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Journal : Amerta Nutrition

Analisis Komparasi Pengaruh Anemia dan Kekurangan Energi Kronis Selama Kehamilan terhadap Berat Badan Lahir Rendah: Meta-Analisis: Comparative Impact of Maternal Anemia and Chronic Energy Deficiency on Low Birth Weight: Meta-Analysis Utami, Citra Tristi; Azrimaidaliza, Azrimaidaliza; Purnakarya, Idral; Dwinatrana, Khiky; Habibi, Nur Ahmad
Amerta Nutrition Vol. 9 No. 1SP (2025): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 5th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i1SP.2025.431-440

Abstract

Background: Low birth weight (LBW) remains a major public health problem, particularly in low- and middle-income countries. It contributes substantially to neonatal morbidity and mortality. Some of the risk factors for LBW are maternal anemia and chronic energy deficiency (CED). These conditions are common during pregnancy and preventable. Objectives: This study aimed to analyze the comparation between maternal anemia and chronic energy deficiency during pregnancy and the risk of low birth weight. Methods: A systematic search of PubMed and Scopus was conducted for studies published between January 2020 and July 2025. Of 1,121 records identified, 22 observational studies (case–control and cohort) met the inclusion criteria. Studies evaluating the association of maternal anemia or CED with LBW were included. Data were extracted independently by two reviewers. Meanwhile, data analysis involved multiple methods. For example, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using meta-analytic models. Heterogeneity was assessed using the I² statistic, and publication bias was evaluated using funnel plots. This study’s protocol was registered in PROSPERO (CRD420251138329). Discussions: From 22 studies, 19 studies assessed maternal anemia (n = 16,219), and 11 studies assessed CED (n = 4,440). Maternal CED was associated with a nearly threefold increased risk of LBW (OR = 2.98; 95% CI: 2.07–4.29; I² = 82%), while maternal anemia increased the risk by 2.4 times (OR = 2.44; 95% CI: 1.73–3.43; I² = 86%). Funnel plots showed no substantial publication bias. Conclusions: Both maternal anemia and chronic energy deficiency are significantly associated with an increased risk of low birth weight, with CED demonstrating a stronger association. Strengthening antenatal nutritional interventions is essential to prevent LBW incidences.
Pengaruh Pemberian Sinbiotik, Probiotik, dan Prebiotik terhadap Depresi, Stres, dan Mood pada Orang Dewasa: Systematic Review dan Meta-Analisis: Effects of Synbiotic, Probiotic, and Prebiotic Supplementation on Depression, Stress, and Mood in Adults: A Systematic Review and Meta-Analysis Habibi, Nur Ahmad; Gusnedi, Gusnedi; Nindrea, Ricvan Dana; Hasniyati, Rina; Afriza, Renita; Rusydi, Riska; Yuska, Defniwita; Darningsih, Sri; Zulkifli, Zulkifli; Ismanilda, Ismanilda; Handayani, Marni; Utami, Citra Tristi; Umar, Hermita Bus; Dwiyanti, Defriani; Yuniritha, Eva
Amerta Nutrition Vol. 9 No. 1SP (2025): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 5th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i1SP.2025.420-430

Abstract

Background: Psychobiotics, including probiotics, prebiotics, and synbiotics, have been proposed to improve mental health through modulation of the gut–brain axis. However, findings from randomized controlled trials (RCTs) remain inconsistent, Objectives: To systematically review and synthesize evidence on the effects of probiotics, prebiotics, and synbiotics on depression, stress, and mood in adult populations. Methods: A comprehensive search was conducted in PubMed, yielding 531 articles, of which 14 RCTs met the inclusion criteria. Risk of bias was assessed using the Cochrane Risk of Bias Tool. Meta-analyses were performed using both fixed- and random-effects models in RevMan. The study protocol was registered in PROSPERO (CRD420251103338). Discussions: Ten RCTs (n = 881) assessing depression did not show consistent benefits (SMD = –0.72; 95% CI: –1.42 to –0.01; p-value = 0.05; I² = 96%). Six RCTs (n = 444) evaluating stress also showed non-significant effects (MD = –1.35; 95% CI: –3.70 to 1.01; p-value = 0.26; I² = 73%). Conversely, six RCTs (n = 376) demonstrated significant improvements in mood (MD = 0.73; 95% CI: 0.25 to 1.20; p-value = 0.003; I² = 75%). Meta-regression indicated that larger sample sizes were associated with more consistent improvements in mood (p-value = 0.04). Sensitivity analyses confirmed the stability of the findings, and no evidence of publication bias was detected. Conclusions: Probiotic, prebiotic, and synbiotic supplementation may provide beneficial effects on mood and could serve as a potential nutritional intervention to enhance psychological health. However, effects on depression and stress inconsistent.