroroh, Alif Rosyidah El Chusna, Nadiya Miftachul Chusniyah, Dina Asmaul Dermawan Saputra Dwi Prasetyo Ekobelawati, Fransiska El Baroroh, Alif Rosyidah Ema Trisnawati Endang Purwaningsih Era Budi Prayekti Fajariman, Ilham Dias Fauzi, Toni Dwi Fauziyah, Arisma Nurul Giovanni, Lucky Harjono, Yusuf Hena Dian Ayu Hendra Susanto Joko Purnomo Koes-H, Supriyono Kormil Saputra Krisnawati, Dyah Ika Laksono, Yoyok Adi Setio Markus Diantoro Maulana, Irham Miasih, Dewi Sekar Moch Sasmito Djati Mufidah, Ikfi Nihayatul Muhammad Akbar Setiawan, Muhammad Akbar Muhammad, Helmi Nadiya Miftachul Chusna Najmi, M. Ikhwan Nandang Mufti Nurul Hidayat Nurwijayanti Prastita, Nenes Pratama, Aryansyah Rachmawati , Hidajah Rahma, Amalia Nur Riana Safitri Ridho, Muhamad Aqil Rifqi, Nadiya Dini Riyandari, Lutvi Rony Irawanto Safitri, Riana Saiya, Selvina Visbad Saman, Muhammad Iqbal Samsul Hidayat sanyoto, Feliks imanuel Sentot Kusairi Setianti, Novita Setiono, Rizki Latif Sholeh , Moch sholeh, moch Siti Imroatul Maslikah Sri Rahayu Lestari Subadra, ST Ulfawanti Intan Sukma Febrianti Sulistiyasni . Supriyono Koes Handayanto Sutopo Sutopo Trijoyo Purnomo, Jerry Dwi Tsania Nur Diyana Wika Purbasari, Wika Wulandari, Nurul Putri Wuragil, Dyah Kinasih Yuliana, Futri Yulianto Yulianto Yundari, Yundari Yusuf Hardjono, Yusuf Zahira, Uvia Ardina