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LITERATUR REVIEW: TERAPI GEN SEBAGAI ALTERNATIF PENGOBATAN PENYAKIT KANKER Hana E Yuliani; Windi P Firdhiana; Selfi A Ningrum; Titis D Vira; Nurce Khasanah; Atip Nurwahyunani; Endah Rita Sulistya Dewi
Jurnal Salome : Multidisipliner Keilmuan Vol. 2 No. 1 (2024): Januari
Publisher : CV. ADIBA AISHA AMIRA

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Abstract

solutions. Gene therapy has shown significant potential as a promising alternative in addressing cancer, transforming the traditional treatment paradigm that is limited. The goal of this article is to thoroughly examine the role of gene therapy as an alternative cancer treatment. The methods employed include a literature study with data analysis using qualitative content. More than 23 articles from 2012 to 2023 were used as literature sources. The research results indicate that the genetic engineering process in gene therapy technology includes the following steps: isolating the target gene, inserting the target gene into a transfer vector, transferring the insertion vector containing the target gene into the body requiring treatment, and transforming cells from the target organism. The target gene inserted into the body for treatment will be able to replace the function of abnormal disease-causing genes in patients. Another implementation of gene therapy in cancer treatment involves tumor suppressor genes, such as p53. Gene therapy has been used in cancer treatment for quite some time, including CAR-T gene therapy. CAR-T stands for chimeric antigen receptor T-cell therapy, where T cells are extracted from the patient and then genetically modified to recognize cancer cells, returning the modified T cells to the patient's body.
Literature Review : Pemanfaatan Kombucha Bunga Telang sebagai Produk Bioteknologi Farmasika Rita Sulistya Dewi, Endah; Nurwahyunani, Atip; Narita Putri Warisman, Andien; Handini, Handini; Panca Faizsyahrani, Lilla; Risnawati, Lia; Shintya Putri, Maharani
NUMBERS : Jurnal Pendidikan Matematika & Ilmu Pengetahuan Alam Vol. 1 No. 4 (2023): October - December
Publisher : CV. ADIBA AISHA AMIRA

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Potensi kombucha bunga telang sebagai sumber bahan aktif dalam kosmetik, obat, dan minuman probiotik, serta dalam mengatasi masalah kesehatan gigi dan organ intim wanita. Penelitian ini bertujuan untuk mengetahui pemanfaatan kombucha bunga telang sebagai produk bioteknologi fermentasi dengan analisis literatur review. Artikel ilmiah yang digunakan pada penelitian ini berjumlah 15 artikel imliah yang berasal dari jurnal nasional terakreditasi. Teknik penyajian data yaitu menggunakan table daftar artikel publikasi ilmiah yang akan dianalisis menjadi data hasil penelitian. Teknik analisis data dilakukan secara deskriptif dengan menganalisis dan mengidentifikasi artikel ilmiah sehingga menghasilkan ringkasan yang lebih formatif. Hasil penelitian literatur review menunjukan bahwa bunga telang ini dimanfaatkan menjadi kombuca dengan rentan waktu yang cukup lama, pada fermentasi bunga telang ini banyak sekali kandungan yang baik dan bisa dimanfaatkan di bidang farmasi yang dibutuhkan dalam kehidupan sehari-hari salah satunya produk sabun. Kesimpulannya kombuca bunga telang dapat dimanfaatkan sebagai produk berupa sabun cuci tangan, sabun mandi, sabun cuci muka dan sabun antifungi.
PEMANFAATAN BIOTEKNOLOGI PADA BIDANG PETERNAKAN SEBAGAI PENGENDALIAN PENYAKIT HEWAN TERNAK: LITERATURE REVIEW R S Dewi, Endah; Nurwahyunani, Atip; Ihtiar, Ade; N Amin, Haliza; Anggraini, Novita; S Sholechah, Faila; Najikhah, Salma
NUMBERS : Jurnal Pendidikan Matematika & Ilmu Pengetahuan Alam Vol. 2 No. 1 (2024): January - March
Publisher : CV. ADIBA AISHA AMIRA

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Bioteknologi telah kontribusi dalam menuntaskan kemiskinan dan kelaparan serta menjamin meningkatkan kelestarian lingkungan terutama pada hasil peternakan. Pemanfaatan bioteknologi dalam menghasilkan vaksin, antibodi, pakan begizi tinggi, hormon pertumbuhan, dan pembuatan hewan transgenik yang gennya telah dimodifikasi dan teknologi induk buatan. Metode dalam penelitian ini menggunakan studi literatur yang memuat beberapa artikel relevan. Kemudian dilakukan analisis artikel, artikel yang dianalisis menggunakan konten kualitatif dengan korelasi antara konten dan konteks. Berdasarkan hasil pembahasan didapati hasil bahwa bioteknologi memiliki potensi besar dalam meningkatkan praktik peternakan, meningkatkan produktivitas ternak, dan menjaga kesehatan hewan. Dengan pengembangan dan penerapan yang tepat, bioteknologi dapat menjadi alat yang kuat dalam mencapai keberlanjutan dan ketahanan pangan di masa depan
Pengaruh Pemberian Pakan Maggot Terhadap Kelangsungan Hidup Dan Pertumbuhan Ikan Lele Dumbo (Clarias gariepinus) Noorsyafina, Nabila; Toharo, Dwi; ., Selma; Anggraini, Ayu; Nurwahyunani, Atip
Florea : Jurnal Biologi dan Pembelajarannya Vol. 10 No. 1 (2023)
Publisher : UNIVERSITAS PGRI MADIUN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/florea.v10i1.15034

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Penelitian ini bertujuan untuk mengetahui pengaruh pemberian maggot terhadap kelangsungan hidup dan pengaruh pemberian pakan terhadap ikan lele dumbo. Penyediaan pakan ternak yang berkualitas merupakan salah satu faktor penentu keberhasilan peternak ikan khususnya lele dan menjadi komponen terbesar dalam kegiatan usaha. Pemanfaatan pellet dan campuran maggot sebagai pakan ternak memiliki keuntungan secara langsung maupun tidak langsung. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) Penelitian ini terdiri dari 2 perlakuan dan 2 ulangan, dengan perlakuan pemberian pakan pellet 100%(kontrol), pemberian pakan pellet 75% + 25% maggot. Proses pengambilan data dilakukan setiap seminggu sekali. Pengamatan parameter meliputi panjang lele menggunakan penggaris, bobot lele menggunakan timbangan digital, dan kelangsungan hidup lele dihitung pada angka kematian setiap harinya. Hasil penelitian menunjukkan bahwa pemberian pellet 75% + 25% maggot lebih baik dibandingkan dengan pemberian pellet 100%. Walaupun selisih nya tidak jauh tipis dibandingkan pakan pellet. Hal ini terjadi karena pakan maggot terdapat protein yang tidak dimiliki oleh pakan pelet.
Water bamboo plant (Equisetum hyemale) as a phytoremediation agent for water pollution waste Kurniawati, Septiana; Ulfah, Maria; Nurwahyunani, Atip; Hayat, Muhammad Syaipul
Biological Environment and Pollution Vol. 3 No. 2 (2023)
Publisher : Association for Scientific Computing, Electronics, and Engineering (ASCEE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31763/bioenvipo.v3i2.687

Abstract

The aquatic bamboo plant (Equisetum hyemale) can be used as a phytoremediation agent because it has hyperaccumulator properties and is hyper-tolerant of pollutants. With the increasing number of industrial and household activities, managing waste before it is disposed of directly into the environment. This research aims to determine the application of phytoremediation in reducing pollutant content in water pollution waste. The research method was carried out using a literature research design review of the Google Scholar and SINTA databases starting from publication year 2014 to 2023 by reviewing a total of ten national journal articles. The research results show that phytoremediation can reduce wastewater pollution content, especially BOD and COD levels accumulated by the roots of aquatic bamboo plants. The effective time for the phytoremediation method is 3 days, 5 days, and 12 days which can reduce the number of contaminants in sample water according to wastewater quality standards. The novelty of this research is in the variables studied, namely BOD and COD levels using aquatic bamboo plants.
Development of Practicum Worksheet on Project Based Learning on Environmental Pollution Material Santoso, Luhur Pujo; Nurwahyunani, Atip; Ulfah, Maria
Unnes Science Education Journal Vol 12 No 2 (2023): August 2023
Publisher : Department of Integrated Science, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang in Collaboration with Perkumpulan Pendidikan IPA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/usej.v12i2.69209

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Problems that are often experienced in learning Environment Pollution material is the lack of participation of learners in the formation his knowledge, this is due to the learning provided only limited to theory without utilizing laboratory facilities for activities practicum. In addition, the teaching materials used are less able to hook material with contextual phenomena in everyday life, so that lack of opportunities for learners to conduct investigations. This research aims to develop practicum worksheet on Project Based Learning on environmental pollution material. The research method used is Research and Development (R&D). The preparation of practicum worksheet uses the ADDIE model, but in this study only focuses on the ADD (Analysis, Design, and Development) stage. Practicum worksheet design that has been prepared before being tested is measured for quality through validation activities by material experts and media experts. Validation was carried out by 2 material experts and 2 media experts, in this case lecturers from PGRI Semarang University. The final average score of validation results by material experts was 92.36% and media experts was 90.33%. This value included in the very valid category, so that the practicum worksheet that has been prepared is suitable for use in learning Environmental Pollution material.
Calla Lily (Zantedeschia aethiopica (L.) Spreng) as a Bioremediation Agent of Jatibarang Landfill Leachate Conterminated Waters Ulfah, Maria; Santoso, Luhur Pujo; Nurwahyunani, Atip
Jurnal Ilmu Lingkungan Vol 23, No 2 (2025): March 2025
Publisher : School of Postgraduate Studies, Diponegoro Univer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jil.23.2.435-442

Abstract

The leachates are formed when the waste mixes with the water and penetrates into the ground. Leachate has a dangerous impact because it contains toxic organic/inorganic pollutants, heavy metals and ammonia. Many problems will arise if the leachate is not treated and left alone. The pollutants from landfill leachate have accumulative and detrimental effect on the ecology and food chains. Bioremediation effectively heals the environment when it's been contaminated by pollutants and toxics. The purpose of this study was to determine the effectiveness of Calla Lily (Zantedeschia aethiopica (L.) Spreng) as a BOD and leachate turbidity removal. This type of research is qualitative research and is presented descriptively. Based on the results of the research, it was shown that calla lily were able to reduce BOD and turbidity removal, but the treatment had no significant effect. The results of the analysis showed that the physical and chemical parameters of leachate at Jatibarang landfill that exceeded the leachate quality standards were BOD 464 mg/L (9.2% removal), turbidity removal 6.3 NTU (96.23% removal). If the leachate is only collected without further treatment, it will result in the leachate entering residential rivers and contaminating the well water in the surrounding Jatibarang area and possibly causing health problems.
Upaya Meningkatkan Keaktifan Pembelajaran Siswa Kelas XI ATPH A SMKN 1 Bawen dengan Implementasi Pendekatan Pembelajaran Berdiferensiasi Safitri, Ulin Nur; Nurwahyunani, Atip; Cahyati, Zubaidah Gesit
Media Penelitian Pendidikan : Jurnal Penelitian dalam Bidang Pendidikan dan Pengajaran Vol 19, No 1 (2025)
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/mpp.v19i1.21638

Abstract

The main problem underlying this research is the lack of activeness of class XI ATPH A SMKN 1 Bawen students in participating in learning. This is because the characteristics of students learning styles are variated so that if teachers don’t accommodate the needs of their learning styles, students will be reluctant to pay attention the learning level of use of learning technology; motivation to learn mathematics and even have difficulty understanding the lesson. The method used in this research is descriptive qualitative. The results of this research are that researchers can find out the teacher's strategy to increase the activeness of class XI ATPH A students in learning, namely by presenting differentiated learning content. The content differentiation strategy is provided by the teacher so that students can explore insight and understanding regarding the material being taught. Student activeness in learning will appear automatically if students understand learning well because their learning needs have been fulfilled.
Implementasi Pendekatan TaRL pada Materi Perbanyakan Tanaman Secara Generative untuk Meningkatkan Hasil Belajar Peserta Didik Ningsih, Sri Sulastri; Nurwahyunani, Atip; Maulida, Zanny Varah
Media Penelitian Pendidikan : Jurnal Penelitian dalam Bidang Pendidikan dan Pengajaran Vol 19, No 1 (2025)
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/mpp.v19i1.21832

Abstract

educate the younger generation. However, there are still many obstacles, including differences in characteristics and learning needs of students. This research aims to determine the learning method using the TaRL (Teaching at The Right Level) approach in generative plant propagation material on the level of students' understanding. This type of research is classroom action research.  The research subjects using 1 class X of SMK Negeri 1 Bawen were 31 students. This research was carried out by providing pre-test and post-test questions regarding generative plant propagation. The implementation of the TaRL approach is carried out by grouping students according to their respective levels of ability, where each group consists of students who get low, medium and high scores. Grouping is done so that cooperation in groups and discussion activities to complete tasks can run smoothly and effectively. The research that has been carried out shows that the TaRL approach can improve students' understanding. The results of the research showed that there was an increase in students' understanding with the increase in the test results by 5.41 or increased from 84.29 to 89.70.
Efektivitas Pendekatan Teaching at The Right Level (TaRL) dalam Meningkatkan Pemahaman Peserta Didik Terhadap Materi Seleksi Benih Astuti, Anik Fitri; Nurwahyunani, Atip; Cahyati, Zubaidah Gesit
Media Penelitian Pendidikan : Jurnal Penelitian dalam Bidang Pendidikan dan Pengajaran Vol 19, No 1 (2025)
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/mpp.v19i1.21834

Abstract

This research was conducted at SMKN 1 Bawen with the research population consisting of all students of class XI ATPH A. The study aimed to evaluate the effectiveness of the Teaching at the Right Level (TaRL) approach in improving students' understanding of seed selection material. The instruments used in this research were pretest and posttest assessments. The TaRL approach was implemented by grouping students based on their initial understanding as measured by pretest scores. Students were categorized into three groups: proficient, sufficient, and low. During the discussion process, teachers provided intensive guidance to the low-category group, while students in the proficient and sufficient categories were given additional challenges in the form of questions designed to enhance critical thinking, creativity, and problem solving. Data analysis was performed using the N-Gain test and the Wilcoxon Signed-Rank Test. The analysis results showed an N-Gain value of 0.6198, indicating a moderate level of effectiveness of the TaRL approach in improving the understanding of seed selection material among students of class XI ATPH A. Additionally, the Wilcoxon Signed-Rank Test revealed that out of 21 students, 15 experienced an increase in their scores from pretest to posttest, with an average score increase of 10.93. The Wilcoxon test's significance value of 0.005 that can indicated significant difference between pretest and posttest. Based on these findings, it can be concluded that the Teaching at the Right Level (TaRL) approach is effective in improving students' understanding of seed selection material in class XI ATPH A.
Co-Authors ., Selma Ade Ihtiar Ade Rahma Pertiwi Aditya Marianti Aftakhul Rizkyana Meilani Agustina Adhi Suryani Ainin Tusamma Salsabila Ainun Nafiatus Ulfah Alfina Damayanti AlfinaSeptiana, Merlly Alifia Hasna Azzah Fillah Aliya Munasyifa Amila Hartanto, Maisabata Farah Ana Meilani, Ifa Andien Narita Putri Warisman Angelica Tricia Wijaya Anggi Septia Pramaista Ani Rusilowati Anwar, Lahib Ary Susatyo Nugroho Asih, Evria Astuti, Anik Fitri Aulia Widiawati Fitriana Dewi Aulia Widiawati Fitriana Dewi Auliatuzahra, Ema Ayu Anggraini Azizul Ghofar Candra Wicaksono, Azizul Ghofar Candra Azuhro, Vionika Bagas Prio Saputro Budi Minarti, Ipah Cahyati, Zubaidah Gesit Choirul Nisa Kismayanti Citraning Rachmawati, Rivanna Cucianingsih Cucianingsih Damayanti, Alfina Danu Handrian Firdaus Devanny Kurniawan Widodo Devany England Filany Devany England Filany Devi Oktaviani Safitri Dewi Purichasari Dina Alfiyana Diska R.P. Andriani Dyah Ayu Widyastuti Eka Maya Putri Anggraeni Eka Septiyana Eko Retno Mulyaningrum Eko Retno Mulyaningrum Elsa Setpiani Rintho Miharjo Ely Murniati Ema Auliatuzahra Endah Rita Sulistya D., Endah Rita Endah Rita Sulistya Dewi Endah Rita Sulistya Dewi Endah Rita Sulistya Dewi Endah Rita Sulistya Dewi Endang Susilaningsih Eny Hartadiyati Eny Hartdiyati W.H Erma Lintang Sari Evria Asih Fafa Nurdyansyah Fahmi Dwi Septiani Faida Pranama, Hanasari Faila Siva Sholechah Faridatul Zuhriyah Farisa Khoirun Nissa Febrina Rachmawati Fibria Kaswinarni Fibria Kaswinarni Fibria Kaswinarni Filia Prima Artharina Firya Luthfiyah Gita Maylita Sari Gita Maylita Sari Haliza Nurul Amin Hana E Yuliani Hana Eldiana Yuliani Hanasari Faida Pranama Handini Handini, Handini Hasna Azzah Fillah, Alifia Hayat, Muhammad Syaipul Ifa A Meilani Ihtiar, Ade Ikhzar Khoirul Annurul Fitriani Ilmi Maehanifa Imarotul Umamah Immas Saniyyah Rosalia Indriastuti, Chindy Arneta Ipah Budi Minarti Ipah Budi Minarti Irmayanti, Amanda Jamali Jamali, Jamali Jian Tikasari Jian Tikasari K Putri, Mery Kamila N Afifah Khoiril, Dina Khoirun Nissa, Farisa Khusna Yurdhika Firdhiani Kurniawati, Septiana Laili Fatrotul Munawaroh Latifa Nur Anisa Lia Novita Sari Lia Risnawati Lila Panca Faizsyahrani Lintang Sari, Erma Lussana Rossita Dewi M. Anas Dzakiy Maharani Shintya Putri Maria Ulfah Maria Ulfah Maulida, Zanny Varah Mayada Nuraini, Anisa Mei Sulistyoningsih -, Mei Sulistyoningsih Merlly Alfina Septiana Muhammad Amiruddin Muhammad Ilham Sagaf Muhammad Syaipul Hayat Muhammad Wisnu Khoriyan Muthmainnah Azizy Mutiara Sabila N Afifah, Kamila N Amin, Haliza Nafiatus Ulfah, Ainun Nailil Mona Najikhah, Salma Najwa Aulia Narita Putri Warisman, Andien Ningsih, Sri Sulastri Nisa Kismayanti, Choirul Noorsyafina, Nabila Novita Anggraini Novita Anggraini Nurce Khasanah Nurce Khasanah Nuryadi, Agung Ocvi Nurma Rizky Oktafia Dewi Putri Panca Faizsyahrani, Lilla Paramitha, Widya Ayu Praptining Rahayu Puji Slamet Rahayu, Kukoh Puput Wulandari Putri Amelia, Septiana Putri Andriani, Diska Rahma R Pertiwi, Ade R S Dewi, Endah R.P. Andriani, Diska Rahayu Putri, Wima Rahmawati Laksita, Rahmawati Reni Rakhmawati -, Reni Rakhmawati Revita Chandra Kusumaningtyas Riska Ayu Nabila Risnawati, Lia Rita Sulistya Dewi, Endah Rivanna Citraning R Rivanna Citraning Rachmawati Rivanna Citraning Rachmawati, Rivanna Citraning Rizky Amalia Putri Rizky N Darillia Rizqi Nova Darillia Robi'atul Bashoriyah S Sholechah, Faila Safira Asanu Lestari Safitri, Ulin Nur Salma Najikhah Santoso, Luhur Pujo Saputri, Amila Sasha Amalia Selfi A Ningrum Selfi Aprillia Ningrum Septiana Kurniawati Septiana Nur Kholifah Septiana Nur Kholifah Septiani R Miharjo, Elsa Shintya Putri, Maharani Sih Hartini Silvi Aifiyyatul Fajriyah Siti Alimah Siti Dzakiyatus Sholekhah Slamet Rahayu, Kukoh Puji Sofia Uly Niama Steffy Amelia Savitri Sumarno Sumarno Suratman, Ikhsan Hidayat Titis D Vira Titis Dewi Vira Toharo, Dwi Tri Fazhilah Via Valenta Kafita Ardian Vionika Azuhro Wijaya, Angelica Tricia Wima Rahayu Putri Windi P Firdhiana Windi Putri Firdhiana Wiwi Isnaeni Wiyanto - Y Habsari, Khusna Yunita Lema Yustisia Nur Millenia Zuhriyah, Faridatul