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Journal : Jurnal Insan Farmasi Indonesia

FORMULASI DAN UJI EFEKTIVITAS SEDIAAN GEL EKSTRAK DAUN BAJAKAH KALALAWIT (Uncaria gambir Roxb.) TERHADAP PROSES PENYEMBUHAN LUKA BAKAR PADA MENCIT PUTIH Ayuchecaria, Noverda; Yohanes Edy Gunawan; Efriyana Oksal; Shesanthi Citrariana
Jurnal Insan Farmasi Indonesia Vol 6 No 2 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i2.1635

Abstract

Burns are tissue loss caused by contact with heat sources. Burns will not only cause skin damage, but also affect the entire body system. Bajakah kalalawit contains polyphenolic compounds. This research aims to design a gel preparation formulation that is effective in the healing process of burn wounds in white mice. The preparation was also tested for its physicochemical characteristics including organoleptic test, homogeneity test, pH test, spreadability and stickiness test and irritation test. The results showed that all formulas were homogeneous and no organoleptic changes occurred after 14 days. The pH range of Bajakah gel is 6.16 – 7.46 which meets the skin's pH requirements. The diameter range of spreading power is between 5-7 cm. The adhesion power of formulas 2 and 3 meets the requirements (<4 seconds). The four formulas did not show irritation in the irritation test. The conclusion of this research is that Bajakah kalalawite extract gel with the composition of Formulas 2 and 3 meets the requirements for physical quality characteristic tests including organoleptic, homogeneity, pH, spreadability, adhesive power and irritation test. The diameter of the burn wound showed that there was a significant difference in treatment compared to the negative control group (p<5%).
SKRINING FITOKIMIA DAN UJI ANTIBAKTERI EKSTRAK ETANOL DAUN HANJUANG MERAH (Cordyline fruticose) TERHADAP BAKTERI Staphylococcus epidermidis Ayuchecaria, Noverda; Sri Martani, Natalia; Kartika Komara, Nisa; Chuchita; Pereiz, Zimon; Oksal, Efriyana
Jurnal Insan Farmasi Indonesia Vol 7 No 1 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i1.1683

Abstract

Hanjuang Merah (Cordyline fruticosa) is one of the plants used by the Dayak people as traditional medicine. Red hanjuang is an ornamental plant that is very abundant in Indonesia, but there is still not much research that proves the efficacy of red hanjuang. The aim of this research was to determine the phytochemical screening and antibacterial activity of leaf extract of hanjuang merah (Cordyline fruticose) against the bacteria Staphylococcus epidermidis. The method used in sample extraction was maceration, while in the antibacterial test used the paper strip diffusion method with concentrations of 25%, 50%, 75% and 100%. The yield of ethanol extract of hanjuang merah leaf was 11.35%. There was an increase in the diameter of the inhibition zone with the addition of the concentration of ethanol extract of hanjuang merah leaf. The addition of ethanol extract of hanjuang merah leaf at a concentration of 75% sensitive inhibited the growth of Staphylococcus epidermidis bacteria. Secondary metabolites such as tannins, alkaloids, saponins, flavonoids and quinones found in ethanol extract of hanjuang merah leaves are considered responsible for inhibiting the growth of Staphylococcus epidermidis bacteria.